{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:33:04Z","timestamp":1794083584967,"version":"4.8.0"},"reference-count":43,"publisher":"Royal Society of Chemistry (RSC)","issue":"20","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"am","delay-in-days":579,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803466"],"award-info":[{"award-number":["81803466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515012525"],"award-info":[{"award-number":["2021A1515012525"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>\n                    MIL-100(Fe) nanoparticles integrated microneedles were employed to codeliver the hydrophobic photosensitizer zinc phthalocyanine (ZnPc) and the chemotherapeutical drug doxorubicin hydrochlorate (Dox) (Z\/D@MOF) for O\n                    <jats:sub>2<\/jats:sub>\n                    -evolving chemophototherapy.\n                  <\/jats:p>","DOI":"10.1039\/d1bm00888a","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T02:44:35Z","timestamp":1627958675000},"page":"6772-6786","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Microneedle-mediated delivery of MIL-100(Fe) as a tumor microenvironment-responsive biodegradable nanoplatform for O\n                    <sub>2<\/sub>\n                    -evolving chemophototherapy"],"prefix":"10.1039","volume":"9","author":[{"given":"Sulan","family":"Luo","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 51006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 51006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 51006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixian","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 51006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilan","family":"Quan","sequence":"additional","affiliation":[{"name":"Guangzhou Neworld Micnanobio Pharmatech Co., Ltd, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguo","family":"Wen","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology, Chongqing Innovation Center, Chongqing 401120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-2780","authenticated-orcid":false,"given":"Xin","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 51006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1661-0201","authenticated-orcid":false,"given":"Chuanbin","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangzhou Neworld Micnanobio Pharmatech Co., Ltd, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1BM00888A\/cit1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","volume":"90","author":"Dougherty","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"D1BM00888A\/cit2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1470-2045(04)01529-3","volume":"5","author":"Brown","year":"2004","journal-title":"Lancet Oncol."},{"key":"D1BM00888A\/cit3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nrc1071","volume":"3","author":"Dolmans","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"D1BM00888A\/cit4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3322\/caac.20114","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA-Cancer J. Clin."},{"key":"D1BM00888A\/cit5","doi-asserted-by":"crossref","first-page":"1900132","DOI":"10.1002\/adhm.201900132","volume":"8","author":"Lan","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"D1BM00888A\/cit6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jcis.2017.01.053","volume":"494","author":"Hou","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"D1BM00888A\/cit7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1634\/theoncologist.9-90005-10","volume":"9","author":"Vaupel","year":"2004","journal-title":"Oncologist"},{"key":"D1BM00888A\/cit8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1126\/science.aad0862","volume":"349","author":"Rivera","year":"2015","journal-title":"Science"},{"key":"D1BM00888A\/cit9","doi-asserted-by":"crossref","first-page":"119578","DOI":"10.1016\/j.biomaterials.2019.119578","volume":"228","author":"Sahu","year":"2020","journal-title":"Biomaterials"},{"key":"D1BM00888A\/cit10","doi-asserted-by":"crossref","first-page":"11936","DOI":"10.1021\/acsnano.8b03007","volume":"12","author":"Tham","year":"2018","journal-title":"ACS Nano"},{"key":"D1BM00888A\/cit11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.07.002","volume":"104","author":"Dai","year":"2016","journal-title":"Biomaterials"},{"key":"D1BM00888A\/cit12","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.2147\/IJN.S179226","volume":"13","author":"Huang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"D1BM00888A\/cit13","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.7150\/thno.25409","volume":"8","author":"Luo","year":"2018","journal-title":"Theranostics"},{"key":"D1BM00888A\/cit14","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s11095-016-1958-5","volume":"33","author":"Bobo","year":"2016","journal-title":"Pharm. Res."},{"key":"D1BM00888A\/cit15","doi-asserted-by":"crossref","first-page":"22985","DOI":"10.1021\/acsami.8b07090","volume":"10","author":"Li","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1BM00888A\/cit16","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1039\/C8TB00334C","volume":"6","author":"Gui","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D1BM00888A\/cit17","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.7150\/thno.44194","volume":"10","author":"Qin","year":"2020","journal-title":"Theranostics"},{"key":"D1BM00888A\/cit18","doi-asserted-by":"crossref","first-page":"e1707365","DOI":"10.1002\/adma.201707365","volume":"30","author":"Simon-Yarza","year":"2018","journal-title":"Adv. Mater."},{"key":"D1BM00888A\/cit19","doi-asserted-by":"crossref","first-page":"e1707634","DOI":"10.1002\/adma.201707634","volume":"30","author":"Lu","year":"2018","journal-title":"Adv. Mater."},{"key":"D1BM00888A\/cit20","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1021\/cr200256v","volume":"112","author":"Horcajada","year":"2012","journal-title":"Chem. Rev."},{"key":"D1BM00888A\/cit21","doi-asserted-by":"crossref","first-page":"1606134","DOI":"10.1002\/adma.201606134","volume":"29","author":"Wu","year":"2017","journal-title":"Adv. Mater."},{"key":"D1BM00888A\/cit22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.biomaterials.2017.01.025","volume":"123","author":"Wuttke","year":"2017","journal-title":"Biomaterials"},{"key":"D1BM00888A\/cit23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1039\/C0CS00042F","volume":"40","author":"Carn\u00e9","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"D1BM00888A\/cit24","doi-asserted-by":"crossref","first-page":"18287","DOI":"10.1021\/jp906429s","volume":"113","author":"Babarao","year":"2009","journal-title":"J. Phys. Chem. C"},{"key":"D1BM00888A\/cit25","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1021\/acsami.6b14446","volume":"9","author":"Liu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1BM00888A\/cit26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.biomaterials.2017.07.026","volume":"142","author":"Li","year":"2017","journal-title":"Biomaterials"},{"key":"D1BM00888A\/cit27","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1021\/jacs.8b01072","volume":"140","author":"Lan","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D1BM00888A\/cit28","doi-asserted-by":"crossref","first-page":"24638","DOI":"10.1021\/acsami.8b07570","volume":"10","author":"Liu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1BM00888A\/cit29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biomaterials.2018.06.007","volume":"178","author":"Gao","year":"2018","journal-title":"Biomaterials"},{"key":"D1BM00888A\/cit30","doi-asserted-by":"crossref","first-page":"119636","DOI":"10.1016\/j.biomaterials.2019.119636","volume":"230","author":"An","year":"2020","journal-title":"Biomaterials"},{"key":"D1BM00888A\/cit31","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.1039\/b704325b","author":"Horcajada","year":"2007","journal-title":"Chem. Commun."},{"key":"D1BM00888A\/cit32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/10717541003667798","volume":"17","author":"Donnelly","year":"2010","journal-title":"Drug Delivery"},{"key":"D1BM00888A\/cit33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jconrel.2009.10.016","volume":"141","author":"Cevc","year":"2010","journal-title":"J. Controlled Release"},{"key":"D1BM00888A\/cit34","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jconrel.2012.01.042","volume":"161","author":"van der Maaden","year":"2012","journal-title":"J. Controlled Release"},{"key":"D1BM00888A\/cit35","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.addr.2012.04.005","volume":"64","author":"Kim","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"D1BM00888A\/cit36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1021\/acsnano.5b05043","volume":"10","author":"Chen","year":"2016","journal-title":"ACS Nano"},{"key":"D1BM00888A\/cit37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.actbio.2019.12.037","volume":"104","author":"Yang","year":"2020","journal-title":"Acta Biomater."},{"key":"D1BM00888A\/cit38","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.apsb.2020.07.025","volume":"10","author":"Wu","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"D1BM00888A\/cit39","doi-asserted-by":"crossref","first-page":"1707519","DOI":"10.1002\/adfm.201707519","volume":"28","author":"Hu","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"D1BM00888A\/cit40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biomaterials.2016.08.039","volume":"107","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"D1BM00888A\/cit41","doi-asserted-by":"crossref","first-page":"34209","DOI":"10.1021\/acsami.6b11378","volume":"8","author":"Zhu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1BM00888A\/cit42","doi-asserted-by":"crossref","first-page":"1700847","DOI":"10.1002\/advs.201700847","volume":"5","author":"Yang","year":"2018","journal-title":"Adv. Sci."},{"key":"D1BM00888A\/cit43","doi-asserted-by":"crossref","first-page":"9804","DOI":"10.1021\/acsami.8b21820","volume":"11","author":"Lan","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"}],"updated-by":[{"DOI":"10.1039\/d1bm90094c","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000}}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/BM\/D1BM00888A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:13:24Z","timestamp":1782929604000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/9\/20\/6772-6786\/716020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":43,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,10,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d1bm00888a","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}