{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:03:07Z","timestamp":1783472587388,"version":"3.55.0"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"am","delay-in-days":565,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-III-P4-ID-PCCF-2016-0142"],"award-info":[{"award-number":["PN-III-P4-ID-PCCF-2016-0142"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>This work presents novel phototheranostic protein nanoagents loaded with a newly synthesized deep red dye, revealing fluorescence imaging, photothermal and photodynamic features simultaneously upon targeted internalization within ovarian cancer cells.<\/jats:p>","DOI":"10.1039\/d1bm01002f","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T07:32:05Z","timestamp":1626852725000},"page":"6183-6202","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antibody-functionalized theranostic protein nanoparticles for the synergistic deep red fluorescence imaging and multimodal therapy of ovarian cancer"],"prefix":"10.1039","volume":"9","author":[{"given":"Raluca","family":"Borlan","sequence":"first","affiliation":[{"name":"Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"},{"name":"Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6735-5146","authenticated-orcid":false,"given":"Monica","family":"Focsan","sequence":"additional","affiliation":[{"name":"Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Perde-Schrepler","sequence":"additional","affiliation":[{"name":"Department of Radiobiology and Tumor Biology, Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Soritau","sequence":"additional","affiliation":[{"name":"Department of Radiobiology and Tumor Biology, Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Campu","sequence":"additional","affiliation":[{"name":"Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Gaina","sequence":"additional","affiliation":[{"name":"The Research Centre on Fundamental and Applied Heterochemistry, Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emoke","family":"Pall","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Pathology, Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Cluj, Romania"},{"name":"Department of Pathology, University of Medicine and Pharmacy Iuliu Ha\u0163ieganu, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Baldasici","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics, Proteomics and Experimental Pathology, Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gherman","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics, Proteomics and Experimental Pathology, Oncology Institute Prof. Dr Ion Chiricuta, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Stoia","sequence":"additional","affiliation":[{"name":"Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-6544","authenticated-orcid":false,"given":"Dana","family":"Maniu","sequence":"additional","affiliation":[{"name":"Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"},{"name":"Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-5651","authenticated-orcid":false,"given":"Simion","family":"Astilean","sequence":"additional","affiliation":[{"name":"Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"},{"name":"Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"issue":"4","key":"D1BM01002F\/cit1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3390\/jcm9041185","volume":"9","author":"Baydoun","year":"2020","journal-title":"J. Clin. Med."},{"key":"D1BM01002F\/cit2","author":"Roser","unstructured":"M.Roser and H.Ritchie , Cancer. Our World in Data [Internet]. 2015 Jul 3 [cited 2021 Jan 13]; Available from: https:\/\/ourworldindata.org\/cancer"},{"issue":"5","key":"D1BM01002F\/cit3","first-page":"181","volume":"33","author":"Copur","year":"2019","journal-title":"Oncology"},{"issue":"2","key":"D1BM01002F\/cit4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.maturitas.2013.11.009","volume":"77","author":"Schmid","year":"2014","journal-title":"Maturitas"},{"issue":"12","key":"D1BM01002F\/cit5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1684\/bdc.2014.1977","volume":"101","author":"Aza\u00efs","year":"2014","journal-title":"Bull. Cancer"},{"issue":"1\u20132","key":"D1BM01002F\/cit6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijpharm.2018.03.020","volume":"542","author":"Alves","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"5","key":"D1BM01002F\/cit7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ddr.21532","volume":"80","author":"Silindir-Gunay","year":"2019","journal-title":"Drug Dev. Res."},{"issue":"2","key":"D1BM01002F\/cit8","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.3390\/cancers3022516","volume":"3","author":"Mroz","year":"2011","journal-title":"Cancers"},{"issue":"25","key":"D1BM01002F\/cit9","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1002\/anie.201916430","volume":"59","author":"Chen","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1BM01002F\/cit10","doi-asserted-by":"crossref","first-page":"111213","DOI":"10.1016\/j.colsurfb.2020.111213","volume":"194","author":"Campu","year":"2020","journal-title":"Colloids Surf., B"},{"key":"D1BM01002F\/cit11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pdpdt.2018.01.008","volume":"21","author":"Ruhi","year":"2018","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"12","key":"D1BM01002F\/cit12","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1021\/acsbiomaterials.7b00480","volume":"3","author":"Pan","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"4","key":"D1BM01002F\/cit13","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1021\/ja511420n","volume":"137","author":"Chen","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"D1BM01002F\/cit14","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3390\/nano9091329","volume":"9","author":"Sandra","year":"2019","journal-title":"Nanomaterials"},{"issue":"2","key":"D1BM01002F\/cit15","doi-asserted-by":"crossref","first-page":"188308","DOI":"10.1016\/j.bbcan.2019.07.003","volume":"1872","author":"Donohoe","year":"2019","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"D1BM01002F\/cit16","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.2147\/IJN.S295234","volume":"16","author":"Borlan","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"D1BM01002F\/cit17","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.bmc.2017.02.061","volume":"25","author":"Haque","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"D1BM01002F\/cit18","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/cm2028367","volume":"24","author":"Pansare","year":"2012","journal-title":"Chem. Mater."},{"issue":"2","key":"D1BM01002F\/cit19","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1002\/bjs.9713","volume":"102","author":"de Boer","year":"2015","journal-title":"Br. J. Surg."},{"issue":"10","key":"D1BM01002F\/cit20","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1016\/j.biomaterials.2014.01.004","volume":"35","author":"Yu","year":"2014","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"D1BM01002F\/cit21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijpharm.2018.09.019","volume":"551","author":"Sarcan","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"40","key":"D1BM01002F\/cit22","doi-asserted-by":"crossref","first-page":"405701","DOI":"10.1088\/1361-6528\/ab2d90","volume":"30","author":"Campu","year":"2019","journal-title":"Nanotechnology"},{"issue":"8","key":"D1BM01002F\/cit23","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1021\/acsami.8b21269","volume":"11","author":"Suarasan","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"D1BM01002F\/cit24","doi-asserted-by":"crossref","first-page":"022002","DOI":"10.1088\/2050-6120\/aa8f57","volume":"6","author":"Rampazzo","year":"2018","journal-title":"Methods Appl. Fluoresc."},{"key":"D1BM01002F\/cit25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jcis.2019.05.050","volume":"552","author":"Zaharie-Butucel","year":"2019","journal-title":"J. Colloid Interface Sci."},{"issue":"9","key":"D1BM01002F\/cit26","doi-asserted-by":"crossref","first-page":"9249","DOI":"10.1021\/acsnano.7b04472","volume":"11","author":"Hu","year":"2017","journal-title":"ACS Nano"},{"issue":"1","key":"D1BM01002F\/cit27","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41467-020-20566-6","volume":"12","author":"Xiang","year":"2021","journal-title":"Nat. Commun."},{"issue":"55","key":"D1BM01002F\/cit28","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1039\/c3cc43633k","volume":"49","author":"Liu","year":"2013","journal-title":"Chem. Commun."},{"issue":"45","key":"D1BM01002F\/cit29","doi-asserted-by":"crossref","first-page":"39249","DOI":"10.1021\/acsami.7b14076","volume":"9","author":"Zhu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"31","key":"D1BM01002F\/cit30","doi-asserted-by":"crossref","first-page":"315102","DOI":"10.1088\/1361-6528\/ab8b90","volume":"31","author":"Borlan","year":"2020","journal-title":"Nanotechnology"},{"key":"D1BM01002F\/cit31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3389\/fphar.2019.01264","volume":"10","author":"Madamsetty","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"D1BM01002F\/cit32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1477-3155-10-36","volume":"10","author":"Cohen","year":"2012","journal-title":"J. Nanobiotechnol."},{"key":"D1BM01002F\/cit33","first-page":"394","volume-title":"Drug delivery nanoparticles formulation and characterization","year":"2009","unstructured":"Drug delivery nanoparticles formulation and characterization , ed. Y. Pathak and D. Thassu , Informa Healthcare , New York , 2009 , p. 394 . (Drugs and the pharmaceutical sciences)"},{"key":"D1BM01002F\/cit34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.actbio.2017.04.017","volume":"61","author":"Wang","year":"2017","journal-title":"Acta Biomater."},{"issue":"1","key":"D1BM01002F\/cit35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1364\/BOE.7.000132","volume":"7","author":"Khalid","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"D1BM01002F\/cit36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.foodhyd.2014.10.004","volume":"44","author":"Penalva","year":"2015","journal-title":"Food Hydrocolloids"},{"key":"D1BM01002F\/cit37","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.2147\/IJN.S131295","volume":"12","author":"Yu","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"D1BM01002F\/cit38","first-page":"970","volume-title":"Supramolecular photosensitive and electroactive materials","year":"2001","unstructured":"Supramolecular photosensitive and electroactive materials , ed. H. S. Nalwa , Academic Press , San Diego, CA , 2001 , p. 970"},{"issue":"1","key":"D1BM01002F\/cit39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20892\/j.issn.2095-3941.2016.0084","volume":"14","author":"Brett","year":"2017","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"D1BM01002F\/cit40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/bjc.1988.174","volume":"58","author":"Workman","year":"1988","journal-title":"Br. J. Cancer"},{"issue":"11","key":"D1BM01002F\/cit41","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/sj.bjc.6605642","volume":"102","author":"An ad hoc committee of the National Cancer Research Institute","year":"2010","journal-title":"Br. J. Cancer"},{"key":"D1BM01002F\/cit42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ccr.2017.10.006","volume":"379","author":"Wong","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"D1BM01002F\/cit43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccr.2017.08.003","volume":"379","author":"Li","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"D1BM01002F\/cit44","doi-asserted-by":"crossref","first-page":"213548","DOI":"10.1016\/j.ccr.2020.213548","volume":"426","author":"Zheng","year":"2021","journal-title":"Coord. Chem. Rev."},{"issue":"13\u201314","key":"D1BM01002F\/cit45","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.ccr.2006.11.011","volume":"251","author":"Nyokong","year":"2007","journal-title":"Coord. Chem. Rev."},{"key":"D1BM01002F\/cit46","doi-asserted-by":"crossref","first-page":"120271","DOI":"10.1016\/j.ica.2021.120271","volume":"519","author":"Pereira","year":"2021","journal-title":"Inorg. Chim. Acta"},{"key":"D1BM01002F\/cit47","doi-asserted-by":"crossref","first-page":"213233","DOI":"10.1016\/j.ccr.2020.213233","volume":"411","author":"Chinna Ayya Swamy","year":"2020","journal-title":"Coord. Chem. Rev."},{"issue":"15\u201316","key":"D1BM01002F\/cit48","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.ccr.2012.03.022","volume":"256","author":"Ishii","year":"2012","journal-title":"Coord. Chem. Rev."},{"issue":"1","key":"D1BM01002F\/cit49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7150\/thno.7193","volume":"4","author":"Kobayashi","year":"2014","journal-title":"Theranostics"},{"issue":"29","key":"D1BM01002F\/cit50","doi-asserted-by":"crossref","first-page":"9972","DOI":"10.1021\/jacs.7b04263","volume":"139","author":"Jung","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D1BM01002F\/cit51","unstructured":"Molecular weight and isoelectric point of various immunoglobulins [Internet]. [cited 2021 Feb 8]. Available from: https:\/\/www.agrisera.com\/en\/info\/molecular-weight-and-isoelectric-point-of-various-immunoglobulins.html"},{"issue":"2","key":"D1BM01002F\/cit52","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0006-3495(02)75240-5","volume":"83","author":"Kuwana","year":"2002","journal-title":"Biophys. J."},{"issue":"6","key":"D1BM01002F\/cit53","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1039\/b108831a","volume":"1","author":"Lacey","year":"2002","journal-title":"Photochem. Photobiol. Sci."},{"issue":"2","key":"D1BM01002F\/cit54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejps.2004.06.004","volume":"23","author":"Sibata","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"issue":"47","key":"D1BM01002F\/cit55","doi-asserted-by":"crossref","first-page":"37943","DOI":"10.1039\/C5RA05125H","volume":"5","author":"Doshi","year":"2015","journal-title":"RSC Adv."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/BM\/D1BM01002F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:45:56Z","timestamp":1782884756000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/9\/18\/6183-6202\/716043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":55,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d1bm01002f","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}