{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:08:45Z","timestamp":1792516125171,"version":"4.5.0"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"20","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"am","delay-in-days":623,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201908210332"],"award-info":[{"award-number":["201908210332"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>We report a novel 3D urothelial clusteroid\/fungal biofilm co-culture model for the advanced testing of antifungal nanotechnologies.<\/jats:p>","DOI":"10.1039\/d1bm01035b","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T05:03:59Z","timestamp":1631768639000},"page":"6927-6939","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Enhanced clearing of\n                    <i>Candida<\/i>\n                    biofilms on a 3D urothelial cell\n                    <i>in vitro<\/i>\n                    model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles"],"prefix":"10.1039","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6616-2828","authenticated-orcid":false,"given":"Anheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Hull, Cottingham Road, Hull, HU67RX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1791-5659","authenticated-orcid":false,"given":"Paul J.","family":"Weldrick","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Hull, Cottingham Road, Hull, HU67RX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-1147","authenticated-orcid":false,"given":"Leigh A.","family":"Madden","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Hull, Hull, HU67RX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-1681","authenticated-orcid":false,"given":"Vesselin N.","family":"Paunov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Nazarbayev University, 53 Kabanbay Batyr Avenue, Nursultan city, 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1BM01035B\/cit1","doi-asserted-by":"crossref","first-page":"e000487","DOI":"10.1136\/bmjpo-2019-000487","volume":"3","author":"Kaufman","year":"2019","journal-title":"BMJ Paediatr. Open"},{"key":"D1BM01035B\/cit2","first-page":"66","volume":"19","author":"Yousefi","year":"2011","journal-title":"J. Adv. Med. Biomed. Res."},{"key":"D1BM01035B\/cit3","doi-asserted-by":"crossref","first-page":"ITC49","DOI":"10.7326\/AITC201710030","volume":"167","author":"Gupta","year":"2017","journal-title":"Ann. Intern. Med."},{"issue":"Suppl 1","key":"D1BM01035B\/cit4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/46.suppl_1.1","volume":"46","author":"Hooton","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"D1BM01035B\/cit5","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","volume":"52","author":"Gupta","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"D1BM01035B\/cit6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.11622\/smedj.2016153","volume":"57","author":"Tan","year":"2016","journal-title":"Singapore Med. J."},{"key":"D1BM01035B\/cit7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0195-6701(00)90821-1","volume":"46","author":"Wagenlehner","year":"2000","journal-title":"J. Hosp. Infect."},{"key":"D1BM01035B\/cit8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/00006454-199702000-00005","volume":"16","author":"Phillips","year":"1997","journal-title":"Pediatr. Infect. Dis. J."},{"key":"D1BM01035B\/cit9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4037\/ajcc2009938","volume":"18","author":"Elpern","year":"2009","journal-title":"Am. J. Crit. Care"},{"key":"D1BM01035B\/cit10","first-page":"1478","volume":"6","author":"Niveditha","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"D1BM01035B\/cit11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/lam.13144","volume":"68","author":"Pelling","year":"2019","journal-title":"Lett. Appl. Microbiol."},{"key":"D1BM01035B\/cit12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s003450050159","volume":"17","author":"Morris","year":"1999","journal-title":"World J. Urol."},{"key":"D1BM01035B\/cit13","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1128\/iai.62.3.915-921.1994","volume":"62","author":"Hawser","year":"1994","journal-title":"Infect. Immun."},{"key":"D1BM01035B\/cit14","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1128\/JB.183.18.5385-5394.2001","volume":"183","author":"Chandra","year":"2001","journal-title":"J. Bacteriol."},{"key":"D1BM01035B\/cit15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrd1008","volume":"2","author":"Davies","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D1BM01035B\/cit16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.micro.54.1.49","volume":"54","author":"O'Toole","year":"2000","journal-title":"Annu. Rev. Microbiol."},{"key":"D1BM01035B\/cit17","first-page":"1288","volume":"54","author":"Trulear","year":"1982","journal-title":"J. \u2013 Water Pollut. Control Fed."},{"key":"D1BM01035B\/cit18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","volume":"45","author":"Lewis","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"D1BM01035B\/cit19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"D1BM01035B\/cit20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2217\/fmb-2019-0327","volume":"15","author":"Robino","year":"2020","journal-title":"Future Microbiol."},{"key":"D1BM01035B\/cit21","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1039\/C7CS00807D","volume":"48","author":"Liu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"D1BM01035B\/cit22","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1039\/C3NR04270G","volume":"6","author":"Taylor","year":"2014","journal-title":"Nanoscale"},{"key":"D1BM01035B\/cit23","first-page":"707","volume":"113","author":"Haghighi","year":"2012","journal-title":"Bratisl. Lek. Listy"},{"key":"D1BM01035B\/cit24","first-page":"4053","volume":"7","author":"Abdelghany","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"D1BM01035B\/cit25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fchem.2019.00742","volume":"7","author":"Qvortrup","year":"2019","journal-title":"Front. Chem."},{"key":"D1BM01035B\/cit26","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1039\/D0QM00874E","volume":"5","author":"Weldrick","year":"2021","journal-title":"Mater. Chem. Front."},{"key":"D1BM01035B\/cit27","doi-asserted-by":"crossref","first-page":"22182","DOI":"10.1021\/acsami.1c02679","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1BM01035B\/cit28","doi-asserted-by":"crossref","first-page":"43902","DOI":"10.1021\/acsami.9b16119","volume":"11","author":"Weldrick","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1BM01035B\/cit29","doi-asserted-by":"crossref","first-page":"12232","DOI":"10.1021\/acsami.8b21862","volume":"11","author":"Halbus","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1BM01035B\/cit30","doi-asserted-by":"crossref","first-page":"10472","DOI":"10.1039\/C8NR10022E","volume":"11","author":"Weldrick","year":"2019","journal-title":"Nanoscale"},{"key":"D1BM01035B\/cit31","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tcb.2011.09.005","volume":"21","author":"Huh","year":"2011","journal-title":"Trends Cell Biol."},{"key":"D1BM01035B\/cit32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jcp.24683","volume":"230","author":"Ravi","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"D1BM01035B\/cit33","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1039\/C7BM00261K","volume":"5","author":"Chaudhuri","year":"2017","journal-title":"Biomater. Sci."},{"key":"D1BM01035B\/cit34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.copbio.2015.05.002","volume":"35","author":"van Duinen","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"D1BM01035B\/cit35","doi-asserted-by":"crossref","first-page":"10487","DOI":"10.1039\/D0TB01658F","volume":"8","author":"Wang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"D1BM01035B\/cit36","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1039\/C7MH00677B","volume":"4","author":"Das","year":"2017","journal-title":"Mater. Horiz."},{"key":"D1BM01035B\/cit37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/biomimetics4030050","volume":"4","author":"Celik","year":"2019","journal-title":"Biomimetics"},{"key":"D1BM01035B\/cit38","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1039\/D0MA00635A","volume":"1","author":"Wang","year":"2020","journal-title":"Mater. Adv."},{"key":"D1BM01035B\/cit39","doi-asserted-by":"crossref","first-page":"e01067","DOI":"10.1016\/j.heliyon.2018.e01067","volume":"4","author":"Khatoon","year":"2018","journal-title":"Heliyon"},{"key":"D1BM01035B\/cit40","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1177\/0954411914556137","volume":"228","author":"Veerachamy","year":"2014","journal-title":"Proc. Inst. Mech. Eng., Part H"},{"key":"D1BM01035B\/cit41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1128\/AAC.00669-09","volume":"54","author":"Fu","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"D1BM01035B\/cit42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2672.1995.tb03128.x","volume":"79","author":"Hodgson","year":"1995","journal-title":"J. Appl. Bacteriol."},{"key":"D1BM01035B\/cit43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1053\/jhin.2002.1320","volume":"53","author":"Marion-Ferey","year":"2003","journal-title":"J. Hosp. Infect."},{"key":"D1BM01035B\/cit44","first-page":"337","volume":"6","author":"Badet","year":"2008","journal-title":"Oral Health Prev. Dent."},{"key":"D1BM01035B\/cit45","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/jac\/dkq105","volume":"65","author":"Hill","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"D1BM01035B\/cit46","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1039\/C8NA00121A","volume":"1","author":"Al-Obaidy","year":"2019","journal-title":"Nanoscale Adv."},{"key":"D1BM01035B\/cit47","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1039\/C8TB03102A","volume":"7","author":"Al-Obaidy","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"D1BM01035B\/cit48","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nnano.2015.141","volume":"10","author":"Richter","year":"2015","journal-title":"Nat. Nanotechnol."},{"key":"D1BM01035B\/cit49","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.1039\/C7TB02262J","volume":"5","author":"Al-Awady","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"D1BM01035B\/cit50","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1039\/C8QM00343B","volume":"2","author":"Al-Awady","year":"2018","journal-title":"Mater. Chem. Front."},{"key":"D1BM01035B\/cit51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomimetics4020041","volume":"4","author":"Halbus","year":"2019","journal-title":"Biomimetics"},{"key":"D1BM01035B\/cit52","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1039\/C9NA00099B","volume":"1","author":"Halbus","year":"2019","journal-title":"Nanoscale Adv."},{"key":"D1BM01035B\/cit53","doi-asserted-by":"crossref","first-page":"37044","DOI":"10.1039\/C5RA05577F","volume":"5","author":"Al-Awady","year":"2015","journal-title":"RSC Adv."},{"key":"D1BM01035B\/cit54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0167-7012(00)00241-4","volume":"44","author":"Herigstad","year":"2001","journal-title":"J. Microbiol. Methods"},{"key":"D1BM01035B\/cit55","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1440-1711.1999.00877.x","volume":"77","author":"Parish","year":"1999","journal-title":"Immunol. Cell Biol."},{"key":"D1BM01035B\/cit56","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1471-2180-6-92","volume":"6","author":"Tuominen-Gustafsson","year":"2006","journal-title":"BMC Microbiol."},{"key":"D1BM01035B\/cit57","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0167-7012(02)00207-5","volume":"52","author":"Hoefel","year":"2003","journal-title":"J. Microbiol. Methods"},{"key":"D1BM01035B\/cit58","doi-asserted-by":"crossref","first-page":"2000027","DOI":"10.1002\/anbr.202000027","volume":"1","author":"Weldrick","year":"2021","journal-title":"Adv. Nanobiomed. Res."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/BM\/D1BM01035B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:58:12Z","timestamp":1782849492000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/9\/20\/6927-6939\/716051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":58,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,10,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d1bm01035b","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}