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Sci."],"abstract":"<jats:p>\n                    In this work we describe the preparation and characterization of lecithin\u2013chitosan nanoparticles (L\n                    <jats:sub>10<\/jats:sub>\n                    C\n                    <jats:sub>i<\/jats:sub>\n                    <jats:sup>+<\/jats:sup>\n                    ), and investigate their ability to deliver the anti-epileptic drug phenytoin (PHT) to mouse brain following intranasal (IN) administration.\n                  <\/jats:p>","DOI":"10.1039\/d1bm01251g","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T13:21:26Z","timestamp":1633008086000},"page":"7547-7564","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model"],"prefix":"10.1039","volume":"9","author":[{"given":"Amal","family":"Yousfan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Rubio","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Materials, Imperial College London, SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Al-Ali","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Hakim","family":"Nattouf","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-2124","authenticated-orcid":false,"given":"Houmam","family":"Kafa","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1BM01251G\/cit1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.seizure.2018.02.002","volume":"56","author":"Espinosa-Jovel","year":"2018","journal-title":"Seizure"},{"key":"D1BM01251G\/cit2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/epi.14458","volume":"60","author":"Trinka","year":"2019","journal-title":"Epilepsia"},{"issue":"4","key":"D1BM01251G\/cit3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.yebeh.2010.09.001","volume":"19","author":"McAuley","year":"2010","journal-title":"Epilepsy Behav."},{"issue":"6","key":"D1BM01251G\/cit4","doi-asserted-by":"crossref","first-page":"a022426","DOI":"10.1101\/cshperspect.a022426","volume":"5","author":"Stafstrom","year":"2015","journal-title":"Cold Spring Harbor Perspect. 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