{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:12:11Z","timestamp":1788930731103,"version":"build-2803163510"},"reference-count":37,"publisher":"Royal Society of Chemistry (RSC)","issue":"27","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"am","delay-in-days":527,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100014434","name":"Narodowa Agencja Wymiany Akademickiej","doi-asserted-by":"crossref","award":["PPN\/BIL\/2018\/1\/00150"],"award-info":[{"award-number":["PPN\/BIL\/2018\/1\/00150"]}],"id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"crossref","award":["2018\/31\/F\/NZ5\/03454"],"award-info":[{"award-number":["2018\/31\/F\/NZ5\/03454"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"crossref","award":["685451"],"award-info":[{"award-number":["685451"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"crossref","award":["CA17140"],"award-info":[{"award-number":["CA17140"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","award":["B2017\/BMD-3703"],"award-info":[{"award-number":["B2017\/BMD-3703"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","award":["SBPLY\/17\/180501\/000358"],"award-info":[{"award-number":["SBPLY\/17\/180501\/000358"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","award":["CTQ2017-86224-P"],"award-info":[{"award-number":["CTQ2017-86224-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<p>\n                    A new family of cationic ruthenium(\n                    <sc>ii<\/sc>\n                    ) metallodendrimers of a carbosilane nature with the metal centre coordinated to 2-aminopyridine ligands have been synthesized and interacted with conventional anticancer drugs.\n                  <\/p>","DOI":"10.1039\/d1dt01388b","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T07:24:00Z","timestamp":1623482640000},"page":"9500-9511","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Combined therapy of ruthenium dendrimers and anti-cancer drugs against human leukemic cells"],"prefix":"10.1039","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8952-469X","authenticated-orcid":false,"given":"Sylwia","family":"Michlewska","sequence":"first","affiliation":[{"name":"Laboratory of Microscopic Imaging & Specialized Biological Techniques. Faculty of Biology & Environmental Protection. University of Lodz"},{"name":"Lodz 90-237"},{"name":"Poland"},{"name":"Department of General Biophysics. Faculty of Biology & Environmental Protection. University of Lodz"},{"name":"Lodz 90-236"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Maroto","sequence":"additional","affiliation":[{"name":"Universidad de Alcal\u00e1. Department of Organic and Inorganic Chemistry"},{"name":"and Research Institute in Chemistry \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR)"},{"name":"Madrid"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Ho\u0142ota","sequence":"additional","affiliation":[{"name":"Department of General Biophysics. Faculty of Biology & Environmental Protection. University of Lodz"},{"name":"Lodz 90-236"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Kubczak","sequence":"additional","affiliation":[{"name":"Department of General Biophysics. Faculty of Biology & Environmental Protection. University of Lodz"},{"name":"Lodz 90-236"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sanz del Olmo","sequence":"additional","affiliation":[{"name":"Universidad de Alcal\u00e1. Department of Organic and Inorganic Chemistry"},{"name":"and Research Institute in Chemistry \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR)"},{"name":"Madrid"},{"name":"Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-5429","authenticated-orcid":false,"given":"Paula","family":"Ortega","sequence":"additional","affiliation":[{"name":"Universidad de Alcal\u00e1. Department of Organic and Inorganic Chemistry"},{"name":"and Research Institute in Chemistry \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR)"},{"name":"Madrid"},{"name":"Spain"},{"name":"Networking Research Center on Bioengineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-4465","authenticated-orcid":false,"given":"Dzmitry","family":"Shcharbin","sequence":"additional","affiliation":[{"name":"Institute of Biophysics & Cell Engineering of NASB"},{"name":"220072 Minsk"},{"name":"Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-3935","authenticated-orcid":false,"given":"Francisco Javier","family":"de la Mata","sequence":"additional","affiliation":[{"name":"Universidad de Alcal\u00e1. Department of Organic and Inorganic Chemistry"},{"name":"and Research Institute in Chemistry \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR)"},{"name":"Madrid"},{"name":"Spain"},{"name":"Networking Research Center on Bioengineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-3743","authenticated-orcid":false,"given":"Maria","family":"Bryszewska","sequence":"additional","affiliation":[{"name":"Department of General Biophysics. Faculty of Biology & Environmental Protection. University of Lodz"},{"name":"Lodz 90-236"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-6864","authenticated-orcid":false,"given":"Maksim","family":"Ionov","sequence":"additional","affiliation":[{"name":"Department of General Biophysics. Faculty of Biology & Environmental Protection. University of Lodz"},{"name":"Lodz 90-236"},{"name":"Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1DT01388B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0140-6736(14)62038-9","volume":"385","author":"Allemani","year":"2015","journal-title":"Lancet"},{"key":"D1DT01388B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.3324\/haematol.2020.247031","volume":"105","author":"Inaba","year":"2020","journal-title":"Haematologica"},{"key":"D1DT01388B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11912-020-01009-3","volume":"23","author":"Conneely","year":"2021","journal-title":"Curr. Oncol. Rep."},{"issue":"1","key":"D1DT01388B-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s11033-020-06073-3","volume":"48","author":"Fujita","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"D1DT01388B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbmt.2017.11.004","volume":"24","author":"Qayed","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"D1DT01388B-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11095-019-2654-z","volume":"36","author":"Chen","year":"2019","journal-title":"Pharm. Res."},{"key":"D1DT01388B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1158\/1078-0432.CCR-05-0622","volume":"11","author":"O'Hare","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"D1DT01388B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.critrevonc.2015.10.015","volume":"98","author":"Young","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"D1DT01388B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4103\/0975-7406.142963","volume":"6","author":"Khatri","year":"2014","journal-title":"J. Pharm. BioAllied Sci."},{"key":"D1DT01388B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ijpharm.2011.08.053","volume":"420","author":"Jin","year":"2011","journal-title":"Int. J. Pharm."},{"key":"D1DT01388B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijpharm.2016.09.002","volume":"513","author":"Zhang","year":"2016","journal-title":"Int. J. Pharm."},{"key":"D1DT01388B-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3390\/ijms16011772","volume":"16","author":"Wong","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"D1DT01388B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"50333","DOI":"10.18632\/oncotarget.10385","volume":"7","author":"Pagliara","year":"2016","journal-title":"Oncotarget"},{"key":"D1DT01388B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1039\/C4PY00601A","volume":"5","author":"Zhang","year":"2014","journal-title":"Polym. Chem."},{"key":"D1DT01388B-(cit15)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814487-9.00008-9","volume-title":"Drug Delivery Systems","author":"Patel","year":"2020","unstructured":"V. Patel  ,  C.Rajani ,  D.Paul ,  P.Borisa ,  K.Rajpoot ,  S. R.Youngren-Ortiz  and  R. K.Tekade , in  Drug Delivery Systems , ed.  R. K. Tekade ,  Academic Press ,  2020 , pp.  333\u2013392 ,  10.1016\/B978-0-12-814487-9.00008-9"},{"key":"D1DT01388B-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ijpharm.2018.07.030","volume":"548","author":"Sherje","year":"2018","journal-title":"Int. J. Pharm."},{"key":"D1DT01388B-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/biom9090411","volume":"9","author":"Michlewska","year":"2019","journal-title":"Biomolecules"},{"key":"D1DT01388B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1039\/C6DT00465B","volume":"45","author":"Maroto-Diaz","year":"2016","journal-title":"Dalton Trans."},{"key":"D1DT01388B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1021\/acs.chemrev.8b00271","volume":"119","author":"Kenny","year":"2019","journal-title":"Chem. Rev."},{"key":"D1DT01388B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"109176","DOI":"10.1016\/j.apradiso.2020.109176","volume":"162","author":"Zuba","year":"2020","journal-title":"Appl. Radiat. Isot."},{"key":"D1DT01388B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"772","DOI":"10.2174\/1389557515666151001142012","volume":"16","author":"Abid","year":"2016","journal-title":"Mini-Rev. Med. Chem."},{"key":"D1DT01388B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10793","DOI":"10.1039\/c1dt11007a","volume":"40","author":"Smith","year":"2011","journal-title":"Dalton Trans."},{"key":"D1DT01388B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jorganchem.2015.09.003","volume":"799\u2013800","author":"Govender","year":"2015","journal-title":"J. Organomet. Chem."},{"key":"D1DT01388B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1039\/C2DT31337E","volume":"42","author":"Govender","year":"2013","journal-title":"Dalton Trans."},{"key":"D1DT01388B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1039\/C0DT00761G","volume":"40","author":"Govender","year":"2011","journal-title":"Dalton Trans."},{"key":"D1DT01388B-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/ijms21114119","volume":"21","author":"Michlewska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D1DT01388B-(cit27)\/*[position()=1]","first-page":"8","volume":"12","author":"Sanz del Olmo","year":"2020","journal-title":"Pharmaceutics"},{"key":"D1DT01388B-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112414","DOI":"10.1016\/j.ejmech.2020.112414","volume":"199","author":"Sanz del Olmo","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D1DT01388B-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1371\/journal.pone.0242497","volume":"15","author":"Turk","year":"2020","journal-title":"PLoS One"},{"key":"D1DT01388B-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/ijms21249390","volume":"21","author":"Jedrzejczyk","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D1DT01388B-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1865086","DOI":"10.1080\/23723556.2020.1865086","volume":"8","author":"Lopez-Lopez","year":"2021","journal-title":"Mol. Cell. Oncol."},{"key":"D1DT01388B-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1007\/s11033-019-05017-w","volume":"46","author":"Dlugosz-Pokorska","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"D1DT01388B-(cit33)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1039\/9781849737296-00115","volume-title":"Dendrimers in Biomedical Applications","author":"Ottaviani","year":"2013","unstructured":"M. F. Ottaviani  ,  D.Appelhans ,  F. J.de la Mata ,  S.Garc\u00eda-Gallego ,  A.Fattori ,  C.Coppola ,  M.Cangiotti ,  L.Fiorani ,  J. P.Majoral ,  A. M.Caminade ,  M.Bryszewska ,  D. K.Smith ,  N.Garti  and  B.Klajnert , in  Dendrimers in Biomedical Applications ,  The Royal Society of Chemistry ,  2013 ,  pp. 115\u2013133 ,  10.1039\/9781849737296-00115"},{"issue":"12","key":"D1DT01388B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/cmdc.201402280","volume":"9","author":"Pavan","year":"2014","journal-title":"Chem. Med. Chem"},{"key":"D1DT01388B-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1039\/b205996g","volume":"32","author":"Ganter","year":"2003","journal-title":"Chem. Soc. Rev."},{"key":"D1DT01388B-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jinorgbio.2018.01.001","volume":"181","author":"Michlewska","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"D1DT01388B-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1016\/j.bbamem.2011.07.021","volume":"1808","author":"Ciolkowski","year":"2011","journal-title":"BBA, Biochim. Biophys. Acta, Biomembr."}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/DT\/D1DT01388B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:24:13Z","timestamp":1782879853000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/dt\/article\/50\/27\/9500-9511\/725189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":37,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2021,7,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d1dt01388b","relation":{},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Sylwia Michlewska (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-8952-469X","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Paula Ortega (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0377-5429","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Paula Ortega (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/K-3910-2014","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Dzmitry Shcharbin (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1414-4465","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Dzmitry Shcharbin (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/G-2046-2011","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Francisco Javier de la Mata (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0418-3935","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Maria Bryszewska (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4676-3743","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Maksim Ionov (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-7227-6864","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Maksim Ionov (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/N-1761-2018","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 26 April 2021; Accepted 11 June 2021;  Accepted Manuscript published 12 June 2021;  Advance Article published 18 June 2021;  Version of Record published 13 July 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}