{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:16:40Z","timestamp":1788524200427,"version":"build-2803163510"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"38","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"am","delay-in-days":589,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803356"],"award-info":[{"award-number":["81803356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017937","name":"Tianjin Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["20JCQNJC01810"],"award-info":[{"award-number":["20JCQNJC01810"]}],"id":[{"id":"10.13039\/100017937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017937","name":"Tianjin Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["20JCQNJC01390"],"award-info":[{"award-number":["20JCQNJC01390"]}],"id":[{"id":"10.13039\/100017937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017937","name":"Tianjin Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["19JCQNJC12200"],"award-info":[{"award-number":["19JCQNJC12200"]}],"id":[{"id":"10.13039\/100017937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["ZC20212"],"award-info":[{"award-number":["ZC20212"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<jats:p>\n                    Novel Cu(\n                    <jats:sc>ii<\/jats:sc>\n                    ) and Fe(\n                    <jats:sc>iii<\/jats:sc>\n                    ) complexes of (\n                    <jats:italic>Z<\/jats:italic>\n                    )-\n                    <jats:italic>N<\/jats:italic>\n                    \u2032-((\n                    <jats:italic>E<\/jats:italic>\n                    )-3-methyl-4-oxothiazolidin-2-ylidene)picolinohydrazonamide (L) as antitumor agents were designed and synthesized in order to explore DNA and serum albumin interaction.\n                  <\/jats:p>","DOI":"10.1039\/d1dt02180j","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T07:06:31Z","timestamp":1628838391000},"page":"13387-13398","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Synthesis, crystal structures, anticancer activities and molecular docking studies of novel thiazolidinone Cu(\n                    <scp>ii<\/scp>\n                    ) and Fe(\n                    <scp>iii<\/scp>\n                    ) complexes targeting lysosomes: special emphasis on their binding to DNA\/BSA"],"prefix":"10.1039","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-0537","authenticated-orcid":false,"given":"Jia","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Tianjin First Central Hospital, Tianjin 300192, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Nankai University, Tianjin 300071, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Yuchi","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug Targets and Drug Leads for Degenerative Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Qing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry, Nankai University, Tianjin 300071, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-1949","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tianjin First Central Hospital, Tianjin 300192, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical College of Nankai University, Tianjin 300071, P. R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tianjin First Central Hospital, Tianjin 300192, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xia","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-2504","authenticated-orcid":false,"given":"Jin-Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Chemistry, Nankai University, Tianjin 300071, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1DT02180J\/cit1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/cncr.31816","volume":"125","author":"Bauml","year":"2019","journal-title":"Cancer"},{"key":"D1DT02180J\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-021-00988-x","author":"Timmins","year":"2021","journal-title":"J. Cancer Surviv."},{"key":"D1DT02180J\/cit3","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1021\/acs.chemrev.8b00271","volume":"119","author":"Kenny","year":"2019","journal-title":"Chem. Rev."},{"key":"D1DT02180J\/cit4","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.ccr.2009.01.028","volume":"253","author":"Arnesano","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"D1DT02180J\/cit5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jinorgbio.2017.11.009","volume":"179","author":"Bisceglie","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"D1DT02180J\/cit6","doi-asserted-by":"crossref","first-page":"111357","DOI":"10.1016\/j.jinorgbio.2021.111357","volume":"217","author":"Barmpa","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"D1DT02180J\/cit7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1021\/acs.chemrestox.5b00471","volume":"29","author":"Wilson","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"D1DT02180J\/cit8","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.apsb.2021.01.013","volume":"11","author":"Hou","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D1DT02180J\/cit9","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1021\/jm0606342","volume":"49","author":"Richardson","year":"2006","journal-title":"J. Med. Chem."},{"key":"D1DT02180J\/cit10","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1039\/D0DT03566A","volume":"50","author":"Sequeira","year":"2021","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit11","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bbamcr.2016.01.026","volume":"1863","author":"Kalinowski","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"D1DT02180J\/cit12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/nyas.12953","volume":"1371","author":"Piao","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D1DT02180J\/cit13","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/onc.2012.292","volume":"32","author":"Kallunki","year":"2013","journal-title":"Oncogene"},{"key":"D1DT02180J\/cit14","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1089\/ars.2012.4885","volume":"18","author":"Terman","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"D1DT02180J\/cit15","doi-asserted-by":"crossref","first-page":"12702","DOI":"10.1021\/acsami.6b03422","volume":"8","author":"Qiu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1DT02180J\/cit16","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.bbamcr.2016.04.017","volume":"1863","author":"Gutierrez","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"D1DT02180J\/cit17","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1074\/jbc.M115.682450","volume":"291","author":"Seebacher","year":"2016","journal-title":"J. Biol. Chem."},{"key":"D1DT02180J\/cit18","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1021\/acs.jmedchem.6b00238","volume":"59","author":"Stacy","year":"2016","journal-title":"J. Med. Chem."},{"key":"D1DT02180J\/cit19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.18632\/aging.100910","volume":"8","author":"Kovacevic","year":"2016","journal-title":"Aging"},{"key":"D1DT02180J\/cit20","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.1021\/acs.jmedchem.6b01050","volume":"59","author":"Stacy","year":"2016","journal-title":"J. Med. Chem."},{"key":"D1DT02180J\/cit21","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1016\/j.bmc.2012.03.069","volume":"20","author":"Jain","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"D1DT02180J\/cit22","doi-asserted-by":"crossref","first-page":"127718","DOI":"10.1016\/j.bmcl.2020.127718","volume":"32","author":"Haroun","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D1DT02180J\/cit23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/35055085","volume":"3","author":"Degterev","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"D1DT02180J\/cit24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejmech.2018.07.075","volume":"157","author":"Song","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D1DT02180J\/cit25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jinorgbio.2014.03.004","volume":"136","author":"Shao","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"D1DT02180J\/cit26","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1039\/D0DT01527J","volume":"49","author":"Arjmand","year":"2020","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00578558","volume":"5","author":"Gullo","year":"1980","journal-title":"Cancer Chemother. Pharmacol."},{"key":"D1DT02180J\/cit28","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1039\/D0DT01343A","volume":"49","author":"Petrovi\u0107","year":"2020","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/bm801120k","volume":"10","author":"Hu","year":"2009","journal-title":"Biomacromolecules"},{"key":"D1DT02180J\/cit30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0006-291X(05)80083-X","volume":"173","author":"Hirayama","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D1DT02180J\/cit31","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.saa.2009.08.018","volume":"74","author":"Han","year":"2009","journal-title":"Spectrochim. Acta, Part A"},{"key":"D1DT02180J\/cit32","doi-asserted-by":"crossref","first-page":"16944","DOI":"10.1039\/C8DT03079K","volume":"47","author":"Hosseini-Kharat","year":"2018","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit33","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1021\/ic202141g","volume":"51","author":"Samari","year":"2012","journal-title":"Inorg. Chem."},{"key":"D1DT02180J\/cit34","doi-asserted-by":"crossref","first-page":"10121","DOI":"10.1039\/C7DT01685A","volume":"46","author":"Mahmudov","year":"2017","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ccr.2017.02.004","volume":"345","author":"Baker","year":"2017","journal-title":"Coord. Chem. Rev."},{"key":"D1DT02180J\/cit36","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1039\/C9QI00030E","volume":"6","author":"Wu","year":"2019","journal-title":"Inorg. Chem. Front."},{"key":"D1DT02180J\/cit37","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1039\/D0DT00209G","volume":"49","author":"Jain","year":"2020","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit38","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1039\/C4NJ00092G","volume":"38","author":"Zheng","year":"2014","journal-title":"New J. Chem."},{"key":"D1DT02180J\/cit39","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1039\/C7NJ00420F","volume":"41","author":"Martins","year":"2017","journal-title":"New J. Chem."},{"key":"D1DT02180J\/cit40","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1039\/C5RA20157H","volume":"6","author":"Palmucci","year":"2016","journal-title":"RSC Adv."},{"key":"D1DT02180J\/cit41","doi-asserted-by":"crossref","first-page":"51730","DOI":"10.1039\/C5RA06357D","volume":"5","author":"Zheng","year":"2015","journal-title":"RSC Adv."},{"key":"D1DT02180J\/cit42","doi-asserted-by":"crossref","first-page":"9516","DOI":"10.1039\/C5DT00931F","volume":"44","author":"Zhou","year":"2015","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit43","doi-asserted-by":"crossref","first-page":"17925","DOI":"10.1039\/C9DT03746B","volume":"48","author":"Yang","year":"2019","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit44","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1039\/C3DT52505H","volume":"43","author":"Gomathi Sankareswari","year":"2014","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.inoche.2019.02.001","volume":"102","author":"Shao","year":"2019","journal-title":"Inorg. Chem. Commun."},{"key":"D1DT02180J\/cit46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.saa.2004.05.028","volume":"61","author":"Bi","year":"2005","journal-title":"Spectrochim. Acta, Part A"},{"key":"D1DT02180J\/cit47","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1021\/bi00745a020","volume":"12","author":"Lakowicz","year":"1973","journal-title":"Biochemistry"},{"key":"D1DT02180J\/cit48","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1039\/c3nj01107k","volume":"38","author":"Zhao","year":"2014","journal-title":"New J. Chem."},{"key":"D1DT02180J\/cit49","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12011-009-8322-0","volume":"130","author":"Zhang","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"D1DT02180J\/cit50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.saa.2011.09.033","volume":"84","author":"Jayabharathi","year":"2011","journal-title":"Spectrochim. Acta, Part A"},{"key":"D1DT02180J\/cit51","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.saa.2017.05.014","volume":"184","author":"Makarska-Bialokoz","year":"2017","journal-title":"Spectrochim. Acta, Part A"},{"key":"D1DT02180J\/cit52","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1021\/jm501853m","volume":"58","author":"Beno","year":"2015","journal-title":"J. Med. Chem."},{"key":"D1DT02180J\/cit53","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.ejmech.2008.10.010","volume":"44","author":"Wang","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"D1DT02180J\/cit54","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1021\/acs.jmedchem.5b01399","volume":"59","author":"Al-Eisawi","year":"2016","journal-title":"J. Med. Chem."},{"key":"D1DT02180J\/cit55","doi-asserted-by":"crossref","first-page":"10498","DOI":"10.1021\/acs.inorgchem.8b01944","volume":"57","author":"Tian","year":"2018","journal-title":"Inorg. Chem."},{"key":"D1DT02180J\/cit56","doi-asserted-by":"crossref","first-page":"8721","DOI":"10.1039\/c3dt53577k","volume":"43","author":"Fu","year":"2014","journal-title":"Dalton Trans."},{"key":"D1DT02180J\/cit57","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ejmech.2016.02.055","volume":"114","author":"Zhou","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"D1DT02180J\/cit58","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1021\/acs.jafc.0c01063","volume":"68","author":"Samurkas","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"D1DT02180J\/cit59","doi-asserted-by":"crossref","first-page":"680879","DOI":"10.3389\/fmicb.2021.680879","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Microbiol."},{"key":"D1DT02180J\/cit60","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/ps.5640","volume":"76","author":"Lin","year":"2020","journal-title":"Pest Manage. Sci."},{"key":"D1DT02180J\/cit61","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/prot.24583","volume":"82","author":"Bujacz","year":"2014","journal-title":"Proteins"}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/DT\/D1DT02180J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:33:35Z","timestamp":1783449215000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/dt\/article\/50\/38\/13387-13398\/725512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":61,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2021,10,5]]}},"URL":"https:\/\/doi.org\/10.1039\/d1dt02180j","relation":{},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}