{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:52:17Z","timestamp":1792291937334,"version":"4.4.0"},"reference-count":62,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"am","delay-in-days":442,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/SAU-NUT\/30448\/2017"],"award-info":[{"award-number":["PTDC\/SAU-NUT\/30448\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/OCE-ETA\/32287\/2017"],"award-info":[{"award-number":["PTDC\/OCE-ETA\/32287\/2017"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["POCI-01-0247-FEDER-046080"],"award-info":[{"award-number":["POCI-01-0247-FEDER-046080"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["NORTE-01-0145-FEDER-000041"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000041"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p>\n                    The effect of procyanidin dimer B3, a common food tannin, on the digestion of gliadin proteins was investigated by monitoring the changes in the immunogenic peptides produced during\n                    <italic>in vitro<\/italic>\n                    digestion and immunoreactivity.\n                  <\/p>","DOI":"10.1039\/d1fo00382h","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T04:33:34Z","timestamp":1616128414000},"page":"4434-4445","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unravelling the effects of procyanidin on gliadin digestion and immunogenicity"],"prefix":"10.1039","volume":"12","author":[{"given":"Dias","family":"Ricardo","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias da Universidade do Porto"},{"name":"4169-007 Porto"},{"name":"Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Telmo","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias da Universidade do Porto"},{"name":"4169-007 Porto"},{"name":"Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bessa Pereira","family":"Catarina","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias da Universidade do Porto"},{"name":"4169-007 Porto"},{"name":"Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus","family":"Nuno","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias da Universidade do Porto"},{"name":"4169-007 Porto"},{"name":"Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"de Freitas","family":"Victor","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias da Universidade do Porto"},{"name":"4169-007 Porto"},{"name":"Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-5799","authenticated-orcid":false,"given":"P\u00e9rez-Gregorio","family":"Rosa","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias da Universidade do Porto"},{"name":"4169-007 Porto"},{"name":"Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1FO00382H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","volume":"391","author":"Lebwohl","year":"2018","journal-title":"Lancet"},{"key":"D1FO00382H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21239301","volume":"21","author":"Falcigno","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D1FO00382H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.smim.2015.11.001","volume":"27","author":"Stamnaes","year":"2015","journal-title":"Semin. Immunol."},{"key":"D1FO00382H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10238-014-0325-2","volume":"15","author":"Vincentini","year":"2015","journal-title":"Clin. Exp. Med."},{"key":"D1FO00382H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/s41598-020-58236-8","volume":"10","author":"Harnett","year":"2020","journal-title":"Sci. Rep."},{"key":"D1FO00382H-(cit6)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-409547-2.14005-3","volume-title":"Encyclopedia of Analytical Science (Third Edition)","author":"Alvarez-Rivera","year":"2019","unstructured":"G. Alvarez-Rivera , S.Toro-Uribe , E.Iba\u00f1ez , A.Cifuentes and M.Bueno , in Encyclopedia of Analytical Science (Third Edition) , ed. P. Worsfold , C. Poole , A. Townshend and M. Mir\u00f3 , Academic Press , Oxford , 2019 , pp. 53\u201362 , 10.1016\/B978-0-12-409547-2.14005-3"},{"key":"D1FO00382H-(cit7)\/*[position()=1]","first-page":"1","author":"Dias","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D1FO00382H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tifs.2020.10.033","volume":"107","author":"Dias","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"D1FO00382H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32151","DOI":"10.1039\/C5RA02968F","volume":"5","author":"Dias","year":"2015","journal-title":"RSC Adv."},{"key":"D1FO00382H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.ijbiomac.2018.02.055","volume":"112","author":"Dias","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D1FO00382H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"125051","DOI":"10.1016\/j.foodchem.2019.125051","volume":"299","author":"Dias","year":"2019","journal-title":"Food Chem."},{"key":"D1FO00382H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/antiox9060463","volume":"9","author":"Ribeiro","year":"2020","journal-title":"Antioxidants"},{"issue":"19","key":"D1FO00382H-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.2174\/1381612823666170202112530","volume":"23","author":"Rosa Perez-Gregorio","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"D1FO00382H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1021\/jf9502459","volume":"44","author":"Siebert","year":"1996","journal-title":"J. Agric. Food Chem."},{"key":"D1FO00382H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.3390\/molecules25153443","volume":"25","author":"P\u00e9rez-Gregorio","year":"2020","journal-title":"Molecules"},{"key":"D1FO00382H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"125051","DOI":"10.1016\/j.foodchem.2019.125051","volume":"299","author":"Dias","year":"2019","journal-title":"Food Chem."},{"issue":"1","key":"D1FO00382H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-73907-2","volume":"10","author":"Pisapia","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"D1FO00382H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3390\/molecules22040669","volume":"22","author":"Martinez-Gonzalez","year":"2017","journal-title":"Molecules"},{"key":"D1FO00382H-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2017.01.126","volume":"228","author":"Liu","year":"2017","journal-title":"Food Chem."},{"key":"D1FO00382H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1039\/c1mb05008g","volume":"7","author":"Xiao","year":"2011","journal-title":"Mol. BioSyst."},{"key":"D1FO00382H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1039\/D0FO02689A","volume":"12","author":"Sun","year":"2021","journal-title":"Food Funct."},{"key":"D1FO00382H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"519","DOI":"10.17113\/ftb.55.04.17.5138","volume":"55","author":"Martinez-Gonzalez","year":"2017","journal-title":"Food Technol. Biotechnol."},{"key":"D1FO00382H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.26152","volume-title":"The proteins of the wheat kernel","author":"Osborne","year":"1907","unstructured":"T. B. Osborne , The proteins of the wheat kernel , Carnegie Institution of Washington , Washington, D.C. , 1907"},{"key":"D1FO00382H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1039\/C7FO00266A","volume":"8","author":"Perez-Gregorio","year":"2017","journal-title":"Food Funct."},{"key":"D1FO00382H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/S0040-4039(00)62004-X","volume":"7","author":"Geissman","year":"1966","journal-title":"Tetrahedron Lett."},{"key":"D1FO00382H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41596-018-0119-1","volume":"14","author":"Brodkorb","year":"2019","journal-title":"Nat. Protoc."},{"key":"D1FO00382H-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"D1FO00382H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/jms.1361","volume":"42","author":"Ferranti","year":"2007","journal-title":"J. Mass Spectrom."},{"key":"D1FO00382H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jsfa.2740180307","volume":"18","author":"Ewart","year":"1967","journal-title":"J. Sci. Food Agric."},{"key":"D1FO00382H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0007","DOI":"10.5041\/RMMJ.10360","volume":"10","author":"Cohen","year":"2019","journal-title":"Rambam Maimonides Med. J"},{"key":"D1FO00382H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1021\/jf305122s","volume":"61","author":"Kasarda","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"D1FO00382H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e2294","DOI":"10.1371\/journal.pone.0002294","volume":"3","author":"Mor\u00f3n","year":"2008","journal-title":"PLoS One"},{"key":"D1FO00382H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ajcn\/87.2.405","volume":"87","author":"Mor\u00f3n","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"D1FO00382H-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.2174\/1381612823666170202112530","volume":"23","author":"Perez-Gregorio","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"D1FO00382H-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1021\/jf000981z","volume":"49","author":"de Freitas","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"D1FO00382H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e0161095","DOI":"10.1371\/journal.pone.0161095","volume":"11","author":"Ma","year":"2016","journal-title":"PLoS One"},{"key":"D1FO00382H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8528","DOI":"10.1021\/la502184f","volume":"30","author":"Perez-Gregorio","year":"2014","journal-title":"Langmuir"},{"key":"D1FO00382H-(cit38)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-100596-5.21858-1","volume-title":"Encyclopedia of Food Chemistry","author":"Yildirim-Elikoglu","year":"2019","unstructured":"S. Yildirim-Elikoglu , in Encyclopedia of Food Chemistry , ed. L. Melton , F. Shahidi and P. Varelis , Academic Press , Oxford , 2019 , pp. 554\u2013559 , 10.1016\/B978-0-08-100596-5.21858-1"},{"key":"D1FO00382H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1039\/C3RA45522J","volume":"4","author":"Rasheed","year":"2014","journal-title":"RSC Adv."},{"key":"D1FO00382H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0733-5210(85)80021-7","volume":"3","author":"Tatham","year":"1985","journal-title":"J. Cereal Sci."},{"key":"D1FO00382H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1432-1033.1994.tb18574.x","volume":"219","author":"Murray","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"D1FO00382H-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.foodres.2013.07.011","volume":"54","author":"Gallo","year":"2013","journal-title":"Food Res. Int."},{"key":"D1FO00382H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"127432","DOI":"10.1016\/j.foodchem.2020.127432","volume":"333","author":"Yu","year":"2020","journal-title":"Food Chem."},{"key":"D1FO00382H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/10408398.2010.499808","volume":"52","author":"Le Bourvellec","year":"2012","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D1FO00382H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.colsurfb.2019.03.051","volume":"179","author":"Rehan","year":"2019","journal-title":"Colloids Surf., B"},{"key":"D1FO00382H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11794","DOI":"10.1021\/jf203060s","volume":"59","author":"Gon\u00e7alves","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"D1FO00382H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8182","DOI":"10.1039\/C9FO01888C","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct."},{"key":"D1FO00382H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/jssc.202000132","volume":"43","author":"Zhang","year":"2020","journal-title":"J. Sep. Sci."},{"key":"D1FO00382H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.dld.2010.05.005","volume":"43","author":"Carroccio","year":"2011","journal-title":"Dig. Liver Dis."},{"issue":"3","key":"D1FO00382H-(cit50)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/73200","volume":"6","author":"Anderson","year":"2000","journal-title":"Nat. Med."},{"issue":"4","key":"D1FO00382H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.191.4.603","volume":"191","author":"Arentz-Hansen","year":"2000","journal-title":"J. Exp. Med."},{"issue":"3","key":"D1FO00382H-(cit52)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1053\/gast.2002.35381","volume":"123","author":"Arentz-Hansen","year":"2002","journal-title":"Gastroenterology"},{"issue":"2","key":"D1FO00382H-(cit53)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2174\/187153012800493549","volume":"12","author":"Camarca","year":"2012","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"},{"issue":"7","key":"D1FO00382H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat. Med."},{"issue":"4 46-4","key":"D1FO00382H-(cit55)\/*[position()=1]","first-page":"G996","volume":"283","author":"Hausch","year":"2002","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"issue":"10","key":"D1FO00382H-(cit56)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1021\/jf505461x","volume":"63","author":"Mamone","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"D1FO00382H-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1124\/jpet.104.068429","volume":"311","author":"Piper","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"D1FO00382H-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.4049\/jimmunol.173.3.1757","volume":"173","author":"Qiao","year":"2004","journal-title":"J. Immunol."},{"issue":"5590","key":"D1FO00382H-(cit59)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1126\/science.1074129","volume":"297","author":"Shan","year":"2002","journal-title":"Science"},{"issue":"1","key":"D1FO00382H-(cit60)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1084\/jem.169.1.345","volume":"169","author":"Sollid","year":"1989","journal-title":"J. Exp. Med."},{"issue":"41","key":"D1FO00382H-(cit61)\/*[position()=1]","doi-asserted-by":"publisher","first-page":"41ra51","DOI":"10.1126\/scitranslmed.3001012","volume":"2","author":"Tye-Din","year":"2010","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"D1FO00382H-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e24455","DOI":"10.1371\/journal.pone.0024455","volume":"6","author":"Zamakhchari","year":"2011","journal-title":"PLoS One"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D1FO00382H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:27:03Z","timestamp":1782966423000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/10\/4434-4445\/728221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,5,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d1fo00382h","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D1FO00382H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"P\u00e9rez-Gregorio Rosa (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-3030-5799","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 5 February 2021; Accepted 18 March 2021; Accepted Manuscript published 19 March 2021; Advance Article published 20 April 2021; Version of Record published 25 May 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}