{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:38:38Z","timestamp":1789580318151,"version":"build-2803163510"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["732640"],"award-info":[{"award-number":["732640"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    Gluten Friendly\u2122 (GF) is a new gluten achieved through a physicochemical process applied to wheat kernels. The goal of this research was to assess the\n                    <jats:italic>in vivo<\/jats:italic>\n                    effects of Gluten Friendly\u2122 bread on celiac gut mucosa and microbiota.\n                  <\/jats:p>","DOI":"10.1039\/d1fo00490e","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T10:48:38Z","timestamp":1642157318000},"page":"1299-1315","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Healthy and pro-inflammatory gut ecology plays a crucial role in the digestion and tolerance of a novel Gluten Friendly\u2122 bread in celiac subjects: a randomized, double blind, placebo control\n                    <i>in vivo<\/i>\n                    study"],"prefix":"10.1039","volume":"13","author":[{"given":"Angelo","family":"Andriulli","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Foggia, Dipartimento di Scienze dell'Agricoltura, degli Alimenti e dell'Ambiente, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazio","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Latiano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Fontana","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Gioffreda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Castellana","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Fondazione IRCCS-Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (Foggia), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-8533","authenticated-orcid":false,"given":"Tommaso","family":"Mazza","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Fondazione IRCCS-Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (Foggia), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Panza","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Menzaghi","sequence":"additional","affiliation":[{"name":"Research Unit of Diabetes and Endocrine Diseases, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Grandone","sequence":"additional","affiliation":[{"name":"Atherosclerosis and Thrombosis Unit, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazzaro","family":"di Mauro","sequence":"additional","affiliation":[{"name":"Immunohaematology and Transfusion Medicine Service, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Decina","sequence":"additional","affiliation":[{"name":"New Gluten World s.r.l., Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Tricarico","sequence":"additional","affiliation":[{"name":"New Gluten World s.r.l., Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Musaico","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Foggia, Dipartimento di Scienze dell'Agricoltura, degli Alimenti e dell'Ambiente, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Isola","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University and Jilab Inc., Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Popp","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d and National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Taavela","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Central Finland Central Hospital, Jyv\u00e4skyl\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Petruzzi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Foggia, Dipartimento di Scienze dell'Agricoltura, degli Alimenti e dell'Ambiente, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Sinigaglia","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Foggia, Dipartimento di Scienze dell'Agricoltura, degli Alimenti e dell'Ambiente, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rosaria Corbo","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Foggia, Dipartimento di Scienze dell'Agricoltura, degli Alimenti e dell'Ambiente, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-5408","authenticated-orcid":false,"given":"Carmela","family":"Lamacchia","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Foggia, Dipartimento di Scienze dell'Agricoltura, degli Alimenti e dell'Ambiente, Foggia, Italy"},{"name":"New Gluten World s.r.l., Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1FO00490E\/cit1\/1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1099\/jmm.0.47410-0","volume":"56","author":"Nadal","year":"2007","journal-title":"J. Med. Microbiol."},{"key":"D1FO00490E\/cit2\/1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10620-015-4020-2","volume":"61","author":"Marasco","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"D1FO00490E\/cit3\/1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/jcp.2010.076950","volume":"63","author":"S\u00e1nchez","year":"2010","journal-title":"J. Clin. Pathol."},{"key":"D1FO00490E\/cit4\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/advances\/nmz080","volume":"11","author":"Bascu\u00f1\u00e1n","year":"2020","journal-title":"Adv. Nutr."},{"key":"D1FO00490E\/cit5\/1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.foodchem.2015.11.016","volume":"197","author":"Lamacchia","year":"2016","journal-title":"Food Chem."},{"key":"D1FO00490E\/cit7\/1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.foodchem.2016.11.031","volume":"221","author":"Landriscina","year":"2017","journal-title":"Food Chem."},{"key":"D1FO00490E\/cit8\/1","doi-asserted-by":"crossref","first-page":"e0162770","DOI":"10.1371\/journal.pone.0162770","volume":"11","author":"Bevilacqua","year":"2016","journal-title":"PLoS One"},{"key":"D1FO00490E\/cit9\/1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.3389\/fmicb.2017.01722","volume":"8","author":"Costabile","year":"2017","journal-title":"Front. Microbiol."},{"key":"D1FO00490E\/cit10\/1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jff.2018.07.047","volume":"48","author":"Lamacchia","year":"2018","journal-title":"J. Funct. Foods"},{"key":"D1FO00490E\/cit11\/1","doi-asserted-by":"crossref","first-page":"5340386","DOI":"10.1155\/2016\/5340386","volume":"2016","author":"Gervasoni","year":"2016","journal-title":"Dis. Markers"},{"key":"D1FO00490E\/cit13\/1","doi-asserted-by":"crossref","first-page":"e76163","DOI":"10.1371\/journal.pone.0076163","volume":"8","author":"Taavela","year":"2013","journal-title":"PLoS One"},{"key":"D1FO00490E\/cit14\/1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s10278-009-9200-1","volume":"23","author":"Tuominen","year":"2010","journal-title":"J. Digital Imaging"},{"key":"D1FO00490E\/cit15\/1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1471-230X-11-129","volume":"11","author":"L\u00e4hdeaho","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"D1FO00490E\/cit16\/1","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1186\/bcr2615","volume":"12","author":"Tuominen","year":"2010","journal-title":"Breast Cancer Res."},{"key":"D1FO00490E\/cit17\/1","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.3390\/molecules23102705","volume":"23","author":"Gervasoni","year":"2018","journal-title":"Molecules"},{"key":"D1FO00490E\/cit18\/1","year":"2013","unstructured":"16S metagenomic sequencing library preparation, 2013 , https:\/\/support.illumina.com\/documents\/documentation\/chemistry_documentation\/16s\/16s-metagenomic-library-prep-guide-15044223-b.pdf"},{"key":"D1FO00490E\/cit19\/1","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.cgh.2009.07.031","volume":"7","author":"Leffler","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"D1FO00490E\/cit20\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1023\/A:1008841022998","volume":"7","author":"Revicki","year":"1998","journal-title":"Qual. Life Res."},{"key":"D1FO00490E\/cit21\/1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/jgh3.12189","volume":"3","author":"Srinivas","year":"2019","journal-title":"JGH Open"},{"key":"D1FO00490E\/cit22\/1","author":"Andrews","unstructured":"S.Andrews , FastQC: A quality control tool for high throughput sequence data, http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/"},{"key":"D1FO00490E\/cit23\/1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/1471-2105-11-485","volume":"11","author":"Cox","year":"2010","journal-title":"BMC Bioinf."},{"key":"D1FO00490E\/cit24\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"D1FO00490E\/cit25\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"D1FO00490E\/cit26\/1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/nar\/gkt1209","volume":"42","author":"Yilmaz","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"D1FO00490E\/cit27\/1","first-page":"1","volume-title":"Wiley StatsRef: Statistics Reference Online","volume":"2017","author":"Anderson","year":"2017","unstructured":"M. J.Anderson , Permutational Multivariate Analysis of Variance (PERMANOVA) , Wiley StatsRef: Statistics Reference Online , 2017 , vol. 2017 , pp. 1\u201315"},{"key":"D1FO00490E\/cit28\/1","first-page":"27663","volume":"26","author":"Mandal","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"D1FO00490E\/cit29\/1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/gutjnl-2012-302196","volume":"62","author":"Leffler","year":"2013","journal-title":"Gut"},{"key":"D1FO00490E\/cit30\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ajcn\/85.1.160","volume":"85","author":"Catassi","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"D1FO00490E\/cit31\/1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1053\/j.gastro.2006.10.004","volume":"131","author":"Rostom","year":"2006","journal-title":"Gastroenterology"},{"key":"D1FO00490E\/cit32\/1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0950-3528(95)90032-2","volume":"9","author":"Marsh","year":"1995","journal-title":"Baillieres Clin. Gastroenterol."},{"key":"D1FO00490E\/cit33\/1","first-page":"85","volume":"10","author":"Niranjan","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"D1FO00490E\/cit34\/1","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1038\/ctg.2016.54","volume":"7","author":"K\u00f6nig","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"D1FO00490E\/cit35\/1","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.3390\/nu11102325","volume":"11","author":"Cardoso-Silva","year":"2019","journal-title":"Nutrients"},{"key":"D1FO00490E\/cit36\/1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/j.gastro.2017.05.015","volume":"153","author":"Silvester","year":"2017","journal-title":"Gastroenterology"},{"key":"D1FO00490E\/cit37\/1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1104-1091","volume":"5","author":"Kelsall","year":"2004","journal-title":"Nat. Immunol."},{"key":"D1FO00490E\/cit38\/1","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/S0140-6736(00)02169-3","volume":"355","author":"Fasano","year":"2000","journal-title":"Lancet"},{"key":"D1FO00490E\/cit39\/1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1136\/gutjnl-2017-314853","volume":"67","author":"Ludvigsson","year":"2018","journal-title":"Gut"},{"key":"D1FO00490E\/cit40\/1","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.3389\/fmicb.2018.02597","volume":"9","author":"Chander","year":"2018","journal-title":"Front. Microbiol."},{"key":"D1FO00490E\/cit41\/1","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1038\/s41598-019-41149-6","volume":"9","author":"Reddel","year":"2019","journal-title":"Sci. Rep."},{"key":"D1FO00490E\/cit42\/1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1007\/s00125-018-4550-1","volume":"61","author":"Allin","year":"2018","journal-title":"Diabetologia"},{"key":"D1FO00490E\/cit43\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"D1FO00490E\/cit44\/1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2017-314281","volume":"67","author":"Coker","year":"2018","journal-title":"Gut"},{"key":"D1FO00490E\/cit45\/1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1053\/j.gastro.2016.06.041","volume":"151","author":"Caminero","year":"2016","journal-title":"Gastroenterology"},{"key":"D1FO00490E\/cit46\/1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"D1FO00490E\/cit47\/1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/cei.12911","volume":"187","author":"Serena","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"D1FO00490E\/cit48\/1","first-page":"253","volume":"48","author":"Li","year":"1998","journal-title":"Lab. Anim. Sci."},{"key":"D1FO00490E\/cit49\/1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jcmgh.2016.11.008","volume":"3","author":"Luna","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"D1FO00490E\/cit50\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s42003-019-0424-4","volume":"2","author":"Qi","year":"2019","journal-title":"Commun. Biol."},{"key":"D1FO00490E\/cit51\/1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"D1FO00490E\/cit52\/1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1099\/ijsem.0.000788","volume":"66","author":"Rosero","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"D1FO00490E\/cit53\/1","doi-asserted-by":"crossref","first-page":"10062","DOI":"10.1038\/ncomms10062","volume":"6","author":"Bui","year":"2015","journal-title":"Nat. Commun."},{"key":"D1FO00490E\/cit54\/1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1099\/ijs.0.057331-0","volume":"64","author":"Amir","year":"2014","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"D1FO00490E\/cit55\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3390\/ijms22010125","volume":"22","author":"Elhag","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D1FO00490E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:49:55Z","timestamp":1782848995000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/3\/1299-1315\/728254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d1fo00490e","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}