{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:58:07Z","timestamp":1790611087172,"version":"4.1.0"},"reference-count":18,"publisher":"Royal Society of Chemistry (RSC)","issue":"23","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"am","delay-in-days":656,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100019034","name":"Hubei Provincial Central Guidance Local Science and Technology Development Project","doi-asserted-by":"publisher","award":["2020ZYYD030"],"award-info":[{"award-number":["2020ZYYD030"]}],"id":[{"id":"10.13039\/501100019034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    Cardamonin (CDM) is a natural chalcone with strong anti-inflammatory properties. CDM ameliorates aortic valve calcification by inhibiting the phenotypical calcific transformation of hVICs\n                    <jats:italic>via<\/jats:italic>\n                    mediating the inactivation of the NF-\u03baB\/NLRP3 inflammasome.\n                  <\/jats:p>","DOI":"10.1039\/d1fo00813g","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T07:41:25Z","timestamp":1634629285000},"page":"11808-11818","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cardamonin inhibits osteogenic differentiation of human valve interstitial cells and ameliorates aortic valve calcification\n                    <i>via<\/i>\n                    interfering in the NF-\u03baB\/NLRP3 inflammasome pathway"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-1797","authenticated-orcid":false,"given":"Chunli","family":"Wang","sequence":"first","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[{"name":"Hubei University of Chinese Medicine, Huangjiahu Hospital, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghang","family":"Qu","sequence":"additional","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanju","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-2058","authenticated-orcid":false,"given":"Kang","family":"Xu","sequence":"additional","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1FO00813G\/cit1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"D1FO00813G\/cit2","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1161\/ATVBAHA.120.314789","volume":"40","author":"Xu","year":"2020","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"D1FO00813G\/cit3","first-page":"7671638","volume":"2019","author":"Huang","year":"2019","journal-title":"Stem Cells Int."},{"key":"D1FO00813G\/cit4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carpath.2012.06.005","volume":"22","author":"Li","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"D1FO00813G\/cit5","doi-asserted-by":"crossref","first-page":"117591","DOI":"10.1016\/j.lfs.2020.117591","volume":"250","author":"Nawaz","year":"2020","journal-title":"Life Sci."},{"key":"D1FO00813G\/cit6","first-page":"1393","volume":"19","author":"Yue","year":"2020","journal-title":"Oncol. Lett."},{"key":"D1FO00813G\/cit7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jep.2011.09.038","volume":"138","author":"Lopez","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"D1FO00813G\/cit8","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1021\/jf073520n","volume":"56","author":"Li","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"D1FO00813G\/cit9","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3389\/fphar.2018.01328","volume":"9","author":"Xu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"D1FO00813G\/cit10","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1002\/ptr.6360","volume":"33","author":"Xu","year":"2019","journal-title":"Phytother. Res."},{"key":"D1FO00813G\/cit11","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/ptr.6674","volume":"34","author":"Zhou","year":"2020","journal-title":"Phytother. Res."},{"key":"D1FO00813G\/cit12","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3389\/fphar.2020.00826","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"D1FO00813G\/cit13","doi-asserted-by":"crossref","first-page":"102495","DOI":"10.1016\/j.ceca.2021.102495","volume":"100","author":"Wang","year":"2021","journal-title":"Cell Calcium"},{"key":"D1FO00813G\/cit14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/wrr.12614","volume":"26","author":"Xu","year":"2018","journal-title":"Wound Repair\nRegen."},{"key":"D1FO00813G\/cit15","doi-asserted-by":"crossref","first-page":"153305","DOI":"10.1016\/j.phymed.2020.153305","volume":"78","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"key":"D1FO00813G\/cit16","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbrc.2015.02.029","volume":"458","author":"Boaru","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D1FO00813G\/cit17","doi-asserted-by":"crossref","first-page":"102985","DOI":"10.1016\/j.ebiom.2020.102985","volume":"60","author":"Niyonzima","year":"2020","journal-title":"EBioMedicine"},{"key":"D1FO00813G\/cit18","doi-asserted-by":"crossref","first-page":"e3074","DOI":"10.1038\/cddis.2017.470","volume":"8","author":"Sun","year":"2017","journal-title":"Cell Death Dis."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D1FO00813G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:53:16Z","timestamp":1782928396000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/23\/11808-11818\/728338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":18,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,11,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d1fo00813g","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}