{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:37:20Z","timestamp":1790361440039,"version":"4.1.0"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"am","delay-in-days":575,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    The present study aims to investigate the protective effects of\n                    <jats:italic>N<\/jats:italic>\n                    -(3-methoxybenzyl)-(9\n                    <jats:italic>Z<\/jats:italic>\n                    ,12\n                    <jats:italic>Z<\/jats:italic>\n                    ,15\n                    <jats:italic>Z<\/jats:italic>\n                    )-octadecatrienamide (M 18:3) on corticosterone-induced neurotoxicity.\n                  <\/jats:p>","DOI":"10.1039\/d1fo01720a","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T04:24:16Z","timestamp":1627619056000},"page":"9211-9228","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Neuroprotective effects of macamide from maca (\n                    <i>Lepidium meyenii<\/i>\n                    Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-8336","authenticated-orcid":false,"given":"Zejun","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Ezhou Industrial Technology Research Institute, Huazhong University of Science and Technology, Ezhou, 436060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Ezhou Industrial Technology Research Institute, Huazhong University of Science and Technology, Ezhou, 436060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbing","family":"Zhai","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Ezhou Industrial Technology Research Institute, Huazhong University of Science and Technology, Ezhou, 436060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2887-6587","authenticated-orcid":false,"given":"Hang","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Ezhou Industrial Technology Research Institute, Huazhong University of Science and Technology, Ezhou, 436060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Ezhou Industrial Technology Research Institute, Huazhong University of Science and Technology, Ezhou, 436060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhang","family":"Ao","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Key Laboratory of Molecular Biophysics, Ministry of Education, Wuhan, 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-5632","authenticated-orcid":false,"given":"Chunfang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Key Laboratory of Molecular Biophysics, Ministry of Education, Wuhan, 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-1816","authenticated-orcid":false,"given":"Wenwen","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Key Laboratory of Molecular Biophysics, Ministry of Education, Wuhan, 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2517-2266","authenticated-orcid":false,"given":"Longjiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China"},{"name":"Hubei Engineering Research Center for both Edible and Medicinal Resources, Wuhan, 430074, China"},{"name":"Key Laboratory of Molecular Biophysics, Ministry of Education, Wuhan, 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1FO01720A\/cit1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0140-6736(07)61415-9","volume":"370","author":"Moussavi","year":"2007","journal-title":"Lancet"},{"key":"D1FO01720A\/cit2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1159\/000366317","volume":"34","author":"Jiang","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"D1FO01720A\/cit3","first-page":"461","volume":"28","author":"Sun","year":"2015","journal-title":"Sichuan Ment. Health"},{"key":"D1FO01720A\/cit4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2008.01.014","volume":"583","author":"Murray","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"D1FO01720A\/cit5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2018.04.031","volume":"1694","author":"Han","year":"2018","journal-title":"Brain Res."},{"key":"D1FO01720A\/cit6","doi-asserted-by":"crossref","first-page":"e0166966","DOI":"10.1371\/journal.pone.0166966","volume":"11","author":"Lam","year":"2016","journal-title":"PLoS One"},{"key":"D1FO01720A\/cit7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neulet.2011.02.030","volume":"493","author":"Huang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"D1FO01720A\/cit8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1471-4159.1992.tb08884.x","volume":"59","author":"Tombaugh","year":"2010","journal-title":"J. Neurochem."},{"key":"D1FO01720A\/cit9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.steroids.2015.05.010","volume":"101","author":"Ali","year":"2015","journal-title":"Steroids"},{"key":"D1FO01720A\/cit10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"D1FO01720A\/cit11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2006.08.009","volume":"7","author":"Castr\u00e9n","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"D1FO01720A\/cit12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2015.06.008","volume":"64","author":"Kim","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"D1FO01720A\/cit13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jep.2016.10.028","volume":"194","author":"Zhang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"D1FO01720A\/cit14","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/sj.npp.1301312","volume":"32","author":"Beneyto","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"D1FO01720A\/cit15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.foodres.2007.02.005","volume":"40","author":"Wang","year":"2007","journal-title":"Food Res. Int."},{"key":"D1FO01720A\/cit16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.59566\/IJBS.2006.2143","volume":"2","author":"Meissner","year":"2006","journal-title":"Int. J. Biomed. Sci."},{"key":"D1FO01720A\/cit17","first-page":"949036","volume":"2015","author":"Dording","year":"2015","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D1FO01720A\/cit18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2165\/00139709-200524010-00002","volume":"24","author":"Valerio","year":"2005","journal-title":"Toxicol. Rev."},{"key":"D1FO01720A\/cit19","doi-asserted-by":"crossref","first-page":"4394261","DOI":"10.1155\/2016\/4394261","volume":"2016","author":"Guo","year":"2016","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D1FO01720A\/cit20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1472-6882-6-23","volume":"6","author":"Rubio","year":"2006","journal-title":"BMC Complementary Altern. Med."},{"key":"D1FO01720A\/cit21","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.fct.2007.04.002","volume":"45","author":"Rubio","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"D1FO01720A\/cit22","doi-asserted-by":"crossref","first-page":"44660","DOI":"10.1038\/srep44660","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."},{"key":"D1FO01720A\/cit23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ptr.1455","volume":"18","author":"L\u00f3pez-Fando","year":"2004","journal-title":"Phytother. Res."},{"key":"D1FO01720A\/cit24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/15376516.2016.1275908","volume":"27","author":"Rodr\u00edguez-Huam\u00e1n","year":"2017","journal-title":"Toxicol. Mech. Methods"},{"key":"D1FO01720A\/cit25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1749-6632.2009.05174.x","volume":"1199","author":"Pino-Figueroa","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D1FO01720A\/cit26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/jmf.2013.2950","volume":"17","author":"Ai","year":"2014","journal-title":"J. Med. Food"},{"key":"D1FO01720A\/cit27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.taap.2017.12.014","volume":"340","author":"Gugnani","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"D1FO01720A\/cit28","doi-asserted-by":"crossref","first-page":"400","DOI":"10.5483\/BMBRep.2018.51.8.099","volume":"51","author":"Noh","year":"2018","journal-title":"BMB Rep."},{"key":"D1FO01720A\/cit29","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jsfa.9318","volume":"99","author":"Zheng","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"D1FO01720A\/cit30","doi-asserted-by":"crossref","first-page":"104570","DOI":"10.1016\/j.yrtph.2019.104570","volume":"111","author":"Yu","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"D1FO01720A\/cit31","doi-asserted-by":"crossref","first-page":"23096","DOI":"10.1039\/C9RA03268A","volume":"9","author":"Yu","year":"2019","journal-title":"RSC Adv."},{"key":"D1FO01720A\/cit32","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1039\/D0FO00890G","volume":"11","author":"Yu","year":"2020","journal-title":"Food Funct."},{"key":"D1FO01720A\/cit33","first-page":"739","volume":"27","author":"Yang","year":"2011","journal-title":"Chin. Pharmacol. Bull."},{"key":"D1FO01720A\/cit34","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jep.2016.09.023","volume":"194","author":"Xu","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"D1FO01720A\/cit35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF02864563","volume":"55","author":"Li","year":"2001","journal-title":"Econ. Bot."},{"key":"D1FO01720A\/cit36","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00276-005-0050-3","volume":"28","author":"Saylam","year":"2006","journal-title":"Surg. Radiol. Anat."},{"key":"D1FO01720A\/cit37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000367849","volume":"100","author":"Sorrells","year":"2014","journal-title":"Neuroendocrinology"},{"key":"D1FO01720A\/cit38","first-page":"2978","volume":"8","author":"Yao","year":"2004","journal-title":"Chin. J. Clin. Rehabil."},{"key":"D1FO01720A\/cit39","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuroscience.2010.04.023","volume":"168","author":"Brummelte","year":"2010","journal-title":"Neuroscience"},{"key":"D1FO01720A\/cit40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13024-015-0013-z","volume":"10","author":"Marttinen","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"D1FO01720A\/cit41","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.bbadis.2013.07.022","volume":"1832","author":"Wuwongse","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"D1FO01720A\/cit42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0896-6273(00)80866-1","volume":"25","author":"Finkbeiner","year":"2000","journal-title":"Neuron"},{"key":"D1FO01720A\/cit43","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.3109\/13880209.2015.1137951","volume":"54","author":"Wang","year":"2016","journal-title":"Pharm. Biol."},{"key":"D1FO01720A\/cit44","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.3390\/molecules19055634","volume":"19","author":"Dong","year":"2014","journal-title":"Molecules"},{"key":"D1FO01720A\/cit45","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/jnr.23960","volume":"95","author":"Shapiro","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"D1FO01720A\/cit46","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1017\/S1461145713001582","volume":"17","author":"Araki","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"D1FO01720A\/cit47","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1039\/C9FO03104A","volume":"11","author":"Sun","year":"2020","journal-title":"Food Funct."},{"key":"D1FO01720A\/cit48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jep.2014.10.062","volume":"159","author":"Jiang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"D1FO01720A\/cit49","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1039\/C6FO01503D","volume":"8","author":"Zhou","year":"2017","journal-title":"Food Funct."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/FO\/D1FO01720A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:04:19Z","timestamp":1783533859000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/12\/19\/9211-9228\/728561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":49,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2021,10,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d1fo01720a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}