{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:25:24Z","timestamp":1789608324839,"version":"build-2803163510"},"reference-count":68,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"am","delay-in-days":382,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    The present study demonstrates the beneficial effects of\u00a0\n                    <jats:italic>Salvia microphylla<\/jats:italic>\n                    \u00a0and\u00a0\n                    <jats:italic>S. officinalis\u00a0<\/jats:italic>\n                    from Egypt and Jordan against scopolamine-induced AD-like disorder.\n                  <\/jats:p>","DOI":"10.1039\/d1fo02988f","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T03:21:25Z","timestamp":1642476085000},"page":"2253-2268","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Insights into the neuroprotective effects of\n                    <i>Salvia officinalis<\/i>\n                    L. and\n                    <i>Salvia microphylla<\/i>\n                    Kunth in the memory impairment rat model"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-8241","authenticated-orcid":false,"given":"Iriny M.","family":"Ayoub","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-9937","authenticated-orcid":false,"given":"Mina Y.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-9113","authenticated-orcid":false,"given":"Esther T.","family":"Menze","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryhan","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Botros","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Essam","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israa","family":"Ashmawy","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pussey","family":"Shendi","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hany","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Galal","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ayman","sequence":"additional","affiliation":[{"name":"Drug Design Program Graduates, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-4552","authenticated-orcid":false,"given":"Rola M.","family":"Labib","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1FO02988F\/cit1\/1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/gps.935","volume":"18","author":"Giacobini","year":"2003","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"D1FO02988F\/cit2\/1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jalz.2019.01.010","volume":"15","author":"A. s. Association","year":"2019","journal-title":"Alzheimer's Dementia"},{"key":"D1FO02988F\/cit3\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.9758\/cpn.2015.13.2.168","volume":"13","author":"Kang Uk Lee","year":"2015","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"D1FO02988F\/cit4\/1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.neubiorev.2010.04.001","volume":"34","author":"Klinkenberg","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"D1FO02988F\/cit5\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neulet.2009.05.045","volume":"461","author":"Oh","year":"2009","journal-title":"Neurosci. Lett."},{"key":"D1FO02988F\/cit6\/1","doi-asserted-by":"crossref","first-page":"30898","DOI":"10.1021\/acsomega.0c03689","volume":"5","author":"Rajashri","year":"2020","journal-title":"ACS Omega"},{"key":"D1FO02988F\/cit7\/1","first-page":"974013","volume":"2012","author":"Goverdhan","year":"2012","journal-title":"Int. J. Alzheimer\u2019s Dis."},{"key":"D1FO02988F\/cit8\/1","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1007\/978-3-642-22144-6_146","volume-title":"Natural products: Phytochemistry, botany, metabolism of alkaloids, phenolics and terpenes","author":"Omar","year":"2013","unstructured":"S.Omar , in Natural products: Phytochemistry, botany, metabolism of alkaloids, phenolics and terpenes , Springer , 2013 , pp. 3697\u20133741"},{"key":"D1FO02988F\/cit9\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1211\/0022357991772808","volume":"51","author":"Perry","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"D1FO02988F\/cit10\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jpba.2016.03.037","volume":"125","author":"Farag","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D1FO02988F\/cit11\/1","first-page":"203","volume":"4","author":"Devansh","year":"2012","journal-title":"Planta Activa"},{"key":"D1FO02988F\/cit12\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.phytochem.2014.01.001","volume":"99","author":"Al-Qudah","year":"2014","journal-title":"Phytochemistry"},{"key":"D1FO02988F\/cit13\/1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/2215083804666180501112743","volume":"4","author":"Ovidi","year":"2018","journal-title":"Curr. Tradit. Med."},{"key":"D1FO02988F\/cit14\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jep.2008.07.031","volume":"120","author":"Hudaib","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"D1FO02988F\/cit15\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2710.2003.00463.x","volume":"28","author":"Akhondzadeh","year":"2003","journal-title":"J. Clin. Pharm. Ther."},{"key":"D1FO02988F\/cit16\/1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jep.2008.12.026","volume":"122","author":"Orhan","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"D1FO02988F\/cit17\/1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fphar.2011.00079","volume":"2","author":"Walch","year":"2011","journal-title":"Front. Pharmacol."},{"key":"D1FO02988F\/cit18\/1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.foodchem.2009.07.010","volume":"119","author":"Kamatou","year":"2010","journal-title":"Food Chem."},{"key":"D1FO02988F\/cit19\/1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1021\/jf00039a012","volume":"42","author":"Cuvelier","year":"1994","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"D1FO02988F\/cit20\/1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fphar.2020.00218","volume":"11","author":"Faheem","year":"2020","journal-title":"Front. Pharmacol."},{"key":"D1FO02988F\/cit21\/1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/molecules25030647","volume":"25","author":"Elkady","year":"2020","journal-title":"Molecules"},{"key":"D1FO02988F\/cit22\/1","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.3390\/molecules25184234","volume":"25","author":"Elshamy","year":"2020","journal-title":"Molecules"},{"key":"D1FO02988F\/cit23\/1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/03601234.2015.1058103","volume":"50","author":"Peter","year":"2015","journal-title":"J. Environ. Sci. Health, Part B"},{"key":"D1FO02988F\/cit24\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbr.2013.02.003","volume":"245","author":"Jang","year":"2013","journal-title":"Behav. Brain Res."},{"key":"D1FO02988F\/cit25\/1","doi-asserted-by":"crossref","first-page":"117535","DOI":"10.1016\/j.lfs.2020.117535","volume":"249","author":"George","year":"2020","journal-title":"Life Sci."},{"key":"D1FO02988F\/cit26\/1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/ilar\/ilu013","volume":"55","author":"Vorhees","year":"2014","journal-title":"ILAR J."},{"key":"D1FO02988F\/cit27\/1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbr.2007.08.012","volume":"186","author":"Enomoto","year":"2008","journal-title":"Behav. Brain Res."},{"key":"D1FO02988F\/cit28\/1","volume-title":"The haematoxylin and eosin. Theory and practice of histological techniques","author":"Bancroft","year":"1996","unstructured":"J. D.Bancroft and A.Stevens , The haematoxylin and eosin. Theory and practice of histological techniques , Churchill Livingstone , London , 4th edn, 1996"},{"key":"D1FO02988F\/cit29\/1","first-page":"86","volume":"23","author":"Jahanshahi","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"D1FO02988F\/cit30\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"D1FO02988F\/cit31\/1","first-page":"882","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"D1FO02988F\/cit32\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"D1FO02988F\/cit33\/1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1021\/acs.jnatprod.7b00476","volume":"81","author":"Ayoub","year":"2018","journal-title":"J. Nat. Prod."},{"key":"D1FO02988F\/cit34\/1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/pca.3028","volume":"5","author":"Gad","year":"2021","journal-title":"Phytochem. Anal."},{"key":"D1FO02988F\/cit35\/1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/molecules25030647","volume":"25","author":"Elkady","year":"2020","journal-title":"Molecules"},{"key":"D1FO02988F\/cit36\/1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3390\/plants10061118","volume":"10","author":"Ayoub","year":"2021","journal-title":"Plants"},{"key":"D1FO02988F\/cit37\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.indcrop.2017.09.065","volume":"111","author":"Zengin","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"D1FO02988F\/cit38\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.25135\/rnp.96.18.07.119","volume":"13","author":"Vergine","year":"2019","journal-title":"Rec. Nat. Prod."},{"key":"D1FO02988F\/cit39\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fphar.2019.00097","volume":"10","author":"Ma","year":"2019","journal-title":"Front. Pharmacol."},{"key":"D1FO02988F\/cit40\/1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.foodchem.2012.07.091","volume":"136","author":"Kontogianni","year":"2013","journal-title":"Food Chem."},{"key":"D1FO02988F\/cit41\/1","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1002\/jsfa.3384","volume":"88","author":"Abreu","year":"2008","journal-title":"J. Sci. Food Agric."},{"issue":"3","key":"D1FO02988F\/cit42\/1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/ijms18030512","volume":"18","author":"Ben Said","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"D1FO02988F\/cit43\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jff.2016.11.031","volume":"29","author":"Pacifico","year":"2017","journal-title":"J. Funct. Foods"},{"key":"D1FO02988F\/cit44\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phytochem.2014.12.026","volume":"115","author":"Birti\u0107","year":"2015","journal-title":"Phytochemistry"},{"key":"D1FO02988F\/cit45\/1","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1016\/j.chroma.2009.11.032","volume":"1217","author":"Herrero","year":"2010","journal-title":"J. Chromatogr., A"},{"key":"D1FO02988F\/cit46\/1","doi-asserted-by":"crossref","first-page":"10576","DOI":"10.1021\/jf102042g","volume":"58","author":"Hossain","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"D1FO02988F\/cit47\/1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jns.2007.01.081","volume":"257","author":"Korczyn","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"D1FO02988F\/cit48\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jep.2006.04.010","volume":"108","author":"Ferreira","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"D1FO02988F\/cit49\/1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.nut.2005.06.010","volume":"22","author":"Eidi","year":"2006","journal-title":"Nutrition"},{"key":"D1FO02988F\/cit50\/1","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1007\/s12035-020-02009-x","volume":"57","author":"Hern\u00e1ndez-Rodr\u00edguez","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"D1FO02988F\/cit51\/1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3389\/fnins.2020.00730","volume":"14","author":"Kowalczyk","year":"2020","journal-title":"Front. Neurosci."},{"key":"D1FO02988F\/cit52\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"key":"D1FO02988F\/cit53\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0079-6123(08)64698-1","volume":"49","author":"Venkov","year":"1979","journal-title":"Prog. Brain Res."},{"key":"D1FO02988F\/cit54\/1","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1021\/acschemneuro.8b00011","volume":"9","author":"Skalicka-Wozniak","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"D1FO02988F\/cit55\/1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.phymed.2015.12.009","volume":"23","author":"Guo","year":"2016","journal-title":"Phytomedicine"},{"key":"D1FO02988F\/cit56\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0168-0102(02)00201-8","volume":"45","author":"Melo","year":"2003","journal-title":"Neurosci. Res."},{"key":"D1FO02988F\/cit57\/1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.phymed.2016.06.014","volume":"23","author":"Sallam","year":"2016","journal-title":"Phytomedicine"},{"key":"D1FO02988F\/cit58\/1","doi-asserted-by":"crossref","first-page":"113711","DOI":"10.1016\/j.jep.2020.113711","volume":"269","author":"Zhao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"D1FO02988F\/cit59\/1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3109\/14756366.2014.965700","volume":"30","author":"Ozturk Sarikaya","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D1FO02988F\/cit60\/1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/cns.12270","volume":"20","author":"Miroddi","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"D1FO02988F\/cit61\/1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jep.2005.03.008","volume":"100","author":"Eidi","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"D1FO02988F\/cit62\/1","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.jff.2013.09.008","volume":"5","author":"Jemia","year":"2013","journal-title":"J. Funct. Foods"},{"key":"D1FO02988F\/cit63\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1179\/1476830512Y.0000000021","volume":"15","author":"Hou","year":"2012","journal-title":"Nutr. Neurosci."},{"key":"D1FO02988F\/cit64\/1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.talanta.2005.09.041","volume":"69","author":"Chen","year":"2006","journal-title":"Talanta"},{"key":"D1FO02988F\/cit65\/1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11030-013-9452-z","volume":"17","author":"Cao","year":"2013","journal-title":"Mol. Diversity"},{"key":"D1FO02988F\/cit66\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12272-017-0983-1","volume":"41","author":"Choi","year":"2018","journal-title":"Arch. Pharmacal Res."},{"key":"D1FO02988F\/cit67\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","volume":"90","author":"Satoh","year":"1978","journal-title":"Clinica Chimica Acta International Journal of Clinical Chemistry"},{"key":"D1FO02988F\/cit68\/1","doi-asserted-by":"crossref","first-page":"2680409","DOI":"10.1155\/2016\/2680409","volume":"2016","author":"Habtemariam","year":"2016","journal-title":"Evidence-Based Complementary Altern. Med."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D1FO02988F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:22:50Z","timestamp":1782926570000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/4\/2253-2268\/728818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d1fo02988f","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}