{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:35:48Z","timestamp":1789986948920,"version":"4.0.1"},"reference-count":66,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"am","delay-in-days":466,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFD0901905"],"award-info":[{"award-number":["2019YFD0901905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["Tsqn202103033"],"award-info":[{"award-number":["Tsqn202103033"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772046"],"award-info":[{"award-number":["31772046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>SC-CII showed a triple-helix structure and alleviating effects on RA through the TLR4\/MyD88-NF\u03baB pathway.<\/jats:p>","DOI":"10.1039\/d1fo03929f","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T07:22:25Z","timestamp":1649748145000},"page":"6152-6165","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Structure of type II collagen from sturgeon cartilage and its effect on adjuvant-induced rheumatoid arthritis in rats"],"prefix":"10.1039","volume":"13","author":[{"given":"Zhaoxia","family":"Li","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, No. 5, YuShan Road, Qingdao, Shandong Province, 266003, P.R. China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, No. 5, YuShan Road, Qingdao, Shandong Province, 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, No. 5, YuShan Road, Qingdao, Shandong Province, 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiannan","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, No. 5, YuShan Road, Qingdao, Shandong Province, 266003, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Technology Center of Qingdao Customs, No. 83, Xinyue Road, Qingdao, Shandong Province 266109, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-4116","authenticated-orcid":false,"given":"Hu","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, No. 5, YuShan Road, Qingdao, Shandong Province, 266003, P.R. China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1FO03929F\/cit1\/1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"D1FO03929F\/cit2\/1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.lfs.2019.01.002","volume":"218","author":"Saad","year":"2019","journal-title":"Life Sci."},{"key":"D1FO03929F\/cit3\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.autrev.2007.08.001","volume":"7","author":"Cho","year":"2007","journal-title":"Autoimmun. Rev."},{"key":"D1FO03929F\/cit4\/1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1046\/j.1365-2249.2003.02167.x","volume":"132","author":"Ding","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"D1FO03929F\/cit5\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cca.2016.02.010","volume":"455","author":"Mateen","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"D1FO03929F\/cit6\/1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.7326\/0003-4819-152-7-201004060-00010","volume":"152","author":"Whiting","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"D1FO03929F\/cit7\/1","first-page":"20","volume":"12","author":"Aswathy","year":"2018","journal-title":"J. Ayurveda Integr. Med."},{"key":"D1FO03929F\/cit8\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.intimp.2010.09.018","volume":"11","author":"Zhao","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"D1FO03929F\/cit9\/1","doi-asserted-by":"crossref","first-page":"107177","DOI":"10.1016\/j.intimp.2020.107177","volume":"90","author":"Tajbakhsh","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"D1FO03929F\/cit10\/1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12906-016-1054-8","volume":"16","author":"Hsiao","year":"2016","journal-title":"BMC Complementary Altern. Med."},{"key":"D1FO03929F\/cit11\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.autrev.2008.05.001","volume":"8","author":"Caporali","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"D1FO03929F\/cit12\/1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/ph5040339","volume":"5","author":"Chen","year":"2012","journal-title":"Pharmaceuticals"},{"key":"D1FO03929F\/cit13\/1","first-page":"284","volume":"116","author":"Hu","year":"2003","journal-title":"China Med. J."},{"key":"D1FO03929F\/cit14\/1","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1111\/jth.13518","volume":"14","author":"Manon-Jensen","year":"2016","journal-title":"J. Thromb. Haemostasis"},{"key":"D1FO03929F\/cit15\/1","doi-asserted-by":"crossref","first-page":"9703609","DOI":"10.1155\/2017\/9703609","volume":"2017","author":"Subhan","year":"2017","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D1FO03929F\/cit16\/1","doi-asserted-by":"crossref","first-page":"127340","DOI":"10.1016\/j.foodchem.2020.127340","volume":"331","author":"Zhu","year":"2020","journal-title":"Food Chem."},{"key":"D1FO03929F\/cit17\/1","first-page":"3852","volume":"12","author":"Jeevithan","year":"2014","journal-title":"Journal"},{"key":"D1FO03929F\/cit18\/1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ijbiomac.2017.08.044","volume":"106","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D1FO03929F\/cit19\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijbiomac.2017.02.057","volume":"99","author":"Sun","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"D1FO03929F\/cit20\/1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/fft2.74","volume":"2","author":"Amakye","year":"2021","journal-title":"Food Front."},{"key":"D1FO03929F\/cit21\/1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1136\/ard.2007.076430","volume":"67","author":"Hegen","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"D1FO03929F\/cit22\/1","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1039\/C7FO01748K","volume":"9","author":"Zhai","year":"2018","journal-title":"Food Funct."},{"key":"D1FO03929F\/cit23\/1","doi-asserted-by":"crossref","first-page":"104376","DOI":"10.1016\/j.jff.2021.104376","volume":"78","author":"Ma","year":"2021","journal-title":"J. Funct. Foods"},{"key":"D1FO03929F\/cit24\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.etap.2006.03.010","volume":"22","author":"Suh","year":"2006","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"D1FO03929F\/cit25\/1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.intimp.2013.04.012","volume":"16","author":"Endale","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"D1FO03929F\/cit26\/1","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1021\/acs.jafc.8b02241","volume":"66","author":"Zhai","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"D1FO03929F\/cit27\/1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"D1FO03929F\/cit28\/1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.procbio.2013.12.003","volume":"49","author":"Liang","year":"2014","journal-title":"Process Biochem."},{"key":"D1FO03929F\/cit29\/1","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1002\/1521-4141(200212)32:12<3776::AID-IMMU3776>3.0.CO;2-A","volume":"32","author":"B\u00e4cklund","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"D1FO03929F\/cit30\/1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.procbio.2013.07.011","volume":"48","author":"Veeruraj","year":"2013","journal-title":"Process Biochem."},{"key":"D1FO03929F\/cit31\/1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.molstruc.2018.09.023","volume":"1176","author":"Oliveira","year":"2019","journal-title":"J. Mol. Struct."},{"key":"D1FO03929F\/cit32\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.saa.2018.03.047","volume":"199","author":"Kaczmarska","year":"2018","journal-title":"Spectrochim. Acta, Part A"},{"key":"D1FO03929F\/cit33\/1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.foodchem.2007.09.022","volume":"108","author":"Cao","year":"2008","journal-title":"Food Chem."},{"key":"D1FO03929F\/cit34\/1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jsfa.6724","volume":"95","author":"Yang","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"D1FO03929F\/cit35\/1","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/bm060250t","volume":"7","author":"Maxwell","year":"2006","journal-title":"Biomacromolecules"},{"key":"D1FO03929F\/cit36\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.foodchem.2018.07.223","volume":"271","author":"Cheng","year":"2019","journal-title":"Food Chem."},{"key":"D1FO03929F\/cit37\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/b103821","volume":"247","author":"Myllyharju","year":"2005","journal-title":"Top. Curr. Chem."},{"key":"D1FO03929F\/cit38\/1","doi-asserted-by":"crossref","first-page":"119001","DOI":"10.1016\/j.lfs.2020.119001","volume":"269","author":"Hu","year":"2021","journal-title":"Life Sci."},{"key":"D1FO03929F\/cit39\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fbioe.2021.740635","volume":"9","author":"Gong","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D1FO03929F\/cit40\/1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/nu5010223","volume":"5","author":"Fan","year":"2013","journal-title":"Nutrients"},{"key":"D1FO03929F\/cit41\/1","doi-asserted-by":"crossref","first-page":"126017","DOI":"10.1016\/j.jclepro.2021.126017","volume":"293","author":"Zhang","year":"2021","journal-title":"J. Cleaner Prod."},{"key":"D1FO03929F\/cit42\/1","first-page":"1","author":"Maheshwari","year":"2022","journal-title":"Food Front."},{"key":"D1FO03929F\/cit43\/1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/01926230600867743","volume":"34","author":"Cesta","year":"2006","journal-title":"Toxicol. Pathol."},{"key":"D1FO03929F\/cit44\/1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.intimp.2004.01.023","volume":"4","author":"Gan","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"D1FO03929F\/cit45\/1","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.intimp.2011.09.011","volume":"11","author":"Liu","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"D1FO03929F\/cit46\/1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.intimp.2008.06.011","volume":"8","author":"Liu","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"D1FO03929F\/cit47\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tifs.2019.08.008","volume":"92","author":"Huang","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"D1FO03929F\/cit48\/1","doi-asserted-by":"crossref","first-page":"45364","DOI":"10.1038\/srep45364","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"D1FO03929F\/cit49\/1","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/ijms22052719","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D1FO03929F\/cit50\/1","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"D1FO03929F\/cit51\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12016-007-8022-5","volume":"34","author":"Szekanecz","year":"2008","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"D1FO03929F\/cit52\/1","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.3899\/jrheum.100399","volume":"37","author":"Zhao","year":"2010","journal-title":"J. Rheumatol."},{"key":"D1FO03929F\/cit53\/1","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.2353\/ajpath.2009.080705","volume":"175","author":"Amano","year":"2009","journal-title":"Am. J. Pathol."},{"key":"D1FO03929F\/cit54\/1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0014-4800(03)00019-4","volume":"74","author":"Woods","year":"2003","journal-title":"Exp. Mol. Pathol."},{"key":"D1FO03929F\/cit55\/1","doi-asserted-by":"crossref","first-page":"107598","DOI":"10.1016\/j.intimp.2021.107598","volume":"101","author":"Singh","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"D1FO03929F\/cit56\/1","doi-asserted-by":"crossref","first-page":"109367","DOI":"10.1016\/j.biopha.2019.109367","volume":"118","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"D1FO03929F\/cit57\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0301-472X(02)00777-4","volume":"30","author":"Li","year":"2002","journal-title":"Exp. Hematol."},{"key":"D1FO03929F\/cit58\/1","doi-asserted-by":"crossref","first-page":"ii90","DOI":"10.1136\/ard.2004.028324","volume":"63","author":"Ospelt","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"D1FO03929F\/cit59\/1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"D1FO03929F\/cit60\/1","first-page":"97","volume":"6","author":"Deguine","year":"2014","journal-title":"Journal"},{"key":"D1FO03929F\/cit61\/1","doi-asserted-by":"crossref","first-page":"45006","DOI":"10.1038\/srep45006","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"D1FO03929F\/cit62\/1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11926-002-0067-0","volume":"4","author":"Vervoordeldonk","year":"2002","journal-title":"Curr. Rheumatol. Rep."},{"key":"D1FO03929F\/cit63\/1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cll.2019.07.002","volume":"39","author":"Allard-Chamard","year":"2019","journal-title":"Clin. Lab. Med."},{"key":"D1FO03929F\/cit64\/1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/annrheumdis-2016-210873","volume":"76","author":"Manivel","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"D1FO03929F\/cit65\/1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s002960100099","volume":"20","author":"Ausar","year":"2001","journal-title":"Rheumatol. Int."},{"key":"D1FO03929F\/cit66\/1","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1021\/acs.jafc.9b00185","volume":"67","author":"Zhai","year":"2019","journal-title":"J. Agric. Food Chem."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D1FO03929F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:06:48Z","timestamp":1782875208000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/11\/6152-6165\/729033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":66,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,6,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d1fo03929f","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}