{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:29:08Z","timestamp":1783538948852,"version":"3.55.0"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003807","name":"People's Government of Jilin Province","doi-asserted-by":"publisher","award":["20190304035YY"],"award-info":[{"award-number":["20190304035YY"]}],"id":[{"id":"10.13039\/501100003807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["JLUXKJC2020106"],"award-info":[{"award-number":["JLUXKJC2020106"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>CRISPR\/dCas9 technology integrated with electrochemical detection was developed for ultrasensitive and fast gene mutation detection of diffuse large B-cell lymphoma above a dCas9\/sgRNA modified porous anodised aluminium sensing chip.<\/jats:p>","DOI":"10.1039\/d1lc01055g","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T21:01:06Z","timestamp":1642021266000},"page":"768-776","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Direct MYD88\n                    <sup>L265P<\/sup>\n                    gene detection for diffuse large B-cell lymphoma (DLBCL)\n                    <i>via<\/i>\n                    a miniaturised CRISPR\/dCas9-based sensing chip"],"prefix":"10.1039","volume":"22","author":[{"given":"Weihan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, 130021 Changchun, China"},{"name":"Institute of Frontier Medical Science, Jilin University, 1163 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Hospital of Jilin University, Jilin University, 71 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Frontier Medical Science, Jilin University, 1163 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sennan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Institute of Frontier Medical Science, Jilin University, 1163 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Frontier Medical Science, Jilin University, 1163 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Institute of Frontier Medical Science, Jilin University, 1163 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-2063","authenticated-orcid":false,"given":"Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, 130021 Changchun, China"},{"name":"Institute of Frontier Medical Science, Jilin University, 1163 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-6175","authenticated-orcid":false,"given":"Shuping","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Ave., 130012 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-9473","authenticated-orcid":false,"given":"Ou","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Hospital of Jilin University, Jilin University, 71 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-7579","authenticated-orcid":false,"given":"Chongyang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, 130021 Changchun, China"},{"name":"Institute of Frontier Medical Science, Jilin University, 1163 Xinmin Street, 130021 Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1LC01055G\/cit1\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature09671","volume":"470","author":"Ngo","year":"2010","journal-title":"Nature"},{"issue":"10","key":"D1LC01055G\/cit2\/1","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.3390\/cancers12102913","volume":"12","author":"Visco","year":"2020","journal-title":"Cancers"},{"key":"D1LC01055G\/cit3\/1","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1021\/acs.analchem.5b04540","volume":"88","author":"Xu","year":"2016","journal-title":"Anal. Chem."},{"key":"D1LC01055G\/cit4\/1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ng.3559","volume":"48","author":"Poznik","year":"2016","journal-title":"Nat. Genet."},{"key":"D1LC01055G\/cit5\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrg.2015.17","volume":"17","author":"Khurana","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"D1LC01055G\/cit6\/1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1373\/clinchem.2013.206359","volume":"59","author":"Taly","year":"2013","journal-title":"Clin. Chem."},{"key":"D1LC01055G\/cit7\/1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.1131370","volume":"314","author":"Ottesen","year":"2006","journal-title":"Science"},{"key":"D1LC01055G\/cit8\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bios.2016.09.082","volume":"90","author":"Cao","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01055G\/cit9\/1","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1128\/JCM.05316-11","volume":"49","author":"White","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"D1LC01055G\/cit10\/1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2353\/jmoldx.2010.090188","volume":"12","author":"Tsiatis","year":"2010","journal-title":"J. Mol. Diagn."},{"key":"D1LC01055G\/cit11\/1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/cbic.201800511","volume":"20","author":"Furlan","year":"2019","journal-title":"ChemBioChem"},{"key":"D1LC01055G\/cit12\/1","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.1138140","volume":"315","author":"Barrangou","year":"2007","journal-title":"Science"},{"key":"D1LC01055G\/cit13\/1","doi-asserted-by":"crossref","first-page":"e145214","DOI":"10.1172\/JCI145214","volume":"131","author":"Uyhazi","year":"2021","journal-title":"J. Clin. Invest."},{"key":"D1LC01055G\/cit14\/1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/d41586-019-00601-3","volume":"566","author":"Maxmen","year":"2019","journal-title":"Nature"},{"key":"D1LC01055G\/cit15\/1","doi-asserted-by":"crossref","first-page":"BSR20200127","DOI":"10.1042\/BSR20200127","volume":"40","author":"Hirakawa","year":"2020","journal-title":"Biosci. Rep."},{"key":"D1LC01055G\/cit16\/1","doi-asserted-by":"crossref","first-page":"29518","DOI":"10.1073\/pnas.2010254117","volume":"117","author":"Ramachandran","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1LC01055G\/cit17\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2017.05.008","volume":"37","author":"Koonin","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"D1LC01055G\/cit18\/1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tig.2019.03.009","volume":"35","author":"Varble","year":"2019","journal-title":"Trends Genet."},{"key":"D1LC01055G\/cit19\/1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/crispr.2018.0012","volume":"1","author":"Klompe","year":"2018","journal-title":"CRISPR J."},{"key":"D1LC01055G\/cit20\/1","doi-asserted-by":"crossref","first-page":"112445","DOI":"10.1016\/j.bios.2020.112445","volume":"166","author":"van Dongen","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01055G\/cit21\/1","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1021\/acssynbio.9b00507","volume":"9","author":"Aman","year":"2020","journal-title":"ACS Synth. Biol."},{"key":"D1LC01055G\/cit22\/1","doi-asserted-by":"crossref","first-page":"112430","DOI":"10.1016\/j.bios.2020.112430","volume":"165","author":"Wang","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01055G\/cit23\/1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41551-019-0371-x","volume":"3","author":"Hajian","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"D1LC01055G\/cit24\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s11671-015-1202-y","volume":"10","author":"Lin","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"D1LC01055G\/cit25\/1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1166\/jbn.2016.2192","volume":"12","author":"Park","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"D1LC01055G\/cit26\/1","doi-asserted-by":"crossref","first-page":"16278","DOI":"10.1039\/C8NR05875J","volume":"10","author":"Zhao","year":"2018","journal-title":"Nanoscale"},{"issue":"2","key":"D1LC01055G\/cit27\/1","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1093\/nar\/gkaa1088","volume":"49","author":"Abid","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"D1LC01055G\/cit28\/1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41551-019-0413-4","volume":"3","author":"Bruch","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"D1LC01055G\/cit29\/1","doi-asserted-by":"crossref","first-page":"e1806739","DOI":"10.1002\/adma.201806739","volume":"31","author":"Dincer","year":"2019","journal-title":"Adv. Mater."},{"key":"D1LC01055G\/cit30\/1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.tibtech.2018.12.005","volume":"37","author":"Li","year":"2019","journal-title":"Trends Biotechnol."},{"key":"D1LC01055G\/cit31\/1","doi-asserted-by":"crossref","first-page":"17241","DOI":"10.1021\/acsnano.0c07264","volume":"14","author":"Kim","year":"2020","journal-title":"ACS Nano"},{"key":"D1LC01055G\/cit32\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10544-008-9217-0","volume":"11","author":"Moon","year":"2009","journal-title":"Biomed. Microdevices"},{"key":"D1LC01055G\/cit33\/1","doi-asserted-by":"crossref","first-page":"8184","DOI":"10.1021\/acs.analchem.9b00638","volume":"91","author":"Mo","year":"2019","journal-title":"Anal. Chem."},{"key":"D1LC01055G\/cit34\/1","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1021\/acsami.9b21714","volume":"12","author":"Gao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D1LC01055G\/cit35\/1","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1021\/nn101050r","volume":"4","author":"Li","year":"2010","journal-title":"ACS Nano"},{"key":"D1LC01055G\/cit36\/1","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1021\/acs.analchem.8b05536","volume":"91","author":"Zhao","year":"2019","journal-title":"Anal. Chem."},{"key":"D1LC01055G\/cit37\/1","doi-asserted-by":"crossref","first-page":"10957","DOI":"10.1021\/acs.analchem.7b02765","volume":"89","author":"Cao","year":"2017","journal-title":"Anal. Chem."},{"key":"D1LC01055G\/cit38\/1","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1021\/acs.nanolett.9b05066","volume":"20","author":"Wang","year":"2020","journal-title":"Nano Lett."},{"key":"D1LC01055G\/cit39\/1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41551-019-0371-x","volume":"3","author":"Hajian","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"D1LC01055G\/cit40\/1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature03001","volume":"431","author":"Heilig","year":"2004","journal-title":"Nature"}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/LC\/D1LC01055G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:59:56Z","timestamp":1783533596000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/22\/4\/768-776\/730831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d1lc01055g","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}