{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:46:53Z","timestamp":1782974813601,"version":"3.54.5"},"reference-count":127,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"am","delay-in-days":483,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["600375"],"award-info":[{"award-number":["600375"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04436\/2020"],"award-info":[{"award-number":["UIDB\/04436\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04436\/2020"],"award-info":[{"award-number":["UIDP\/04436\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2020.02304.CEECIND"],"award-info":[{"award-number":["2020.02304.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-000008: BRAINHEALTH 2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000008: BRAINHEALTH 2020"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","award":["CENTRO-01-0145- FEDER-000012: HealthyAging2020"],"award-info":[{"award-number":["CENTRO-01-0145- FEDER-000012: HealthyAging2020"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>Diabetic retinopathy (DR) is the most common diabetic eye disease and the worldwide leading cause of vision loss in working-age adults.<\/jats:p>","DOI":"10.1039\/d1lc01138c","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T09:31:41Z","timestamp":1651224701000},"page":"1876-1889","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lab-on-a-chip technologies for minimally invasive molecular sensing of diabetic retinopathy"],"prefix":"10.1039","volume":"22","author":[{"given":"Maria","family":"Vieira","sequence":"first","affiliation":[{"name":"International Iberian Nanotechnology Laboratory (INL), Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7828-2296","authenticated-orcid":false,"given":"Rosa","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal"},{"name":"Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-1641","authenticated-orcid":false,"given":"Ant\u00f3nio F.","family":"Ambr\u00f3sio","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal"},{"name":"Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Cardoso","sequence":"additional","affiliation":[{"name":"CMEMS-UMinho, University of Minho, Campus of Azur\u00e9m, Guimar\u00e3es, Portugal"},{"name":"LABBELS \u2013 Associate Laboratory, Guimar\u00e3es, Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-5799","authenticated-orcid":false,"given":"Mariana","family":"Carvalho","sequence":"additional","affiliation":[{"name":"International Iberian Nanotechnology Laboratory (INL), Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7984-9319","authenticated-orcid":false,"given":"Peng","family":"Weng Kung","sequence":"additional","affiliation":[{"name":"Spin Dynamics in Health Engineering Group, Songshan Lake Materials Laboratory, Dongguan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-486X","authenticated-orcid":false,"given":"Miguel Ant\u00f3nio Dias","family":"Neves","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-7767","authenticated-orcid":false,"given":"In\u00eas","family":"Mendes Pinto","sequence":"additional","affiliation":[{"name":"International Iberian Nanotechnology Laboratory (INL), Braga, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1LC01138C\/cit1\/1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/jcm8071033","volume":"8","author":"Biswas","year":"2019","journal-title":"J. Clin. Med."},{"key":"D1LC01138C\/cit2\/1","doi-asserted-by":"crossref","first-page":"107840","DOI":"10.1016\/j.diabres.2019.107840","volume":"157","author":"Thomas","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"D1LC01138C\/cit3\/1","first-page":"E2655","volume":"113","author":"Sohn","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1LC01138C\/cit4\/1","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1007\/s00125-018-4692-1","volume":"61","author":"Sim\u00f3","year":"2018","journal-title":"Diabetologia"},{"key":"D1LC01138C\/cit5\/1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuroscience.2019.02.026","volume":"406","author":"Haider","year":"2019","journal-title":"Neuroscience"},{"key":"D1LC01138C\/cit6\/1","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/nrdp.2016.12","volume":"2","author":"Wong","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D1LC01138C\/cit7\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ddr.20222","volume":"69","author":"Chu","year":"2008","journal-title":"Drug Dev. Res."},{"key":"D1LC01138C\/cit8\/1","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1210\/jc.2017-01922","volume":"102","author":"Barrett","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"D1LC01138C\/cit9\/1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3389\/fphys.2018.00820","volume":"9","author":"Santiago","year":"2018","journal-title":"Front. Physiol."},{"key":"D1LC01138C\/cit10\/1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.3390\/ijms19061816","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"D1LC01138C\/cit11\/1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.tibtech.2017.03.013","volume":"35","author":"Dincer","year":"2017","journal-title":"Trends Biotechnol."},{"key":"D1LC01138C\/cit12\/1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0161-6420(13)38012-9","volume":"98","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1991","journal-title":"Ophthalmology"},{"key":"D1LC01138C\/cit13\/1","doi-asserted-by":"crossref","first-page":"e16658","DOI":"10.2196\/16658","volume":"22","author":"Tan","year":"2020","journal-title":"J. Med. Internet Res."},{"key":"D1LC01138C\/cit14\/1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1167\/iovs.17-21873","volume":"59","author":"Abramoff","year":"2018","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit15\/1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1109\/RBME.2010.2084567","volume":"3","author":"Abramoff","year":"2010","journal-title":"IEEE Rev. Biomed. Eng."},{"key":"D1LC01138C\/cit16\/1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0161-6420(13)38013-0","volume":"98","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1991","journal-title":"Ophthalmology"},{"key":"D1LC01138C\/cit17\/1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0161-6420(13)38014-2","volume":"98","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1991","journal-title":"Ophthalmology"},{"key":"D1LC01138C\/cit18\/1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0161-6420(87)33524-9","volume":"94","author":"Goldberg","year":"1987","journal-title":"Ophthalmology"},{"key":"D1LC01138C\/cit19\/1","first-page":"253","volume":"86","author":"Friedenwald","year":"1950","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"D1LC01138C\/cit20\/1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0002-9394(50)90988-3","volume":"33","author":"Friedenwald","year":"1950","journal-title":"Am. J. Ophthalmol."},{"key":"D1LC01138C\/cit21\/1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archopht.1986.01050190047037","volume":"104","author":"Bresnick","year":"1986","journal-title":"Arch. Ophthalmol."},{"key":"D1LC01138C\/cit22\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/(SICI)1099-0895(199703)13:1<15::AID-DMR176>3.0.CO;2-M","volume":"13","author":"Ghirlanda","year":"1997","journal-title":"Diabetes\/Metab. Rev."},{"key":"D1LC01138C\/cit23\/1","first-page":"2781","volume":"33","author":"Greenstein","year":"1992","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit24\/1","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.2337\/db05-1635","volume":"55","author":"Antonetti","year":"2006","journal-title":"Diabetes"},{"key":"D1LC01138C\/cit25\/1","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1167\/iovs.15-17334","volume":"56","author":"Chhablani","year":"2015","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit26\/1","doi-asserted-by":"crossref","first-page":"110235","DOI":"10.1016\/j.forsciint.2020.110235","volume":"310","author":"Pigaiani","year":"2020","journal-title":"Forensic Sci. Int."},{"issue":"4","key":"D1LC01138C\/cit27\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/02713683.2020.1826977","volume":"46","author":"Tram","year":"2021","journal-title":"Curr. Eye Res."},{"key":"D1LC01138C\/cit28\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jprot.2016.06.034","volume":"150","author":"Cs\u0151sz","year":"2017","journal-title":"J. Proteomics"},{"key":"D1LC01138C\/cit29\/1","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1021\/pr800112g","volume":"7","author":"Gao","year":"2008","journal-title":"J. Proteome Res."},{"key":"D1LC01138C\/cit30\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/tvst.7.5.12","volume":"7","author":"Velez","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"D1LC01138C\/cit31\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0082140","volume":"8","author":"Skeie","year":"2013","journal-title":"PLoS One"},{"key":"D1LC01138C\/cit32\/1","doi-asserted-by":"crossref","first-page":"e8158","DOI":"10.1371\/journal.pone.0008158","volume":"4","author":"Yoshimura","year":"2009","journal-title":"PLoS One"},{"key":"D1LC01138C\/cit33\/1","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.jprot.2011.12.006","volume":"75","author":"Chiang","year":"2012","journal-title":"J. Proteomics"},{"key":"D1LC01138C\/cit34\/1","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1167\/iovs.10-5531","volume":"51","author":"Chowdhury","year":"2010","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit35\/1","volume-title":"WHO Best Practices for Injections and Related Procedures Toolkit","year":"2010","unstructured":"WHO Best Practices for Injections and Related Procedures Toolkit , World Health Organization , Geneva , 2010"},{"key":"D1LC01138C\/cit36\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2415-13-40","volume":"13","author":"Torok","year":"2013","journal-title":"BMC Ophthalmol."},{"key":"D1LC01138C\/cit37\/1","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.3390\/ijms20194755","volume":"20","author":"Youngblood","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D1LC01138C\/cit38\/1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fphys.2016.00200","volume":"7","author":"Pusparajah","year":"2016","journal-title":"Front. Physiol."},{"key":"D1LC01138C\/cit39\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0039-6257(81)90145-4","volume":"26","author":"Van Haeringen","year":"1981","journal-title":"Surv. Ophthalmol."},{"key":"D1LC01138C\/cit40\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0002-9394(83)90473-7","volume":"96","author":"Berta","year":"1983","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"D1LC01138C\/cit41\/1","doi-asserted-by":"crossref","first-page":"e648","DOI":"10.1111\/aos.14954","volume":"100","author":"Frudd","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"D1LC01138C\/cit42\/1","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.3390\/jcm9113643","volume":"9","author":"Blighe","year":"2020","journal-title":"J. Clin. Med."},{"key":"D1LC01138C\/cit43\/1","first-page":"1","volume-title":"Handbook of Immunoassay Technologies: Approaches, Performances, and Applications","author":"Vashist","year":"2018","unstructured":"S. K.Vashist and J. H. T.Luong , in Handbook of Immunoassay Technologies: Approaches, Performances, and Applications , ed. S. K. Vashist and J. H. T. Luong , Academic Press , 2018 , pp. 1\u201318"},{"key":"D1LC01138C\/cit44\/1","first-page":"61","volume-title":"Methods in Molecular Biology","volume":"1318","author":"Lin","year":"2015","unstructured":"A. V.Lin , in Methods in Molecular Biology , Humana Press Inc. , 2015 , vol. 1318 , pp. 61\u201367"},{"key":"D1LC01138C\/cit45\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-4939-2742-5_5","volume":"1318","author":"Lin","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"D1LC01138C\/cit46\/1","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.3390\/s17122934","volume":"17","author":"Wu","year":"2017","journal-title":"Sensors"},{"key":"D1LC01138C\/cit47\/1","doi-asserted-by":"crossref","first-page":"116327","DOI":"10.1016\/j.trac.2021.116327","volume":"142","author":"Sharma","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D1LC01138C\/cit48\/1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ces.2005.06.024","volume":"61","author":"Gervais","year":"2006","journal-title":"Chem. Eng. Sci."},{"key":"D1LC01138C\/cit49\/1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1177\/2211068215589580","volume":"21","author":"Wilson","year":"2016","journal-title":"J. Lab. Autom."},{"key":"D1LC01138C\/cit50\/1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nbt.1641","volume":"28","author":"Rissin","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"D1LC01138C\/cit51\/1","first-page":"1","volume-title":"Advances in Biochemical Engineering\/Biotechnology","author":"Arshavsky-Graham","year":"2020","unstructured":"S.Arshavsky-Graham and E.Segal , in Advances in Biochemical Engineering\/Biotechnology , Springer , Berlin, Heidelberg , 2020 , pp. 1\u201319"},{"key":"D1LC01138C\/cit52\/1","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1021\/acsnano.0c10035","volume":"15","author":"Liu","year":"2021","journal-title":"ACS Nano"},{"key":"D1LC01138C\/cit53\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13167-016-0065-3","volume":"7","author":"Hagan","year":"2016","journal-title":"EPMA J."},{"key":"D1LC01138C\/cit54\/1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1021\/ac202878q","volume":"84","author":"Kimmel","year":"2012","journal-title":"Anal. Chem."},{"key":"D1LC01138C\/cit55\/1","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1039\/C9QI00602H","volume":"6","author":"Ramachandran","year":"2019","journal-title":"Inorg. Chem. Front."},{"key":"D1LC01138C\/cit56\/1","doi-asserted-by":"crossref","first-page":"167505","DOI":"10.1149\/1945-7111\/abcbb5","volume":"167","author":"Krishnan","year":"2020","journal-title":"J. Electrochem. Soc."},{"key":"D1LC01138C\/cit57\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40824-019-0181-y","volume":"24","author":"Cho","year":"2020","journal-title":"Biomater. Res."},{"key":"D1LC01138C\/cit58\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11671-018-2843-4","volume":"14","author":"Liu","year":"2019","journal-title":"Nanoscale Res. Lett."},{"key":"D1LC01138C\/cit59\/1","doi-asserted-by":"crossref","first-page":"112726","DOI":"10.1016\/j.bios.2020.112726","volume":"171","author":"Tanak","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit60\/1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bios.2015.05.038","volume":"72","author":"Neves","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit61\/1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bios.2016.03.038","volume":"81","author":"Mohseni","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit62\/1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ajo.2020.01.032","volume":"213","author":"Hainsworth","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"D1LC01138C\/cit63\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"Hsu","year":"2016","journal-title":"Sci. Rep."},{"key":"D1LC01138C\/cit64\/1","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1016\/j.biomaterials.2014.01.030","volume":"35","author":"Hsu","year":"2014","journal-title":"Biomaterials"},{"key":"D1LC01138C\/cit65\/1","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1039\/C4LC01052C","volume":"15","author":"Hsu","year":"2015","journal-title":"Lab Chip"},{"key":"D1LC01138C\/cit66\/1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.bios.2016.11.014","volume":"89","author":"Wang","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit67\/1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bios.2016.05.028","volume":"85","author":"Zhao","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit68\/1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1039\/C9LC00975B","volume":"20","author":"Wang","year":"2020","journal-title":"Lab Chip"},{"key":"D1LC01138C\/cit69\/1","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1021\/acschemneuro.9b00036","volume":"10","author":"Cruz","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"D1LC01138C\/cit70\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bios.2017.10.002","volume":"101","author":"Chuang","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit71\/1","doi-asserted-by":"crossref","first-page":"629529","DOI":"10.1155\/2013\/629529","volume":"2013","author":"Costagliola","year":"2013","journal-title":"Mediators Inflammation"},{"key":"D1LC01138C\/cit72\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1109\/HIC.2017.8227587","volume-title":"2017 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2017","volume":"2017","author":"Khan","year":"2017","unstructured":"M. S.Khan , K.Dighe , Z.Wang , E.Daza , A. S.Schwartz-Duval , C. P.Rowley , I. A.Calvillo , S. K.Misra , L. T.Labriola and D.Pan , in 2017 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2017 , 2017 , vol. 2017 , pp. 72\u201375"},{"key":"D1LC01138C\/cit73\/1","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1021\/acsnano.8b00829","volume":"12","author":"Elsherif","year":"2018","journal-title":"ACS Nano"},{"key":"D1LC01138C\/cit74\/1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41587-019-0045-y","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"D1LC01138C\/cit75\/1","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.3390\/s18082651","volume":"18","author":"Tseng","year":"2018","journal-title":"Sensors"},{"key":"D1LC01138C\/cit76\/1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet"},{"key":"D1LC01138C\/cit77\/1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","volume":"96","author":"Pascolini","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"D1LC01138C\/cit78\/1","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1167\/iovs.15-16793","volume":"56","author":"Kovacs","year":"2015","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit79\/1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s10384-011-0004-8","volume":"55","author":"Suzuki","year":"2011","journal-title":"Jpn. J. Ophthalmol."},{"key":"D1LC01138C\/cit80\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12886-017-0572-6","volume":"17","author":"Chen","year":"2017","journal-title":"BMC Ophthalmol."},{"key":"D1LC01138C\/cit81\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8480193","volume":"2020","author":"Abu-Yaghi","year":"2020","journal-title":"J. Ophthalmol."},{"key":"D1LC01138C\/cit82\/1","doi-asserted-by":"crossref","first-page":"S451","DOI":"10.1016\/j.dsx.2017.03.034","volume":"11","author":"Nalini","year":"2017","journal-title":"Diabetes Metab. Syndr."},{"key":"D1LC01138C\/cit83\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12886-019-1277-9","volume":"20","author":"Wu","year":"2020","journal-title":"BMC Ophthalmol."},{"key":"D1LC01138C\/cit84\/1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000447776","volume":"57","author":"Xing","year":"2017","journal-title":"Ophthalmic Res."},{"key":"D1LC01138C\/cit85\/1","doi-asserted-by":"crossref","first-page":"e10154","DOI":"10.15252\/emmm.201810154","volume":"12","author":"Wu","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"D1LC01138C\/cit86\/1","doi-asserted-by":"crossref","first-page":"e559","DOI":"10.1111\/aos.14331","volume":"98","author":"Dan-Brezis","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"D1LC01138C\/cit87\/1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/kjm2.12125","volume":"35","author":"Lee","year":"2019","journal-title":"Kaohsiung J. Med. Sci."},{"key":"D1LC01138C\/cit88\/1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1900\/RDS.2015.12.159","volume":"12","author":"Jenkins","year":"2015","journal-title":"Rev. Diabet. Stud."},{"key":"D1LC01138C\/cit89\/1","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1167\/iovs.17-21973","volume":"58","author":"Boss","year":"2017","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit90\/1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s12020-020-02353-x","volume":"69","author":"Khaloo","year":"2020","journal-title":"Endocrine"},{"key":"D1LC01138C\/cit91\/1","first-page":"2931","volume":"16","author":"Liu","year":"2010","journal-title":"Mol. Vision"},{"key":"D1LC01138C\/cit92\/1","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.1038\/nutd.2017.30","volume":"7","author":"Long","year":"2017","journal-title":"Nutr. Diabetes"},{"key":"D1LC01138C\/cit93\/1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/jcp.22822","volume":"227","author":"Mohammad","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"D1LC01138C\/cit94\/1","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.2337\/db12-1141","volume":"62","author":"Zhong","year":"2013","journal-title":"Diabetes"},{"key":"D1LC01138C\/cit95\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40942-020-00222-3","volume":"6","author":"Suzuki","year":"2020","journal-title":"Int. J. Retina Vitreous"},{"key":"D1LC01138C\/cit96\/1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s10792-019-01252-z","volume":"40","author":"Han","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"D1LC01138C\/cit97\/1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1515\/tjb-2020-0575","volume":"46","author":"Sirin","year":"2021","journal-title":"Turkish J. Biochem."},{"key":"D1LC01138C\/cit98\/1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1007\/s00125-018-4601-7","volume":"61","author":"Siddiqui","year":"2018","journal-title":"Diabetologia"},{"key":"D1LC01138C\/cit99\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fimmu.2020.00154","volume":"11","author":"Shahulhameed","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"D1LC01138C\/cit100\/1","first-page":"313","volume":"128","author":"Yasir","year":"2022","journal-title":"Journal of Metabolic Diseases"},{"key":"D1LC01138C\/cit101\/1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.exer.2010.05.017","volume":"91","author":"Barcelona","year":"2010","journal-title":"Exp. Eye Res."},{"key":"D1LC01138C\/cit102\/1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/eye.2017.87","volume":"31","author":"Mutlu","year":"2017","journal-title":"Eye"},{"key":"D1LC01138C\/cit103\/1","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1167\/iovs.15-16470","volume":"56","author":"Dong","year":"2015","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit104\/1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1080\/02713683.2019.1632350","volume":"44","author":"Dong","year":"2019","journal-title":"Curr. Eye Res."},{"key":"D1LC01138C\/cit105\/1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jdiacomp.2019.05.021","volume":"33","author":"Zhang","year":"2019","journal-title":"J. Diabetes Its Complications"},{"key":"D1LC01138C\/cit106\/1","doi-asserted-by":"crossref","first-page":"e15703","DOI":"10.1097\/MD.0000000000015703","volume":"98","author":"Chung","year":"2019","journal-title":"Medicine"},{"key":"D1LC01138C\/cit107\/1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jcjd.2020.01.007","volume":"44","author":"Moosaie","year":"2020","journal-title":"Can. J. Diabetes"},{"key":"D1LC01138C\/cit108\/1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ajo.2007.11.011","volume":"145","author":"Park","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"D1LC01138C\/cit109\/1","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1167\/iovs.16-19468","volume":"57","author":"Kwon","year":"2016","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D1LC01138C\/cit110\/1","first-page":"e12028","volume":"12","author":"Rashid","year":"2020","journal-title":"Cureus"},{"key":"D1LC01138C\/cit111\/1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10654-013-9839-2","volume":"28","author":"He","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"D1LC01138C\/cit112\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00109-020-02000-y","volume":"99","author":"Tawfik","year":"2021","journal-title":"J. Mol. Med."},{"key":"D1LC01138C\/cit113\/1","first-page":"1352","volume":"22","author":"Srivastav","year":"2016","journal-title":"Mol. Vision"},{"key":"D1LC01138C\/cit114\/1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.abb.2012.11.004","volume":"529","author":"Lu","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"D1LC01138C\/cit115\/1","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1021\/acschemneuro.9b00036","volume":"10","author":"Cruz","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"D1LC01138C\/cit116\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/JSEN.2020.3014328","volume":"20","author":"Lin","year":"2020","journal-title":"Sensors"},{"key":"D1LC01138C\/cit117\/1","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.20964\/2019.12.16","volume":"14","author":"Pohanka","year":"2019","journal-title":"Int. J. Electrochem. Sci."},{"key":"D1LC01138C\/cit118\/1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.snb.2019.01.093","volume":"285","author":"Pandey","year":"2019","journal-title":"Sens. Actuators, B"},{"key":"D1LC01138C\/cit119\/1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.talanta.2019.04.006","volume":"201","author":"Lopes","year":"2019","journal-title":"Talanta"},{"key":"D1LC01138C\/cit120\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bios.2018.11.022","volume":"126","author":"Peng","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit121\/1","first-page":"100026","volume":"2","author":"Zubiate","year":"2019","journal-title":"Biosens. Bioelectron.: X"},{"key":"D1LC01138C\/cit122\/1","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1021\/acssensors.9b00827","volume":"4","author":"Kotlarek","year":"2019","journal-title":"ACS Sens."},{"key":"D1LC01138C\/cit123\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"Yoo","year":"2016","journal-title":"Sci. Rep."},{"key":"D1LC01138C\/cit124\/1","doi-asserted-by":"crossref","first-page":"10864","DOI":"10.3390\/s140610864","volume":"14","author":"Canovi","year":"2014","journal-title":"Sensors"},{"key":"D1LC01138C\/cit125\/1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bios.2017.07.013","volume":"98","author":"Lim","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D1LC01138C\/cit126\/1","doi-asserted-by":"crossref","first-page":"5662550","DOI":"10.1155\/2021\/5662550","volume":"2021","author":"Gao","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D1LC01138C\/cit127\/1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1021\/ac0303721","volume":"76","author":"Badugu","year":"2004","journal-title":"Anal. Chem."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/LC\/D1LC01138C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:18:30Z","timestamp":1782969510000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/22\/10\/1876-1889\/730861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":127,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5,17]]}},"URL":"https:\/\/doi.org\/10.1039\/d1lc01138c","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}