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Chem."],"abstract":"<p>\n                    This work reports the design and synthesis of a library of thieno[2,3-\n                    <italic>d<\/italic>\n                    ]pyrimidine derivatives and screened for their\n                    <italic>in vitro<\/italic>\n                    anti-plasmodial and cytotoxic assessment to identify a lead compound in the development of potential antimalarials.\n                  <\/p>","DOI":"10.1039\/d1md00038a","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T05:54:11Z","timestamp":1621317251000},"page":"970-981","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-\n                    <i>d<\/i>\n                    ]pyrimidine derivatives"],"prefix":"10.1039","volume":"12","author":[{"given":"Kavita","family":"Pal","sequence":"first","affiliation":[{"name":"Drug Design and Synthesis Laboratory"},{"name":"Department of chemistry"},{"name":"Jamia Millia Islamia"},{"name":"New Delhi 110025"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Kausar","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Physical Chemistry"},{"name":"Indian Institute of Science"},{"name":"Bangalore 560012"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Legac","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"University of California"},{"name":"San Francisco"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Ataur Rahman","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology"},{"name":"Harvard University"},{"name":"Cambridge"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Laboratory"},{"name":"Department of chemistry"},{"name":"Jamia Millia Islamia"},{"name":"New Delhi 110025"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"University of California"},{"name":"San Francisco"},{"name":"USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1363-4884","authenticated-orcid":false,"given":"Nasimul","family":"Hoda","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Laboratory"},{"name":"Department of chemistry"},{"name":"Jamia Millia Islamia"},{"name":"New Delhi 110025"},{"name":"India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1MD00038A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/S0140-6736(18)30324-6","volume":"391","author":"Ashley","year":"2018","journal-title":"Lancet"},{"key":"D1MD00038A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(12)60034-8","volume":"379","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"D1MD00038A-(cit3)\/*[position()=1]","volume-title":"World malaria report 2020: 20 years of global progress and challenges","author":"WHO","year":"2020","unstructured":"WHO , World malaria report 2020: 20 years of global progress and challenges , 2020"},{"key":"D1MD00038A-(cit4)\/*[position()=1]","first-page":"520","volume":"88","author":"Geary","year":"2002","journal-title":"J. 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