{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:31:17Z","timestamp":1788993077928,"version":"build-2803163510"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"am","delay-in-days":642,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI090048"],"award-info":[{"award-number":["AI090048"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    Haloperidol analogues were developed as inhibitors of the\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    resistance enzyme Eis to serve as kanamycin adjuvants.\n                  <\/jats:p>","DOI":"10.1039\/d1md00239b","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T15:18:59Z","timestamp":1633619939000},"page":"1894-1909","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from\n                    <i>Mycobacterium tuberculosis<\/i>\n                    to overcome kanamycin resistance"],"prefix":"10.1039","volume":"12","author":[{"given":"Ankita","family":"Punetha","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Garzan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishad","family":"Thamban Chandrika","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa J.","family":"Willby","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of Tuberculosis Elimination, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-6445","authenticated-orcid":false,"given":"Allan H.","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina Y. L.","family":"Holbrook","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Krieger","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue N, Seattle, WA, 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Posey","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of Tuberculosis Elimination, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7507-0423","authenticated-orcid":false,"given":"Tanya","family":"Parish","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue N, Seattle, WA, 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-4216","authenticated-orcid":false,"given":"Oleg V.","family":"Tsodikov","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-5555","authenticated-orcid":false,"given":"Sylvie","family":"Garneau-Tsodikova","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1MD00239B\/cit1","volume-title":"Global tuberculosis report 2020","author":"World Health Organization","year":"2020","unstructured":"World Health Organization ,  Global tuberculosis report 2020 ,  Geneva ,  2020 , Licence: CC BY-NC-SA 3.0 Igo"},{"key":"D1MD00239B\/cit2","doi-asserted-by":"crossref","first-page":"20004","DOI":"10.1073\/pnas.0907925106","volume":"106","author":"Zaunbrecher","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1MD00239B\/cit3","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1128\/AAC.01550-10","volume":"55","author":"Campbell","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"D1MD00239B\/cit4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12941-018-0285-6","volume":"17","author":"Sowajassatakul","year":"2018","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"D1MD00239B\/cit5","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1128\/AAC.02191-12","volume":"57","author":"Reeves","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"D1MD00239B\/cit6","doi-asserted-by":"crossref","first-page":"9804","DOI":"10.1073\/pnas.1105379108","volume":"108","author":"Chen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1MD00239B\/cit7","doi-asserted-by":"crossref","first-page":"e92370","DOI":"10.1371\/journal.pone.0092370","volume":"9","author":"Tsodikov","year":"2014","journal-title":"PLoS One"},{"key":"D1MD00239B\/cit8","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1039\/c2mb25341k","volume":"8","author":"Pricer","year":"2012","journal-title":"Mol. BioSyst."},{"key":"D1MD00239B\/cit9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1021\/acs.biochem.7b01089","volume":"57","author":"Green","year":"2018","journal-title":"Biochemistry"},{"key":"D1MD00239B\/cit10","doi-asserted-by":"crossref","first-page":"eaao1478","DOI":"10.1126\/sciadv.aao1478","volume":"4","author":"Sakatos","year":"2018","journal-title":"Sci. Adv."},{"key":"D1MD00239B\/cit11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/mmi.13339","volume":"100","author":"Ghosh","year":"2016","journal-title":"Mol. Microbiol."},{"key":"D1MD00239B\/cit12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/cmdc.201100332","volume":"7","author":"Green","year":"2012","journal-title":"ChemMedChem"},{"key":"D1MD00239B\/cit13","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1021\/acschembio.6b00110","volume":"11","author":"Willby","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"D1MD00239B\/cit14","doi-asserted-by":"crossref","first-page":"10619","DOI":"10.1021\/acs.jmedchem.6b01161","volume":"59","author":"Garzan","year":"2016","journal-title":"J. Med. Chem."},{"key":"D1MD00239B\/cit15","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/acsmedchemlett.6b00261","volume":"7","author":"Garzan","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"D1MD00239B\/cit16","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1021\/acsinfecdis.6b00193","volume":"3","author":"Garzan","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"D1MD00239B\/cit17","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1021\/acsinfecdis.8b00074","volume":"4","author":"Ngo","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"D1MD00239B\/cit18","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1021\/acsinfecdis.9b00228","volume":"5","author":"Green","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"D1MD00239B\/cit19","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1021\/acschembio.0c00184","volume":"15","author":"Punetha","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"D1MD00239B\/cit20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D1MD00239B\/cit21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/448645a","volume":"448","author":"Chong","year":"2007","journal-title":"Nature"},{"key":"D1MD00239B\/cit22","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/cbic.201300359","volume":"14","author":"Houghton","year":"2013","journal-title":"ChemBioChem"},{"key":"D1MD00239B\/cit23","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1021\/jm050418d","volume":"48","author":"Hulshof","year":"2005","journal-title":"J. Med. Chem."},{"key":"D1MD00239B\/cit24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cbic.200900584","volume":"11","author":"Green","year":"2010","journal-title":"ChemBioChem"},{"key":"D1MD00239B\/cit25","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1128\/AAC.00474-11","volume":"55","author":"Ramon-Garcia","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"D1MD00239B\/cit26","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/17425255.2016.1179281","volume":"12","author":"Franken","year":"2016","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"D1MD00239B\/cit27","first-page":"245","volume":"21","author":"Forsman","year":"1977","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"D1MD00239B\/cit28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2125.1981.tb01135.x","volume":"11","author":"Rowell","year":"1981","journal-title":"Br. J. Clin. Pharmacol."},{"key":"D1MD00239B\/cit29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(67)90065-9","volume":"1","author":"Soudijn","year":"1967","journal-title":"Eur. J. Pharmacol."},{"key":"D1MD00239B\/cit30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-4347(93)80318-X","volume":"614","author":"Fang","year":"1993","journal-title":"J. Chromatogr."},{"key":"D1MD00239B\/cit31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/00498259309059390","volume":"23","author":"Gorrod","year":"1993","journal-title":"Xenobiotica"},{"key":"D1MD00239B\/cit32","first-page":"1029","volume":"21","author":"Grossman","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"D1MD00239B\/cit33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0378-4347(96)00075-8","volume":"682","author":"Fang","year":"1996","journal-title":"J. Chromatogr. B: Biomed. Sci. Appl."},{"key":"D1MD00239B\/cit34","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1176\/ajp.148.6.790","volume":"148","author":"Goff","year":"1991","journal-title":"Am. J. Psychiatry"},{"key":"D1MD00239B\/cit35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00007691-198802000-00011","volume":"10","author":"Midha","year":"1988","journal-title":"Ther. Drug Monit."},{"key":"D1MD00239B\/cit36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00004714-199206000-00004","volume":"12","author":"Someya","year":"1992","journal-title":"J. Clin. Psychopharmacol."},{"key":"D1MD00239B\/cit37","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0006-291X(90)91936-M","volume":"166","author":"Subramanyam","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D1MD00239B\/cit38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/tx00039a002","volume":"7","author":"Van der Schyf","year":"1994","journal-title":"Chem. Res. Toxicol."},{"key":"D1MD00239B\/cit39","first-page":"1638","volume":"29","author":"Fang","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"D1MD00239B\/cit40","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1021\/tx0600090","volume":"19","author":"Avent","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"D1MD00239B\/cit41","first-page":"567","volume":"24","author":"Forsman","year":"1978","journal-title":"Curr. Ther. Res."},{"key":"D1MD00239B\/cit42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0378-4274(91)90062-B","volume":"59","author":"Fang","year":"1991","journal-title":"Toxicol. Lett."},{"key":"D1MD00239B\/cit43","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/clpt.1994.172","volume":"56","author":"Eyles","year":"1994","journal-title":"Clin. Pharmacol. Ther."},{"key":"D1MD00239B\/cit44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cellsig.2017.07.003","volume":"41","author":"Moritz","year":"2018","journal-title":"Cell. Signalling"},{"key":"D1MD00239B\/cit45","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1021\/jm500126s","volume":"57","author":"Xiao","year":"2014","journal-title":"J. Med. Chem."},{"key":"D1MD00239B\/cit46","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1021\/acschembio.7b00493","volume":"12","author":"Mannel","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"D1MD00239B\/cit47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tips.2010.12.003","volume":"32","author":"Lober","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"D1MD00239B\/cit48","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1021\/acs.jmedchem.5b01612","volume":"59","author":"Zou","year":"2016","journal-title":"J. Med. Chem."},{"key":"D1MD00239B\/cit49","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41467-020-14884-y","volume":"11","author":"Fan","year":"2020","journal-title":"Nat. Commun."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/MD\/D1MD00239B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:35:53Z","timestamp":1783532153000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/12\/11\/1894-1909\/731915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11,17]]}},"URL":"https:\/\/doi.org\/10.1039\/d1md00239b","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}