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Chem."],"abstract":"<jats:p>Pyrophosphates (diphosphates) and bisphosphonates are potentially important drugs but are anionic and too polar to penetrate cells; here we review approaches that have been taken to create cell-permeable prodrugs of these type of compounds.<\/jats:p>","DOI":"10.1039\/d1md00297j","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T06:04:56Z","timestamp":1646114696000},"page":"375-391","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions"],"prefix":"10.1039","volume":"13","author":[{"given":"Emma S.","family":"Rudge","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H. 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