{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:30:49Z","timestamp":1791318649381,"version":"4.3.1"},"reference-count":33,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"am","delay-in-days":367,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["F.No. 02(392)\/21\/EMR II"],"award-info":[{"award-number":["F.No. 02(392)\/21\/EMR II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006464","name":"Birla Institute of Technology and Science, Pilani","doi-asserted-by":"publisher","award":["201920-NFST-TEL- 01497"],"award-info":[{"award-number":["201920-NFST-TEL- 01497"]}],"id":[{"id":"10.13039\/501100006464","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    34 imidazo[1,2-\n                    <jats:italic>a<\/jats:italic>\n                    ]pyridine amides &amp; sulfonamides are synthesized &amp; evaluated for\n                    <jats:italic>in vitro<\/jats:italic>\n                    anti-TB activity against MTB H37Rv.\n                    <jats:bold>IPA-<\/jats:bold>\n                    6 is most potent with MIC 0.05 \u03bcg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    &amp; 125 times active than ethambutol &amp; docked to MTB enoyl acyl protein reductase.\n                  <\/jats:p>","DOI":"10.1039\/d1md00367d","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T06:05:13Z","timestamp":1641189913000},"page":"327-342","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-\n                    <i>a<\/i>\n                    ]pyridine analogues"],"prefix":"10.1039","volume":"13","author":[{"given":"Yogesh Mahadu","family":"Khetmalis","sequence":"first","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500 078, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendar","family":"Chitti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500 078, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjani","family":"Umarani Wunnava","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530 003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-6944","authenticated-orcid":false,"given":"Banoth","family":"Karan Kumar","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, 333031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthyala","family":"Murali Krishna Kumar","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530 003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-1577","authenticated-orcid":false,"given":"Sankaranarayanan","family":"Murugesan","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, 333031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-8297","authenticated-orcid":false,"given":"Kondapalli Venkata Gowri","family":"Chandra Sekhar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500 078, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1MD00367D\/cit1\/1","first-page":"113139","author":"Urban","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D1MD00367D\/cit2\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2010.01959.x","volume":"308","author":"Bald","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"key":"D1MD00367D\/cit3\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.14745\/ccdr.v43i34a01","volume":"43","author":"Kiazyk","year":"2017","journal-title":"Commun. Dis. Rep. CDR Rev."},{"key":"D1MD00367D\/cit4\/1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/cbdd.13739","volume":"96","author":"Onajole","year":"2020","journal-title":"Chem. Biol. Drug Des."},{"key":"D1MD00367D\/cit5\/1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/1568026616666160530153233","volume":"17","author":"Deep","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"D1MD00367D\/cit6\/1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.2174\/138955707781662645","volume":"7","author":"Enguehard-Gueiffier","year":"2007","journal-title":"Mini-Rev. Med. Chem."},{"key":"D1MD00367D\/cit7\/1","first-page":"793","volume":"299","author":"Berson","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"D1MD00367D\/cit8\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.steroids.2015.09.010","volume":"104","author":"Dar","year":"2015","journal-title":"Steroids"},{"issue":"12","key":"D1MD00367D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.2042-7158.1993.tb07184.x","volume":"45","author":"Uemura","year":"1993","journal-title":"J. Pharm. Pharmacol."},{"key":"D1MD00367D\/cit10\/1","first-page":"105","volume":"18","author":"Celli","year":"1975","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"D1MD00367D\/cit11\/1","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1016\/j.bmcl.2019.08.013","volume":"29","author":"Chitti","year":"2019","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D1MD00367D\/cit12\/1","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1021\/jm5003606","author":"Kang","year":"2014","journal-title":"J. Med. Chem."},{"key":"D1MD00367D\/cit13\/1","doi-asserted-by":"crossref","first-page":"87483","DOI":"10.1371\/journal.pone.0087483","volume":"9","author":"Cheng","year":"2014","journal-title":"PLoS One"},{"key":"D1MD00367D\/cit14\/1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/acsmedchemlett.6b00330","volume":"7","author":"Wu","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"D1MD00367D\/cit15\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ejmech.2014.10.079","volume":"89","author":"Jose","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D1MD00367D\/cit16\/1","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1016\/j.bmcl.2016.04.088","volume":"26","author":"Pulipati","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D1MD00367D\/cit17\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejmech.2018.12.071","volume":"165","author":"Wang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D1MD00367D\/cit18\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.ejmech.2019.06.038","volume":"178","author":"Wang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D1MD00367D\/cit19\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cclet.2019.07.038","volume":"31","author":"Li","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"D1MD00367D\/cit20\/1","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.bmc.2014.05.038","volume":"22","author":"Samala","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"D1MD00367D\/cit21\/1","doi-asserted-by":"crossref","first-page":"105137","DOI":"10.1016\/j.tiv.2021.105137","volume":"74","author":"Nandikolla","year":"2021","journal-title":"Toxicol. In Vitro"},{"key":"D1MD00367D\/cit22\/1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejmech.2013.08.036","volume":"69","author":"Samala","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"D1MD00367D\/cit23\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11030-009-9162-8","volume":"14","author":"Manvar","year":"2010","journal-title":"Mol. Diversity"},{"key":"D1MD00367D\/cit24\/1","doi-asserted-by":"crossref","first-page":"127512","DOI":"10.1016\/j.bmcl.2020.127512","volume":"30","author":"Konduri","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D1MD00367D\/cit25\/1","first-page":"237","volume":"65","author":"Narasimha","year":"2021","journal-title":"J. Mex. Chem. Soc."},{"key":"D1MD00367D\/cit26\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ejmech.2014.10.079","volume":"89","author":"Jose","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D1MD00367D\/cit27\/1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/0929867326666181203125229","volume":"27","author":"de \u00c1vila","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"D1MD00367D\/cit28\/1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jmgm.2017.07.005","volume":"76","author":"Lone","year":"2017","journal-title":"J. Mol. Graphics Modell."},{"key":"D1MD00367D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/AAC.41.5.1004","volume":"41","author":"Collins","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"D1MD00367D\/cit30\/1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/JCM.36.2.362-366.1998","volume":"36","author":"Franzblau","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"D1MD00367D\/cit31\/1","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1021\/jm060715y","volume":"49","author":"He","year":"2006","journal-title":"J. Med. Chem."},{"key":"D1MD00367D\/cit32\/1","doi-asserted-by":"crossref","first-page":"D464","DOI":"10.1093\/nar\/gky1004","volume":"47","author":"Burley","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"D1MD00367D\/cit33\/1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00044-020-02602-8","volume":"29","author":"Pola","year":"2020","journal-title":"Med. Chem. Res."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/MD\/D1MD00367D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:33:54Z","timestamp":1783449234000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/13\/3\/327-342\/731943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d1md00367d","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}