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However, the pathogenesis of OPLL is largely unclear. In this study, transcriptome expression profiles (circRNAs, lncRNAs, and mRNAs) were identified via high-throughput sequencing using peripheral blood mononuclear cells (PBMCs) from OPLL and non-OPLL patients. We found that 1150 mRNAs, 331 circRNAs, and 1429 lncRNAs were significantly differentially expressed in the PBMCs of OPLL patients. GO and KEGG enrichment analyses revealed that most mRNAs were associated with inflammation. The co-expression networks indicated that circRNAs and lncRNAs could regulate the mRNAs through influencing the inflammation of OPLL. The circRNA\u2013miRNA\u2013mRNA integrated network showed that circRNA-regulated mRNAs associated with TGF-\u03b2 and TNF-\u03b1 signaling pathways. These analyses indicate that circRNAs, lncRNAs, and mRNAs from PBMCs might contribute to inflammation in OPLL.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d1mo00060h","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T03:24:01Z","timestamp":1622431441000},"page":"607-619","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comprehensive expression profiles of CircRNAs, LncRNAs, and mRNAs in PBMCs from patients with the ossification of the posterior longitudinal ligament"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7771-8665","authenticated-orcid":false,"given":"Ning","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huading","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fifth Affiliated Hospital of Sun Yat-Sen University a , Zhuhai 519000, Guangdong, China \u00a0 johnniehuading@163.com \u00a0 xuxh28@mail.sysu.edu.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"2026010813081788100_cit1","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/j.wneu.2018.06.023","article-title":"Prevalence, Incidence, Comorbidity, and Mortality Rates of Ossification of Posterior Longitudinal Ligament in the Cervical Spine: A Nested Case-Control Cohort Study","volume":"117","author":"Moon","year":"2018","journal-title":"World Neurosurg."},{"key":"2026010813081788100_cit2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2147\/IJGM.S48941","article-title":"A higher frequency of lumbar ossification of the posterior longitudinal ligament in elderly in an outpatient clinic in Japan","volume":"6","author":"Okumura","year":"2013","journal-title":"Int. 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