{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:30:32Z","timestamp":1767915032878,"version":"3.49.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009053","name":"The Wellcome Trust DBT India Alliance","doi-asserted-by":"publisher","award":["Margdarshi Fellowship grant (IA\/M\/15\/1\/502023)"],"award-info":[{"award-number":["Margdarshi Fellowship grant (IA\/M\/15\/1\/502023)"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009053","name":"The Wellcome Trust DBT India Alliance","doi-asserted-by":"publisher","award":["Margdarshi Fellowship grant (IA\/M\/15\/1\/502023)"],"award-info":[{"award-number":["Margdarshi Fellowship grant (IA\/M\/15\/1\/502023)"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To discover lipidomic alterations during pregnancy in mothers who subsequently delivered small for gestational age (SGA) neonates and identify predictive lipid markers that can help recognize and manage these mothers, we carried out untargeted lipidomics on maternal serum samples collected between 24\u201328 weeks of gestation. We used a nested case-control study design and serum from mothers who delivered SGA and appropriate for gestational age babies. We applied untargeted lipidomics using mass spectrometry to characterize lipids and discover changes associated with SGA births during pregnancy. Multivariate pattern recognition software Collaborative Laboratory Integrated Reports (CLIR) was used for the post-analytical recognition of range differences in lipid ratios that could differentiate between SGA and control mothers and their integration for complete separation between the two groups. Here, we report changes in lipids from serum collected during pregnancy in mothers who delivered SGA neonates. In contrast to normal pregnancies where lysophosphatidic acid increased over the course of the pregnancy owing to increased activity of lysophospholipase D, we observed a decrease (32%; P = 0.05) of 20:4-lysophosphatidic acid in SGA mothers, which could potentially compromise fetal growth and development. Integration of lipid ratios in an interpretive tool (CLIR) could completely separate SGA mothers from controls demonstrating the power of untargeted lipidomic analyses for identifying novel predictive biomarkers. Additional studies are required for further assessment of the lipid biomarkers identified in this report.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d1mo00131k","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T11:05:17Z","timestamp":1631617517000},"page":"956-966","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal serum lipidomics identifies lysophosphatidic acid as a predictor of small for gestational age neonates"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-4841","authenticated-orcid":false,"given":"Seul Kee","family":"Byeon","sequence":"first","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine b , Baltimore, MD 21205, USA"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic a , Rochester, MN 55905, USA \u00a0 Pandey.Akhilesh@mayo.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasheda","family":"Khanam","sequence":"additional","affiliation":[{"name":"International Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health c , Baltimore, MD 21205, USA \u00a0 abaqui@jhu.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4445-3699","authenticated-orcid":false,"given":"Sayedur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Projahnmo Research Foundation d , Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik","family":"Hasan","sequence":"additional","affiliation":[{"name":"Projahnmo Research Foundation d , Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Jafar Raza","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Projahnmo Research Foundation d , Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-7316","authenticated-orcid":false,"given":"Anil K","family":"Madugundu","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, National Institute of Mental Health and Neurosciences g , Hosur Road, Bangalore, 560029, Karnataka, India"},{"name":"Manipal Academy of Higher Education f , Manipal, Karnataka, 576104, India"},{"name":"Institute of Bioinformatics, International Technology Park e , Bangalore 560006, India"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic a , Rochester, MN 55905, USA \u00a0 Pandey.Akhilesh@mayo.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madan Gopal","family":"Ramarajan","sequence":"additional","affiliation":[{"name":"Manipal Academy of Higher Education f , Manipal, Karnataka, 576104, India"},{"name":"Institute of Bioinformatics, International Technology Park e , Bangalore 560006, India"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic a , Rochester, MN 55905, USA \u00a0 Pandey.Akhilesh@mayo.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kyung Hee University h , Yongin 17104, South Korea"},{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine b , Baltimore, MD 21205, USA"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic a , Rochester, MN 55905, USA \u00a0 Pandey.Akhilesh@mayo.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-1152","authenticated-orcid":false,"given":"Nabidul H","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Projahnmo Research Foundation d , Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-0638","authenticated-orcid":false,"given":"Salahuddin","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Projahnmo Research Foundation d , Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubhana","family":"Raqib","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, International Centre for Diarrhoeal Disease Research i , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-3787","authenticated-orcid":false,"given":"Kwang Pyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kyung Hee University h , Yongin 17104, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-0255","authenticated-orcid":false,"given":"Amy L","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic a , Rochester, MN 55905, USA \u00a0 Pandey.Akhilesh@mayo.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic a , Rochester, MN 55905, USA \u00a0 Pandey.Akhilesh@mayo.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-6127","authenticated-orcid":false,"given":"Akhilesh","family":"Pandey","sequence":"additional","affiliation":[{"name":"Center for Individualized Medicine, Mayo Clinic j , Rochester, MN 55905, USA"},{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine b , Baltimore, MD 21205, USA"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic a , Rochester, MN 55905, USA \u00a0 Pandey.Akhilesh@mayo.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah H","family":"Baqui","sequence":"additional","affiliation":[{"name":"International Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health c , Baltimore, MD 21205, USA \u00a0 abaqui@jhu.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"AMANHI Bio-banking Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"2026010813091582800_cit1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1701-2163(15)30865-3","volume":"35","author":"Lausman","year":"2013","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"2026010813091582800_cit2","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1016\/j.vaccine.2017.01.040","article-title":"Collaboration Small for Gestational Age Working","volume":"35","author":"Schlaudecker","year":"2017","journal-title":"Vaccine"},{"key":"2026010813091582800_cit3","doi-asserted-by":"crossref","first-page":"j3677","DOI":"10.1136\/bmj.j3677","volume":"358","author":"Lee","year":"2017","journal-title":"BMJ"},{"key":"2026010813091582800_cit4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(13)60993-9","volume":"382","author":"Katz","year":"2013","journal-title":"Lancet"},{"key":"2026010813091582800_cit5","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1016\/S2214-109X(13)70006-8","volume":"1","author":"Lee","year":"2013","journal-title":"Lancet Glob. Health"},{"key":"2026010813091582800_cit6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrm2335","volume":"9","author":"Wymann","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026010813091582800_cit7","doi-asserted-by":"crossref","first-page":"e48889","DOI":"10.1371\/journal.pone.0048889","volume":"7","author":"Zhou","year":"2012","journal-title":"PLoS One"},{"key":"2026010813091582800_cit8","doi-asserted-by":"crossref","first-page":"107899","DOI":"10.18632\/oncotarget.22391","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"2026010813091582800_cit9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11010-015-2549-1","volume":"410","author":"Sapandowski","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"2026010813091582800_cit10","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.113.002500","volume":"129","author":"Stegemann","year":"2014","journal-title":"Circulation"},{"key":"2026010813091582800_cit11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4939-6996-8_8","volume":"1609","author":"Gugiu","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"2026010813091582800_cit12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.trac.2014.04.017","volume":"61","author":"Cajka","year":"2014","journal-title":"Trends Anal. Chem."},{"key":"2026010813091582800_cit13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0029-7844(96)00514-5","volume":"89","author":"Sattar","year":"1997","journal-title":"Obstet Gynecol"},{"key":"2026010813091582800_cit14","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jacl.2017.08.020","volume":"11","author":"Kim","year":"2017","journal-title":"J. Clin. Lipidol."},{"key":"2026010813091582800_cit15","first-page":"e1420","volume":"9","author":"Ghodke","year":"2017","journal-title":"Cureus"},{"key":"2026010813091582800_cit16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12291-012-0252-5","volume":"28","author":"Nayak","year":"2013","journal-title":"Indian J. Clin. Biochem."},{"key":"2026010813091582800_cit17","first-page":"527","volume":"93","author":"Jones","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"2026010813091582800_cit18","first-page":"230","volume":"16","author":"Arsic","year":"2012","journal-title":"Hippokratia"},{"key":"2026010813091582800_cit19","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1021\/pr2002897","volume":"10","author":"Horgan","year":"2011","journal-title":"J. Proteome Res."},{"key":"2026010813091582800_cit20","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jpeds.2013.05.014","volume":"163","author":"Kramer","year":"2013","journal-title":"J. Pediatr."},{"key":"2026010813091582800_cit21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11306-020-01740-9","volume":"17","author":"Morillon","year":"2021","journal-title":"Metabolomics"},{"key":"2026010813091582800_cit22","doi-asserted-by":"crossref","first-page":"S619","DOI":"10.1016\/j.ajog.2017.12.010","volume":"218","author":"Kiserud","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2026010813091582800_cit23","doi-asserted-by":"crossref","first-page":"021202","DOI":"10.7189\/jogh.07.021202","volume":"7","author":"Baqui","year":"2017","journal-title":"J. Global Health"},{"key":"2026010813091582800_cit24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","volume":"384","author":"Villar","year":"2014","journal-title":"Lancet"},{"key":"2026010813091582800_cit25","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1021\/acs.jproteome.6b00848","volume":"16","author":"Lee","year":"2017","journal-title":"J. Proteome Res."},{"key":"2026010813091582800_cit26","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1074\/mcp.O115.056879","volume":"15","author":"Mitchell","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"2026010813091582800_cit27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/gim.2017.194","volume":"20","author":"Minter Baerg","year":"2018","journal-title":"Genet. Med."},{"key":"2026010813091582800_cit28","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/gim.2017.190","volume":"20","author":"Tortorelli","year":"2018","journal-title":"Genet. Med."},{"key":"2026010813091582800_cit29","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/gim.2012.2","volume":"14","author":"Marquardt","year":"2012","journal-title":"Genet. Med."},{"key":"2026010813091582800_cit30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/GIM.0b013e31820d5e67","volume":"13","author":"McHugh","year":"2011","journal-title":"Genet. Med."},{"key":"2026010813091582800_cit31","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1095\/biolreprod.102.004051","volume":"67","author":"Tokumura","year":"2002","journal-title":"Biol. Reprod."},{"key":"2026010813091582800_cit32","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.biochi.2010.04.015","volume":"92","author":"Okudaira","year":"2010","journal-title":"Biochimie"},{"key":"2026010813091582800_cit33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/nu10040399","volume":"10","author":"D\u2019Souza","year":"2018","journal-title":"Nutrients"},{"key":"2026010813091582800_cit34","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1242\/dev.121723","volume":"142","author":"Sheng","year":"2015","journal-title":"Development"},{"key":"2026010813091582800_cit35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0014-5793(94)00815-9","volume":"351","author":"Kobayashi","year":"1994","journal-title":"FEBS Lett."},{"key":"2026010813091582800_cit36","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.135.4.1071","volume":"135","author":"Hecht","year":"1996","journal-title":"J. Cell Biol."},{"key":"2026010813091582800_cit37","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1182\/blood-2010-03-272443","volume":"116","author":"Sumida","year":"2010","journal-title":"Blood"},{"key":"2026010813091582800_cit38","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1095\/biolreprod.108.068783","volume":"79","author":"Ye","year":"2008","journal-title":"Biol. Reprod."},{"key":"2026010813091582800_cit39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1056\/NEJM199107253250403","volume":"325","author":"Hack","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"2026010813091582800_cit40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000271911","volume":"73","author":"de Bie","year":"2010","journal-title":"Horm. Res. Paediatr."},{"key":"2026010813091582800_cit41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.plefa.2007.10.016","volume":"77","author":"Brenna","year":"2007","journal-title":"Prostaglandins, Leukotrienes Essent. Fatty Acids"},{"key":"2026010813091582800_cit42","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/jc.2006-1281","volume":"92","author":"Wang","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026010813091582800_cit43","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/0971-5916.195025","volume":"144","author":"Lobo","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"2026010813091582800_cit44","first-page":"677","volume":"13","author":"Serpytis","year":"2012","journal-title":"JOP"},{"key":"2026010813091582800_cit45","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1194\/jlr.M036699","volume":"54","author":"Hentschke","year":"2013","journal-title":"J. Lipid Res."},{"key":"2026010813091582800_cit46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000359969","volume":"36","author":"Mifsud","year":"2014","journal-title":"Fetal. Diagn. Ther."},{"key":"2026010813091582800_cit47","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/path.4678","volume":"238","author":"Mizuuchi","year":"2016","journal-title":"J. Pathol."},{"key":"2026010813091582800_cit48","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/14767058.2012.715006","volume":"26","author":"Longo","year":"2013","journal-title":"J. Matern.-Fetal Neonat. Med."}],"container-title":["Molecular Omics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/17\/6\/956\/65033509\/d1mo00131k.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/17\/6\/956\/65033509\/d1mo00131k.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:13:45Z","timestamp":1767896025000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article\/17\/6\/956\/8286658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d1mo00131k","relation":{},"ISSN":["2515-4184"],"issn-type":[{"value":"2515-4184","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,9,14]]}}}