{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:47:07Z","timestamp":1790718427551,"version":"4.1.0"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":95,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale Adv."],"abstract":"<jats:p>Graphene oxide based nanogel composite; an efficient oral drug delivery system for sustainable release of insulin.<\/jats:p>","DOI":"10.1039\/d1na00887k","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T03:01:53Z","timestamp":1649214113000},"page":"2303-2312","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis of an insulin intercalated graphene oxide nanogel composite: evaluation of its release profile and stability for oral delivery of insulin"],"prefix":"10.1039","volume":"4","author":[{"given":"Shabana Gul","family":"Baloch","sequence":"first","affiliation":[{"name":"National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-3452","authenticated-orcid":false,"given":"Huma","family":"Shaikh","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnila","family":"Shah","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahabuddin","family":"Memon","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9018-4856","authenticated-orcid":false,"given":"Ayaz Ali","family":"Memon","sequence":"additional","affiliation":[{"name":"National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1NA00887K\/cit1\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jiec.2016.12.023","volume":"49","author":"Zhao","year":"2017","journal-title":"J. Ind. Eng. Chem."},{"issue":"5","key":"D1NA00887K\/cit2\/1","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1021\/nn400630x","volume":"7","author":"Gu","year":"2013","journal-title":"ACS Nano"},{"key":"D1NA00887K\/cit3\/1","author":"Federation","year":"2013","unstructured":"I. D.Federation  and  I. D. J. I. D. F.Atlas ,  Brussels ,  2013"},{"key":"D1NA00887K\/cit4\/1","first-page":"5","author":"Langer","year":"1998","journal-title":"Nature"},{"key":"D1NA00887K\/cit5\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0167-7799(92)90194-Z","volume":"10","author":"Kost","year":"1992","journal-title":"Trends Biotechnol."},{"issue":"2","key":"D1NA00887K\/cit6\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diacare.5.2.77","volume":"5","author":"Berger","year":"1982","journal-title":"Diabetes Care"},{"issue":"1","key":"D1NA00887K\/cit7\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4239\/wjd.v4.i1.1","volume":"4","author":"Yaturu","year":"2013","journal-title":"World Journal of Diabetes"},{"issue":"2","key":"D1NA00887K\/cit8\/1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s40618-015-0326-3","volume":"39","author":"Akbari","year":"2016","journal-title":"J. Endocrinol. Invest."},{"issue":"8","key":"D1NA00887K\/cit9\/1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4155\/TDE.15.47","volume":"6","author":"Lopes","year":"2015","journal-title":"Ther. Delivery"},{"issue":"6","key":"D1NA00887K\/cit10\/1","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.biomaterials.2010.11.002","volume":"32","author":"Chen","year":"2011","journal-title":"Biomaterials"},{"key":"D1NA00887K\/cit11\/1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ijcard.2014.12.005","volume":"182","author":"Von Bibra","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"5","key":"D1NA00887K\/cit12\/1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s11892-013-0411-y","volume":"13","author":"Awoniyi","year":"2013","journal-title":"Curr. Diabetes Rep."},{"issue":"6","key":"D1NA00887K\/cit13\/1","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.3109\/10717544.2016.1153745","volume":"23","author":"Zhang","year":"2016","journal-title":"Drug Delivery"},{"issue":"1","key":"D1NA00887K\/cit14\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0168-3659(92)90212-A","volume":"18","author":"Klumb","year":"1992","journal-title":"J. Controlled Release"},{"issue":"8","key":"D1NA00887K\/cit15\/1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/pol.1986.140240809","volume":"24","author":"Ishihara","year":"1986","journal-title":"J. Polym. Sci., Part C: Polym. Lett."},{"issue":"3","key":"D1NA00887K\/cit16\/1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/02652049609026019","volume":"13","author":"Hari","year":"1996","journal-title":"J. Microencapsulation"},{"issue":"8","key":"D1NA00887K\/cit17\/1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0032-9592(96)00032-5","volume":"31","author":"Huguet","year":"1996","journal-title":"Process Biochem."},{"issue":"1\u20132","key":"D1NA00887K\/cit18\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-3659(96)01582-9","volume":"46","author":"Rubinstein","year":"1997","journal-title":"J. Controlled Release"},{"issue":"6","key":"D1NA00887K\/cit19\/1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.addr.2011.10.006","volume":"64","author":"Maroni","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"issue":"9","key":"D1NA00887K\/cit20\/1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1089\/dia.2011.0298","volume":"14","author":"Krzywon","year":"2012","journal-title":"Diabetes Technol. Ther."},{"issue":"1","key":"D1NA00887K\/cit21\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2230-973X.176456","volume":"6","author":"Shah","year":"2016","journal-title":"Int. J. Pharm. Invest."},{"issue":"12","key":"D1NA00887K\/cit22\/1","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1021\/ma00064a011","volume":"26","author":"Akiyoshi","year":"1993","journal-title":"Macromolecules"},{"key":"D1NA00887K\/cit23\/1","first-page":"367","volume-title":"16 Hydrophilic Colloidal Networks (Micro- and Nanogels) in Drug Delivery and Diagnostics","volume":"146","author":"Vinogradov","year":"2009","unstructured":"S. V. J. S.Vinogradov  and  f. p. o. c. systems ,  16 Hydrophilic Colloidal Networks (Micro- and Nanogels) in Drug Delivery and Diagnostics ,  2009 ,  vol. 146 ,  p. 367"},{"issue":"30","key":"D1NA00887K\/cit24\/1","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1002\/anie.200900441","volume":"48","author":"Kabanov","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"issue":"4","key":"D1NA00887K\/cit25\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/10837450.2017.1295064","volume":"23","author":"Wang","year":"2018","journal-title":"Pharm. Dev. Technol."},{"issue":"3","key":"D1NA00887K\/cit26\/1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1021\/ma062254w","volume":"40","author":"Hoare","year":"2007","journal-title":"Macromolecules"},{"issue":"13","key":"D1NA00887K\/cit27\/1","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1002\/app.12624","volume":"89","author":"Lee","year":"2003","journal-title":"J. Appl. Polym. Sci."},{"issue":"18","key":"D1NA00887K\/cit28\/1","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1039\/b821416f","volume":"19","author":"Yang","year":"2009","journal-title":"J. Mater. Chem."},{"issue":"33","key":"D1NA00887K\/cit29\/1","doi-asserted-by":"crossref","first-page":"10876","DOI":"10.1021\/ja803688x","volume":"130","author":"Liu","year":"2008","journal-title":"J. Am. Chem. Soc."},{"issue":"01","key":"D1NA00887K\/cit30\/1","first-page":"58","volume":"2","author":"Shahriary","year":"2014","journal-title":"International Journal of Renewable Energy and Environmental Engineering"},{"issue":"3","key":"D1NA00887K\/cit31\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1081\/BIO-120004343","volume":"30","author":"\u00d6nal","year":"2002","journal-title":"Artif. Cells, Blood Substitutes, Biotechnol."},{"issue":"3","key":"D1NA00887K\/cit32\/1","first-page":"217","volume":"67","author":"Dash","year":"2010","journal-title":"Acta Pol. Pharm."},{"issue":"12","key":"D1NA00887K\/cit33\/1","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3109\/03639048509087779","volume":"11","author":"Najib","year":"1985","journal-title":"Drug Dev. Ind. Pharm."},{"key":"D1NA00887K\/cit34\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jconrel.2014.06.041","volume":"190","author":"Peppas","year":"2014","journal-title":"J. Controlled Release"},{"issue":"12","key":"D1NA00887K\/cit35\/1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jps.2600521210","volume":"52","author":"Higuchi","year":"1963","journal-title":"J. Pharm. Sci."},{"key":"D1NA00887K\/cit36\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.carbon.2012.10.013","volume":"53","author":"Krishnamoorthy","year":"2013","journal-title":"Carbon"},{"issue":"2","key":"D1NA00887K\/cit37\/1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.apsusc.2011.08.074","volume":"258","author":"He","year":"2011","journal-title":"Appl. Surf. Sci."},{"issue":"1","key":"D1NA00887K\/cit38\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.polymertesting.2010.07.013","volume":"30","author":"Rezaei","year":"2011","journal-title":"Polym. Test."},{"key":"D1NA00887K\/cit39\/1","doi-asserted-by":"crossref","first-page":"116594","DOI":"10.1016\/j.carbpol.2020.116594","volume":"247","author":"Sarkar","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"D1NA00887K\/cit40\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.apmt.2016.04.003","volume":"4","author":"Jasim","year":"2016","journal-title":"Appl. Mater. Today"},{"key":"D1NA00887K\/cit41\/1","first-page":"51","volume":"2","author":"Mindivan","year":"2016","journal-title":"Mach., Technol., Mater."},{"issue":"2","key":"D1NA00887K\/cit42\/1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jcis.2011.05.009","volume":"360","author":"Bao","year":"2011","journal-title":"J. Colloid Interface Sci."},{"issue":"90","key":"D1NA00887K\/cit43\/1","doi-asserted-by":"crossref","first-page":"49264","DOI":"10.1039\/C4RA09693B","volume":"4","author":"Patil","year":"2014","journal-title":"RSC Adv."},{"issue":"sup1","key":"D1NA00887K\/cit44\/1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/21691401.2018.1439840","volume":"46","author":"Bakhshpour","year":"2018","journal-title":"Artif. Cells, Nanomed., Biotechnol."},{"issue":"2","key":"D1NA00887K\/cit45\/1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/acscentsci.9b01139","volume":"6","author":"Yu","year":"2020","journal-title":"ACS Cent. Sci."},{"issue":"02","key":"D1NA00887K\/cit46\/1","first-page":"1","volume":"6","author":"Gouda","year":"2017","journal-title":"J. Dev. Drugs"}],"container-title":["Nanoscale Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/NA\/D1NA00887K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:25:00Z","timestamp":1783275900000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/na\/article\/4\/10\/2303-2312\/733085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5,17]]}},"URL":"https:\/\/doi.org\/10.1039\/d1na00887k","relation":{},"ISSN":["2516-0230"],"issn-type":[{"value":"2516-0230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}