{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:36:31Z","timestamp":1785537391402,"version":"3.56.0"},"reference-count":74,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"am","delay-in-days":389,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>\n                    Iron(\n                    <jats:sc>ii<\/jats:sc>\n                    )-based complexes were able to penetrate into the\u00a0cytoplasm without disrupting the\u00a0cell membrane.\u00a0The complexes induced size, morphological, stiffness and cytoarchitectural changes in both triple negative breast cancer and normal\u00a0cells.\n                  <\/jats:p>","DOI":"10.1039\/d1nr08301e","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T03:21:46Z","timestamp":1643080906000},"page":"2735-2749","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Structural and morphological changes of breast cancer cells induced by iron(\n                    <scp>ii<\/scp>\n                    ) complexes"],"prefix":"10.1039","volume":"14","author":[{"given":"Janske","family":"Nel","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine, LIBio, F-54000, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Siniscalco","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, LPCME UMR 7564, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cilia","family":"Hognon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, LPCT UMR 7019, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Bouch\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, L2CM UMR 7053, F-54000, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0174-5859","authenticated-orcid":false,"given":"Nad\u00e9ge","family":"Touche","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, CRAN UMR 7039, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9milie","family":"Brunner","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, CRAN UMR 7039, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4905-1581","authenticated-orcid":false,"given":"Philippe C.","family":"Gros","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, L2CM UMR 7053, F-54000, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-1463","authenticated-orcid":false,"given":"Antonio","family":"Monari","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, LPCT UMR 7019, F-54000 Nancy, France"},{"name":"Universit\u00e9 de Paris, ITODYS, CNRS, F-75006, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Grandemange","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, CRAN UMR 7039, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-9449","authenticated-orcid":false,"given":"Gr\u00e9gory","family":"Francius","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine and CNRS, LPCME UMR 7564, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1NR08301E\/cit1\/1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers3011351","volume":"3","author":"Florea","year":"2011","journal-title":"Cancers"},{"key":"D1NR08301E\/cit2\/1","doi-asserted-by":"crossref","first-page":"e1257","DOI":"10.1038\/cddis.2013.428","volume":"5","author":"Galluzzi","year":"2014","journal-title":"Cell Death Dis."},{"key":"D1NR08301E\/cit3\/1","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D1NR08301E\/cit4\/1","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1039\/b508531b","author":"Yan","year":"2005","journal-title":"Chem. Commun."},{"key":"D1NR08301E\/cit5\/1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2174\/092986706776360941","volume":"13","author":"Kostova","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"D1NR08301E\/cit6\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejmech.2017.04.007","volume":"142","author":"Lazarevi\u0107","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D1NR08301E\/cit7\/1","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1039\/D0DT02135K","volume":"49","author":"Bouch\u00e9","year":"2020","journal-title":"Dalton Trans."},{"key":"D1NR08301E\/cit8\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/jm00202a016","volume":"21","author":"Fiorina","year":"1978","journal-title":"J. Med. Chem."},{"key":"D1NR08301E\/cit9\/1","doi-asserted-by":"crossref","first-page":"112109","DOI":"10.1016\/j.ejmech.2020.112109","volume":"190","author":"Wang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D1NR08301E\/cit10\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/9781119640868.ch4","author":"Shoukat","year":"2020","journal-title":"Adv. Metallodrugs"},{"key":"D1NR08301E\/cit11\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/anie.200502925","volume":"45","author":"Hillard","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1NR08301E\/cit12\/1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2533\/chimia.2007.716","volume":"61","author":"Nguyen","year":"2007","journal-title":"Chimia"},{"key":"D1NR08301E\/cit13\/1","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1039\/c1nj20192a","volume":"35","author":"Pigeon","year":"2011","journal-title":"New J. Chem."},{"key":"D1NR08301E\/cit14\/1","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1002\/cbic.202000311","volume":"21","author":"Cunningham","year":"2020","journal-title":"ChemBioChem"},{"key":"D1NR08301E\/cit15\/1","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1039\/c1nj20172g","volume":"35","author":"Ornelas","year":"2011","journal-title":"New J. Chem."},{"key":"D1NR08301E\/cit16\/1","doi-asserted-by":"crossref","first-page":"0066","DOI":"10.1038\/s41570-017-0066","volume":"1","author":"Patra","year":"2017","journal-title":"Nat. Rev. Chem."},{"key":"D1NR08301E\/cit17\/1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-3-319-74814-6_10","volume-title":"Biomedical Applications of Metals","author":"Mej\u00eda","year":"2018","unstructured":"C.Mej\u00eda ,  S.Ortega-Rosales  and  L.Ruiz-Azuara , in  Biomedical Applications of Metals ,  Springer International Publishing ,  2018 , pp.  213\u2013234"},{"key":"D1NR08301E\/cit18\/1","first-page":"813","volume":"12","author":"Spinello","year":"2017","journal-title":"Expert Opin. Drug Discovery"},{"key":"D1NR08301E\/cit19\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cbpa.2020.02.006","volume":"55","author":"Wang","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D1NR08301E\/cit20\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fchem.2015.00067","volume":"3","author":"Gattuso","year":"2015","journal-title":"Front. Chem."},{"key":"D1NR08301E\/cit21\/1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1046-2023(03)00032-X","volume":"30","author":"Debnath","year":"2003","journal-title":"Methods"},{"key":"D1NR08301E\/cit22\/1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.3892\/ol.2016.4852","volume":"12","author":"Jeong","year":"2016","journal-title":"Oncol. Lett."},{"key":"D1NR08301E\/cit23\/1","first-page":"801","volume":"34","author":"Cailleau","year":"1974","journal-title":"Cancer Res."},{"key":"D1NR08301E\/cit24\/1","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1529\/biophysj.104.045476","volume":"88","author":"Guck","year":"2005","journal-title":"Biophys. J."},{"key":"D1NR08301E\/cit25\/1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc2544","volume":"9","author":"Butcher","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"D1NR08301E\/cit26\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.semcancer.2015.09.001","volume":"35","author":"Nagelkerke","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"D1NR08301E\/cit27\/1","doi-asserted-by":"crossref","first-page":"20946","DOI":"10.18632\/oncotarget.4173","volume":"6","author":"Lin","year":"2015","journal-title":"Oncotarget"},{"key":"D1NR08301E\/cit28\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12668-016-0191-3","volume":"6","author":"Lekka","year":"2016","journal-title":"BioNanoScience"},{"key":"D1NR08301E\/cit29\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/wjnse.2019.91001","volume":"09","author":"Dutta","year":"2019","journal-title":"World J. Nano Sci. Eng."},{"key":"D1NR08301E\/cit30\/1","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1080\/00268976.2013.813594","volume":"111","author":"Fiorin","year":"2013","journal-title":"Mol. Phys."},{"key":"D1NR08301E\/cit31\/1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","volume":"26","author":"Phillips","year":"2005","journal-title":"J. Comput. Chem."},{"key":"D1NR08301E\/cit32\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graphics"},{"key":"D1NR08301E\/cit33\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/jcc.540070216","volume":"7","author":"Weiner","year":"1986","journal-title":"J. Comput. Chem."},{"key":"D1NR08301E\/cit34\/1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"D1NR08301E\/cit35\/1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graphics Modell."},{"key":"D1NR08301E\/cit36\/1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cmdc.201900677","volume":"15","author":"Notaro","year":"2020","journal-title":"ChemMedChem"},{"key":"D1NR08301E\/cit37\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0005-2736(00)00288-1","volume":"1509","author":"Leonenko","year":"2000","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D1NR08301E\/cit38\/1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.bbamem.2009.07.026","volume":"1798","author":"El Kirat","year":"2010","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D1NR08301E\/cit39\/1","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1016\/j.bbamem.2016.07.015","volume":"1858","author":"Freudenthal","year":"2016","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D1NR08301E\/cit40\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0020-7225(65)90019-4","volume":"3","author":"Sneddon","year":"1965","journal-title":"Int. J. Eng. Sci."},{"key":"D1NR08301E\/cit41\/1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nnano.2012.163","volume":"7","author":"Gavara","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"D1NR08301E\/cit42\/1","doi-asserted-by":"crossref","first-page":"18887","DOI":"10.1371\/journal.pone.0018887","volume":"6","author":"Polyakov","year":"2011","journal-title":"PLoS One"},{"key":"D1NR08301E\/cit43\/1","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1021\/acsnano.5b07162","volume":"10","author":"Calzado-Mart\u00edn","year":"2016","journal-title":"ACS Nano"},{"key":"D1NR08301E\/cit44\/1","first-page":"1","volume":"14","author":"Dutta","year":"2020","journal-title":"Breast Cancer: Basic Clin. Res."},{"key":"D1NR08301E\/cit45\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/cyto.a.20050","volume":"59","author":"Lincoln","year":"2004","journal-title":"Cytometry, Part A"},{"key":"D1NR08301E\/cit46\/1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s002490050213","volume":"28","author":"Lekka","year":"1999","journal-title":"Eur. Biophys. J."},{"key":"D1NR08301E\/cit47\/1","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/onc.2012.494","volume":"32","author":"Zhao","year":"2013","journal-title":"Oncogene"},{"key":"D1NR08301E\/cit48\/1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI64264","volume":"123","author":"Santidrian","year":"2013","journal-title":"J. Clin. Invest."},{"key":"D1NR08301E\/cit49\/1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41419-020-2658-y","volume":"11","author":"Biel","year":"2020","journal-title":"Cell Death Dis."},{"key":"D1NR08301E\/cit50\/1","first-page":"1281","volume":"33","author":"Bergamo","year":"2008","journal-title":"Int. J. Oncol."},{"key":"D1NR08301E\/cit51\/1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s10534-015-9877-1","volume":"28","author":"Dhivya","year":"2015","journal-title":"BioMetals"},{"key":"D1NR08301E\/cit52\/1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3390\/ijms18091869","volume":"18","author":"Lee","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"D1NR08301E\/cit53\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep45236","volume":"7","author":"Irace","year":"2017","journal-title":"Sci. Rep."},{"key":"D1NR08301E\/cit54\/1","doi-asserted-by":"crossref","first-page":"12197","DOI":"10.1039\/C8DT02236D","volume":"47","author":"Pracharova","year":"2018","journal-title":"Dalton Trans."},{"key":"D1NR08301E\/cit55\/1","author":"Daniel","year":"2019","unstructured":"R.Daniel ,  A.Mengeta ,  P.Bilodeau  and  J. M.Lee ,  bioRxiv ,  2019"},{"key":"D1NR08301E\/cit56\/1","first-page":"1","volume":"3","author":"Agus","year":"2013","journal-title":"Sci. Rep."},{"key":"D1NR08301E\/cit57\/1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.5732\/cjc.011.10226","volume":"30","author":"Wang","year":"2011","journal-title":"Chin. J. Cancer"},{"key":"D1NR08301E\/cit58\/1","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1021\/acs.jmedchem.9b00489","volume":"62","author":"Kostrhunova","year":"2019","journal-title":"J. Med. Chem."},{"key":"D1NR08301E\/cit59\/1","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1111\/cas.13830","volume":"109","author":"long Xie","year":"2018","journal-title":"Cancer Sci."},{"key":"D1NR08301E\/cit60\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbrc.2017.06.192","volume":"500","author":"Kashatus","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D1NR08301E\/cit61\/1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-3-319-74814-6_10","volume-title":"Biomedical Applications of Metals","volume":"10","author":"Mej\u00eda","year":"2018","unstructured":"C.Mej\u00eda ,  S.Ortega-Rosales  and  L.Ruiz-Azuara ,  Biomedical Applications of Metals , ed.  M. Rai ,  A. Ingle  and  S. Medici ,  Springer International Publishing ,  Berlin\/Heidelberg, Germany ,  2018 , vol.  10 , pp.  213\u2013234"},{"key":"D1NR08301E\/cit62\/1","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1039\/c2sc20627g","volume":"3","author":"Casini","year":"2012","journal-title":"Chem. Sci."},{"key":"D1NR08301E\/cit63\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1039\/b907567d","volume":"1","author":"Todd","year":"2009","journal-title":"Metallomics"},{"key":"D1NR08301E\/cit64\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.drup.2010.12.002","volume":"14","author":"Burger","year":"2011","journal-title":"Drug Resist. Updates"},{"key":"D1NR08301E\/cit65\/1","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"D1NR08301E\/cit66\/1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ica.2016.02.044","volume":"452","author":"Pinheiro Araujo","year":"2016","journal-title":"Inorg. Chim. Acta"},{"key":"D1NR08301E\/cit67\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1515\/MGMC.1997.20.1.19","volume":"20","author":"Kafer","year":"1997","journal-title":"Main Group Met. Chem."},{"key":"D1NR08301E\/cit68\/1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/277665a0","volume":"277","author":"Schiff","year":"1979","journal-title":"Nature"},{"key":"D1NR08301E\/cit69\/1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1021\/jm00107a017","volume":"34","author":"Gu\u00e9ritte-Voegelein","year":"1991","journal-title":"J. Med. Chem."},{"key":"D1NR08301E\/cit70\/1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3109\/01480545.2013.776579","volume":"36","author":"Bostanc\u0131o\u011flu","year":"2013","journal-title":"Drug Chem. Toxicol."},{"key":"D1NR08301E\/cit71\/1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1021\/acsmedchemlett.6b00046","volume":"7","author":"Wieczorek","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"D1NR08301E\/cit72\/1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.3390\/molecules25071592","volume":"25","author":"Pilon","year":"2020","journal-title":"Molecules"},{"key":"D1NR08301E\/cit73\/1","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.3390\/app11125626","volume":"11","author":"Iacopetta","year":"2021","journal-title":"Appl. Sci."},{"key":"D1NR08301E\/cit74\/1","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1021\/acs.inorgchem.0c03820","volume":"60","author":"Acharya","year":"2021","journal-title":"Inorg. Chem."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/NR\/D1NR08301E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:18:00Z","timestamp":1782929880000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/14\/7\/2735-2749\/737518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":74,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,2,17]]}},"URL":"https:\/\/doi.org\/10.1039\/d1nr08301e","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}