{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:04:03Z","timestamp":1787004243318,"version":"build-2736575974"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"8","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"am","delay-in-days":382,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770996"],"award-info":[{"award-number":["31770996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20210204197YY"],"award-info":[{"award-number":["20210204197YY"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>A schematic overview showing nanoparticle preparation, BALB\/c mice immunization, and viral challenge. Humoral and cellular immune responses were determined after three immunizations, and protective effects were evaluated after the challenge.<\/jats:p>","DOI":"10.1039\/d1nr08460g","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T02:21:35Z","timestamp":1642472495000},"page":"3250-3260","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response"],"prefix":"10.1039","volume":"14","author":[{"given":"Yongbo","family":"Qiao","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Jin","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kong","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"},{"name":"Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8373-6088","authenticated-orcid":false,"given":"Yaming","family":"Shan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"},{"name":"Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1NR08460G\/cit1\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.14745\/ccdr.v47i03a02","volume":"47","author":"Lagace-Wiens","year":"2021","journal-title":"Can. Commun. Dis. Rep."},{"key":"D1NR08460G\/cit2\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/imr.12887","volume":"296","author":"Fukuyama","year":"2020","journal-title":"Immunol. Rev."},{"key":"D1NR08460G\/cit3\/1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3390\/microorganisms8111745","volume":"8","author":"Rockman","year":"2020","journal-title":"Microorganisms"},{"key":"D1NR08460G\/cit4\/1","doi-asserted-by":"crossref","first-page":"e03617","DOI":"10.1128\/mBio.03617-20","volume":"12","author":"Roubidoux","year":"2021","journal-title":"mBio"},{"key":"D1NR08460G\/cit5\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fmicb.2020.00135","volume":"11","author":"Vogel","year":"2020","journal-title":"Front. Microbiol."},{"key":"D1NR08460G\/cit6\/1","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1039\/c2nr30388d","volume":"4","author":"Weng","year":"2012","journal-title":"Nanoscale"},{"key":"D1NR08460G\/cit7\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/vaccines9030257","volume":"9","author":"Bullard","year":"2021","journal-title":"Vaccines"},{"key":"D1NR08460G\/cit8\/1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41573-019-0056-x","volume":"19","author":"Wei","year":"2020","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D1NR08460G\/cit9\/1","doi-asserted-by":"crossref","first-page":"a038778","DOI":"10.1101\/cshperspect.a038778","volume":"10","author":"Wu","year":"2020","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D1NR08460G\/cit10\/1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nsmb.1566","volume":"16","author":"Sui","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"D1NR08460G\/cit11\/1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature12202","volume":"499","author":"Kanekiyo","year":"2013","journal-title":"Nature"},{"key":"D1NR08460G\/cit12\/1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm.3927","volume":"21","author":"Yassine","year":"2015","journal-title":"Nat. Med."},{"key":"D1NR08460G\/cit13\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jmb.2009.04.078","volume":"390","author":"Cho","year":"2009","journal-title":"J. Mol. Biol."},{"key":"D1NR08460G\/cit14\/1","doi-asserted-by":"crossref","first-page":"e1703207","DOI":"10.1002\/smll.201703207","volume":"14","author":"Qi","year":"2018","journal-title":"Small"},{"key":"D1NR08460G\/cit15\/1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nri3488","volume":"13","author":"Smith","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"D1NR08460G\/cit16\/1","doi-asserted-by":"crossref","first-page":"22268","DOI":"10.1039\/D0NR04520A","volume":"12","author":"Shan","year":"2020","journal-title":"Nanoscale"},{"key":"D1NR08460G\/cit17\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.nano.2018.11.009","volume":"16","author":"Wang","year":"2019","journal-title":"Nanomedicine"},{"key":"D1NR08460G\/cit18\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41565-020-0648-y","volume":"15","author":"Wang","year":"2020","journal-title":"Nat. Nanotechnol."},{"key":"D1NR08460G\/cit19\/1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cell.2015.07.043","volume":"162","author":"Kanekiyo","year":"2015","journal-title":"Cell"},{"key":"D1NR08460G\/cit20\/1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1021\/acsinfecdis.7b00192","volume":"4","author":"Georgiev","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"D1NR08460G\/cit21\/1","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1021\/acsnano.0c08379","volume":"15","author":"Kang","year":"2021","journal-title":"ACS Nano"},{"key":"D1NR08460G\/cit22\/1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1021\/acs.bioconjchem.1c00208","volume":"32","author":"Li","year":"2021","journal-title":"Bioconjugate Chem."},{"key":"D1NR08460G\/cit23\/1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.immuni.2020.11.015","volume":"53","author":"Ma","year":"2020","journal-title":"Immunity"},{"key":"D1NR08460G\/cit24\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/acscentsci.0c01405","volume":"7","author":"Powell","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"D1NR08460G\/cit25\/1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res."},{"key":"D1NR08460G\/cit26\/1","doi-asserted-by":"crossref","first-page":"e1297","DOI":"10.1002\/cti2.1297","volume":"10","author":"Kavian","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"D1NR08460G\/cit27\/1","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1128\/JVI.00273-13","volume":"87","author":"Srivastava","year":"2013","journal-title":"J. Virol."},{"key":"D1NR08460G\/cit28\/1","doi-asserted-by":"crossref","first-page":"571999","DOI":"10.3389\/fvets.2020.571999","volume":"7","author":"Kalaiyarasu","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"D1NR08460G\/cit29\/1","doi-asserted-by":"crossref","first-page":"10722","DOI":"10.1021\/acsnano.1c04078","volume":"15","author":"Kang","year":"2021","journal-title":"ACS Nano"},{"key":"D1NR08460G\/cit30\/1","doi-asserted-by":"crossref","first-page":"18979","DOI":"10.1073\/pnas.1013387107","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1NR08460G\/cit31\/1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/14760584.2018.1541408","volume":"17","author":"Wang","year":"2018","journal-title":"Expert Rev. Vaccines"},{"key":"D1NR08460G\/cit32\/1","doi-asserted-by":"crossref","first-page":"e02810","DOI":"10.1128\/mBio.02810-18","volume":"10","author":"Corbett","year":"2019","journal-title":"mBio"},{"key":"D1NR08460G\/cit33\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41591-020-1118-7","volume":"27","author":"Nachbagauer","year":"2021","journal-title":"Nat. Med."},{"key":"D1NR08460G\/cit34\/1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1586\/14760584.6.6.939","volume":"6","author":"Ben-Yedidia","year":"2007","journal-title":"Expert Rev. Vaccines"},{"key":"D1NR08460G\/cit35\/1","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1021\/acsinfecdis.8b00206","volume":"4","author":"Deng","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"D1NR08460G\/cit36\/1","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s10529-020-02944-8","volume":"42","author":"Qu","year":"2020","journal-title":"Biotechnol. Lett."},{"key":"D1NR08460G\/cit37\/1","doi-asserted-by":"crossref","first-page":"e2000087","DOI":"10.1002\/biot.202000087","volume":"15","author":"Pan","year":"2020","journal-title":"Biotechnol. J."},{"key":"D1NR08460G\/cit38\/1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1039\/C5SC03892H","volume":"7","author":"Skwarczynski","year":"2016","journal-title":"Chem. Sci."},{"key":"D1NR08460G\/cit39\/1","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/j.vaccine.2019.04.048","volume":"37","author":"Cohet","year":"2019","journal-title":"Vaccine"},{"key":"D1NR08460G\/cit40\/1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10875-010-9490-6","volume":"31","author":"Moris","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"D1NR08460G\/cit41\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2016.05.001","volume":"120","author":"Karch","year":"2016","journal-title":"Biochem. Pharmacol."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/NR\/D1NR08460G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:01:39Z","timestamp":1783533699000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/14\/8\/3250-3260\/737512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,2,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d1nr08460g","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}