{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:48:17Z","timestamp":1782856097174,"version":"3.54.5"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21172200"],"award-info":[{"award-number":["21172200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21702191"],"award-info":[{"award-number":["21702191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>The first metal-free method for alkylation of quinoxalinones using cheap and stable aryl alkyl ketones as nucleophilic alkylation reagents is reported.<\/jats:p>","DOI":"10.1039\/d1ob02260a","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T20:21:27Z","timestamp":1642018887000},"page":"1391-1395","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Metal-free alkylation of quinoxalinones with aryl alkyl ketones"],"prefix":"10.1039","volume":"20","author":[{"given":"Xinya","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-5854","authenticated-orcid":false,"given":"Zhuangzhuang","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpeng","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Li","sequence":"additional","affiliation":[{"name":"TetranovBiopharm, LLC., Zhengzhou, 450052, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-0870","authenticated-orcid":false,"given":"Yangjie","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-9541","authenticated-orcid":false,"given":"Yusheng","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450052, People's Republic of China"},{"name":"Tetranov International, Inc., 100 Jersey Avenue, Suite A340, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1OB02260A\/cit1\/1","doi-asserted-by":"crossref","first-page":"11905","DOI":"10.1021\/acs.joc.1c01325","volume":"86","author":"Liu","year":"2021","journal-title":"J. Org. Chem."},{"key":"D1OB02260A\/cit2\/1","doi-asserted-by":"crossref","first-page":"12247","DOI":"10.1021\/acs.joc.1c01558","volume":"86","author":"Byun","year":"2021","journal-title":"J. Org. Chem."},{"key":"D1OB02260A\/cit3\/1","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1039\/D0CS00973C","volume":"50","author":"Aynetdinova","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D1OB02260A\/cit4\/1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1021\/bi020599a","volume":"42","author":"Finer-Moore","year":"2003","journal-title":"Biochemistry"},{"key":"D1OB02260A\/cit5\/1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1126\/science.1063852","volume":"293","author":"Jones","year":"2001","journal-title":"Science"},{"key":"D1OB02260A\/cit6\/1","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1016\/j.chempr.2021.08.001","volume":"7","author":"Zhao","year":"2021","journal-title":"Chem"},{"key":"D1OB02260A\/cit7\/1","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1039\/C7SC03768F","volume":"8","author":"McCallum","year":"2017","journal-title":"Chem. Sci."},{"key":"D1OB02260A\/cit8\/1","doi-asserted-by":"crossref","first-page":"9131","DOI":"10.1002\/anie.201801573","volume":"57","author":"Zhang","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1OB02260A\/cit9\/1","doi-asserted-by":"crossref","first-page":"9705","DOI":"10.1039\/D1OB01858B","volume":"19","author":"Peng","year":"2021","journal-title":"Org. Biomol. Chem."},{"key":"D1OB02260A\/cit10\/1","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1039\/D1QO00210D","volume":"8","author":"Zhu","year":"2021","journal-title":"Org. Chem. Front."},{"key":"D1OB02260A\/cit11\/1","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1021\/acs.orglett.9b01439","volume":"21","author":"Li","year":"2019","journal-title":"Org. Lett."},{"key":"D1OB02260A\/cit12\/1","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1021\/acs.orglett.9b02539","volume":"21","author":"Tian","year":"2019","journal-title":"Org. Lett."},{"key":"D1OB02260A\/cit13\/1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1039\/D0OB02383C","volume":"19","author":"Pan","year":"2021","journal-title":"Org. Biomol. Chem."},{"key":"D1OB02260A\/cit14\/1","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1021\/acscatal.7b01133","volume":"7","author":"Garza-Sanchez","year":"2017","journal-title":"ACS Catal."},{"key":"D1OB02260A\/cit15\/1","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1002\/anie.201902134","volume":"58","author":"Yan","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1OB02260A\/cit16\/1","doi-asserted-by":"crossref","first-page":"15309","DOI":"10.1002\/anie.201707958","volume":"56","author":"Nuhant","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1OB02260A\/cit17\/1","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1039\/C6SC00807K","volume":"7","author":"McCallum","year":"2016","journal-title":"Chem. Sci."},{"key":"D1OB02260A\/cit18\/1","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1039\/C6SC05622A","volume":"8","author":"Theunissen","year":"2017","journal-title":"Chem. Sci."},{"key":"D1OB02260A\/cit19\/1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1021\/acs.jnatprod.8b01022","volume":"82","author":"Ertl","year":"2019","journal-title":"J. Nat. Prod."},{"key":"D1OB02260A\/cit20\/1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-3-642-73432-8_11","volume-title":"Industrial Aromatic Chemistry: Raw Materials Processes Products","author":"Franck","year":"1988","unstructured":"H.-G.Franck  and  J. W.Stadelhofer ,  Anthracene-production and uses , in  Industrial Aromatic Chemistry: Raw Materials Processes Products , ed.  H.-G. Franck  and  J. W. Stadelhofer ,  Springer Berlin Heidelberg ,  Berlin, Heidelberg ,  1988 , pp.  343\u2013361"},{"key":"D1OB02260A\/cit21\/1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1039\/b100919m","volume":"19","author":"Walter","year":"2002","journal-title":"Nat. Prod. Rep."},{"key":"D1OB02260A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/jacs.6b12293","volume":"139","author":"Morioka","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D1OB02260A\/cit23\/1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1039\/B308864M","volume":"33","author":"Jun","year":"2004","journal-title":"Chem. Soc. Rev."},{"key":"D1OB02260A\/cit24\/1","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1021\/ol400815y","volume":"15","author":"Dermenci","year":"2013","journal-title":"Org. Lett."},{"key":"D1OB02260A\/cit25\/1","doi-asserted-by":"crossref","first-page":"14388","DOI":"10.1002\/anie.202006740","volume":"59","author":"Li","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1OB02260A\/cit26\/1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/370540a0","volume":"370","author":"Murakami","year":"1994","journal-title":"Nature"},{"key":"D1OB02260A\/cit27\/1","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1021\/jacs.8b02462","volume":"140","author":"Xia","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D1OB02260A\/cit28\/1","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1021\/acscatal.0c05372","volume":"11","author":"Xu","year":"2021","journal-title":"ACS Catal."},{"key":"D1OB02260A\/cit29\/1","first-page":"14713","volume":"83","author":"Zhu","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D1OB02260A\/cit30\/1","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1021\/ol900874z","volume":"11","author":"Schmink","year":"2009","journal-title":"Org. Lett."},{"key":"D1OB02260A\/cit31\/1","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.1002\/ejoc.201300594","volume":"2013","author":"Wang","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"D1OB02260A\/cit32\/1","doi-asserted-by":"crossref","first-page":"6345","DOI":"10.1021\/acs.orglett.8b02498","volume":"20","author":"Wu","year":"2018","journal-title":"Org. Lett."},{"key":"D1OB02260A\/cit33\/1","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1021\/jm200394x","volume":"54","author":"Liu","year":"2011","journal-title":"J. Med. Chem."},{"key":"D1OB02260A\/cit34\/1","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1016\/j.tetlet.2014.03.061","volume":"55","author":"Kobayashi","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"D1OB02260A\/cit35\/1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/jm000282d","volume":"44","author":"Lawrence","year":"2001","journal-title":"J. Med. Chem."},{"key":"D1OB02260A\/cit36\/1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ardp.200600061","volume":"339","author":"El-Hawash","year":"2006","journal-title":"Arch. Pharm."},{"key":"D1OB02260A\/cit37\/1","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1021\/acs.orglett.0c02080","volume":"22","author":"He","year":"2020","journal-title":"Org. Lett."},{"key":"D1OB02260A\/cit38\/1","doi-asserted-by":"crossref","first-page":"14685","DOI":"10.1039\/C9CC07840A","volume":"55","author":"Lian","year":"2019","journal-title":"Chem. Commun."},{"key":"D1OB02260A\/cit39\/1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1039\/D0GC03892J","volume":"23","author":"Niu","year":"2021","journal-title":"Green Chem."},{"key":"D1OB02260A\/cit40\/1","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1039\/D0CC05391K","volume":"56","author":"Niu","year":"2020","journal-title":"Chem. Commun."},{"key":"D1OB02260A\/cit41\/1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ajoc.201900758","volume":"9","author":"Rong","year":"2020","journal-title":"Asian J. Org. Chem."},{"key":"D1OB02260A\/cit42\/1","doi-asserted-by":"crossref","first-page":"152720","DOI":"10.1016\/j.tetlet.2020.152720","volume":"64","author":"Wang","year":"2021","journal-title":"Tetrahedron Lett."},{"key":"D1OB02260A\/cit43\/1","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.1021\/acssuschemeng.9b02822","volume":"7","author":"Xie","year":"2019","journal-title":"ACS Sustainable Chem. Eng."},{"key":"D1OB02260A\/cit44\/1","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1002\/asia.201900904","volume":"14","author":"Yan","year":"2019","journal-title":"Chem. \u2013 Asian J."},{"key":"D1OB02260A\/cit45\/1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/anie.202010958","volume":"60","author":"Ghosh","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1OB02260A\/cit46\/1","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1039\/C9OB02653C","volume":"18","author":"Shen","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"D1OB02260A\/cit47\/1","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1021\/acs.joc.0c02739","volume":"86","author":"Chen","year":"2021","journal-title":"J. Org. Chem."},{"key":"D1OB02260A\/cit48\/1","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/adsc.201801541","volume":"361","author":"Han","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"D1OB02260A\/cit49\/1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1039\/C8QO01281D","volume":"6","author":"Han","year":"2019","journal-title":"Org. Chem. Front."},{"key":"D1OB02260A\/cit50\/1","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1021\/acs.orglett.8b01216","volume":"20","author":"Gao","year":"2018","journal-title":"Org. Lett."},{"key":"D1OB02260A\/cit51\/1","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1002\/adsc.201800100","volume":"360","author":"Han","year":"2018","journal-title":"Adv. Synth. Catal."},{"key":"D1OB02260A\/cit52\/1","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1039\/C9GC01880H","volume":"21","author":"Zhao","year":"2019","journal-title":"Green Chem."},{"key":"D1OB02260A\/cit53\/1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/ja01512a031","volume":"81","author":"Stiles","year":"1959","journal-title":"J. Am. Chem. Soc."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/OB\/D1OB02260A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:38:56Z","timestamp":1782851936000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/20\/7\/1391-1395\/738731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,2,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d1ob02260a","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}