{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:03:39Z","timestamp":1782882219465,"version":"3.54.5"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"41","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2017YFE0113900"],"award-info":[{"award-number":["2017YFE0113900"]}]},{"DOI":"10.13039\/501100007925","name":"Huazhong Agricultural University","doi-asserted-by":"crossref","award":["42000481-7"],"award-info":[{"award-number":["42000481-7"]}],"id":[{"id":"10.13039\/501100007925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>\n                    A series of novel piperine\u2013resveratrol hybrids\n                    <bold>5a\u2013h<\/bold>\n                    was designed, synthesized, and structurally elucidated by IR, and\n                    <sup>1<\/sup>\n                    H,\n                    <sup>13<\/sup>\n                    C, and\n                    <sup>19<\/sup>\n                    F NMR.\n                  <\/p>","DOI":"10.1039\/d1ra04061h","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T07:19:37Z","timestamp":1627456777000},"page":"25738-25751","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Structure-based design, synthesis, and biological evaluation of novel piperine\u2013resveratrol hybrids as antiproliferative agents targeting SIRT-2"],"prefix":"10.1039","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-7827","authenticated-orcid":false,"given":"Ahmed H.","family":"Tantawy","sequence":"first","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory"},{"name":"College of Plant Science and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan 430070"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Gao","family":"Meng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pesticide and Chemical Biology"},{"name":"Ministry of Education"},{"name":"School of Chemistry"},{"name":"Central China Normal University"},{"name":"Wuhan 430079"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel A.","family":"Marzouk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry"},{"name":"Faculty of Pharmacy"},{"name":"Al-Azhar University"},{"name":"Assiut 71524"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Fouad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry"},{"name":"Faculty of Pharmacy"},{"name":"Al-Azhar University"},{"name":"Assiut 71524"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed H.","family":"Abdelazeem","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry"},{"name":"Faculty of Pharmacy"},{"name":"Beni-Suef University"},{"name":"Beni-Suef 62514"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-6548","authenticated-orcid":false,"given":"Bahaa G. M.","family":"Youssif","sequence":"additional","affiliation":[{"name":"Pharmaceutical Organic Chemistry Department"},{"name":"Faculty of Pharmacy"},{"name":"Assiut University"},{"name":"Assiut 71526"},{"name":"Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Chemistry"},{"name":"College of Science"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan"},{"name":"China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory"},{"name":"College of Plant Science and Technology"},{"name":"Huazhong Agricultural University"},{"name":"Wuhan 430070"},{"name":"People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1RA04061H-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ejmech.2018.01.042","volume":"146","author":"Youssif","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bioorg.2017.09.009","volume":"75","author":"Abdelazeem","year":"2017","journal-title":"Bioorg. Chem."},{"key":"D1RA04061H-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bioorg.2018.06.003","volume":"80","author":"Abdelbaset","year":"2018","journal-title":"Bioorg. Chem."},{"key":"D1RA04061H-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4155\/fmc.14.44","volume":"6","author":"Hu","year":"2014","journal-title":"Future Med. Chem."},{"key":"D1RA04061H-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.3390\/molecules20033898","volume":"20","author":"Mottamal","year":"2015","journal-title":"Molecules"},{"key":"D1RA04061H-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.18632\/oncotarget.12157","volume":"8","author":"Ye","year":"2017","journal-title":"Oncotarget"},{"key":"D1RA04061H-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"750","DOI":"10.14348\/molcells.2015.0167","volume":"38","author":"Jeong","year":"2015","journal-title":"Mol. Cells"},{"key":"D1RA04061H-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1089\/dna.2016.3280","volume":"35","author":"Wu","year":"2016","journal-title":"DNA Cell Biol."},{"key":"D1RA04061H-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/febs.13053","volume":"282","author":"Bosch-Presegu_e","year":"2015","journal-title":"FEBS J."},{"key":"D1RA04061H-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/bs.mie.2016.03.011","volume":"574","author":"Bedalov","year":"2016","journal-title":"Methods Enzymol."},{"key":"D1RA04061H-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev-biochem-060815-014537","volume":"85","author":"Bheda","year":"2016","journal-title":"Rev. Biochem."},{"key":"D1RA04061H-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1016\/j.bmcl.2015.04.068","volume":"25","author":"Therrien","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D1RA04061H-(cit13)\/*[position()=1]","first-page":"5355","volume":"37","author":"Garmpis","year":"2017","journal-title":"Anticancer Res."},{"key":"D1RA04061H-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1080\/15384101.2016.1200774","volume":"15","author":"Wang","year":"2016","journal-title":"Cell Cycle"},{"key":"D1RA04061H-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/1568026619666190510103416","volume":"19","author":"Wang","year":"2019","journal-title":"Curr. Top. Med. Chem."},{"key":"D1RA04061H-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neo.2018.03.008","volume":"20","author":"Li","year":"2018","journal-title":"Neoplasia"},{"key":"D1RA04061H-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms18071414","volume":"18","author":"Eckschlager","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"D1RA04061H-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.tranon.2017.09.006","volume":"10","author":"Huang","year":"2017","journal-title":"Transl. Oncol."},{"key":"D1RA04061H-(cit19)\/*[position()=1]","first-page":"162","volume":"4","author":"Kaladhar","year":"2017","journal-title":"Metabolism"},{"key":"D1RA04061H-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1158\/0008-5472.CAN-15-2733","volume":"76","author":"George","year":"2016","journal-title":"Cancer Res."},{"key":"D1RA04061H-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signaling"},{"key":"D1RA04061H-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1007\/s00044-013-0541-4","volume":"22","author":"Umadevi","year":"2013","journal-title":"Med. Chem. Res."},{"key":"D1RA04061H-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jep.2016.04.047","volume":"188","author":"Deng","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"D1RA04061H-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10295-015-1723-5","volume":"43","author":"Katz","year":"2016","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"D1RA04061H-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1021\/np030096l","volume":"66","author":"Newman","year":"2003","journal-title":"J. Nat. Prod."},{"key":"D1RA04061H-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.ejmech.2015.01.001","volume":"92","author":"Ali","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit27)\/*[position()=1]","first-page":"107","volume":"9","author":"Conaway","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"D1RA04061H-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"D1RA04061H-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1021\/jm060118b","volume":"49","author":"Trapp","year":"2006","journal-title":"J. Med. Chem."},{"key":"D1RA04061H-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0049761","volume":"7","author":"Gertz","year":"2012","journal-title":"PLoS One"},{"key":"D1RA04061H-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1074\/jbc.M501250200","volume":"280","author":"Borra","year":"2005","journal-title":"J. Biol. Chem."},{"key":"D1RA04061H-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/mnfr.201100117","volume":"55","author":"Johnson","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"issue":"15","key":"D1RA04061H-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.3390\/ijms21155244","volume":"21","author":"Schmidt","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D1RA04061H-(cit34)\/*[position()=1]","first-page":"119510","author":"Tantawy","year":"2019","journal-title":"J. Cleaner Prod."},{"key":"D1RA04061H-(cit35)\/*[position()=1]","first-page":"103464","author":"Tantawy","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D1RA04061H-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1016\/j.bmcl.2013.08.053","volume":"23","author":"Qu","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D1RA04061H-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.1002\/ejoc.201501072","author":"Le Goff","year":"2015","journal-title":"Eur. J. Org. Chem."},{"key":"D1RA04061H-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1002\/chem.201405094","volume":"21","author":"Le\nGoff","year":"2015","journal-title":"Chem.\u2013Eur. J."},{"key":"D1RA04061H-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejmech.2014.12.027","volume":"92","author":"Yang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1039\/B203191B","volume":"4","author":"Spackman","year":"2002","journal-title":"CrystEngComm"},{"key":"D1RA04061H-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/B818330A","volume":"11","author":"Spackman","year":"2009","journal-title":"CrystEngComm"},{"key":"D1RA04061H-(cit42)\/*[position()=1]","volume-title":"Novel tools for visualizing and exploring intermolecular interactions in molecular crystals","volume":"vol. 60","author":"McKinnon","year":"2004","unstructured":"J. J.McKinnon ,  M. A.Spackman  and  A. S.Mitchell ,  Novel tools for visualizing and exploring intermolecular interactions in molecular crystals ,  2004 ,  vol. 60"},{"key":"D1RA04061H-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ejmech.2018.01.042","volume":"146","author":"Youssif","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112662","DOI":"10.1016\/j.ejmech.2020.112662","volume":"205","author":"Abdelazeem","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.ejmech.2016.11.006","volume":"127","author":"Abdelrahman","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejmech.2017.04.025","volume":"135","author":"Zha","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1038\/ncomms7263","volume":"6","author":"Rumpf","year":"2015","journal-title":"Nat. Commun."},{"key":"D1RA04061H-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"20170083","DOI":"10.1098\/rstb.2017.0083","volume":"373","author":"Swyter","year":"2018","journal-title":"Philos. Trans. R. Soc., B"},{"key":"D1RA04061H-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1021\/acs.orglett.9b02072","volume":"21","author":"Zeng","year":"2019","journal-title":"Org. Lett."},{"key":"D1RA04061H-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16520","DOI":"10.1002\/anie.201809112","volume":"57","author":"Zhu","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1RA04061H-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.1002\/anie.201501538","volume":"54","author":"Poh","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1RA04061H-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bioorg.2017.12.013","volume":"76","author":"El-Sherief","year":"2018","journal-title":"Bioorg. Chem."},{"key":"D1RA04061H-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/cmdc.201000030","author":"Rotili","year":"2010","journal-title":"ChemMedChem"},{"key":"D1RA04061H-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2019.05.040","volume":"177","author":"Youssif","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D1RA04061H-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"102997","DOI":"10.1016\/j.bioorg.2019.102997","volume":"89","author":"Abou-zied","year":"2019","journal-title":"Bioorg. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/RA\/D1RA04061H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:57:34Z","timestamp":1782878254000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/11\/41\/25738-25751\/743280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":55,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2021,7,27]]}},"URL":"https:\/\/doi.org\/10.1039\/d1ra04061h","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/D1RA04061H","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Crystal Structure Data","URL":"http:\/\/xlink.rsc.org?ccdc=true&msid=D1RA04061H","name":"related_data"},{"value":"Ahmed H. Tantawy (ORCID)","URL":"http:\/\/orcid.org\/0000-0001-5139-7827","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Bahaa G. M. Youssif (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-6834-6548","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 25 May 2021; Accepted 23 June 2021;  Version of Record published 27 July 2021","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}