{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:57:38Z","timestamp":1791338258284,"version":"4.3.1"},"reference-count":79,"publisher":"Royal Society of Chemistry (RSC)","issue":"44","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":221,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>A portable microfluidic paper-based colorimetric sensor based on various type of gold nanoparticle (AuNPs) for the monitoring of UA was developed.<\/jats:p>","DOI":"10.1039\/d1ra04764g","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T06:02:03Z","timestamp":1628575323000},"page":"27298-27308","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Architecture of a multi-channel and easy-to-make microfluidic paper-based colorimetric device (\u03bcPCD) towards selective and sensitive recognition of uric acid by AuNPs: an innovative portable tool for the rapid and low-cost identification of clinically relevant biomolecules"],"prefix":"10.1039","volume":"11","author":[{"given":"Fatemeh","family":"Farshchi","sequence":"first","affiliation":[{"name":"Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China"},{"name":"Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Saadati","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-1239","authenticated-orcid":false,"given":"Mohammad","family":"Hasanzadeh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"},{"name":"Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-9554","authenticated-orcid":false,"given":"Farzad","family":"Seidi","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1RA04764G\/cit1","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2174\/138161205774913255","volume":"11","author":"Glantzounis","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"D1RA04764G\/cit2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/15257770802138558","volume":"27","author":"Sautin","year":"2008","journal-title":"Nucleosides, Nucleotides Nucleic Acids"},{"key":"D1RA04764G\/cit3","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1097\/01.ASN.0000034910.58454.FD","volume":"13","author":"Kang","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"D1RA04764G\/cit4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/abbi.1993.1204","volume":"302","author":"Elsayed","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"D1RA04764G\/cit5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/clinchem\/3.2.102","volume":"3","author":"Archibald","year":"1957","journal-title":"Clin. Chem."},{"key":"D1RA04764G\/cit6","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jash.2015.05.010","volume":"9","author":"Leiba","year":"2015","journal-title":"J. Am. Soc. Hypertens."},{"key":"D1RA04764G\/cit7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01.cco.0000152664.87204.3c","volume":"17","author":"Choi","year":"2005","journal-title":"Curr. Opin. Rheumatol."},{"key":"D1RA04764G\/cit8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jare.2017.03.003","volume":"8","author":"El Ridi","year":"2017","journal-title":"J. Adv. Res."},{"key":"D1RA04764G\/cit9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/HYPERTENSIONAHA.119.13643","volume":"75","author":"Virdis","year":"2020","journal-title":"Hypertension"},{"key":"D1RA04764G\/cit10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000484283","volume-title":"Uric Acid in Chronic Kidney Disease","volume":"192","author":"King","year":"2018","unstructured":"C.King ,  M. A.Lanaspa ,  T.Jensen ,  D. R.Tolan ,  L. G.S\u00e1nchez-Lozada  and  R. J.Johnson ,  Uric Acid in Chronic Kidney Disease ,  2018 ,  vol. 192 ,  pp. 88\u2013102"},{"key":"D1RA04764G\/cit11","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1148\/radiol.11102485","volume":"261","author":"Glazebrook","year":"2011","journal-title":"Radiology"},{"key":"D1RA04764G\/cit12","doi-asserted-by":"crossref","first-page":"100852","DOI":"10.18632\/oncotarget.20135","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"D1RA04764G\/cit13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nchembio768","volume":"2","author":"Ramazzina","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"D1RA04764G\/cit14","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2174\/092986707781058797","volume":"14","author":"Dawson","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"D1RA04764G\/cit15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/HJH.0000000000002589","volume":"39","author":"Muiesan","year":"2021","journal-title":"J. Hypertens."},{"key":"D1RA04764G\/cit16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1367-5931(98)80087-2","volume":"2","author":"Ziegler","year":"1998","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D1RA04764G\/cit17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fbioe.2016.00011","volume":"4","author":"Vigneshvar","year":"2016","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"D1RA04764G\/cit18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-017-2562-z","volume":"185","author":"Farzin","year":"2018","journal-title":"Microchim. Acta"},{"key":"D1RA04764G\/cit19","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1007\/s00216-020-02860-w","volume":"412","author":"Shi","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"D1RA04764G\/cit20","doi-asserted-by":"crossref","first-page":"21850","DOI":"10.1021\/jp063749q","volume":"110","author":"Huang","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"D1RA04764G\/cit21","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.bios.2017.01.020","volume":"91","author":"Liu","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D1RA04764G\/cit22","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.foodchem.2014.10.015","volume":"173","author":"Khajvand","year":"2015","journal-title":"Food Chem."},{"key":"D1RA04764G\/cit23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.snb.2016.12.127","volume":"244","author":"Lu","year":"2017","journal-title":"Sens. Actuators, B"},{"key":"D1RA04764G\/cit24","doi-asserted-by":"crossref","first-page":"111228","DOI":"10.1016\/j.colsurfb.2020.111228","volume":"195","author":"Alizadeh","year":"2020","journal-title":"Colloids Surf., B"},{"key":"D1RA04764G\/cit25","doi-asserted-by":"crossref","first-page":"111420","DOI":"10.1016\/j.bios.2019.111420","volume":"141","author":"Badoei-Dalfard","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"D1RA04764G\/cit26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aca.2018.02.073","volume":"1021","author":"He","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"D1RA04764G\/cit27","doi-asserted-by":"crossref","first-page":"24463","DOI":"10.1039\/D0RA03792C","volume":"10","author":"Khachornsakkul","year":"2020","journal-title":"RSC Adv."},{"key":"D1RA04764G\/cit28","volume-title":"Fundamentals and applications of microfluidics","author":"Nguyen","year":"2019","unstructured":"N.-T.Nguyen ,  S. T.Wereley  and  S. A. M.Shaegh ,  Fundamentals and applications of microfluidics ,  Artech House ,  2019"},{"key":"D1RA04764G\/cit29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature05058","volume":"442","author":"Whitesides","year":"2006","journal-title":"Nature"},{"key":"D1RA04764G\/cit30","doi-asserted-by":"crossref","first-page":"011301","DOI":"10.1063\/1.3687398","volume":"6","author":"Li","year":"2012","journal-title":"Biomicrofluidics"},{"key":"D1RA04764G\/cit31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mee.2018.12.002","volume":"206","author":"Carrell","year":"2019","journal-title":"Microelectron. Eng."},{"key":"D1RA04764G\/cit32","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1039\/b817915h","volume":"8","author":"Sia","year":"2008","journal-title":"Lab Chip"},{"key":"D1RA04764G\/cit33","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/bios5030577","volume":"5","author":"Sharma","year":"2015","journal-title":"Biosensors"},{"key":"D1RA04764G\/cit34","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1039\/C4CS00125G","volume":"43","author":"Sun","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"D1RA04764G\/cit35","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1039\/D0AY01516D","volume":"12","author":"Farshchi","year":"2020","journal-title":"Anal. Methods"},{"key":"D1RA04764G\/cit36","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/elan.201400036","volume":"26","author":"Liu","year":"2014","journal-title":"Electroanalysis"},{"key":"D1RA04764G\/cit37","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/elan.201600043","volume":"28","author":"He","year":"2016","journal-title":"Electroanalysis"},{"key":"D1RA04764G\/cit38","doi-asserted-by":"crossref","first-page":"30011","DOI":"10.3390\/s151229783","volume":"15","author":"Luka","year":"2015","journal-title":"Sensors"},{"key":"D1RA04764G\/cit39","doi-asserted-by":"crossref","first-page":"37637","DOI":"10.1039\/C4RA07112C","volume":"4","author":"de Tarso Garcia","year":"2014","journal-title":"RSC Adv."},{"key":"D1RA04764G\/cit40","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1021\/ac901071p","volume":"81","author":"Carrilho","year":"2009","journal-title":"Anal. Chem."},{"key":"D1RA04764G\/cit42","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/smll.201000946","volume":"7","author":"Yeo","year":"2011","journal-title":"Small"},{"key":"D1RA04764G\/cit43","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/2211068214560609","volume":"20","author":"Guckenberger","year":"2015","journal-title":"J. Lab. Autom."},{"key":"D1RA04764G\/cit44","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1021\/acs.analchem.7b00726","volume":"89","author":"Li","year":"2017","journal-title":"Anal. Chem."},{"key":"D1RA04764G\/cit45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/ac9013989","volume":"82","author":"Martinez","year":"2010","journal-title":"Anal. Chem."},{"key":"D1RA04764G\/cit46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bios.2012.03.018","volume":"35","author":"Chen","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"D1RA04764G\/cit47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/bios10110187","volume":"10","author":"Baek","year":"2020","journal-title":"Biosensors"},{"key":"D1RA04764G\/cit48","doi-asserted-by":"crossref","first-page":"125573","DOI":"10.1016\/j.cej.2020.125573","volume":"398","author":"Hou","year":"2020","journal-title":"Chem. Eng. J."},{"key":"D1RA04764G\/cit49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s41664-021-00157-0","volume":"5","author":"Zhang","year":"2021","journal-title":"J. Anal. Test."},{"key":"D1RA04764G\/cit50","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/smll.200700757","volume":"4","author":"Zhao","year":"2008","journal-title":"Small"},{"key":"D1RA04764G\/cit51","doi-asserted-by":"crossref","first-page":"116038","DOI":"10.1016\/j.trac.2020.116038","author":"Nguyen","year":"2020","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D1RA04764G\/cit52","doi-asserted-by":"crossref","first-page":"111810","DOI":"10.1016\/j.msec.2020.111810","volume":"121","author":"Jafari","year":"2021","journal-title":"Mater. Sci. Eng., C"},{"key":"D1RA04764G\/cit53","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4028\/www.scientific.net\/SSP.271.76","volume":"271","author":"Gerelbaatar","year":"2018","journal-title":"Solid State Phenom."},{"key":"D1RA04764G\/cit54","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.talanta.2013.11.026","volume":"119","author":"Wang","year":"2014","journal-title":"Talanta"},{"key":"D1RA04764G\/cit55","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1016\/j.snb.2017.09.134","volume":"255","author":"Chen","year":"2018","journal-title":"Sens. Actuators, B"},{"key":"D1RA04764G\/cit56","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.snb.2018.01.083","volume":"260","author":"Sun","year":"2018","journal-title":"Sens. Actuators, B"},{"key":"D1RA04764G\/cit57","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1039\/C4AN02333A","volume":"140","author":"Kumar","year":"2015","journal-title":"Analyst"},{"key":"D1RA04764G\/cit58","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1039\/C6AY01926A","volume":"8","author":"Kumar","year":"2016","journal-title":"Anal. Methods"},{"key":"D1RA04764G\/cit59","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1039\/c3ob42207k","volume":"12","author":"Takale","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"D1RA04764G\/cit60","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1039\/C6AY00335D","volume":"8","author":"Vinoth","year":"2016","journal-title":"Anal. Methods"},{"key":"D1RA04764G\/cit61","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","volume":"235","author":"Bhattacharjee","year":"2016","journal-title":"J. Controlled Release"},{"key":"D1RA04764G\/cit62","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.micron.2014.08.001","volume":"67","author":"Havrdova","year":"2014","journal-title":"Micron"},{"key":"D1RA04764G\/cit63","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1520\/JFS11219J","volume":"32","author":"White","year":"1987","journal-title":"J. Forensic Sci."},{"key":"D1RA04764G\/cit64","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.micron.2004.02.003","volume":"35","author":"Egerton","year":"2004","journal-title":"Micron"},{"key":"D1RA04764G\/cit65","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11051-008-9435-7","volume":"10","author":"Hoo","year":"2008","journal-title":"J. Nanopart. Res."},{"key":"D1RA04764G\/cit66","doi-asserted-by":"crossref","first-page":"704708","DOI":"10.1155\/2014\/704708","volume":"2014","author":"Saeb","year":"2014","journal-title":"Sci. World\nJ."},{"key":"D1RA04764G\/cit67","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1039\/D1AY00142F","volume":"13","author":"Farshchi","year":"2021","journal-title":"Anal. Methods"},{"key":"D1RA04764G\/cit68","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.snb.2018.01.118","volume":"260","author":"Apyari","year":"2018","journal-title":"Sens. Actuators, B"},{"key":"D1RA04764G\/cit69","doi-asserted-by":"crossref","first-page":"105212","DOI":"10.1016\/j.microc.2020.105212","volume":"158","author":"Kateshiya","year":"2020","journal-title":"Microchem. J."},{"key":"D1RA04764G\/cit70","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.mee.2008.11.045","volume":"86","author":"Fischer","year":"2009","journal-title":"Microelectron. Eng."},{"key":"D1RA04764G\/cit71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.matchemphys.2007.09.001","volume":"108","author":"Patungwasa","year":"2008","journal-title":"Mater. Chem. Phys."},{"key":"D1RA04764G\/cit72","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1517\/17425247.2014.891582","volume":"11","author":"Cao-Mil\u00e1n","year":"2014","journal-title":"Expert Opin. Drug Delivery"},{"key":"D1RA04764G\/cit73","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1039\/D0AY02135K","volume":"13","author":"Mobed","year":"2021","journal-title":"Anal. Methods"},{"key":"D1RA04764G\/cit74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioelechem.2014.11.001","volume":"102","author":"Ghosh","year":"2015","journal-title":"Bioelectrochemistry"},{"key":"D1RA04764G\/cit75","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijbiomac.2019.02.121","volume":"130","author":"Verma","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"D1RA04764G\/cit76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-017-2562-z","volume":"185","author":"Wang","year":"2018","journal-title":"Microchim. Acta"},{"key":"D1RA04764G\/cit77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56847-4","volume":"10","author":"Yan","year":"2020","journal-title":"Sci. Rep."},{"key":"D1RA04764G\/cit78","doi-asserted-by":"crossref","first-page":"12251","DOI":"10.1039\/C5CC04231C","volume":"51","author":"Lu","year":"2015","journal-title":"Chem. Commun."},{"key":"D1RA04764G\/cit79","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0003-2670(02)01484-8","volume":"478","author":"Yao","year":"2003","journal-title":"Anal. Chim. Acta"},{"key":"D1RA04764G\/cit80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1021\/acscombsci.7b00146","volume":"20","author":"Burinaru","year":"2018","journal-title":"ACS Comb. Sci."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/RA\/D1RA04764G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:12:19Z","timestamp":1783447939000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/11\/44\/27298-27308\/743553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":79,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2021,8,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d1ra04764g","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}