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Sci."],"abstract":"<p>\n                    A toluene solution of\n                    <italic>s<\/italic>\n                    Bu\n                    <sub>2<\/sub>\n                    Mg allowed a regioselective\n                    <italic>ortho<\/italic>\n                    -magnesiation of aromatic and heterocyclic systems. A second\n                    <italic>ortho<\/italic>\n                    ,\n                    <italic>ortho<\/italic>\n                    \u2032-functionalization was achieved in the case of aryl oxazolines,\n                    <italic>N<\/italic>\n                    -aryl pyrazoles as well as\n                    <italic>N<\/italic>\n                    -aryl triazoles.\n                  <\/p>","DOI":"10.1039\/d1sc01777b","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T03:24:26Z","timestamp":1621308266000},"page":"8424-8429","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Directed regioselective\n                    <i>ortho<\/i>\n                    ,\n                    <i>ortho<\/i>\n                    \u2032-magnesiations of aromatics and heterocycles using\n                    <i>s<\/i>\n                    Bu\n                    <sub>2<\/sub>\n                    Mg in toluene"],"prefix":"10.1039","volume":"12","author":[{"given":"Andreas","family":"Hess","sequence":"first","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Department Chemie"},{"name":"81377 M\u00fcnchen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P.","family":"Prohaska","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Department Chemie"},{"name":"81377 M\u00fcnchen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina B.","family":"Doerrich","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Department Chemie"},{"name":"81377 M\u00fcnchen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Trauner","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Department Chemie"},{"name":"81377 M\u00fcnchen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand H.","family":"Lutter","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Department Chemie"},{"name":"81377 M\u00fcnchen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Lemaire","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica"},{"name":"Chemical Process Research & Development"},{"name":"B-2340 Beerse"},{"name":"Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1979-5838","authenticated-orcid":false,"given":"Simon","family":"Wagschal","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica"},{"name":"Chemical Process Research & Development"},{"name":"8200 Schaffhausen"},{"name":"Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Karaghiosoff","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Department Chemie"},{"name":"81377 M\u00fcnchen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-4332","authenticated-orcid":false,"given":"Paul","family":"Knochel","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"},{"name":"Department Chemie"},{"name":"81377 M\u00fcnchen"},{"name":"Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1SC01777B-(cit1a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1002\/anie.200604369","volume":"46","author":"Mulvey","year":"2007","journal-title":"Angew. 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