{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:06:45Z","timestamp":1782943605779,"version":"3.54.5"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"43","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21922702"],"award-info":[{"award-number":["21922702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973279"],"award-info":[{"award-number":["81973279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770885"],"award-info":[{"award-number":["31770885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFA0501303"],"award-info":[{"award-number":["2016YFA0501303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    Natural systems produce various \u03b3-dicarbonyl-bearing compounds that can covalently modify lysine in protein targets\n                    <jats:italic>via<\/jats:italic>\n                    the classic Paal\u2013Knorr reaction.\n                  <\/jats:p>","DOI":"10.1039\/d1sc02230j","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T13:46:18Z","timestamp":1634305578000},"page":"14557-14563","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Paal\u2013Knorr agent for chemoproteomic profiling of targets of isoketals in cells"],"prefix":"10.1039","volume":"12","author":[{"given":"Min-Ran","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Proteomics, National Center for Protein Sciences \u2013 Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 38 Life Sci. Park Road, Changping District, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, National Center for Protein Sciences \u2013 Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 38 Life Sci. Park Road, Changping District, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Xiang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, National Center for Protein Sciences \u2013 Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 38 Life Sci. Park Road, Changping District, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Ke","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, National Center for Protein Sciences \u2013 Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 38 Life Sci. Park Road, Changping District, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-273X","authenticated-orcid":false,"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, National Center for Protein Sciences \u2013 Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 38 Life Sci. Park Road, Changping District, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2021]]},"reference":[{"key":"D1SC02230J\/cit1","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1126\/science.287.5460.2007","volume":"287","author":"Saxon","year":"2000","journal-title":"Science"},{"key":"D1SC02230J\/cit2","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5","volume":"40","author":"Kolb","year":"2001","journal-title":"Angew. Chem."},{"key":"D1SC02230J\/cit3","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1038\/ncomms5740","volume":"5","author":"Spicer","year":"2014","journal-title":"Nat. Commun."},{"key":"D1SC02230J\/cit4","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1021\/jacs.8b11912","volume":"141","author":"Jia","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D1SC02230J\/cit5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.aal3316","volume":"355","author":"Lin","year":"2017","journal-title":"Science"},{"key":"D1SC02230J\/cit6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41589-019-0404-5","volume":"16","author":"Hahm","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"D1SC02230J\/cit7","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1021\/jacs.9b12116","volume":"142","author":"Ma","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D1SC02230J\/cit8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1021\/acscentsci.9b01268","volume":"6","author":"Bach","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"D1SC02230J\/cit9","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/cber.188401702228","volume":"17","author":"Paal","year":"1884","journal-title":"Chem. Ber."},{"key":"D1SC02230J\/cit10","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/cber.18840170220","volume":"17","author":"Knorr","year":"1884","journal-title":"Chem Ber"},{"key":"D1SC02230J\/cit11","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1074\/mcp.RA117.000116","volume":"16","author":"Sun","year":"2017","journal-title":"Mol. Cell. Proteomics"},{"key":"D1SC02230J\/cit12","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/cbic.201700210","volume":"18","author":"Dasari","year":"2017","journal-title":"ChemBioChem"},{"key":"D1SC02230J\/cit13","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1039\/C6OB01418F","volume":"14","author":"Beuzer","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"D1SC02230J\/cit14","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1039\/C7NP00024C","volume":"34","author":"Kornienko","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"D1SC02230J\/cit15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chemphyslip.2003.10.007","volume":"128","author":"Davies","year":"2004","journal-title":"Chem. Phys. Lipids"},{"key":"D1SC02230J\/cit16","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1021\/cr200084z","volume":"111","author":"Yin","year":"2011","journal-title":"Chem. Rev."},{"key":"D1SC02230J\/cit17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/ars.2020.8022","volume":"33","author":"Dias","year":"2020","journal-title":"Antioxid. Redox Signaling"},{"key":"D1SC02230J\/cit18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D1SC02230J\/cit19","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1021\/bi401673b","volume":"53","author":"Carrier","year":"2014","journal-title":"Biochemistry"},{"key":"D1SC02230J\/cit20","doi-asserted-by":"crossref","first-page":"9176","DOI":"10.1074\/jbc.RA117.001099","volume":"293","author":"May-Zhang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"D1SC02230J\/cit21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2010.04.037","volume":"49","author":"Stavrovskaya","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"D1SC02230J\/cit22","doi-asserted-by":"crossref","first-page":"S477","DOI":"10.1016\/S0168-8278(15)30647-4","volume":"62","author":"Longato","year":"2015","journal-title":"J. Hepatol."},{"key":"D1SC02230J\/cit23","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1089\/ars.2014.6154","volume":"22","author":"Salomon","year":"2015","journal-title":"Antioxid. Redox Signaling"},{"key":"D1SC02230J\/cit24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nmeth.2759","volume":"11","author":"Wang","year":"2014","journal-title":"Nat. Methods"},{"key":"D1SC02230J\/cit25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41589-018-0217-y","volume":"15","author":"Kulkarni","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"D1SC02230J\/cit26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41589-019-0304-8","volume":"15","author":"Spradlin","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"D1SC02230J\/cit27","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.chembiol.2017.08.022","volume":"24","author":"Tian","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"D1SC02230J\/cit28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nature18002","volume":"534","author":"Backus","year":"2016","journal-title":"Nature"},{"key":"D1SC02230J\/cit29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.cell.2020.07.001","volume":"182","author":"Vinogradova","year":"2020","journal-title":"Cell"},{"key":"D1SC02230J\/cit30","doi-asserted-by":"crossref","first-page":"11385","DOI":"10.1002\/anie.201905829","volume":"58","author":"Senkane","year":"2019","journal-title":"Angew. Chem."},{"key":"D1SC02230J\/cit31","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nchem.2826","volume":"9","author":"Hacker","year":"2017","journal-title":"Nat. Chem."},{"key":"D1SC02230J\/cit32","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1021\/acschembio.7b00125","volume":"12","author":"Ward","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"D1SC02230J\/cit33","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1021\/jacs.8b01462","volume":"140","author":"Chen","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D1SC02230J\/cit34","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.redox.2017.04.001","volume":"12","author":"Chen","year":"2017","journal-title":"Redox Biol"},{"key":"D1SC02230J\/cit35","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.cell.2015.05.045","volume":"161","author":"Niphakis","year":"2015","journal-title":"Cell"},{"key":"D1SC02230J\/cit36","doi-asserted-by":"crossref","first-page":"7912","DOI":"10.1021\/acs.orglett.8b03461","volume":"20","author":"Bao","year":"2018","journal-title":"Org. Lett."},{"key":"D1SC02230J\/cit37","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1074\/jbc.274.19.13139","volume":"274","author":"Brame","year":"1999","journal-title":"J. Biol. Chem."},{"key":"D1SC02230J\/cit38","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.22.461295","author":"He","year":"2021","journal-title":"BioRxiv"},{"key":"D1SC02230J\/cit39","doi-asserted-by":"publisher","DOI":"10.33774\/chemrxiv-2021-w7rss-v2","author":"Zanon","year":"2021","journal-title":"ChemRxiv"},{"key":"D1SC02230J\/cit40","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nmeth.2646","volume":"10","author":"O'Shea","year":"2013","journal-title":"Nat. Methods"},{"key":"D1SC02230J\/cit41","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1038\/nprot.2007.298","volume":"2","author":"Davies","year":"2007","journal-title":"Nat. Protoc."},{"key":"D1SC02230J\/cit42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2011.03.008","volume":"8","author":"Abell","year":"2011","journal-title":"Cell Stem Cell"},{"key":"D1SC02230J\/cit43","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1038\/s41467-018-07189-8","volume":"9","author":"Ruiz","year":"2018","journal-title":"Nat. Commun."},{"key":"D1SC02230J\/cit44","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1101\/gr.201038.115","volume":"26","author":"Kumar","year":"2016","journal-title":"Genome Res."},{"key":"D1SC02230J\/cit45","doi-asserted-by":"crossref","first-page":"11864","DOI":"10.1021\/ja503604t","volume":"136","author":"Galligan","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D1SC02230J\/cit46","doi-asserted-by":"crossref","first-page":"12304","DOI":"10.1021\/jacs.6b04977","volume":"138","author":"Jin","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"D1SC02230J\/cit47","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/s41589-018-0116-2","volume":"14","author":"Akter","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"D1SC02230J\/cit48","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1021\/ac504685y","volume":"87","author":"Yang","year":"2015","journal-title":"Anal. Chem."},{"key":"D1SC02230J\/cit49","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-00478-8","volume":"21","author":"Muri","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"D1SC02230J\/cit50","first-page":"S2451","volume":"21","author":"Cho","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"D1SC02230J\/cit51","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1124\/dmd.114.059261","volume":"42","author":"Lin","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"D1SC02230J\/cit52","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1021\/tx7001405","volume":"20","author":"Druckova","year":"2007","journal-title":"Chem. Res. Toxicol."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2021\/SC\/D1SC02230J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:33:55Z","timestamp":1782941635000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/12\/43\/14557-14563\/746217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":52,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2021,11,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d1sc02230j","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}