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Sci."],"abstract":"<jats:p>We report a general method for the preparation of enantiomerically enriched secondary alkylmagnesium reagents, which undergo highly stereoselective transition-metal free electrophilic aminations, leading to \u03b1-chiral amines in up to 97% ee.<\/jats:p>","DOI":"10.1039\/d1sc05315a","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T05:15:37Z","timestamp":1634620537000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["General stereoretentive preparation of chiral secondary mixed alkylmagnesium reagents and their use for enantioselective electrophilic aminations"],"prefix":"10.1039","volume":"13","author":[{"given":"Alexander","family":"Kremsmair","sequence":"first","affiliation":[{"name":"Department of Chemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Butenandtstra\u00dfe 5-13, 81377 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik R.","family":"Wilke","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Butenandtstra\u00dfe 5-13, 81377 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias M.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Butenandtstra\u00dfe 5-13, 81377 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirin","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Butenandtstra\u00dfe 5-13, 81377 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-730X","authenticated-orcid":false,"given":"Konstantin","family":"Karaghiosoff","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Butenandtstra\u00dfe 5-13, 81377 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-4332","authenticated-orcid":false,"given":"Paul","family":"Knochel","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Butenandtstra\u00dfe 5-13, 81377 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1SC05315A\/cit1a\/1","volume-title":"Grignard Reagents: New Developments","author":"Richey","year":"1999","unstructured":"H. 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