{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:11:41Z","timestamp":1783455101719,"version":"3.55.0"},"reference-count":27,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":109,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["GOIPG\/2017\/1179"],"award-info":[{"award-number":["GOIPG\/2017\/1179"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["GOIPG\/2018\/2256"],"award-info":[{"award-number":["GOIPG\/2018\/2256"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI-IFA\/19\/7427"],"award-info":[{"award-number":["SFI-IFA\/19\/7427"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["12\/RC\/2275"],"award-info":[{"award-number":["12\/RC\/2275"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Easily applied enantioselective addition of aliphatic and aromatic Grignard reagents to ketones provides modular and universal access to challenging chiral tertiary alcohols, enabling the straightforward preparation of natural products and APIs.<\/jats:p>","DOI":"10.1039\/d1sc06350b","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T09:34:59Z","timestamp":1650447299000},"page":"6262-6269","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Asymmetric addition of Grignard reagents to ketones: culmination of the ligand-mediated methodology allows modular construction of chiral tertiary alcohols"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8896-9163","authenticated-orcid":false,"given":"Claudio","family":"Monasterolo","sequence":"first","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"O'Gara","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranna E.","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-5482","authenticated-orcid":false,"given":"Sadbh E.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Bieszczad","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wiesinger","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-034X","authenticated-orcid":false,"given":"Rebecca A.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-234X","authenticated-orcid":false,"given":"Kirill","family":"Nikitin","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-4423","authenticated-orcid":false,"given":"Declan G.","family":"Gilheany","sequence":"additional","affiliation":[{"name":"Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1SC06350B\/cit1\/1","first-page":"1322","volume":"130","author":"Grignard","year":"1900","journal-title":"Compt. Rend. Hebd. S\u00e9ances Acad. Sci."},{"key":"D1SC06350B\/cit2\/1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/9781118484722.ch2","volume-title":"Organometallics in Synthesis, Third Manual","author":"Knochel","year":"2013","unstructured":"P.Knochel , Organomagnesium and Organozinc Chemistry , in Organometallics in Synthesis, Third Manual , ed. Schlosser, M. , Wiley & Sons , Hoboken, NJ , 2013 ; pp. 223\u2013372"},{"key":"D1SC06350B\/cit3\/1","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1021\/jacs.9b11829","volume":"142","author":"Peltzer","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D1SC06350B\/cit4a\/1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/9780470751879.ch12","volume-title":"The Chemistry of Organomagnesium Compounds","author":"Knochel","year":"2008","unstructured":"P.Knochel , A.Gavryushin and K.Brade , Functionalized organomagnesium compounds: Synthesis and reactivity , in The Chemistry of Organomagnesium Compounds , ed. Z. Rappoport and I. Marek , Jonh Wiley & Sons , 2008 , pp. 511\u2013594"},{"key":"D1SC06350B\/cit4b\/1","volume-title":"Grignard Reagents: New Developments","author":"Richey","year":"2000","unstructured":"H. G.Richey , Grignard Reagents: New Developments , ed. H. G. Richey , Wiley & Sons , Chichester, U.K. , 2000"},{"key":"D1SC06350B\/cit4c\/1","volume-title":"Best Synthetic Methods","author":"Wakefield","year":"1995","unstructured":"B. J.Wakefield , Organomagnesium Methods in Organic Synthesis , in Best Synthetic Methods , ed. B. J. Wakefield , Academic Press , 1995"},{"key":"D1SC06350B\/cit5a\/1","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1021\/acscatal.5b02832","volume":"6","author":"Collados","year":"2016","journal-title":"ACS Catal."},{"key":"D1SC06350B\/cit5b\/1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.tetasy.2009.03.015","volume":"20","author":"Luderera","year":"2009","journal-title":"Tetrahedron: Asymmetry"},{"key":"D1SC06350B\/cit5c\/1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1039\/b617746h","volume":"5","author":"Riant","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"D1SC06350B\/cit6a\/1","volume-title":"Molecules That Changed the World","author":"Nicolaou","year":"2008","unstructured":"K. C.Nicolaou and T.Montagnon , Molecules That Changed the World , Wiley-VCH , Weinheim , 2008"},{"key":"D1SC06350B\/cit6b\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/3527606858.ch2","volume-title":"Quaternary Stereocenters: Challenges and Solutions for Organic Synthesis","author":"de Vries","year":"2005","unstructured":"J. G.de Vries , Important Pharmaceuticals and Intermediates , in Quaternary Stereocenters: Challenges and Solutions for Organic Synthesis , ed. J. Christoffers and A. Baro , Wiley-VCH , Weinheim , 2005 , pp. 25\u201350"},{"key":"D1SC06350B\/cit7a\/1","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1039\/p29790001600","author":"Pinkus","year":"1979","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"D1SC06350B\/cit7b\/1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1021\/ar50080a006","volume":"7","author":"Ashby","year":"1974","journal-title":"Acc. Chem. Res."},{"key":"D1SC06350B\/cit8a\/1","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1002\/anie.201109040","volume":"51","author":"Madduri","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1SC06350B\/cit8b\/1","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1039\/C1CC16725A","volume":"48","author":"Madduri","year":"2012","journal-title":"Chem. Commun."},{"key":"D1SC06350B\/cit8c\/1","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1002\/ejoc.201402935","volume":"2014","author":"Fern\u00e1ndez-Mateos","year":"2014","journal-title":"Eur. J. Org. Chem."},{"key":"D1SC06350B\/cit9\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/anie.199200841","volume":"31","author":"Weber","year":"1992","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1SC06350B\/cit10\/1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1021\/acs.orglett.5b03379","volume":"18","author":"Osakama","year":"2016","journal-title":"Org. Lett."},{"key":"D1SC06350B\/cit11\/1","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1002\/anie.201610462","volume":"56","author":"Bieszczad","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1SC06350B\/cit12\/1","doi-asserted-by":"crossref","first-page":"8198","DOI":"10.1021\/acs.orglett.0c02629","volume":"22","author":"Kavanagh","year":"2020","journal-title":"Org. Lett."},{"key":"D1SC06350B\/cit13\/1","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1039\/C7OB00751E","volume":"15","author":"Bieszczad","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"D1SC06350B\/cit14\/1","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1039\/C9SC00978G","volume":"10","author":"Monasterolo","year":"2019","journal-title":"Chem. Sci."},{"key":"D1SC06350B\/cit22a\/1","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/hlca.19760590721","volume":"59","author":"Ebn\u00f6ther","year":"1976","journal-title":"Helv. Chim. Acta"},{"key":"D1SC06350B\/cit22b\/1","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1021\/ol100627c","volume":"12","author":"Fournier","year":"2010","journal-title":"Org. Lett."},{"key":"D1SC06350B\/cit22c\/1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature07592","volume":"456","author":"Stymiest","year":"2008","journal-title":"Nature"},{"key":"D1SC06350B\/cit22d\/1","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1002\/anie.201600979","volume":"55","author":"Huang","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1SC06350B\/cit22e\/1","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1021\/ol702074a","volume":"9","author":"Hatano","year":"2007","journal-title":"Org. Lett."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/SC\/D1SC06350B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:55:26Z","timestamp":1783450526000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/13\/21\/6262-6269\/747027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":27,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d1sc06350b","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}