{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:06:08Z","timestamp":1782893168561,"version":"3.54.5"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"am","delay-in-days":574,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H04527"],"award-info":[{"award-number":["JP20H04527"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K19904"],"award-info":[{"award-number":["JP18K19904"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K19224"],"award-info":[{"award-number":["JP19K19224"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K17108"],"award-info":[{"award-number":["JP21K17108"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Effects of cyclodextrins and polyrotaxanes (PRXs) on osteoclastogenesis were examined. PRXs suppressed RANKL-induced free cholesterol overload and osteoclastogenesis in macrophages.<\/jats:p>","DOI":"10.1039\/d2bm00833e","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T05:31:22Z","timestamp":1659072682000},"page":"5230-5242","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mitigating RANKL-induced cholesterol overload in macrophages with \u03b2-cyclodextrin-threaded polyrotaxanes suppresses osteoclastogenesis"],"prefix":"10.1039","volume":"10","author":[{"given":"Hongfei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-7364","authenticated-orcid":false,"given":"Atsushi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Terauchi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yoda","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-1371","authenticated-orcid":false,"given":"Nobuhiko","family":"Yui","sequence":"additional","affiliation":[{"name":"Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2BM00833E\/cit1\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"D2BM00833E\/cit2\/1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"D2BM00833E\/cit3\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2005.11.007","volume":"12","author":"Wada","year":"2006","journal-title":"Trends Mol. Med."},{"key":"D2BM00833E\/cit4\/1","first-page":"66","volume":"13","author":"Suda","year":"1992","journal-title":"Endocr. Rev."},{"key":"D2BM00833E\/cit5\/1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"D2BM00833E\/cit6\/1","doi-asserted-by":"crossref","first-page":"778078","DOI":"10.3389\/fimmu.2021.778078","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"D2BM00833E\/cit7\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3390\/cells10010089","volume":"10","author":"Kim","year":"2021","journal-title":"Cells"},{"key":"D2BM00833E\/cit8\/1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/nu11061394","volume":"11","author":"Yin","year":"2019","journal-title":"Nutrients"},{"key":"D2BM00833E\/cit9\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1507\/endocrj.K07E-004","volume":"55","author":"Majima","year":"2008","journal-title":"Endocr. J."},{"key":"D2BM00833E\/cit10\/1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ajpath.2012.05.034","volume":"181","author":"Pelton","year":"2012","journal-title":"Am. J. Pathol."},{"key":"D2BM00833E\/cit11\/1","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/aps.2011.135","volume":"32","author":"You","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"D2BM00833E\/cit12\/1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.bone.2007.02.019","volume":"40","author":"Uzzan","year":"2007","journal-title":"Bone"},{"key":"D2BM00833E\/cit13\/1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","volume":"49","author":"Russell","year":"2011","journal-title":"Bone"},{"key":"D2BM00833E\/cit14\/1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cmet.2015.12.010","volume":"23","author":"Wei","year":"2016","journal-title":"Cell Metab."},{"key":"D2BM00833E\/cit15\/1","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1038\/s41418-019-0484-5","volume":"27","author":"Zheng","year":"2020","journal-title":"Cell Death Differ."},{"key":"D2BM00833E\/cit16\/1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cmet.2010.04.015","volume":"11","author":"Wei","year":"2010","journal-title":"Cell Metab."},{"key":"D2BM00833E\/cit17\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF03026321","volume":"23","author":"Mashiba","year":"2005","journal-title":"J. Bone Miner. Metab."},{"key":"D2BM00833E\/cit18\/1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","volume":"144","author":"Woo","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"D2BM00833E\/cit19\/1","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1021\/cr970025p","volume":"98","author":"Uekama","year":"1998","journal-title":"Chem. Rev."},{"key":"D2BM00833E\/cit20\/1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bbamem.2007.03.026","volume":"1768","author":"Zidovetzki","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"D2BM00833E\/cit21\/1","doi-asserted-by":"crossref","first-page":"333ra50","DOI":"10.1126\/scitranslmed.aad6100","volume":"8","author":"Zimmer","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"D2BM00833E\/cit22\/1","doi-asserted-by":"crossref","first-page":"e6951","DOI":"10.1371\/journal.pone.0006951","volume":"4","author":"Davidson","year":"2009","journal-title":"PLoS One"},{"key":"D2BM00833E\/cit23\/1","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/S0140-6736(17)31465-4","volume":"390","author":"Ory","year":"2017","journal-title":"Lancet"},{"key":"D2BM00833E\/cit24\/1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.fct.2005.03.007","volume":"43","author":"Gould","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"D2BM00833E\/cit25\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/0192623307310945","volume":"36","author":"Stella","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"D2BM00833E\/cit26\/1","doi-asserted-by":"crossref","first-page":"e53280","DOI":"10.1371\/journal.pone.0053280","volume":"7","author":"Crumling","year":"2012","journal-title":"PLoS One"},{"key":"D2BM00833E\/cit27\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10162-015-0528-6","volume":"16","author":"Cronin","year":"2015","journal-title":"Assoc. Res. Otolaryngol."},{"key":"D2BM00833E\/cit28\/1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1023\/A:1015929720063","volume":"7","author":"Frijlink","year":"1990","journal-title":"Pharm. Res."},{"key":"D2BM00833E\/cit29\/1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/s41563-019-0378-4","volume":"18","author":"Huang","year":"2019","journal-title":"Nat. Mater."},{"key":"D2BM00833E\/cit30\/1","doi-asserted-by":"crossref","first-page":"1806158","DOI":"10.1002\/adma.201806158","volume":"32","author":"Zhang","year":"2020","journal-title":"Adv. Mater."},{"key":"D2BM00833E\/cit31\/1","doi-asserted-by":"crossref","first-page":"101408","DOI":"10.1016\/j.progpolymsci.2021.101408","volume":"118","author":"Liu","year":"2021","journal-title":"Prog. Polym. Sci."},{"key":"D2BM00833E\/cit32\/1","doi-asserted-by":"crossref","first-page":"1700513","DOI":"10.1002\/advs.201700513","volume":"5","author":"Miao","year":"2018","journal-title":"Adv. Sci."},{"key":"D2BM00833E\/cit33\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1248\/cpb.c17-00765","volume":"66","author":"Higashi","year":"2018","journal-title":"Chem. Pharm. Bull."},{"key":"D2BM00833E\/cit34\/1","doi-asserted-by":"crossref","first-page":"1800557","DOI":"10.1002\/marc.201800557","volume":"40","author":"Puglisi","year":"2019","journal-title":"Macromol. Rapid Commun."},{"key":"D2BM00833E\/cit35\/1","doi-asserted-by":"crossref","first-page":"13433","DOI":"10.1039\/C4CC03709J","volume":"50","author":"Tamura","year":"2014","journal-title":"Chem. Commun."},{"key":"D2BM00833E\/cit36\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2017.11.016","volume":"269","author":"Tamura","year":"2018","journal-title":"J. Controlled Release"},{"key":"D2BM00833E\/cit37\/1","doi-asserted-by":"crossref","first-page":"9442","DOI":"10.1074\/jbc.M115.636803","volume":"290","author":"Tamura","year":"2015","journal-title":"J. Biol. Chem."},{"key":"D2BM00833E\/cit38\/1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/14686996.2016.1200948","volume":"17","author":"Tamura","year":"2016","journal-title":"Sci. Technol. Adv. Mater."},{"key":"D2BM00833E\/cit39\/1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/14686996.2021.1935315","volume":"22","author":"Zhang","year":"2021","journal-title":"Sci. Technol. Adv. Mater."},{"key":"D2BM00833E\/cit40\/1","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1021\/acs.molpharmaceut.7b00859","volume":"14","author":"Tamura","year":"2017","journal-title":"Mol. Pharm."},{"key":"D2BM00833E\/cit41\/1","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1021\/acsapm.2c00336","volume":"4","author":"Zhang","year":"2022","journal-title":"ACS Appl. Polym. Mater."},{"key":"D2BM00833E\/cit42\/1","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1161\/01.ATV.0000131264.66417.d5","volume":"24","author":"Soccio","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"D2BM00833E\/cit43\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/jcmm.12689","volume":"20","author":"Chistiakov","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"D2BM00833E\/cit44\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1211\/jpp.58.1.0002","volume":"58","author":"Jadhav","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"D2BM00833E\/cit45\/1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1749-6632.2011.06283.x","volume":"1240","author":"Teirelbaum","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D2BM00833E\/cit46\/1","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1172\/JCI89935","volume":"127","author":"Bae","year":"2017","journal-title":"J. Clin. Invest."},{"key":"D2BM00833E\/cit47\/1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"key":"D2BM00833E\/cit48\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1210\/me.2007-0237","volume":"22","author":"Kim","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"D2BM00833E\/cit49\/1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4049\/jimmunol.169.3.1516","volume":"169","author":"Takami","year":"2002","journal-title":"J. Immunol."},{"key":"D2BM00833E\/cit50\/1","doi-asserted-by":"crossref","first-page":"11993","DOI":"10.1074\/jbc.275.16.11993","volume":"275","author":"Chellaiah","year":"2000","journal-title":"J. Biol. Chem."},{"key":"D2BM00833E\/cit51\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/15216540500494508","volume":"58","author":"Kerkis","year":"2006","journal-title":"IUBMB Life"},{"key":"D2BM00833E\/cit52\/1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.addr.2007.10.006","volume":"60","author":"Nakase","year":"2008","journal-title":"Adv. Drug Delivery Rev."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/BM\/D2BM00833E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:11:21Z","timestamp":1782886281000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/10\/18\/5230-5242\/756152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":52,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,9,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d2bm00833e","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}