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Sci."],"abstract":"<jats:p>\n                    Self-assembling polymer micelle (Nano\n                    <jats:sup>VPA<\/jats:sup>\n                    ) composed of PEG-\n                    <jats:italic>b<\/jats:italic>\n                    -poly(vinyl valproate) was developed. IP administration of Nano\n                    <jats:sup>VPA<\/jats:sup>\n                    extended the bioavailability of VPA, which increased its therapeutic effect against epilepsy, reducing its adverse effects.\n                  <\/jats:p>","DOI":"10.1039\/d2bm01064j","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T05:40:37Z","timestamp":1663911637000},"page":"6307-6314","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Design of self-assembling anti-epileptic drug for long-acting drug delivery\n                    <i>in vivo<\/i>"],"prefix":"10.1039","volume":"10","author":[{"given":"Yutaka","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Tajika","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-6510","authenticated-orcid":false,"given":"Yukio","family":"Nagasaki","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan"},{"name":"Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan"},{"name":"Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2BM01064J\/cit1\/1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.2174\/1570159X17666181227165722","volume":"17","author":"Romoli","year":"2019","journal-title":"Curr. 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