{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:59:03Z","timestamp":1787507943757,"version":"build-2736575974"},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"53","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"am","delay-in-days":521,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["18JCJQJC46900"],"award-info":[{"award-number":["18JCJQJC46900"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871500"],"award-info":[{"award-number":["81871500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81921004"],"award-info":[{"award-number":["81921004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925021"],"award-info":[{"award-number":["81925021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFE0200503"],"award-info":[{"award-number":["2018YFE0200503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>Codelivery of nitric oxide and hydrogen sulfide from an enzyme-responsive hybrid prodrug provides potent therapeutic efficacy for heart failure.<\/jats:p>","DOI":"10.1039\/d2cc02267b","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T03:21:06Z","timestamp":1654485666000},"page":"7396-7399","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy"],"prefix":"10.1039","volume":"58","author":[{"given":"Qi","family":"Liu","sequence":"first","affiliation":[{"name":"State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbo","family":"Ji","sequence":"additional","affiliation":[{"name":"State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushu","family":"Chu","sequence":"additional","affiliation":[{"name":"State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Hao","sequence":"additional","affiliation":[{"name":"State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qian","sequence":"additional","affiliation":[{"name":"State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-6002","authenticated-orcid":false,"given":"Qiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2CC02267B\/cit1\/1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/jama.2020.10262","volume":"324","author":"Murphy","year":"2020","journal-title":"JAMA"},{"key":"D2CC02267B\/cit2\/1","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/CIRCRESAHA.119.315268","volume":"124","author":"Willerson","year":"2019","journal-title":"Circ. Res."},{"key":"D2CC02267B\/cit3\/1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/eurheartj\/ehaa1012","volume":"42","author":"Bauersachs","year":"2021","journal-title":"Eur. Heart J."},{"key":"D2CC02267B\/cit4\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2017.224","volume":"15","author":"Farah","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"D2CC02267B\/cit5\/1","first-page":"774","volume":"38","author":"Heusch","year":"2016","journal-title":"Eur. Heart J."},{"key":"D2CC02267B\/cit6\/1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/01.RES.78.1.58","volume":"78","author":"Smith","year":"1996","journal-title":"Circ. Res."},{"key":"D2CC02267B\/cit7\/1","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1038\/s41467-021-24804-3","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."},{"key":"D2CC02267B\/cit8\/1","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1016\/S0040-4039(01)00614-1","volume":"42","author":"Wu","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"D2CC02267B\/cit9\/1","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1016\/j.biomaterials.2013.07.045","volume":"34","author":"Zhao","year":"2013","journal-title":"Biomaterials"},{"key":"D2CC02267B\/cit10\/1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.actbio.2017.03.011","volume":"54","author":"Zhou","year":"2017","journal-title":"Acta Biomater."},{"key":"D2CC02267B\/cit11\/1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biomaterials.2015.04.046","volume":"60","author":"Yao","year":"2015","journal-title":"Biomaterials"},{"key":"D2CC02267B\/cit12\/1","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"D2CC02267B\/cit13\/1","first-page":"605","volume":"309","author":"Yoo","year":"2015","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"D2CC02267B\/cit14\/1","doi-asserted-by":"crossref","first-page":"13101","DOI":"10.1002\/anie.201806854","volume":"57","author":"Zhao","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2CC02267B\/cit15\/1","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1039\/C4CC00968A","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem. Commun."},{"key":"D2CC02267B\/cit16\/1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/acssensors.9b01093","volume":"5","author":"Zhang","year":"2020","journal-title":"ACS Sens."},{"key":"D2CC02267B\/cit17\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bioactmat.2021.07.011","volume":"9","author":"Yao","year":"2021","journal-title":"Bioact. Mater."},{"key":"D2CC02267B\/cit18\/1","doi-asserted-by":"crossref","first-page":"16365","DOI":"10.1021\/jacs.7b09527","volume":"139","author":"Zhao","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D2CC02267B\/cit19\/1","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1039\/D1BM00448D","volume":"9","author":"Lee","year":"2021","journal-title":"Biomater. Sci."},{"key":"D2CC02267B\/cit20\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/cvr\/cvw037","volume":"110","author":"Sun","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"D2CC02267B\/cit21\/1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cvr\/cvq248","volume":"88","author":"Yong","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"D2CC02267B\/cit22\/1","doi-asserted-by":"crossref","first-page":"15997","DOI":"10.1021\/acs.inorgchem.1c01061","volume":"60","author":"Neuman","year":"2021","journal-title":"Inorg. Chem."},{"key":"D2CC02267B\/cit23\/1","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1073\/pnas.0937302100","volume":"29","author":"Paolocci","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2CC02267B\/cit24\/1","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1089\/ars.2010.3859","volume":"14","author":"Tocchetti","year":"2011","journal-title":"Antioxid. Redox Signaling"},{"key":"D2CC02267B\/cit25\/1","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1038\/ncomms5381","volume":"15","author":"Eberhardt","year":"2014","journal-title":"Nat. Commun."},{"key":"D2CC02267B\/cit26\/1","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/glia.22553","volume":"61","author":"Lee","year":"2013","journal-title":"Glia"},{"key":"D2CC02267B\/cit27\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fncel.2017.00154","volume":"11","author":"Ji","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"D2CC02267B\/cit28\/1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/ars.2015.6607","volume":"25","author":"Hu","year":"2016","journal-title":"Antioxid. Redox Signaling"},{"key":"D2CC02267B\/cit29\/1","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/jm00115a013","volume":"34","author":"Maragos","year":"1991","journal-title":"J. Med. Chem."},{"key":"D2CC02267B\/cit30\/1","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1039\/c2ob25252j","volume":"10","author":"Huang","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"D2CC02267B\/cit31\/1","doi-asserted-by":"crossref","first-page":"e202112734","DOI":"10.1002\/anie.202112734","volume":"61","author":"Chen","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2CC02267B\/cit32\/1","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1039\/C8CC02428F","volume":"54","author":"Zhao","year":"2018","journal-title":"Chem. Commun."},{"key":"D2CC02267B\/cit33\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejheart.2003.12.015","volume":"6","author":"Hall","year":"2004","journal-title":"Eur. J. Heart Failure"},{"key":"D2CC02267B\/cit34\/1","doi-asserted-by":"crossref","first-page":"e2105408","DOI":"10.1002\/advs.202105408","volume":"9","author":"Hao","year":"2022","journal-title":"Adv. Sci."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/CC\/D2CC02267B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:51:55Z","timestamp":1782885115000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/58\/53\/7396-7399\/757515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":34,"journal-issue":{"issue":"53","published-print":{"date-parts":[[2022,6,30]]}},"URL":"https:\/\/doi.org\/10.1039\/d2cc02267b","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}