{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:27:07Z","timestamp":1789194427580,"version":"build-2803163510"},"reference-count":13,"publisher":"Royal Society of Chemistry (RSC)","issue":"93","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":300,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/V02213X\/1"],"award-info":[{"award-number":["MR\/V02213X\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBSRC\/UKRI BB\/V011456\/1"],"award-info":[{"award-number":["BBSRC\/UKRI BB\/V011456\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>\n                    Here we show using mass photometry how proline substitutions, commonly used for SARS-CoV-2 spike stabilisation in vaccine design, directly affects ACE2 receptor interactions\n                    <jats:italic>via<\/jats:italic>\n                    dynamics of open and closed states.\n                  <\/jats:p>","DOI":"10.1039\/d2cc04711j","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T11:41:14Z","timestamp":1666957274000},"page":"12939-12942","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Mass photometry reveals SARS-CoV-2 spike stabilisation to impede ACE2 binding through altered conformational dynamics"],"prefix":"10.1039","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-8608","authenticated-orcid":false,"given":"Sean A.","family":"Burnap","sequence":"first","affiliation":[{"name":"Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, OX1 3TA, UK"},{"name":"The Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, OX1 3QU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-226X","authenticated-orcid":false,"given":"Weston B.","family":"Struwe","sequence":"additional","affiliation":[{"name":"Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, OX1 3TA, UK"},{"name":"The Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, OX1 3QU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2CC04711J\/cit1\/1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"key":"D2CC04711J\/cit2\/1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.abd0826","volume":"369","author":"Hsieh","year":"2020","journal-title":"Science"},{"key":"D2CC04711J\/cit3\/1","doi-asserted-by":"crossref","first-page":"10774","DOI":"10.1002\/anie.202001578","volume":"59","author":"Soltermann","year":"2020","journal-title":"Angew. 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