{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:52:05Z","timestamp":1782881525165,"version":"3.54.5"},"reference-count":30,"publisher":"Royal Society of Chemistry (RSC)","issue":"24","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"am","delay-in-days":514,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100007059","name":"Univerzita Palack\u00e9ho v Olomouci","doi-asserted-by":"publisher","award":["PrF_2020_016"],"award-info":[{"award-number":["PrF_2020_016"]}],"id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007059","name":"Univerzita Palack\u00e9ho v Olomouci","doi-asserted-by":"publisher","award":["PrF_2021_009"],"award-info":[{"award-number":["PrF_2021_009"]}],"id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["PROGRES\/UK Q40\/01"],"award-info":[{"award-number":["PROGRES\/UK Q40\/01"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Dalton Trans."],"abstract":"<jats:p>\n                    The hydrolytically stable half-sandwich complex [Os(\u03b7\n                    <jats:sup>6<\/jats:sup>\n                    -pcym)(L2)Cl]PF\n                    <jats:sub>6<\/jats:sub>\n                    (2) partially releases the bioactive substituent indomethacin in the presence of carboxypeptidase A.\n                  <\/jats:p>","DOI":"10.1039\/d2dt01085b","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T08:20:56Z","timestamp":1653898856000},"page":"9213-9217","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Stability of a half-sandwich Os(\n                    <scp>ii<\/scp>\n                    ) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A"],"prefix":"10.1039","volume":"51","author":[{"given":"Luk\u00e1\u0161","family":"Masaryk","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, Palacky University in Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darina","family":"Muthn\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, \u0160imkova 870, 500 03 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Hala\u0161","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, Palacky University in Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Zoufal\u00fd","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, Palacky University in Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Peterov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, \u0160imkova 870, 500 03 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-1334","authenticated-orcid":false,"given":"Radim","family":"Havelek","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, \u0160imkova 870, 500 03 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-4530","authenticated-orcid":false,"given":"Bohuslav","family":"Draho\u0161","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, Palacky University in Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-6728","authenticated-orcid":false,"given":"David","family":"Milde","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science, Palack\u00fd University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Mrkvicov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, \u0160imkova 870, 500 03 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-045X","authenticated-orcid":false,"given":"Pavel","family":"\u0160tarha","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, Palacky University in Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2DT01085B\/cit1\/1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"D2DT01085B\/cit2a\/1","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"D2DT01085B\/cit2b\/1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ccr.2019.06.001","volume":"395","author":"\u0160tarha","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"D2DT01085B\/cit3a\/1","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/ja055886r","volume":"128","author":"Peacock","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"D2DT01085B\/cit3b\/1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1039\/C7CS00332C","volume":"47","author":"Meier-Menches","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"D2DT01085B\/cit4a\/1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/molecules23020420","volume":"23","author":"\u0160tarha","year":"2018","journal-title":"Molecules"},{"key":"D2DT01085B\/cit4b\/1","doi-asserted-by":"crossref","first-page":"12197","DOI":"10.1039\/C8DT02236D","volume":"47","author":"Pracharova","year":"2018","journal-title":"Dalton Trans."},{"key":"D2DT01085B\/cit4c\/1","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1039\/C8DT00193F","volume":"47","author":"\u0160tarha","year":"2018","journal-title":"Dalton Trans."},{"key":"D2DT01085B\/cit4d\/1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1021\/acs.organomet.6b00197","volume":"35","author":"Agonigi","year":"2016","journal-title":"Organometallics"},{"key":"D2DT01085B\/cit5\/1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/jhet.5570230514","volume":"23","author":"Omar","year":"1986","journal-title":"J. Heterocycl. Chem."},{"key":"D2DT01085B\/cit6\/1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3810\/pgm.2014.07.2787","volume":"126","author":"Nalamachu","year":"2014","journal-title":"Postgrad. Med."},{"key":"D2DT01085B\/cit7a\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/cmdc.201402353","volume":"10","author":"Neumann","year":"2015","journal-title":"ChemMedChem"},{"key":"D2DT01085B\/cit7b\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jinorgbio.2017.07.002","volume":"175","author":"Hu","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"D2DT01085B\/cit7c\/1","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1039\/C7NJ04416J","volume":"42","author":"Tadi\u0107","year":"2018","journal-title":"New J. Chem."},{"key":"D2DT01085B\/cit8\/1","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1021\/acs.inorgchem.5b02690","volume":"55","author":"P\u0103unescu","year":"2016","journal-title":"Inorg. Chem."},{"key":"D2DT01085B\/cit9\/1","doi-asserted-by":"crossref","first-page":"8017","DOI":"10.1039\/D1DT00466B","volume":"50","author":"Masaryk","year":"2021","journal-title":"Dalton Trans."},{"key":"D2DT01085B\/cit10\/1","first-page":"871","volume":"12","author":"Zhang","year":"1998","journal-title":"Int. J. Oncol."},{"key":"D2DT01085B\/cit11\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1039\/D0CB00150C","volume":"2","author":"Banerjee","year":"2021","journal-title":"RSC Chem. Biol."},{"key":"D2DT01085B\/cit12a\/1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/anie.201610290","volume":"56","author":"Needham","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2DT01085B\/cit12b\/1","doi-asserted-by":"crossref","first-page":"14602","DOI":"10.1039\/C9CC06725F","volume":"55","author":"Zhang","year":"2019","journal-title":"Chem. Commun."},{"key":"D2DT01085B\/cit12c\/1","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1021\/acs.inorgchem.1c00467","volume":"60","author":"Berger","year":"2021","journal-title":"Inorg. Chem."},{"key":"D2DT01085B\/cit13a\/1","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/anie.201108175","volume":"51","author":"Betanzos-Lara","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2DT01085B\/cit13b\/1","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1038\/ncomms7582","volume":"6","author":"Soldevila-Barreda","year":"2015","journal-title":"Nat. Commun."},{"key":"D2DT01085B\/cit14\/1","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1039\/c2sc20220d","volume":"3","author":"Fu","year":"2012","journal-title":"Chem. Sci."},{"key":"D2DT01085B\/cit15\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccr.2018.07.012","volume":"376","author":"Brabec","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"D2DT01085B\/cit16\/1","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1021\/ic062350d","volume":"46","author":"Peacock","year":"2007","journal-title":"Inorg. Chem."},{"key":"D2DT01085B\/cit17\/1","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1021\/jm701538w","volume":"51","author":"Kostrhunova","year":"2008","journal-title":"J. Med. Chem."},{"key":"D2DT01085B\/cit18\/1","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.4161\/cbt.6.9.4559","volume":"6","author":"Shen","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"D2DT01085B\/cit19\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12935-016-0279-4","volume":"16","author":"Mirmalek","year":"2016","journal-title":"Cancer Cell Int."},{"key":"D2DT01085B\/cit20\/1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1021\/om3012272","volume":"32","author":"Filak","year":"2013","journal-title":"Organometallics"}],"container-title":["Dalton Transactions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/DT\/D2DT01085B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:49:53Z","timestamp":1782877793000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/dt\/article\/51\/24\/9213-9217\/765310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":30,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2022,6,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d2dt01085b","relation":{},"ISSN":["1477-9226","1477-9234"],"issn-type":[{"value":"1477-9226","type":"print"},{"value":"1477-9234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}