{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:44:57Z","timestamp":1792237497359,"version":"4.4.0"},"reference-count":69,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"am","delay-in-days":531,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073764"],"award-info":[{"award-number":["82073764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017538","name":"Zhejiang Provincial Ten Thousand Plan for Young Top Talents","doi-asserted-by":"publisher","award":["2019R52026"],"award-info":[{"award-number":["2019R52026"]}],"id":[{"id":"10.13039\/501100017538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>This study suggested that bioactive peptides from blue mussel could serve as a therapeutic alternative in the treatment of hypertension because of their ACE inhibitory activity and protective effects on oxidative damaged HUVECs.<\/jats:p>","DOI":"10.1039\/d2fo00275b","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T20:21:10Z","timestamp":1655324470000},"page":"7831-7846","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Seventeen novel angiotensin converting enzyme (ACE) inhibitory peptides from the protein hydrolysate of\n                    <i>Mytilus edulis<\/i>\n                    : isolation, identification, molecular docking study, and protective function on HUVECs"],"prefix":"10.1039","volume":"13","author":[{"given":"Shi-Kun","family":"Suo","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yang","family":"Pan","sequence":"additional","affiliation":[{"name":"National and Provincial Joint Laboratory of Exploration and Utilization of Marine Aquatic Genetic Resources, National Engineering Research Center of Marine Facilities Aquaculture, School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Feng","family":"Chi","sequence":"additional","affiliation":[{"name":"National and Provincial Joint Laboratory of Exploration and Utilization of Marine Aquatic Genetic Resources, National Engineering Research Center of Marine Facilities Aquaculture, School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-9045","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2FO00275B\/cit1\/1","volume-title":"Global health observatory data: Raised blood pressure, situation and trends","author":"WHO, World Health Organization","year":"2018","unstructured":"WHO, World Health Organization , Global health observatory data: Raised blood pressure, situation and trends , 2018"},{"issue":"3","key":"D2FO00275B\/cit2\/1","doi-asserted-by":"crossref","first-page":"166037","DOI":"10.1016\/j.bbadis.2020.166037","volume":"1867","author":"Gao","year":"2021","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"D2FO00275B\/cit3\/1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.tifs.2019.04.002","volume":"88","author":"Abdelhedi","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"D2FO00275B\/cit4\/1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.foodres.2019.03.035","volume":"121","author":"Zhao","year":"2019","journal-title":"Food Res. Int."},{"key":"D2FO00275B\/cit5\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jff.2016.07.006","volume":"26","author":"Paiva","year":"2016","journal-title":"J. Funct. Foods"},{"issue":"11","key":"D2FO00275B\/cit6\/1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/md17110613","volume":"17","author":"Abachi","year":"2019","journal-title":"Mar. Drugs"},{"key":"D2FO00275B\/cit7\/1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.foodchem.2017.06.112","volume":"239","author":"Abdelhedi","year":"2018","journal-title":"Food Chem."},{"issue":"11","key":"D2FO00275B\/cit8\/1","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.3390\/md11114641","volume":"11","author":"Wang","year":"2013","journal-title":"Mar. Drugs"},{"issue":"3","key":"D2FO00275B\/cit9\/1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3390\/app10030817","volume":"10","author":"Wang","year":"2020","journal-title":"Appl. Sci."},{"issue":"9","key":"D2FO00275B\/cit10\/1","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1111\/1750-3841.14299","volume":"83","author":"Yu","year":"2018","journal-title":"J. Food Sci."},{"issue":"11","key":"D2FO00275B\/cit11\/1","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1007\/s13197-020-04427-0","volume":"57","author":"Shi","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"D2FO00275B\/cit12\/1","doi-asserted-by":"crossref","first-page":"109908","DOI":"10.1016\/j.foodres.2020.109908","volume":"139","author":"Wang","year":"2021","journal-title":"Food Res. Int."},{"issue":"3","key":"D2FO00275B\/cit13\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/md17030179","volume":"17","author":"Sun","year":"2019","journal-title":"Mar. Drugs"},{"issue":"1","key":"D2FO00275B\/cit14\/1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jsfa.10041","volume":"100","author":"Chen","year":"2020","journal-title":"J. Sci. Food Agric."},{"issue":"2\u20133","key":"D2FO00275B\/cit15\/1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.foodchem.2012.12.002","volume":"138","author":"Wang","year":"2013","journal-title":"Food Chem."},{"issue":"2","key":"D2FO00275B\/cit16\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/md17020135","volume":"17","author":"Oh","year":"2019","journal-title":"Mar. Drugs"},{"issue":"7","key":"D2FO00275B\/cit17\/1","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.3390\/ijms19072100","volume":"19","author":"Qiao","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"MAR.1","key":"D2FO00275B\/cit18\/1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.foodchem.2017.09.043","volume":"242","author":"Hyung","year":"2018","journal-title":"Food Chem."},{"issue":"14","key":"D2FO00275B\/cit19\/1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.biortech.2005.01.001","volume":"96","author":"Je","year":"2005","journal-title":"Bioresour. Technol."},{"key":"D2FO00275B\/cit20\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jff.2015.10.023","volume":"20","author":"Park","year":"2016","journal-title":"J. Funct. Foods"},{"issue":"1","key":"D2FO00275B\/cit21\/1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/ijms19010138","volume":"19","author":"Qiao","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"D2FO00275B\/cit22\/1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1021\/acs.jafc.8b06530","volume":"67","author":"Xu","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"D2FO00275B\/cit23\/1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/antiox9090866","volume":"9","author":"Oh","year":"2020","journal-title":"Antioxidants"},{"key":"D2FO00275B\/cit24\/1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.foodchem.2014.07.117","volume":"168","author":"Chi","year":"2015","journal-title":"Food Chem."},{"key":"D2FO00275B\/cit25\/1","doi-asserted-by":"crossref","first-page":"9987844","DOI":"10.1155\/2021\/9987844","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"21","key":"D2FO00275B\/cit26\/1","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.3390\/ijms20215425","volume":"20","author":"Cai","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO00275B\/cit27\/1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.foodchem.2013.07.067","volume":"143","author":"Ngo","year":"2014","journal-title":"Food Chem."},{"key":"D2FO00275B\/cit28\/1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.foodres.2010.12.022","volume":"44","author":"Wijesekara","year":"2011","journal-title":"Food Res. Int."},{"issue":"27","key":"D2FO00275B\/cit29\/1","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.1021\/acs.jafc.8b01558","volume":"66","author":"Liao","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"D2FO00275B\/cit30\/1","doi-asserted-by":"crossref","first-page":"e0197644","DOI":"10.1371\/journal.pone.0197644","volume":"14","author":"Auwal","year":"2019","journal-title":"PLoS One"},{"issue":"10","key":"D2FO00275B\/cit31\/1","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1039\/C8FO01146J","volume":"9","author":"Chen","year":"2018","journal-title":"Food Funct."},{"key":"D2FO00275B\/cit32\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.lwt.2016.08.047","volume":"75","author":"Wang","year":"2017","journal-title":"LWT\u2013Food Sci. Technol."},{"key":"D2FO00275B\/cit33\/1","doi-asserted-by":"crossref","first-page":"128855","DOI":"10.1016\/j.foodchem.2020.128855","volume":"345","author":"Xu","year":"2021","journal-title":"Food Chem."},{"issue":"1","key":"D2FO00275B\/cit34\/1","doi-asserted-by":"crossref","first-page":"e12572","DOI":"10.1111\/jfbc.12572","volume":"43","author":"Fan","year":"2019","journal-title":"J. Food Biochem."},{"key":"D2FO00275B\/cit35\/1","doi-asserted-by":"crossref","first-page":"104701","DOI":"10.1016\/j.jff.2021.104701","volume":"86","author":"Wang","year":"2021","journal-title":"J. Funct. Foods"},{"issue":"10","key":"D2FO00275B\/cit36\/1","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1039\/C8FO01146J","volume":"9","author":"Chen","year":"2018","journal-title":"Food Funct."},{"key":"D2FO00275B\/cit37\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-food-022814-015520","volume":"6","author":"Aluko","year":"2015","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"D2FO00275B\/cit38\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lwt.2019.01.054","volume":"105","author":"He","year":"2019","journal-title":"LWT\u2013Food Sci. Technol."},{"key":"D2FO00275B\/cit39\/1","doi-asserted-by":"crossref","first-page":"127094","DOI":"10.1016\/j.foodchem.2020.127094","volume":"327","author":"Han","year":"2020","journal-title":"Food Chem."},{"issue":"2","key":"D2FO00275B\/cit40\/1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/md17020078","volume":"17","author":"Yang","year":"2019","journal-title":"Mar. Drugs"},{"key":"D2FO00275B\/cit41\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jff.2015.11.007","volume":"21","author":"Sila","year":"2016","journal-title":"J. Funct. Foods"},{"issue":"5","key":"D2FO00275B\/cit42\/1","doi-asserted-by":"crossref","first-page":"e12827","DOI":"10.1111\/jfbc.12827","volume":"43","author":"Lan","year":"2019","journal-title":"J. Food Biochem."},{"issue":"5","key":"D2FO00275B\/cit43\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/10498850.2014.898004","volume":"25","author":"Chi","year":"2016","journal-title":"J. Aquat. Food Prod. Technol."},{"key":"D2FO00275B\/cit44\/1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.foodres.2012.12.031","volume":"51","author":"Li","year":"2013","journal-title":"Food Res. Int."},{"issue":"1","key":"D2FO00275B\/cit45\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.peptides.2011.11.006","volume":"33","author":"Chen","year":"2012","journal-title":"Peptides"},{"key":"D2FO00275B\/cit46\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jff.2015.09.031","volume":"19","author":"Mirzaei","year":"2015","journal-title":"J. Funct. Foods"},{"key":"D2FO00275B\/cit47\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.foodchem.2017.10.095","volume":"245","author":"Liu","year":"2018","journal-title":"Food Chem."},{"issue":"15","key":"D2FO00275B\/cit48\/1","doi-asserted-by":"crossref","first-page":"4364e6","DOI":"10.1016\/j.bmcl.2009.05.079","volume":"19","author":"Chaudhary","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D2FO00275B\/cit49\/1","doi-asserted-by":"crossref","first-page":"359e69","DOI":"10.1016\/j.jprot.2013.10.006","volume":"94","author":"Rawendra","year":"2013","journal-title":"J. Proteomics"},{"issue":"27","key":"D2FO00275B\/cit50\/1","doi-asserted-by":"crossref","first-page":"8717e24","DOI":"10.1021\/bi049480n","volume":"43","author":"Natesh","year":"2004","journal-title":"Biochemistry"},{"issue":"16","key":"D2FO00275B\/cit51\/1","doi-asserted-by":"crossref","first-page":"7807","DOI":"10.1073\/pnas.91.16.7807","volume":"91","author":"Deddish","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2FO00275B\/cit52\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jff.2016.11.021","volume":"28","author":"Zheng","year":"2017","journal-title":"J. Funct. Foods"},{"key":"D2FO00275B\/cit53\/1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ifset.2016.03.014","volume":"37","author":"Hayes","year":"2016","journal-title":"Innovative Food Sci. Emerging Technol."},{"issue":"3","key":"D2FO00275B\/cit54\/1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/87559129.2011.563395","volume":"27","author":"Segura-Campos","year":"2011","journal-title":"Food Rev. Int."},{"key":"D2FO00275B\/cit55\/1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biotechadv.2014.12.003","volume":"33","author":"Saadi","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"D2FO00275B\/cit56\/1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.procbio.2016.01.009","volume":"51","author":"Ko","year":"2016","journal-title":"Process Biochem."},{"key":"D2FO00275B\/cit57\/1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3390\/md10051066","volume":"10","author":"Wu","year":"2012","journal-title":"Mar. Drugs"},{"key":"D2FO00275B\/cit58\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/md20030176","volume":"20","author":"Zheng","year":"2022","journal-title":"Mar. Drugs"},{"issue":"11","key":"D2FO00275B\/cit59\/1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/md16110411","volume":"16","author":"Yu","year":"2018","journal-title":"Mar. Drugs"},{"key":"D2FO00275B\/cit60\/1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jff.2018.07.060","volume":"48","author":"Zhao","year":"2018","journal-title":"J. Funct. Foods"},{"key":"D2FO00275B\/cit61\/1","doi-asserted-by":"crossref","first-page":"111265","DOI":"10.1016\/j.lwt.2021.111265","volume":"144","author":"Zhang","year":"2021","journal-title":"LWT\u2013Food Sci. Technol."},{"key":"D2FO00275B\/cit62\/1","doi-asserted-by":"crossref","first-page":"868681","DOI":"10.3389\/fnut.2022.868681","volume":"9","author":"Qiao","year":"2022","journal-title":"Front. Nutr."},{"key":"D2FO00275B\/cit63\/1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3390\/md16040100","volume":"16","author":"Tao","year":"2018","journal-title":"Mar. Drugs"},{"issue":"5","key":"D2FO00275B\/cit64\/1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/md17050251","volume":"17","author":"Yang","year":"2019","journal-title":"Mar. Drugs"},{"issue":"3","key":"D2FO00275B\/cit65\/1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/md18030156","volume":"18","author":"Wang","year":"2020","journal-title":"Mar. Drugs"},{"key":"D2FO00275B\/cit66\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jff.2017.12.003","volume":"42","author":"Liu","year":"2018","journal-title":"J. Funct. Foods"},{"key":"D2FO00275B\/cit67\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jff.2018.08.033","volume":"51","author":"Zheng","year":"2018","journal-title":"J. Funct. Foods"},{"key":"D2FO00275B\/cit68\/1","doi-asserted-by":"crossref","first-page":"103696","DOI":"10.1016\/j.jff.2019.103696","volume":"64","author":"Tonolo","year":"2020","journal-title":"J. Funct. Foods"},{"key":"D2FO00275B\/cit69\/1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.foodchem.2017.06.106","volume":"239","author":"Rahman","year":"2018","journal-title":"Food Chem."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D2FO00275B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:00:59Z","timestamp":1782968459000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/14\/7831-7846\/768697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":69,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2022,7,18]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo00275b","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}