{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T11:03:44Z","timestamp":1787483024563,"version":"build-2736575974"},"reference-count":65,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"am","delay-in-days":495,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100019076","name":"Outstanding Young and Middle-aged Scientific Innovation Team of Colleges and Universities of Hubei Province","doi-asserted-by":"publisher","award":["T2020013"],"award-info":[{"award-number":["T2020013"]}],"id":[{"id":"10.13039\/501100019076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202102AE090042"],"award-info":[{"award-number":["202102AE090042"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873098"],"award-info":[{"award-number":["81873098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    In this study, novel\n                    <jats:italic>Poria cocos<\/jats:italic>\n                    oligosaccharides (PCO) were prepared by enzymatic degradation, and their polymerization degree was determined to be 2\u20136 by LC-MS analysis.\n                  <\/jats:p>","DOI":"10.1039\/d2fo00638c","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T03:40:51Z","timestamp":1652240451000},"page":"6813-6829","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Structural characterization of\n                    <i>Poria cocos<\/i>\n                    oligosaccharides and their effects on the hepatic metabolome in high-fat diet-fed mice"],"prefix":"10.1039","volume":"13","author":[{"given":"Lin","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Life Science, Wuchang University of Technology, Synergy Innovation Center of Biological Peptide Antidiabetics of Hubei Province, Engineering Technology Research Center of Biological Peptide Antidiabetics of Hubei Province, Jiangxia Avenue 16, Wuhan 430223, P. R. China"},{"name":"College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-0530","authenticated-orcid":false,"given":"Yanlei","family":"Guo","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Chinese Materia Medica, Chongqing 400065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabing","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjie","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science, Wuchang University of Technology, Synergy Innovation Center of Biological Peptide Antidiabetics of Hubei Province, Engineering Technology Research Center of Biological Peptide Antidiabetics of Hubei Province, Jiangxia Avenue 16, Wuhan 430223, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-4877","authenticated-orcid":false,"given":"Baifei","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2FO00638C\/cit1\/1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11418-011-0612-0","volume":"66","author":"Kobira","year":"2012","journal-title":"J. Nat. Med."},{"key":"D2FO00638C\/cit2\/1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.jep.2013.10.043","volume":"150","author":"Feng","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"D2FO00638C\/cit3\/1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ijbiomac.2016.05.046","volume":"91","author":"Wu","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"D2FO00638C\/cit4\/1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.carbpol.2013.03.015","volume":"95","author":"Zhang","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"D2FO00638C\/cit5\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/cells7090116","volume":"7","author":"Lee","year":"2018","journal-title":"Cells"},{"key":"D2FO00638C\/cit6\/1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijbiomac.2018.03.107","volume":"114","author":"Wu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D2FO00638C\/cit7\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.carbpol.2014.01.049","volume":"105","author":"Tang","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"D2FO00638C\/cit8\/1","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.ijbiomac.2018.09.171","volume":"120","author":"Zhang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D2FO00638C\/cit9\/1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ijbiomac.2018.11.140","volume":"123","author":"Li","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"D2FO00638C\/cit10\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3389\/fphar.2020.00833","volume":"11","author":"Hong","year":"2020","journal-title":"Front. Pharmacol."},{"key":"D2FO00638C\/cit11\/1","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1021\/acs.jafc.9b02434","volume":"67","author":"Luo","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"D2FO00638C\/cit12\/1","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.3390\/ijms20194801","volume":"20","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO00638C\/cit13\/1","first-page":"3","volume":"17","author":"Sun","year":"2019","journal-title":"Chin. J. Nat. Med."},{"key":"D2FO00638C\/cit14\/1","first-page":"3630260","volume":"2019","author":"Hao","year":"2019","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D2FO00638C\/cit15\/1","doi-asserted-by":"crossref","first-page":"115475","DOI":"10.1016\/j.carbpol.2019.115475","volume":"229","author":"Bai","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"D2FO00638C\/cit16\/1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00125-015-3656-y","volume":"58","author":"Giesbertz","year":"2015","journal-title":"Diabetologia"},{"key":"D2FO00638C\/cit17\/1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrm1489","volume":"5","author":"Taub","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D2FO00638C\/cit18\/1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"D2FO00638C\/cit19\/1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/bs.pmbts.2019.02.011","volume":"163","author":"Li","year":"2019","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"D2FO00638C\/cit20\/1","doi-asserted-by":"crossref","first-page":"104942","DOI":"10.1016\/j.phrs.2020.104942","volume":"159","author":"Hu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"D2FO00638C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.ijbiomac.2018.08.024","volume":"119","author":"Chai","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D2FO00638C\/cit22\/1","first-page":"205","volume":"55","author":"Hakomori","year":"1964","journal-title":"J. Biochem."},{"key":"D2FO00638C\/cit23\/1","doi-asserted-by":"crossref","first-page":"116271","DOI":"10.1016\/j.carbpol.2020.116271","volume":"240","author":"Zhu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"D2FO00638C\/cit24\/1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3390\/ijms20051220","volume":"20","author":"Xu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO00638C\/cit25\/1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/10408398.2014.887055","volume":"57","author":"Sarao","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D2FO00638C\/cit26\/1","doi-asserted-by":"crossref","first-page":"11655","DOI":"10.1096\/fj.201802802RRR","volume":"33","author":"Zhu","year":"2019","journal-title":"FASEB J."},{"key":"D2FO00638C\/cit27\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0065-2318(08)60077-3","volume":"44","author":"Mathlouthi","year":"1986","journal-title":"Adv. Carbohydr. Chem. Biochem."},{"key":"D2FO00638C\/cit28\/1","first-page":"13","volume":"12","author":"Neely","year":"1957","journal-title":"Adv. Carbohydr. Chem."},{"key":"D2FO00638C\/cit29\/1","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1016\/0031-9422(92)83678-R","volume":"31","author":"Agrawal","year":"1992","journal-title":"Phytochemistry"},{"key":"D2FO00638C\/cit30\/1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.carbpol.2017.12.083","volume":"184","author":"Cai","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"D2FO00638C\/cit31\/1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.carbpol.2015.10.102","volume":"137","author":"Huang","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"D2FO00638C\/cit32\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"D2FO00638C\/cit33\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Invest."},{"key":"D2FO00638C\/cit34\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cytogfr.2018.10.002","volume":"44","author":"Wang","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"D2FO00638C\/cit35\/1","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1021\/acs.jafc.0c00717","volume":"68","author":"Wu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"D2FO00638C\/cit36\/1","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.jnutbio.2013.05.008","volume":"24","author":"Polakof","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"D2FO00638C\/cit37\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cmet.2016.09.018","volume":"25","author":"Newgard","year":"2017","journal-title":"Cell Metab."},{"key":"D2FO00638C\/cit38\/1","doi-asserted-by":"crossref","first-page":"784214","DOI":"10.3389\/fphar.2022.784214","volume":"13","author":"Camera","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D2FO00638C\/cit39\/1","doi-asserted-by":"crossref","first-page":"624657","DOI":"10.3389\/fphys.2020.624657","volume":"11","author":"Arnardottir","year":"2020","journal-title":"Front. Physiol."},{"key":"D2FO00638C\/cit40\/1","doi-asserted-by":"crossref","first-page":"103909","DOI":"10.1016\/j.ebiom.2022.103909","volume":"77","author":"Fisk","year":"2022","journal-title":"EBioMedicine"},{"key":"D2FO00638C\/cit41\/1","doi-asserted-by":"crossref","first-page":"153345","DOI":"10.1016\/j.phymed.2020.153345","volume":"79","author":"Fan","year":"2020","journal-title":"Phytomedicine"},{"key":"D2FO00638C\/cit42\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41390-019-0740-x","volume":"88","author":"Meng","year":"2020","journal-title":"Pediatr. Res."},{"key":"D2FO00638C\/cit43\/1","first-page":"1359","volume":"12","author":"Geng","year":"2018","journal-title":"J Crohns Colitis"},{"key":"D2FO00638C\/cit44\/1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D2FO00638C\/cit45\/1","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.3390\/ijms15022991","volume":"15","author":"Eisinger","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO00638C\/cit46\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/0008-5472.CAN-06-3016","volume":"67","author":"Foster","year":"2007","journal-title":"Cancer Res."},{"key":"D2FO00638C\/cit47\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jssc.201500899","volume":"39","author":"Yang","year":"2016","journal-title":"J. Sep. Sci."},{"key":"D2FO00638C\/cit48\/1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/aps.2016.135","volume":"38","author":"Huang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"D2FO00638C\/cit49\/1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jnutbio.2014.04.011","volume":"25","author":"Dossi","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"D2FO00638C\/cit50\/1","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.clnu.2017.08.031","volume":"37","author":"Okada","year":"2018","journal-title":"Clin. Nutr."},{"key":"D2FO00638C\/cit51\/1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-2036.2009.04230.x","volume":"31","author":"Masterton","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"key":"D2FO00638C\/cit52\/1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.clnu.2015.05.001","volume":"35","author":"Nogueira","year":"2016","journal-title":"Clin. Nutr."},{"key":"D2FO00638C\/cit53\/1","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1080\/10408398.2015.1126549","volume":"57","author":"Tortosa-Caparros","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D2FO00638C\/cit54\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins, Leukotrienes Essent. Fatty Acids"},{"key":"D2FO00638C\/cit55\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1172\/JCI115591","volume":"89","author":"Sano","year":"1992","journal-title":"J. Clin. Invest."},{"key":"D2FO00638C\/cit56\/1","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/nar\/gkw1186","volume":"45","author":"Pan","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"D2FO00638C\/cit57\/1","doi-asserted-by":"crossref","first-page":"e108069","DOI":"10.15252\/embj.2021108069","volume":"40","author":"Xu","year":"2021","journal-title":"EMBO J."},{"key":"D2FO00638C\/cit58\/1","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","volume":"9","author":"Roager","year":"2018","journal-title":"Nat. Commun."},{"key":"D2FO00638C\/cit59\/1","doi-asserted-by":"crossref","first-page":"2056250","DOI":"10.1155\/2018\/2056250","volume":"2018","author":"Sa-Nakanishi","year":"2018","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D2FO00638C\/cit60\/1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1096\/fj.201901510RR","volume":"34","author":"Annunziata","year":"2020","journal-title":"FASEB J."},{"key":"D2FO00638C\/cit61\/1","doi-asserted-by":"crossref","first-page":"e1003970","DOI":"10.1371\/journal.pgen.1003970","volume":"9","author":"Walls Jr.","year":"2013","journal-title":"PLoS Genet."},{"key":"D2FO00638C\/cit62\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2741\/4474","volume":"22","author":"Boini","year":"2017","journal-title":"Front. Biosci."},{"key":"D2FO00638C\/cit63\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"D2FO00638C\/cit64\/1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1126\/science.aar5551","volume":"366","author":"Cartier","year":"2019","journal-title":"Science"},{"key":"D2FO00638C\/cit65\/1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41467-022-28138-6","volume":"13","author":"Lee","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D2FO00638C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:28:04Z","timestamp":1782880084000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/12\/6813-6829\/768772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":65,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,6,20]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo00638c","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}