{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:14:53Z","timestamp":1793459693913,"version":"4.5.0"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"am","delay-in-days":600,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","award":["20JCZDJC00710"],"award-info":[{"award-number":["20JCZDJC00710"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773727"],"award-info":[{"award-number":["81773727"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973316"],"award-info":[{"award-number":["81973316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173807"],"award-info":[{"award-number":["82173807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","award":["63211045"],"award-info":[{"award-number":["63211045"]}],"id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","award":["JZ2021HGTA0127"],"award-info":[{"award-number":["JZ2021HGTA0127"]}],"id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Daidzein improves doxorubicin-induced heart failure in mice by activating AMPK\u03b1 and SIRT3\/FOXO3a pathway-mediated energy balance and improving mitochondrial function, thereby inhibiting inflammation, fibrosis, apoptosis, oxidative stress in heart.<\/jats:p>","DOI":"10.1039\/d2fo00772j","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T04:59:20Z","timestamp":1661317160000},"page":"9576-9588","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Daidzein alleviates doxorubicin-induced heart failure\n                    <i>via<\/i>\n                    the SIRT3\/FOXO3a signaling pathway"],"prefix":"10.1039","volume":"13","author":[{"given":"Huaxin","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Biomedicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengteng","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianshe","family":"Meng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-5288","authenticated-orcid":false,"given":"Xiaoxiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-3847","authenticated-orcid":false,"given":"Yuanli","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"},{"name":"College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-9070","authenticated-orcid":false,"given":"Yajun","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"},{"name":"Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-4305","authenticated-orcid":false,"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2FO00772J\/cit1\/1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/S0140-6736(05)70801-1","volume":"365","author":"Zhang","year":"2005","journal-title":"Lancet"},{"key":"D2FO00772J\/cit2\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccep.2018.11.001","volume":"11","author":"Snipelisky","year":"2019","journal-title":"Card. Electrophysiol. Clin."},{"key":"D2FO00772J\/cit3\/1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1242\/dmm.005017","volume":"3","author":"Breckenridge","year":"2010","journal-title":"Dis. Models Mech."},{"key":"D2FO00772J\/cit4\/1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ejhf.1369","volume":"21","author":"Mullens","year":"2019","journal-title":"Eur. J. Heart Failure"},{"key":"D2FO00772J\/cit5\/1","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/eurjpc\/zwaa147","volume":"28","author":"Bragazzi","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"D2FO00772J\/cit6\/1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s10741-019-09857-3","volume":"25","author":"Qian","year":"2020","journal-title":"Heart Failure Rev."},{"key":"D2FO00772J\/cit7\/1","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","volume":"128","author":"Zhou","year":"2018","journal-title":"J. Clin. Invest."},{"key":"D2FO00772J\/cit8\/1","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.7150\/thno.47845","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"D2FO00772J\/cit9\/1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/ejhf.2149","volume":"23","author":"Packer","year":"2021","journal-title":"Eur. J. Heart Failure"},{"issue":"9","key":"D2FO00772J\/cit10\/1","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.3390\/nu11092231","volume":"11","author":"Mayo","year":"2019","journal-title":"Nutrients"},{"key":"D2FO00772J\/cit11\/1","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1021\/jf500231t","volume":"62","author":"Bao","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"D2FO00772J\/cit12\/1","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1039\/C8FO01718B","volume":"9","author":"Luo","year":"2018","journal-title":"Food Funct."},{"key":"D2FO00772J\/cit13\/1","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.3945\/jn.109.107029","volume":"139","author":"Ronis","year":"2009","journal-title":"J. Nutr."},{"key":"D2FO00772J\/cit14\/1","doi-asserted-by":"crossref","first-page":"109803","DOI":"10.1016\/j.biopha.2019.109803","volume":"123","author":"Xu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"D2FO00772J\/cit15\/1","doi-asserted-by":"crossref","first-page":"111531","DOI":"10.1016\/j.biopha.2021.111531","volume":"138","author":"Feng","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"D2FO00772J\/cit16\/1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/bph.14886","volume":"177","author":"Zhang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"D2FO00772J\/cit17\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/13880209.2020.1761403","volume":"58","author":"Sun","year":"2020","journal-title":"Pharm. Biol."},{"key":"D2FO00772J\/cit18\/1","doi-asserted-by":"crossref","first-page":"e012338","DOI":"10.1161\/JAHA.119.012338","volume":"8","author":"Liu","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"9","key":"D2FO00772J\/cit19\/1","doi-asserted-by":"crossref","first-page":"e132747","DOI":"10.1172\/jci.insight.132747","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"key":"D2FO00772J\/cit20\/1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41418-019-0372-z","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"key":"D2FO00772J\/cit21\/1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.apsb.2019.03.003","volume":"9","author":"Hu","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"D2FO00772J\/cit22\/1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/CIRCRESAHA.119.315529","volume":"125","author":"Zhu","year":"2019","journal-title":"Circ. Res."},{"key":"D2FO00772J\/cit23\/1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5114\/aoms.2018.81037","volume":"15","author":"Zhang","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"D2FO00772J\/cit24\/1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.freeradbiomed.2021.03.013","volume":"167","author":"Tian","year":"2021","journal-title":"Free Radicals Biol. Med."},{"key":"D2FO00772J\/cit25\/1","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1039\/D0FO02942D","volume":"12","author":"Zhou","year":"2021","journal-title":"Food Funct."},{"issue":"2","key":"D2FO00772J\/cit26\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1139\/bcb-2019-0450","volume":"100","author":"Chen","year":"2020","journal-title":"Biochem. Cell Biol."},{"key":"D2FO00772J\/cit27\/1","first-page":"4830418","volume":"2020","author":"Deng","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D2FO00772J\/cit28\/1","first-page":"1294","volume":"45","author":"Zhi","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"D2FO00772J\/cit29\/1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2337\/db19-0526","volume":"69","author":"Gao","year":"2020","journal-title":"Diabetes"},{"key":"D2FO00772J\/cit30\/1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvy217","volume":"115","author":"Xu","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"D2FO00772J\/cit31\/1","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/eurheartj\/ehx501.P440","volume":"38","author":"Du","year":"2017","journal-title":"Eur. Heart J."},{"key":"D2FO00772J\/cit32\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/rapm-2020-101918","volume":"46","author":"Zhou","year":"2021","journal-title":"Reg. Anesth. Pain Med."},{"key":"D2FO00772J\/cit33\/1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.2147\/DDDT.S248628","volume":"14","author":"Wu","year":"2020","journal-title":"Drug Des., Dev. Ther."},{"key":"D2FO00772J\/cit34\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2019.05.181","volume":"516","author":"Shi","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D2FO00772J\/cit35\/1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neuroscience.2015.10.048","volume":"311","author":"Rangarajan","year":"2015","journal-title":"Neuroscience"},{"key":"D2FO00772J\/cit36\/1","doi-asserted-by":"publisher","first-page":"e13820","DOI":"10.1111\/jfbc.13820","author":"Yang","year":"2021","journal-title":"J. Food Biochem."},{"key":"D2FO00772J\/cit37\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41416-019-0658-4","volume":"122","author":"Zhang","year":"2020","journal-title":"Br. J. Cancer"},{"key":"D2FO00772J\/cit38\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yjmcc.2019.04.006","volume":"130","author":"Haileselassie","year":"2019","journal-title":"J. Mol. Cell Cardiol."},{"key":"D2FO00772J\/cit39\/1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/2047487319870344","volume":"27","author":"Aimo","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"D2FO00772J\/cit40\/1","doi-asserted-by":"crossref","first-page":"173399","DOI":"10.1016\/j.ejphar.2020.173399","volume":"885","author":"Yu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"D2FO00772J\/cit41\/1","doi-asserted-by":"crossref","first-page":"102884","DOI":"10.1016\/j.ebiom.2020.102884","volume":"57","author":"Ramachandra","year":"2020","journal-title":"EBioMedicine"},{"key":"D2FO00772J\/cit42\/1","first-page":"H2181","volume":"301","author":"Tsutsui","year":"2011","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"D2FO00772J\/cit43\/1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.21037\/atm-21-378","volume":"9","author":"Li","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"D2FO00772J\/cit44\/1","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.18632\/aging.103197","volume":"12","author":"Pang","year":"2020","journal-title":"Aging"},{"key":"D2FO00772J\/cit45\/1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/hmg\/ddy405","volume":"28","author":"Banerji","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"D2FO00772J\/cit46\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biochi.2014.04.005","volume":"103","author":"Soumyakrishnan","year":"2014","journal-title":"Biochimie"},{"key":"D2FO00772J\/cit47\/1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3892\/or.2015.4133","volume":"34","author":"Han","year":"2015","journal-title":"Oncol. Rep."},{"key":"D2FO00772J\/cit48\/1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.fct.2013.08.022","volume":"60","author":"Park","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"D2FO00772J\/cit49\/1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mito.2019.05.008","volume":"47","author":"Santos-Alves","year":"2019","journal-title":"Mitochondrion"},{"key":"D2FO00772J\/cit50\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","volume":"307","author":"Songbo","year":"2019","journal-title":"Toxicol. Lett."},{"key":"D2FO00772J\/cit51\/1","doi-asserted-by":"crossref","first-page":"109139","DOI":"10.1016\/j.biopha.2019.109139","volume":"121","author":"Wei","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"D2FO00772J\/cit52\/1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1161\/CIRCULATIONAHA.115.017355","volume":"133","author":"Aubert","year":"2016","journal-title":"Circulation"},{"key":"D2FO00772J\/cit53\/1","doi-asserted-by":"crossref","first-page":"108315","DOI":"10.1016\/j.jnutbio.2019.108315","volume":"77","author":"Kitamura","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"D2FO00772J\/cit54\/1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/ATVBAHA.120.315337","volume":"41","author":"Wei","year":"2021","journal-title":"Arterioscler., Thromb., Vasc. Biol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D2FO00772J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:23:49Z","timestamp":1782966229000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/18\/9576-9588\/768795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":54,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,9,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo00772j","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}