{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:22:40Z","timestamp":1783275760436,"version":"3.54.6"},"reference-count":19,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"am","delay-in-days":585,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Chum salmon milt deoxyribonucleic acid is a food material that shows the potential fatty liver improvement and anti-obesity action and can improved liver-to-spleen (L\/S) ratio.<\/jats:p>","DOI":"10.1039\/d2fo01149b","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T03:01:16Z","timestamp":1660014076000},"page":"9383-9390","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dietary supplementation of deoxyribonucleic acid derived from chum salmon milt improves liver function in healthy Japanese individuals: a placebo-controlled, randomised, double-blind, parallel-group clinical trial"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5811-6175","authenticated-orcid":false,"given":"Yoshinori","family":"Takahashi","sequence":"first","affiliation":[{"name":"Central Research Institute, Maruha Nichiro Corporation, 16-2, Wadai, Tsukuba, Ibaraki, 300-4295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Konishi","sequence":"additional","affiliation":[{"name":"Central Research Institute, Maruha Nichiro Corporation, 16-2, Wadai, Tsukuba, Ibaraki, 300-4295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Medical Management and Informatics, Hokkaido Information University, 59-2, Nishi-nopporo, Ebetsu, Hokkaido, 069-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nishihira","sequence":"additional","affiliation":[{"name":"Department of Medical Management and Informatics, Hokkaido Information University, 59-2, Nishi-nopporo, Ebetsu, Hokkaido, 069-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2FO01149B\/cit1\/1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MD.0b013e3182779d49","volume":"91","author":"Younossi","year":"2012","journal-title":"Medicine"},{"key":"D2FO01149B\/cit2\/1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00125-016-3902-y","volume":"59","author":"European Association for the Study of the Liver (EASL)","year":"2016","journal-title":"Diabetologia"},{"key":"D2FO01149B\/cit3\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12933-015-0222-3","volume":"14","author":"Buday","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"D2FO01149B\/cit4\/1","doi-asserted-by":"crossref","first-page":"g4596","DOI":"10.1136\/bmj.g4596","volume":"349","author":"Sattar","year":"2014","journal-title":"Br. Med. J."},{"key":"D2FO01149B\/cit5\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/nu9040387","volume":"9","author":"Kitade","year":"2017","journal-title":"Nutrients"},{"key":"D2FO01149B\/cit6\/1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3136\/nskkk.55.510","volume":"55","author":"Mitarai","year":"2008","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"D2FO01149B\/cit7\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3136\/nskkk.55.461","volume":"55","author":"Mitarai","year":"2008","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"D2FO01149B\/cit8\/1","author":"Michitatsu","year":"2022","journal-title":"Fish Sci."},{"key":"D2FO01149B\/cit9\/1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3136\/nskkk.55.632","volume":"55","author":"Kawarasaki","year":"2008","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"D2FO01149B\/cit10\/1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO01145J","author":"Takahashi","year":"2022","journal-title":"Food\u00a0 Funct."},{"key":"D2FO01149B\/cit11\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000514848","volume":"14","author":"Xing","year":"2021","journal-title":"Obes. Facts"},{"key":"D2FO01149B\/cit12\/1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1210\/jc.2015-3444","volume":"101","author":"Loomis","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"D2FO01149B\/cit13\/1","doi-asserted-by":"crossref","first-page":"15273","DOI":"10.1038\/s41598-018-33419-6","volume":"8","author":"Fan","year":"2018","journal-title":"Sci. Rep."},{"key":"D2FO01149B\/cit14\/1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00535-015-1050-7","volume":"50","author":"Watanabe","year":"2015","journal-title":"J. Gastroenterol."},{"key":"D2FO01149B\/cit15\/1","doi-asserted-by":"crossref","first-page":"e19878","DOI":"10.1371\/journal.pone.0019878","volume":"6","author":"Masharani","year":"2011","journal-title":"PLoS One"},{"key":"D2FO01149B\/cit16\/1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/jdi.12271","volume":"6","author":"Kato","year":"2015","journal-title":"J. Diabetes Invest."},{"key":"D2FO01149B\/cit17\/1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.metabol.2015.11.006","volume":"65","author":"Polyzos","year":"2016","journal-title":"Metabolism"},{"key":"D2FO01149B\/cit18\/1","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/ijms18081649","volume":"18","author":"Adolph","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO01149B\/cit19\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.15403\/jgld-179","volume":"28","author":"Mirhafez","year":"2019","journal-title":"J. Gastrointest. Liver Dis."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D2FO01149B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:13:59Z","timestamp":1783275239000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/18\/9383-9390\/768877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":19,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,9,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo01149b","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}