{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:00:31Z","timestamp":1789754431022,"version":"4.0.1"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"am","delay-in-days":580,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["CAAS-ASTIP-2022-IFST"],"award-info":[{"award-number":["CAAS-ASTIP-2022-IFST"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-04"],"award-info":[{"award-number":["CARS-04"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013211","name":"Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences","doi-asserted-by":"publisher","award":["Y2022LM09"],"award-info":[{"award-number":["Y2022LM09"]}],"id":[{"id":"10.13039\/501100013211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Depression is highly prevalent in patients suffering from chronic inflammatory diseases.<\/jats:p>","DOI":"10.1039\/d2fo01437h","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T20:21:13Z","timestamp":1659558073000},"page":"9513-9522","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-6867","authenticated-orcid":false,"given":"Cong","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China"},{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-0275","authenticated-orcid":false,"given":"Litao","family":"Tong","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2FO01437H\/cit1\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2020.06.019","volume":"88","author":"Wang","year":"2020","journal-title":"Brain, Behav., Immun."},{"key":"D2FO01437H\/cit2\/1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbi.2017.10.025","volume":"72","author":"Franklin","year":"2018","journal-title":"Brain, Behav., Immun."},{"key":"D2FO01437H\/cit3\/1","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1111\/bph.15261","volume":"177","author":"Xu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"D2FO01437H\/cit4\/1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/mp.2016.144","volume":"22","author":"Bouvier","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"D2FO01437H\/cit5\/1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.freeradbiomed.2011.04.039","volume":"51","author":"Hillman","year":"2011","journal-title":"Free Radical Biol. Med."},{"key":"D2FO01437H\/cit6\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.semradonc.2018.10.002","volume":"29","author":"Hillman","year":"2019","journal-title":"Semin. Radiat. Oncol."},{"key":"D2FO01437H\/cit7\/1","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.clnu.2017.11.002","volume":"37","author":"Lu","year":"2018","journal-title":"Clin. Nutr."},{"key":"D2FO01437H\/cit8\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1301\/nr.2003.janr.1-33","volume":"61","author":"Munro","year":"2003","journal-title":"Nutr. Rev."},{"key":"D2FO01437H\/cit9\/1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3233\/JAD-142958","volume":"47","author":"Gleason","year":"2015","journal-title":"J. Alzheimer's Dis."},{"key":"D2FO01437H\/cit10\/1","doi-asserted-by":"crossref","first-page":"e202004029","DOI":"10.1083\/jcb.202004029","volume":"219","author":"Killackey","year":"2020","journal-title":"J. Cell Biol."},{"key":"D2FO01437H\/cit11\/1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7354","author":"Lu","year":"2022","journal-title":"Phytother. Res."},{"key":"D2FO01437H\/cit12\/1","doi-asserted-by":"crossref","first-page":"10011","DOI":"10.1039\/D0FO02042G","volume":"11","author":"Lu","year":"2020","journal-title":"Food Funct."},{"key":"D2FO01437H\/cit13\/1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s11427-020-1815-6","volume":"64","author":"Jia","year":"2021","journal-title":"Sci. China: Life Sci."},{"key":"D2FO01437H\/cit14\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"D2FO01437H\/cit15\/1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3390\/nu10070853","volume":"10","author":"Lu","year":"2018","journal-title":"Nutrients"},{"key":"D2FO01437H\/cit16\/1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/ptr.5797","volume":"31","author":"Lu","year":"2017","journal-title":"Phytother. Res."},{"key":"D2FO01437H\/cit17\/1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7017","author":"Jiang","year":"2021","journal-title":"Phytother. Res."},{"key":"D2FO01437H\/cit18\/1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/npp.2013.71","volume":"38","author":"Walker","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"D2FO01437H\/cit19\/1","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1002\/ptr.6713","volume":"34","author":"Jiang","year":"2020","journal-title":"Phytother. Res."},{"key":"D2FO01437H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/s41380-018-0285-0","volume":"25","author":"Zhang","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"D2FO01437H\/cit21\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2019.01.021","volume":"163","author":"He","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"D2FO01437H\/cit22\/1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3389\/fimmu.2019.01511","volume":"10","author":"Arioz","year":"2019","journal-title":"Front. Immunol."},{"key":"D2FO01437H\/cit23\/1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.physbeh.2018.02.034","volume":"188","author":"Taniguti","year":"2018","journal-title":"Physiol. Behav."},{"key":"D2FO01437H\/cit24\/1","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/glia.23343","volume":"66","author":"Albertini","year":"2018","journal-title":"Glia"},{"key":"D2FO01437H\/cit25\/1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41401-019-0317-6","volume":"41","author":"Huang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"D2FO01437H\/cit26\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"D2FO01437H\/cit27\/1","doi-asserted-by":"crossref","first-page":"e12667","DOI":"10.1111\/jpi.12667","volume":"69","author":"Ali","year":"2020","journal-title":"J. Pineal Res."},{"key":"D2FO01437H\/cit28\/1","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1111\/bph.15261","volume":"177","author":"Xu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"D2FO01437H\/cit29\/1","doi-asserted-by":"crossref","first-page":"644383","DOI":"10.3389\/fpsyt.2021.644383","volume":"12","author":"Chao","year":"2021","journal-title":"Front. Psychiatry"},{"key":"D2FO01437H\/cit30\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2020.11.008","volume":"92","author":"Li","year":"2021","journal-title":"Brain, Behav., Immun."},{"key":"D2FO01437H\/cit31\/1","doi-asserted-by":"crossref","first-page":"109680","DOI":"10.1016\/j.biopha.2019.109680","volume":"125","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"D2FO01437H\/cit32\/1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.brainresbull.2019.09.007","volume":"153","author":"Jiang","year":"2019","journal-title":"Brain Res. Bull."},{"key":"D2FO01437H\/cit33\/1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9794","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"D2FO01437H\/cit34\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jpba.2018.11.058","volume":"165","author":"Xu","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D2FO01437H\/cit35\/1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4002148","volume":"14","author":"O'Connor","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"D2FO01437H\/cit36\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bbi.2020.04.016","volume":"88","author":"Zhang","year":"2020","journal-title":"Brain, Behav., Immun."},{"key":"D2FO01437H\/cit37\/1","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.3390\/ijms21041460","volume":"21","author":"Tao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO01437H\/cit38\/1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s13311-019-00807-3","volume":"17","author":"Li","year":"2020","journal-title":"Neurotherapeutics"},{"key":"D2FO01437H\/cit39\/1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1039\/C9FO03104A","volume":"11","author":"Sun","year":"2020","journal-title":"Food Funct."},{"key":"D2FO01437H\/cit40\/1","doi-asserted-by":"crossref","first-page":"113459","DOI":"10.1016\/j.expneurol.2020.113459","volume":"334","author":"Camargo","year":"2020","journal-title":"Exp. Neurol."},{"key":"D2FO01437H\/cit41\/1","first-page":"276","volume":"8","author":"Chen","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"D2FO01437H\/cit42\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jad.2019.01.031","volume":"248","author":"Shen","year":"2019","journal-title":"J. Affective Disord."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D2FO01437H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:18:12Z","timestamp":1782886692000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/13\/18\/9513-9522\/768943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":42,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,9,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo01437h","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}