{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:06:46Z","timestamp":1787004406950,"version":"build-2736575974"},"reference-count":47,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant 81773425"],"award-info":[{"award-number":["Grant 81773425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017"],"award-info":[{"award-number":["2017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 82073542, 2020"],"award-info":[{"award-number":["Grant No. 82073542, 2020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Different ratios of DHA\/EPA-reversed IR by improving adipocyte dysfunction and lipid disorders in HFD-induced IR mice, and a 1.5\u2009:\u20091 ratio of DHA\/EPA (4%) supplement is recommended in people with abnormal glucose metabolism.<\/jats:p>","DOI":"10.1039\/d2fo02686d","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T02:04:01Z","timestamp":1670810641000},"page":"1179-1197","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Different ratios of DHA\/EPA reverses insulin resistance by improving adipocyte dysfunction and lipid disorders in HFD-induced IR mice"],"prefix":"10.1039","volume":"14","author":[{"given":"Siyan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-3565","authenticated-orcid":false,"given":"Manjiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-7102","authenticated-orcid":false,"given":"Limei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D2FO02686D\/cit1\/1","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1161\/CIRCULATIONAHA.105.504670","volume":"112","author":"Reaven","year":"2005","journal-title":"Circulation"},{"key":"D2FO02686D\/cit2\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1590\/S0103-05822014000100010","volume":"32","author":"Gobato","year":"2014","journal-title":"Rev. Paul. Pediatr."},{"key":"D2FO02686D\/cit3\/1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.amjhyper.2004.10.026","volume":"18","author":"Mohteshamzadeh","year":"2005","journal-title":"Am. J. Hypertens."},{"key":"D2FO02686D\/cit4\/1","first-page":"25","volume":"62","author":"Gorgisen","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"D2FO02686D\/cit5\/1","first-page":"CD003053","volume":"11","author":"Morley","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"D2FO02686D\/cit6\/1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1089\/jmf.2020.0114","volume":"24","author":"Kontostathi","year":"2021","journal-title":"J. Med. Food"},{"key":"D2FO02686D\/cit7\/1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41392-022-00964-6","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduction Targeted Ther."},{"key":"D2FO02686D\/cit8\/1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/nu9060573","volume":"9","author":"Jacobo-Cejudo","year":"2017","journal-title":"Nutrients"},{"key":"D2FO02686D\/cit9\/1","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1002\/mnfr.201600230","volume":"60","author":"Zheng","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"D2FO02686D\/cit10\/1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3390\/nu13030754","volume":"13","author":"da Cunha de S\u00e1","year":"2021","journal-title":"Nutrients"},{"key":"D2FO02686D\/cit11\/1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1080\/10408398.2018.1425978","volume":"59","author":"Ghasemi Fard","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D2FO02686D\/cit12\/1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1017\/S0007114514004437","volume":"113","author":"Molinar-Toribio","year":"2015","journal-title":"Br. J. Nutr."},{"key":"D2FO02686D\/cit13\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1476-511X-13-82","volume":"13","author":"Bj\u00f8rndal","year":"2014","journal-title":"Lipids Health Dis."},{"key":"D2FO02686D\/cit14\/1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/md18090483","volume":"18","author":"Hu","year":"2020","journal-title":"Mar. Drugs"},{"key":"D2FO02686D\/cit15\/1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1079\/BJN20061877","volume":"96","author":"Burdge","year":"2006","journal-title":"Br. J. Nutr."},{"key":"D2FO02686D\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/an.111.000893","volume":"3","author":"Swanson","year":"2012","journal-title":"Adv. Nutr."},{"key":"D2FO02686D\/cit17\/1","doi-asserted-by":"crossref","first-page":"e0139565","DOI":"10.1371\/journal.pone.0139565","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"D2FO02686D\/cit18\/1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.biopha.2017.01.182","volume":"89","author":"Sunil","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D2FO02686D\/cit19\/1","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1039\/D0FO02448A","volume":"12","author":"Wei","year":"2021","journal-title":"Food Funct."},{"key":"D2FO02686D\/cit20\/1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/nu8030128","volume":"8","author":"Simopoulos","year":"2016","journal-title":"Nutrients"},{"key":"D2FO02686D\/cit21\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12916-020-01688-6","volume":"18","author":"Kolb","year":"2020","journal-title":"BMC Med."},{"key":"D2FO02686D\/cit22\/1","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1039\/D0FO01445A","volume":"11","author":"S\u00e1inz","year":"2020","journal-title":"Food Funct."},{"key":"D2FO02686D\/cit23\/1","first-page":"311","volume":"37","author":"Chinese Diabetes Society","year":"2021","journal-title":"Chin. J. Endocrinol. Metab."},{"key":"D2FO02686D\/cit24\/1","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1113\/JP272541","volume":"594","author":"de S\u00e1","year":"2016","journal-title":"J. Physiol."},{"key":"D2FO02686D\/cit25\/1","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3390\/nu12061612","volume":"12","author":"Thota","year":"2020","journal-title":"Nutrients"},{"key":"D2FO02686D\/cit26\/1","doi-asserted-by":"crossref","first-page":"9764","DOI":"10.1039\/D0FO01942A","volume":"11","author":"Pavlisova","year":"2020","journal-title":"Food Funct."},{"key":"D2FO02686D\/cit27\/1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1046\/j.1471-4159.2002.01015.x","volume":"82","author":"Akbar","year":"2002","journal-title":"J. Neurochem."},{"key":"D2FO02686D\/cit28\/1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1055\/s-2007-985879","volume":"39","author":"Graham","year":"2007","journal-title":"Horm. Metab. Res."},{"key":"D2FO02686D\/cit29\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-511X-13-3","volume":"13","author":"Prostek","year":"2014","journal-title":"Lipids Health Dis."},{"key":"D2FO02686D\/cit30\/1","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.3390\/ijms20092358","volume":"20","author":"Longo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO02686D\/cit31\/1","doi-asserted-by":"crossref","first-page":"108216","DOI":"10.1016\/j.jnutbio.2019.07.007","volume":"72","author":"Monk","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"D2FO02686D\/cit32\/1","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3202-10.2010","volume":"30","author":"Koch","year":"2010","journal-title":"J. Neurosci."},{"key":"D2FO02686D\/cit33\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"D2FO02686D\/cit34\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1042\/CS20060323","volume":"112","author":"Song","year":"2007","journal-title":"Clin. Sci."},{"key":"D2FO02686D\/cit35\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mrgentox.2015.03.009","volume":"782","author":"Karaman","year":"2015","journal-title":"Mutat. Res., Genet. Toxicol. Environ. Mutagen."},{"key":"D2FO02686D\/cit36\/1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.phrs.2008.05.002","volume":"57","author":"Richard","year":"2008","journal-title":"Pharmacol. Res."},{"key":"D2FO02686D\/cit37\/1","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.3390\/antiox10122005","volume":"10","author":"Ro\u0161kari\u0107","year":"2021","journal-title":"Antioxidants"},{"key":"D2FO02686D\/cit38\/1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.fsi.2019.10.029","volume":"97","author":"Chen","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"D2FO02686D\/cit39\/1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/ijms21051769","volume":"21","author":"Peng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO02686D\/cit40\/1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11745-014-3892-9","volume":"49","author":"Bargut","year":"2014","journal-title":"Lipids"},{"key":"D2FO02686D\/cit41\/1","doi-asserted-by":"publisher","first-page":"CD003205","DOI":"10.1002\/14651858.CD003205.pub2","author":"Hartweg","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"D2FO02686D\/cit42\/1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11745-002-0959-2","volume":"37","author":"le Morvan","year":"2002","journal-title":"Lipids"},{"key":"D2FO02686D\/cit43\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12944-016-0250-3","volume":"15","author":"Xie","year":"2016","journal-title":"Lipids Health Dis."},{"key":"D2FO02686D\/cit44\/1","doi-asserted-by":"crossref","first-page":"6256802","DOI":"10.1155\/2018\/6256802","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D2FO02686D\/cit45\/1","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1093\/jn\/nxaa183","volume":"150","author":"Van Name","year":"2020","journal-title":"J. Nutr."},{"key":"D2FO02686D\/cit46\/1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.bcp.2008.10.020","volume":"77","author":"Russo","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"D2FO02686D\/cit47\/1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/427504a","volume":"427","author":"Kang","year":"2004","journal-title":"Nature"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/FO\/D2FO02686D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:28:47Z","timestamp":1783013327000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/14\/2\/1179-1197\/769208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo02686d","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}