{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:20:40Z","timestamp":1789996840088,"version":"4.0.1"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"am","delay-in-days":390,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173518"],"award-info":[{"award-number":["82173518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>GABA was shown to have an antagonistic effect on AD by regulating CNTN1\/2. Furthermore, circAPLP2 was found to be down-regulated in the AD brain, and the CEBP\u03b1\/circAPLP2\/miR-671-5p pathway mediates the regulation of CNTN1\/2 expression by GABA.<\/jats:p>","DOI":"10.1039\/d2fo03049g","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T08:21:25Z","timestamp":1674721285000},"page":"2082-2095","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The molecular mechanism of \u03b3-aminobutyric acid against AD: the role of CEBP\u03b1\/circAPLP2\/miR-671-5p in regulating CNTN1\/2 expression"],"prefix":"10.1039","volume":"14","author":[{"given":"Na","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-3519","authenticated-orcid":false,"given":"Li","family":"An","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D2FO03049G\/cit1\/1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"key":"D2FO03049G\/cit2\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mcn.2016.12.003","volume":"81","author":"Gulisano","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"D2FO03049G\/cit3\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4161\/cam.3.1.7462","volume":"3","author":"Bizzoca","year":"2009","journal-title":"Cell Adhes. Migr."},{"key":"D2FO03049G\/cit4\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0304-3940(98)00179-7","volume":"245","author":"Shimazaki","year":"1998","journal-title":"Neurosci. Lett."},{"key":"D2FO03049G\/cit5\/1","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.neurobiolaging.2015.01.004","volume":"36","author":"Puzzo","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"D2FO03049G\/cit6\/1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-1326-9-4","volume":"9","author":"Gautam","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"D2FO03049G\/cit7\/1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/ncb0308-249","volume":"10","author":"Mattson","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"D2FO03049G\/cit8\/1","doi-asserted-by":"crossref","first-page":"e103525","DOI":"10.1371\/journal.pone.0103525","volume":"9","author":"Kaur","year":"2014","journal-title":"PLoS One"},{"key":"D2FO03049G\/cit9\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.arr.2014.02.006","volume":"17","author":"Lau","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"D2FO03049G\/cit10\/1","doi-asserted-by":"crossref","first-page":"e12902","DOI":"10.1111\/acel.12902","volume":"18","author":"Tang","year":"2019","journal-title":"Aging Cell"},{"key":"D2FO03049G\/cit11\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000341944","volume":"59","author":"Powers","year":"2012","journal-title":"Med. Sport Sci."},{"key":"D2FO03049G\/cit12\/1","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1097\/00004647-200110000-00012","volume":"21","author":"Takanaga","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"D2FO03049G\/cit13\/1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41564-018-0307-3","volume":"4","author":"Strandwitz","year":"2019","journal-title":"Nat. Microbiol."},{"key":"D2FO03049G\/cit14\/1","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3390\/nu13062099","volume":"13","author":"Chen","year":"2021","journal-title":"Nutrients"},{"key":"D2FO03049G\/cit15\/1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3233\/JAD-2012-120535","volume":"31","author":"Sun","year":"2012","journal-title":"J. Alzheimer's Dis."},{"key":"D2FO03049G\/cit16\/1","volume-title":"CP-CEBP\u03b1-miR-34a mediate the inhibition of GABA on HDAC2\/3 and its role in antagonizing the increase of inflammatory cytokines expression induced by A\u03b2 in U251 cells","author":"Sining","year":"2021","unstructured":"W.Sining ,  CP-CEBP\u03b1-miR-34a mediate the inhibition of GABA on HDAC2\/3 and its role in antagonizing the increase of inflammatory cytokines expression induced by A\u03b2 in U251 cells ,  China Medical University ,  2021"},{"key":"D2FO03049G\/cit17\/1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00726-020-02848-x","volume":"52","author":"Kumrungsee","year":"2020","journal-title":"Amino Acids"},{"key":"D2FO03049G\/cit18\/1","doi-asserted-by":"crossref","first-page":"e25338","DOI":"10.1371\/journal.pone.0025338","volume":"6","author":"Tian","year":"2011","journal-title":"PLoS One"},{"key":"D2FO03049G\/cit19\/1","doi-asserted-by":"crossref","first-page":"14396","DOI":"10.3390\/ijms150814396","volume":"15","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO03049G\/cit20\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fnagi.2017.00121","volume":"9","author":"Zhang","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"D2FO03049G\/cit21\/1","doi-asserted-by":"crossref","first-page":"e1900001","DOI":"10.1002\/mnfr.201900001","volume":"63","author":"Xing","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"D2FO03049G\/cit22\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2018.00001","volume":"12","author":"Zhang","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"D2FO03049G\/cit23\/1","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"D2FO03049G\/cit24\/1","first-page":"457","volume":"27","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"D2FO03049G\/cit25\/1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1083\/jcb.136.4.907","volume":"136","author":"Sakurai","year":"1997","journal-title":"J. Cell Biol."},{"key":"D2FO03049G\/cit26\/1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0960-9822(02)00680-2","volume":"12","author":"Murai","year":"2002","journal-title":"Curr. Biol."},{"key":"D2FO03049G\/cit27\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"D2FO03049G\/cit28\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/bs.ircmb.2017.04.002","volume":"334","author":"Quinlan","year":"2017","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"D2FO03049G\/cit29\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.pmbts.2016.12.009","volume":"146","author":"Reddy","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"D2FO03049G\/cit30\/1","doi-asserted-by":"crossref","first-page":"110028","DOI":"10.1016\/j.biopha.2020.110028","volume":"125","author":"Tang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"D2FO03049G\/cit31\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.arr.2014.02.006","volume":"17","author":"Lau","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"D2FO03049G\/cit32\/1","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1038\/ncomms11215","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"key":"D2FO03049G\/cit33\/1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","volume":"58","author":"Rybak-Wolf","year":"2015","journal-title":"Mol. Cell"},{"key":"D2FO03049G\/cit34\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fgene.2016.00053","volume":"7","author":"Lu","year":"2016","journal-title":"Front. Genet."},{"key":"D2FO03049G\/cit35\/1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1080\/15476286.2020.1783487","volume":"17","author":"Lo","year":"2020","journal-title":"RNA Biol."},{"key":"D2FO03049G\/cit36\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/109662003322233512","volume":"6","author":"Oh","year":"2003","journal-title":"J. Med. Food"},{"key":"D2FO03049G\/cit37\/1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1079\/BJN20041221","volume":"92","author":"Hayakawa","year":"2004","journal-title":"Br. J. Nutr."},{"key":"D2FO03049G\/cit38\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jff.2014.07.004","volume":"10","author":"Diana","year":"2014","journal-title":"J. Funct. Foods"},{"key":"D2FO03049G\/cit39\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3136\/nskkk.62.95","volume":"62","author":"Yoshida","year":"2015","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"D2FO03049G\/cit40\/1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3136\/nskkk.47.596","volume":"47","author":"Okada","year":"2000","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"D2FO03049G\/cit41\/1","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3390\/molecules23102711","volume":"23","author":"Zhang","year":"2018","journal-title":"Molecules"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/FO\/D2FO03049G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:27:41Z","timestamp":1782970061000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/14\/4\/2082-2095\/769293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo03049g","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}