{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:51:40Z","timestamp":1789156300767,"version":"build-2803163510"},"reference-count":77,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"am","delay-in-days":501,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0905600"],"award-info":[{"award-number":["2019YFA0905600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770132"],"award-info":[{"award-number":["31770132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873969"],"award-info":[{"award-number":["81873969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Refractory constipation is the most severe form of constipation, and its etiology remains unknown.<\/jats:p>","DOI":"10.1039\/d2fo03574j","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T06:49:39Z","timestamp":1684219779000},"page":"5702-5715","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Gut indigenous\n                    <i>Ruminococcus gnavus<\/i>\n                    alleviates constipation and stress-related behaviors in mice with loperamide-induced constipation"],"prefix":"10.1039","volume":"14","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan 430074, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Bioengineering, Wuhan Polytechnic, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan 430074, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi'an Mayinglong Anorectal Hospital, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center for Artificial Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center for Artificial Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-9276","authenticated-orcid":false,"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan 430074, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D2FO03574J\/cit1\/1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2468-1253(19)30199-2","volume":"4","author":"Schiller","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"D2FO03574J\/cit2\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5694\/mja18.00241","volume":"209","author":"Black","year":"2018","journal-title":"Med. J. Aust."},{"issue":"Suppl. 2","key":"D2FO03574J\/cit3\/1","first-page":"S3","volume":"4","author":"Talley","year":"2004","journal-title":"Rev. Gastroenterol. Disord."},{"key":"D2FO03574J\/cit4\/1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.cgh.2007.04.019","volume":"5","author":"Singh","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"D2FO03574J\/cit5\/1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1053\/j.gastro.2017.12.010","volume":"154","author":"Chang","year":"2018","journal-title":"Gastroenterology"},{"key":"D2FO03574J\/cit6\/1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.gtc.2010.08.001","volume":"39","author":"Singh","year":"2010","journal-title":"Gastroenterol. Clin. North Am."},{"key":"D2FO03574J\/cit7\/1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"D2FO03574J\/cit8\/1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2702.2002.00626.x","volume":"11","author":"Annells","year":"2002","journal-title":"J. Clin. Nurs."},{"key":"D2FO03574J\/cit9\/1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.archger.2009.04.007","volume":"50","author":"Cardin","year":"2010","journal-title":"Arch. Gerontol. Geriatr."},{"key":"D2FO03574J\/cit10\/1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S1543-5946(10)80003-0","volume":"8","author":"Fleming","year":"2010","journal-title":"Am. J. Geriatr. Pharmacother."},{"key":"D2FO03574J\/cit11\/1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/ajg.2013.137","volume":"108","author":"Koloski","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"D2FO03574J\/cit12\/1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/PSY.0000000000000958","volume":"83","author":"Li","year":"2021","journal-title":"Psychosom. Med."},{"key":"D2FO03574J\/cit13\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00042737-200101000-00007","volume":"13","author":"Dykes","year":"2001","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"D2FO03574J\/cit14\/1","doi-asserted-by":"crossref","first-page":"e54183","DOI":"10.1371\/journal.pone.0054183","volume":"8","author":"Dong","year":"2013","journal-title":"PLoS One"},{"key":"D2FO03574J\/cit15\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/SGA.0000000000000196","volume":"40","author":"Canbulat Sahiner","year":"2017","journal-title":"Gastroenterol. Nurs."},{"key":"D2FO03574J\/cit16\/1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11938-017-0142-2","volume":"15","author":"Baffy","year":"2017","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"D2FO03574J\/cit17\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00535-008-2207-4","volume":"43","author":"Adachi","year":"2008","journal-title":"J. Gastroenterol."},{"key":"D2FO03574J\/cit18\/1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pbiomolbio.2010.05.007","volume":"102","author":"Takaki","year":"2010","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"D2FO03574J\/cit19\/1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1113\/jphysiol.2006.116624","volume":"576","author":"Komuro","year":"2006","journal-title":"J. Physiol."},{"key":"D2FO03574J\/cit20\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0166-4328(96)00075-7","volume":"73","author":"Racke","year":"1996","journal-title":"Behav. Brain Res."},{"key":"D2FO03574J\/cit21\/1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s00535-019-01610-9","volume":"54","author":"Yeh","year":"2019","journal-title":"J. Gastroenterol."},{"key":"D2FO03574J\/cit22\/1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.me.29.020178.001515","volume":"29","author":"McGuigan","year":"1978","journal-title":"Annu. Rev. Med."},{"key":"D2FO03574J\/cit23\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3177\/jnsv.61.131","volume":"61","author":"Zhao","year":"2015","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"D2FO03574J\/cit24\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"D2FO03574J\/cit25\/1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.chom.2012.10.012","volume":"12","author":"Backhed","year":"2012","journal-title":"Cell Host Microbe"},{"key":"D2FO03574J\/cit26\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/cmi.2010.67","volume":"8","author":"Tlaskalova-Hogenova","year":"2011","journal-title":"Cell. Mol. Immunol."},{"key":"D2FO03574J\/cit27\/1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1152\/physiolgenomics.00082.2014","volume":"46","author":"Zhu","year":"2014","journal-title":"Physiol. Genomics"},{"key":"D2FO03574J\/cit28\/1","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.dld.2005.06.008","volume":"37","author":"Khalif","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"D2FO03574J\/cit29\/1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ajg.2009.655","volume":"105","author":"Attaluri","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"D2FO03574J\/cit30\/1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/BF02056950","volume":"39","author":"Agachan","year":"1996","journal-title":"Dis. Colon Rectum"},{"key":"D2FO03574J\/cit31\/1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrgastro.2016.53","volume":"13","author":"Rao","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D2FO03574J\/cit32\/1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1053\/j.gastro.2017.01.009","volume":"152","author":"Tsoi","year":"2017","journal-title":"Gastroenterology"},{"key":"D2FO03574J\/cit33\/1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/09637486.2015.1024204","volume":"66","author":"Li","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"D2FO03574J\/cit34\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"Cao","year":"2017","journal-title":"Sci. Rep."},{"key":"D2FO03574J\/cit35\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jnutbio.2019.01.007","volume":"66","author":"Tian","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"D2FO03574J\/cit36\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-11641-8","volume":"10","author":"Tunc-Ozcan","year":"2019","journal-title":"Nat. Commun."},{"key":"D2FO03574J\/cit37\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fmed.2019.00019","volume":"6","author":"Ohkusa","year":"2019","journal-title":"Front. Med."},{"key":"D2FO03574J\/cit38\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40064-015-1659-2","volume":"5","author":"Zhao","year":"2016","journal-title":"SpringerPlus"},{"key":"D2FO03574J\/cit39\/1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3892\/etm.2017.4133","volume":"13","author":"Chai","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"D2FO03574J\/cit40\/1","doi-asserted-by":"crossref","first-page":"100506","DOI":"10.1016\/j.fbio.2019.100506","volume":"33","author":"Jia","year":"2020","journal-title":"Food Biosci."},{"key":"D2FO03574J\/cit41\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s13765-014-4024-1","volume":"57","author":"Li","year":"2014","journal-title":"J. Korean Soc. Appl. Biol. Chem."},{"key":"D2FO03574J\/cit42\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.chom.2014.09.001","volume":"16","author":"Williams","year":"2014","journal-title":"Cell Host Microbe"},{"key":"D2FO03574J\/cit43\/1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.chom.2018.05.004","volume":"23","author":"Bhattarai","year":"2018","journal-title":"Cell Host Microbe"},{"key":"D2FO03574J\/cit44\/1","first-page":"159","volume":"4","author":"Hosseinzadeh","year":"2011","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"D2FO03574J\/cit45\/1","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1080\/19490976.2020.1756690","volume":"11","author":"Oh","year":"2020","journal-title":"Gut Microbes"},{"key":"D2FO03574J\/cit46\/1","doi-asserted-by":"crossref","first-page":"e150097","DOI":"10.1172\/JCI150097","volume":"132","author":"Chen","year":"2022","journal-title":"J. Clin. Invest."},{"key":"D2FO03574J\/cit47\/1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cgh.2008.12.006","volume":"7","author":"Tack","year":"2009","journal-title":"Clin. Gastroenterol.\nHepatol."},{"issue":"Suppl. B","key":"D2FO03574J\/cit48\/1","doi-asserted-by":"crossref","first-page":"22B","DOI":"10.1155\/2011\/360463","volume":"25","author":"Liu","year":"2011","journal-title":"Can. J. Gastroenterol."},{"key":"D2FO03574J\/cit49\/1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/nmo.12553","volume":"27","author":"Piessevaux","year":"2015","journal-title":"Neurogastroenterol. Motil."},{"key":"D2FO03574J\/cit50\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/j.gastro.2006.05.031","volume":"131","author":"Van Outryve","year":"2006","journal-title":"Gastroenterology"},{"key":"D2FO03574J\/cit51\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00384-011-1355-9","volume":"27","author":"Hart","year":"2011","journal-title":"Int. J. Colorectal Dis."},{"key":"D2FO03574J\/cit52\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fmed.2014.00005","volume":"1","author":"Lee","year":"2014","journal-title":"Front. Med."},{"key":"D2FO03574J\/cit53\/1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2982.2011.01709.x","volume":"23","author":"Tack","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"D2FO03574J\/cit54\/1","first-page":"449","volume-title":"New Advances in the Basic and Clinical Gastroenterology","author":"Uchiyama-Tanaka","year":"2012","unstructured":"Y.Uchiyama-Tanaka ,  The Influence of Colonic Irrigation on Human Intestinal Microbiota ,  New Advances in the Basic and Clinical Gastroenterology ,  2012 , pp.  449\u2013458"},{"key":"D2FO03574J\/cit55\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00535-018-1488-5","volume":"54","author":"Takagi","year":"2019","journal-title":"J. Gastroenterol."},{"key":"D2FO03574J\/cit56\/1","first-page":"629","volume":"30","author":"Miller","year":"2017","journal-title":"Ann. Gastroenterol."},{"key":"D2FO03574J\/cit57\/1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3109\/00365521.2011.584895","volume":"46","author":"Waller","year":"2011","journal-title":"Scand. J. Gastroenterol."},{"key":"D2FO03574J\/cit58\/1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1365-2036.2002.01188.x","volume":"16","author":"Marteau","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"D2FO03574J\/cit59\/1","first-page":"315","volume":"292","author":"Caballero-Franco","year":"2007","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"D2FO03574J\/cit60\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/j.gastro.2019.03.045","volume":"157","author":"Chandrasekharan","year":"2019","journal-title":"Gastroenterology"},{"key":"D2FO03574J\/cit61\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.15403\/jgld.2014.1121.234.elr","volume":"23","author":"Ojetti","year":"2014","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"D2FO03574J\/cit62\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"D2FO03574J\/cit63\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00008877-200207000-00008","volume":"13","author":"Van Oekelen","year":"2002","journal-title":"Behav. Pharmacol."},{"key":"D2FO03574J\/cit64\/1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1358\/dot.2004.40.12.872576","volume":"40","author":"Cole","year":"2004","journal-title":"Drugs Today"},{"key":"D2FO03574J\/cit65\/1","doi-asserted-by":"crossref","first-page":"10368","DOI":"10.1039\/C9RA10446A","volume":"10","author":"Mu","year":"2020","journal-title":"RSC Adv."},{"key":"D2FO03574J\/cit66\/1","first-page":"1","volume":"8","author":"Zhang","year":"2018","journal-title":"Appl. Sci."},{"key":"D2FO03574J\/cit67\/1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/ajcn\/76.2.447","volume":"76","author":"Setchell","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"D2FO03574J\/cit68\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3810\/pgm.2013.03.2640","volume":"125","author":"Nellesen","year":"2013","journal-title":"Postgrad. Med."},{"key":"D2FO03574J\/cit69\/1","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1111\/j.1572-0241.2000.02313.x","volume":"95","author":"Mason","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"D2FO03574J\/cit70\/1","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/nmo.12427","volume":"26","author":"Savignac","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"D2FO03574J\/cit71\/1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1365-2982.2011.01796.x","volume":"23","author":"Bercik","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"D2FO03574J\/cit72\/1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","volume":"10","author":"Mawe","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D2FO03574J\/cit73\/1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3892\/ijmm.2014.1887","volume":"34","author":"El-Salhy","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"D2FO03574J\/cit74\/1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"D2FO03574J\/cit75\/1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neuropharm.2016.10.011","volume":"113","author":"Sundaramurthy","year":"2017","journal-title":"Neuropharmacology"},{"key":"D2FO03574J\/cit76\/1","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1039\/C9FO01630A","volume":"10","author":"Tian","year":"2019","journal-title":"Food Funct."},{"key":"D2FO03574J\/cit77\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"Marin","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/FO\/D2FO03574J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:27:40Z","timestamp":1783448860000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/14\/12\/5702-5715\/769388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":77,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,6,19]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo03574j","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}