{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:46:02Z","timestamp":1789623962632,"version":"build-2803163510"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"am","delay-in-days":486,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2101500"],"award-info":[{"award-number":["2021YFC2101500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2022ZDLSF05-12"],"award-info":[{"award-number":["2022ZDLSF05-12"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21978235"],"award-info":[{"award-number":["21978235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22078264"],"award-info":[{"award-number":["22078264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278335"],"award-info":[{"award-number":["22278335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Ginsenoside Rh4 inhibited inflammation, oxidative stress and apoptosis in mice with gastric ulcers through modulation of MAPK\/NF-\u03baB and PGE2-Cox pathways, thereby ameliorating gastric injury.<\/jats:p>","DOI":"10.1039\/d2fo03693b","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T08:21:16Z","timestamp":1682929276000},"page":"5167-5181","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK\/NF-\u03baB signaling pathway"],"prefix":"10.1039","volume":"14","author":[{"given":"Yuqing","family":"Wu","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"},{"name":"Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Duan","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"},{"name":"Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Qu","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"},{"name":"Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"},{"name":"Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-2288","authenticated-orcid":false,"given":"Chenhui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"},{"name":"Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-1674","authenticated-orcid":false,"given":"Daidi","family":"Fan","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"},{"name":"Biotech & Biomed Research Institute, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D2FO03693B\/cit1\/1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000090167","volume":"23","author":"Franke","year":"2005","journal-title":"Dig. Dis."},{"key":"D2FO03693B\/cit2\/1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1053\/j.gastro.2013.08.038","volume":"145","author":"Kahrilas","year":"2013","journal-title":"Gastroenterology"},{"key":"D2FO03693B\/cit3\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"key":"D2FO03693B\/cit4\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ame2.12060","volume":"2","author":"Sim\u00f5es","year":"2019","journal-title":"Anim. Models Exp. Med."},{"key":"D2FO03693B\/cit5\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"D2FO03693B\/cit6\/1","first-page":"845","volume":"63","author":"Ko","year":"2000","journal-title":"Chin. Med. J."},{"key":"D2FO03693B\/cit7\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000171159","volume":"5","author":"Guslandi","year":"1987","journal-title":"Dig. Dis."},{"key":"D2FO03693B\/cit8\/1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0016-5085(90)90015-S","volume":"98","author":"Kvietys","year":"1990","journal-title":"Gastroenterology"},{"key":"D2FO03693B\/cit9\/1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jep.2018.05.040","volume":"224","author":"Boutemine","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"D2FO03693B\/cit10\/1","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.3390\/molecules25235623","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"D2FO03693B\/cit11\/1","first-page":"39","volume":"53","author":"Kwiecien","year":"2002","journal-title":"J. Physiol. Pharmacol."},{"key":"D2FO03693B\/cit12\/1","doi-asserted-by":"crossref","first-page":"49423","DOI":"10.1039\/C7RA08879E","volume":"7","author":"Su","year":"2017","journal-title":"RSC Adv."},{"key":"D2FO03693B\/cit13\/1","doi-asserted-by":"crossref","first-page":"22424","DOI":"10.1002\/jcp.28807","volume":"234","author":"Arab","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"D2FO03693B\/cit14\/1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jgr.2016.08.004","volume":"41","author":"Kim","year":"2017","journal-title":"J. Ginseng Res."},{"key":"D2FO03693B\/cit15\/1","first-page":"8174345","volume":"2018","author":"Zheng","year":"2018","journal-title":"BioMed Res. Int."},{"key":"D2FO03693B\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-8546-5-20","volume":"5","author":"Leung","year":"2010","journal-title":"Chin. Med."},{"key":"D2FO03693B\/cit17\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-2006-957816","volume":"62","author":"Baek","year":"1996","journal-title":"Planta Med."},{"key":"D2FO03693B\/cit18\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM198901123200201","volume":"320","author":"Walan","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"D2FO03693B\/cit19\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/00365528609090881","volume":"21","author":"Wallmark","year":"1987","journal-title":"Scand. J. Gastroenterol."},{"key":"D2FO03693B\/cit20\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/j.1875-9114.1993.tb02689.x","volume":"13","author":"Massoomi","year":"1993","journal-title":"Pharmacotherapy"},{"key":"D2FO03693B\/cit21\/1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/aps.2016.135","volume":"38","author":"Huang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"D2FO03693B\/cit22\/1","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.3390\/ijms20122951","volume":"20","author":"Yao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO03693B\/cit23\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10715762.2016.1234710","volume":"51","author":"Gao","year":"2017","journal-title":"Free Radical Res."},{"key":"D2FO03693B\/cit24\/1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.biopha.2017.09.129","volume":"96","author":"Jiang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D2FO03693B\/cit25\/1","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.3382\/ps\/pey132","volume":"97","author":"Bi","year":"2018","journal-title":"Poult. Sci."},{"key":"D2FO03693B\/cit26\/1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbrc.2018.03.174","volume":"499","author":"Duan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D2FO03693B\/cit27\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bcp.2017.12.004","volume":"148","author":"Wu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"D2FO03693B\/cit28\/1","doi-asserted-by":"crossref","first-page":"114038","DOI":"10.1016\/j.bcp.2020.114038","volume":"178","author":"Deng","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"D2FO03693B\/cit29\/1","doi-asserted-by":"crossref","first-page":"113104","DOI":"10.1016\/j.jep.2020.113104","volume":"261","author":"Mohan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"D2FO03693B\/cit30\/1","doi-asserted-by":"crossref","first-page":"115191","DOI":"10.1016\/j.jep.2022.115191","volume":"292","author":"Neto","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"D2FO03693B\/cit31\/1","doi-asserted-by":"crossref","first-page":"156765","DOI":"10.1155\/2011\/156765","volume":"2011","author":"Abdelwahab","year":"2011","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D2FO03693B\/cit32\/1","doi-asserted-by":"crossref","first-page":"e64751","DOI":"10.1371\/journal.pone.0064751","volume":"8","author":"Al","year":"2013","journal-title":"PLoS One"},{"key":"D2FO03693B\/cit33\/1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol. Rev."},{"key":"D2FO03693B\/cit34\/1","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/tox.23548","volume":"37","author":"Li","year":"2022","journal-title":"Environ. Toxicol."},{"key":"D2FO03693B\/cit35\/1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s12272-020-01279-2","volume":"43","author":"Wang","year":"2020","journal-title":"Arch. Pharmacal Res."},{"key":"D2FO03693B\/cit36\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"D2FO03693B\/cit37\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/antiox6040082","volume":"6","author":"Case","year":"2017","journal-title":"Antioxidants"},{"key":"D2FO03693B\/cit38\/1","doi-asserted-by":"crossref","first-page":"114260","DOI":"10.1016\/j.jep.2021.114260","volume":"278","author":"Luz","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"D2FO03693B\/cit39\/1","doi-asserted-by":"crossref","first-page":"114752","DOI":"10.1016\/j.jep.2021.114752","volume":"284","author":"Ma","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"D2FO03693B\/cit40\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cyto.2016.08.014","volume":"101","author":"Mitoma","year":"2018","journal-title":"Cytokine"},{"key":"D2FO03693B\/cit41\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.15252\/embj.201694660","volume":"36","author":"Miyoshi","year":"2017","journal-title":"EMBO J."},{"key":"D2FO03693B\/cit42\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07882-8","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."},{"key":"D2FO03693B\/cit43\/1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/intimm\/dxz021","volume":"31","author":"Tsuge","year":"2019","journal-title":"Int. Immunol."},{"key":"D2FO03693B\/cit44\/1","doi-asserted-by":"crossref","first-page":"106499","DOI":"10.1016\/j.prostaglandins.2020.106499","volume":"152","author":"Heeney","year":"2021","journal-title":"Prostaglandins Other Lipid Mediators"},{"key":"D2FO03693B\/cit45\/1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.4155\/fmc-2017-0115","volume":"9","author":"Abdelgawad","year":"2017","journal-title":"Future Med. Chem."},{"key":"D2FO03693B\/cit46\/1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/bph.14527","volume":"176","author":"Wallace","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"D2FO03693B\/cit47\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fphys.2018.00125","volume":"9","author":"Helms","year":"2018","journal-title":"Front. Physiol."},{"key":"D2FO03693B\/cit48\/1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"D2FO03693B\/cit49\/1","first-page":"1997","volume":"19","author":"Guo","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"D2FO03693B\/cit50\/1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.biopha.2016.11.068","volume":"85","author":"Hui","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D2FO03693B\/cit51\/1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.intimp.2015.07.031","volume":"28","author":"Chang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"D2FO03693B\/cit52\/1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.biopha.2017.09.031","volume":"95","author":"Akanda","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D2FO03693B\/cit53\/1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","volume":"263","author":"Atreya","year":"2008","journal-title":"J. Intern. Med."},{"key":"D2FO03693B\/cit54\/1","first-page":"3","volume":"51","author":"Szabo","year":"2000","journal-title":"J. Physiol. Pharmacol."},{"key":"D2FO03693B\/cit55\/1","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1039\/C9FO01152H","volume":"10","author":"Han","year":"2019","journal-title":"Food Funct."},{"key":"D2FO03693B\/cit56\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004290050254","volume":"200","author":"Huppertz","year":"1999","journal-title":"Anat. Embryol."},{"key":"D2FO03693B\/cit57\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.immunol.16.1.395","volume":"16","author":"Chao","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"D2FO03693B\/cit58\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/01926230390183715","volume":"31","author":"Wang","year":"2003","journal-title":"Toxicol. Pathol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/FO\/D2FO03693B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:25:59Z","timestamp":1782926759000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/14\/11\/5167-5181\/769413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo03693b","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}