{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:56:45Z","timestamp":1792173405024,"version":"4.4.0"},"reference-count":60,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":213,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/T013567\/1"],"award-info":[{"award-number":["EP\/T013567\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102182"],"award-info":[{"award-number":["82102182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YJ202152"],"award-info":[{"award-number":["YJ202152"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>We develop a quantitative lateral flow assay (LFA) device that is able to measure the tear level of brain derived neurotrophic factor (BDNF). The device shows great potential to serve as an ideal platform for early detection of glaucoma.<\/jats:p>","DOI":"10.1039\/d2lc00431c","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T05:21:13Z","timestamp":1659417673000},"page":"3521-3532","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Quantitative brain-derived neurotrophic factor lateral flow assay for point-of-care detection of glaucoma"],"prefix":"10.1039","volume":"22","author":[{"given":"Yue","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Imperial College London, South Kensington, London, UK"},{"name":"Department of Surgery and Cancer, Imperial College London, South Kensington, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-0067","authenticated-orcid":false,"given":"Yubing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Imperial College London, South Kensington, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeevan","family":"Anantharanjit","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, South Kensington, London, UK"},{"name":"The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0896-267X","authenticated-orcid":false,"given":"Ali K.","family":"Yetisen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Imperial College London, South Kensington, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-6525","authenticated-orcid":false,"given":"M. Francesca","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, South Kensington, London, UK"},{"name":"The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London, UK"},{"name":"The Western Eye Hospital, Imperial College Healthcare NHS Trust (ICHNT), London, UK"},{"name":"Glaucoma and Retinal Neurodegeneration Group, Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2LC00431C\/cit1\/1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"D2LC00431C\/cit2\/1","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"D2LC00431C\/cit3\/1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/brain\/awx088","volume":"140","author":"Cordeiro","year":"2017","journal-title":"Brain"},{"key":"D2LC00431C\/cit4\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/ICU.0b013e32835cf078","volume":"24","author":"McManus","year":"2013","journal-title":"Curr. Opin. Ophthalmol."},{"key":"D2LC00431C\/cit5\/1","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.ophtha.2009.11.001","volume":"117","author":"Maul","year":"2010","journal-title":"Ophthalmology"},{"key":"D2LC00431C\/cit6\/1","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1097\/IJG.0000000000000117","volume":"23","author":"McNally","year":"2014","journal-title":"J. Glaucoma"},{"key":"D2LC00431C\/cit7\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13167-016-0065-3","volume":"7","author":"Hagan","year":"2016","journal-title":"EPMA J."},{"key":"D2LC00431C\/cit8\/1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3390\/biology10080763","volume":"10","author":"Fern\u00e1ndez-Vega Cueto","year":"2021","journal-title":"Biology"},{"key":"D2LC00431C\/cit9\/1","doi-asserted-by":"crossref","first-page":"113700","DOI":"10.1016\/j.bios.2021.113700","volume":"196","author":"Wu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"D2LC00431C\/cit10\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/17469899.2017.1259566","volume":"12","author":"Mysona","year":"2017","journal-title":"Expert Rev. Ophthalmol."},{"key":"D2LC00431C\/cit11\/1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retinal Eye Res."},{"key":"D2LC00431C\/cit12\/1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.optm.2008.09.014","volume":"80","author":"Ghaffariyeh","year":"2009","journal-title":"Optometry"},{"key":"D2LC00431C\/cit13\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/02713683.2017.1396617","volume":"43","author":"Shpak","year":"2018","journal-title":"Curr. Eye Res."},{"key":"D2LC00431C\/cit14\/1","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1021\/acs.analchem.8b01642","volume":"90","author":"Bockaj","year":"2018","journal-title":"Anal. Chem."},{"key":"D2LC00431C\/cit15\/1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ymeth.2018.02.008","volume":"146","author":"Gonzalez","year":"2018","journal-title":"Methods"},{"key":"D2LC00431C\/cit16\/1","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1039\/C9LC00104B","volume":"19","author":"Bishop","year":"2019","journal-title":"Lab Chip"},{"key":"D2LC00431C\/cit17\/1","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1039\/c3lc50169h","volume":"13","author":"Yetisen","year":"2013","journal-title":"Lab Chip"},{"key":"D2LC00431C\/cit18\/1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fmicb.2019.02917","volume":"10","author":"Tom\u00e1s","year":"2019","journal-title":"Front. Microbiol."},{"key":"D2LC00431C\/cit19\/1","doi-asserted-by":"crossref","first-page":"100924","DOI":"10.1016\/j.eclinm.2021.100924","volume":"36","author":"Peto","year":"2021","journal-title":"EClinicalMedicine"},{"key":"D2LC00431C\/cit20\/1","first-page":"3845","volume":"2018","author":"Hamad","year":"2018","journal-title":"Annu. Int. Conf. IEEE Eng. Med. Biol. Soc."},{"key":"D2LC00431C\/cit21\/1","doi-asserted-by":"crossref","first-page":"115842","DOI":"10.1016\/j.trac.2020.115842","volume":"125","author":"Mahmoudi","year":"2020","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D2LC00431C\/cit22\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1001\/jamaophthalmol.2013.561","volume":"131","author":"Sambursky","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"D2LC00431C\/cit23\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1167\/tvst.7.5.31","volume":"7","author":"Park","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"D2LC00431C\/cit24\/1","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1039\/D1LC00090J","volume":"21","author":"Bergua","year":"2021","journal-title":"Lab Chip"},{"key":"D2LC00431C\/cit25\/1","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1039\/C2AN15844B","volume":"137","author":"Lou","year":"2012","journal-title":"Analyst"},{"key":"D2LC00431C\/cit26\/1","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.3390\/s16122154","volume":"16","author":"Kim","year":"2016","journal-title":"Sensors"},{"key":"D2LC00431C\/cit27\/1","doi-asserted-by":"crossref","first-page":"11634","DOI":"10.1021\/ac403040a","volume":"85","author":"Murdock","year":"2013","journal-title":"Anal. Chem."},{"key":"D2LC00431C\/cit28\/1","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1016\/j.bios.2009.02.024","volume":"24","author":"Jia","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"D2LC00431C\/cit29\/1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.peptides.2015.04.012","volume":"72","author":"Aydin","year":"2015","journal-title":"Peptides"},{"key":"D2LC00431C\/cit30\/1","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.3168\/jds.2017-14265","volume":"101","author":"Pan","year":"2018","journal-title":"J. Dairy Sci."},{"key":"D2LC00431C\/cit31\/1","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1021\/acsanm.9b00956","volume":"2","author":"Khlebtsov","year":"2019","journal-title":"ACS Appl. Nano Mater."},{"key":"D2LC00431C\/cit32\/1","doi-asserted-by":"crossref","first-page":"112370","DOI":"10.1016\/j.bios.2020.112370","volume":"165","author":"Zhang","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"D2LC00431C\/cit33\/1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1039\/c2an36467k","volume":"138","author":"James","year":"2013","journal-title":"Analyst"},{"key":"D2LC00431C\/cit34\/1","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.2147\/IJN.S135735","volume":"12","author":"Gong","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"D2LC00431C\/cit35\/1","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1038\/s41596-020-0357-x","volume":"15","author":"Parolo","year":"2020","journal-title":"Nat. Protoc."},{"key":"D2LC00431C\/cit36\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1042\/EBC20150012","volume":"60","author":"Koczula","year":"2016","journal-title":"Essays Biochem."},{"key":"D2LC00431C\/cit37\/1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/17458080.2020.1775197","volume":"15","author":"Amini","year":"2020","journal-title":"J. Exp. Nanosci."},{"key":"D2LC00431C\/cit38\/1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1039\/C6LC01450J","volume":"17","author":"Yetisen","year":"2017","journal-title":"Lab Chip"},{"key":"D2LC00431C\/cit39\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00604-018-3195-6","volume":"186","author":"Ruppert","year":"2019","journal-title":"Microchim. Acta"},{"key":"D2LC00431C\/cit40\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s40135-019-00213-0","volume":"7","author":"Beykin","year":"2019","journal-title":"Curr. Ophthalmol. Rep."},{"key":"D2LC00431C\/cit41\/1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1039\/c3mb25463a","volume":"9","author":"Pieragostino","year":"2013","journal-title":"Mol. BioSyst."},{"key":"D2LC00431C\/cit42\/1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/1120672118795399","volume":"29","author":"Benitez-Del-Castillo","year":"2019","journal-title":"Eur J Ophthalmol"},{"key":"D2LC00431C\/cit43\/1","first-page":"799","volume":"23","author":"Shpak","year":"2017","journal-title":"Mol. Vision"},{"key":"D2LC00431C\/cit44\/1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1001\/archopht.1981.03930010303017","volume":"99","author":"Abelson","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"D2LC00431C\/cit45\/1","first-page":"485","volume":"66","author":"Norn","year":"1988","journal-title":"Arch. Ophthalmol."},{"key":"D2LC00431C\/cit46\/1","first-page":"120","volume":"06","author":"Azuamah","year":"2019","journal-title":"Int. J. Res."},{"key":"D2LC00431C\/cit47\/1","first-page":"185","volume":"8","author":"Salvisberg","year":"2014","journal-title":"Proteomics: Clin. Appl."},{"key":"D2LC00431C\/cit48\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s13167-021-00265-y","volume":"12","author":"Zhan","year":"2021","journal-title":"EPMA J."},{"key":"D2LC00431C\/cit49\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13167-016-0065-3","volume":"7","author":"Hagan","year":"2016","journal-title":"EPMA J."},{"key":"D2LC00431C\/cit50\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/17469899.2017.1259566","volume":"12","author":"Mysona","year":"2017","journal-title":"Expert Rev. Ophthalmol."},{"key":"D2LC00431C\/cit51\/1","doi-asserted-by":"crossref","first-page":"e0142067","DOI":"10.1371\/journal.pone.0142067","volume":"10","author":"Dekeyster","year":"2015","journal-title":"PLoS One"},{"key":"D2LC00431C\/cit52\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s42269-020-00288-x","volume":"44","author":"Fathy","year":"2020","journal-title":"Bull. Natl. Res. Cent."},{"key":"D2LC00431C\/cit53\/1","first-page":"764","volume":"41","author":"Pease","year":"2000","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D2LC00431C\/cit54\/1","first-page":"431","volume":"41","author":"Johnson","year":"2000","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D2LC00431C\/cit55\/1","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1167\/iovs.12-11207","volume":"54","author":"Galindo-Romero","year":"2013","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D2LC00431C\/cit56\/1","doi-asserted-by":"crossref","first-page":"e0168565","DOI":"10.1371\/journal.pone.0168565","volume":"12","author":"Oddone","year":"2017","journal-title":"PLoS One"},{"key":"D2LC00431C\/cit57\/1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1272\/jnms.JNMS.2020_87-605","volume":"87","author":"Igarashi","year":"2020","journal-title":"J. Nippon Med. Sch."},{"key":"D2LC00431C\/cit58\/1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/OPX.0b013e3181fc329f","volume":"88","author":"Ghaffariyeh","year":"2011","journal-title":"Optom. Vis. Sci."},{"key":"D2LC00431C\/cit59\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jim.2016.05.008","volume":"435","author":"Gwyn","year":"2016","journal-title":"J. Immunol. Methods"},{"key":"D2LC00431C\/cit60\/1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000127832","volume":"40","author":"Roedl","year":"2008","journal-title":"Ophthalmic Res."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/LC\/D2LC00431C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:57:51Z","timestamp":1782885471000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/22\/18\/3521-3532\/770935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":60,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,9,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d2lc00431c","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}