{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:32:56Z","timestamp":1791415976362,"version":"4.3.3"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"am","delay-in-days":409,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071481"],"award-info":[{"award-number":["32071481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009988","name":"Huzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2021GZ50"],"award-info":[{"award-number":["2021GZ50"]}],"id":[{"id":"10.13039\/501100009988","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>The ready-to-used 3D microwell array chip enables measurement of the concentrations and antimicrobial susceptibilities of uropathogens in 3 h.<\/jats:p>","DOI":"10.1039\/d2lc01095j","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T05:41:37Z","timestamp":1676353297000},"page":"2399-2410","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Direct single-cell antimicrobial susceptibility testing of\n                    <i>Escherichia coli<\/i>\n                    in urine using a ready-to-use 3D microwell array chip"],"prefix":"10.1039","volume":"23","author":[{"given":"Wenshuai","family":"Wu","sequence":"first","affiliation":[{"name":"Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaozhe","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Suo","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hydraulic Engineering, College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jin","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, China"},{"name":"Huzhou Institute of Zhejiang University, Huzhou 313002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4322-2522","authenticated-orcid":false,"given":"Ying","family":"Mu","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D2LC01095J\/cit1\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1756287219832172","volume":"11","author":"Medina","year":"2019","journal-title":"Ther. Adv. Urol."},{"key":"D2LC01095J\/cit2\/1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators","year":"2018","journal-title":"Lancet"},{"key":"D2LC01095J\/cit3\/1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJMcp1104429","volume":"366","author":"Hooton","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"D2LC01095J\/cit4\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","volume":"13","author":"Flores-Mireles","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"Suppl 1","key":"D2LC01095J\/cit5\/1","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1093\/jac\/dkn241","volume":"62","author":"Hawkey","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"D2LC01095J\/cit6\/1","doi-asserted-by":"crossref","first-page":"e1700750","DOI":"10.1002\/biot.201700750","volume":"14","author":"Maugeri","year":"2019","journal-title":"Biotechnol. J."},{"key":"D2LC01095J\/cit7\/1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1086\/647952","volume":"49","author":"Jorgensen","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"D2LC01095J\/cit8\/1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.7150\/thno.19217","volume":"7","author":"Syal","year":"2017","journal-title":"Theranostics"},{"key":"D2LC01095J\/cit9\/1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10529-018-02638-2","volume":"41","author":"Khan","year":"2019","journal-title":"Biotechnol. Lett."},{"key":"D2LC01095J\/cit10\/1","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1039\/D0SC01353F","volume":"11","author":"Zhang","year":"2020","journal-title":"Chem. Sci."},{"key":"D2LC01095J\/cit11\/1","doi-asserted-by":"publisher","DOI":"10.1101\/199505","volume-title":"bioRxiv","author":"Pivetal","year":"2018","unstructured":"J.Pivetal ,  M. J.Woodward ,  N. M.Reis  and  A. D.Edwards ,  bioRxiv ,  2018 , preprint,  10.1101\/199505"},{"key":"D2LC01095J\/cit12\/1","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3201\/eid2109.150512","volume":"21","author":"Fridkin","year":"2015","journal-title":"Emerging Infect. Dis."},{"key":"D2LC01095J\/cit13\/1","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1073\/pnas.1922172117","volume":"117","author":"Yang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2LC01095J\/cit14\/1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1039\/D0LC00937G","volume":"21","author":"Scherer","year":"2021","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit15\/1","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1039\/C4LC00451E","volume":"14","author":"Hou","year":"2014","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit16\/1","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1039\/C8LC00042E","volume":"18","author":"Tang","year":"2018","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit17\/1","doi-asserted-by":"crossref","first-page":"10270","DOI":"10.1073\/pnas.1819569116","volume":"116","author":"Li","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2LC01095J\/cit18\/1","doi-asserted-by":"crossref","first-page":"14137","DOI":"10.1021\/acs.analchem.8b03817","volume":"90","author":"Azizi","year":"2018","journal-title":"Anal. Chem."},{"key":"D2LC01095J\/cit19\/1","doi-asserted-by":"crossref","first-page":"19581","DOI":"10.1021\/acsami.0c23096","volume":"13","author":"Azizi","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D2LC01095J\/cit20\/1","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1039\/D1LC00216C","volume":"21","author":"Osaid","year":"2021","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit21\/1","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1039\/D1LC00296A","volume":"21","author":"Liu","year":"2021","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit22\/1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1021\/acs.analchem.0c04095","volume":"93","author":"Chen","year":"2021","journal-title":"Anal. Chem."},{"key":"D2LC01095J\/cit23\/1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1039\/b804911d","volume":"8","author":"Boedicker","year":"2008","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit24\/1","doi-asserted-by":"crossref","first-page":"9170","DOI":"10.1073\/pnas.1708558114","volume":"114","author":"Baltekin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2LC01095J\/cit25\/1","doi-asserted-by":"crossref","first-page":"eaal3693","DOI":"10.1126\/scitranslmed.aal3693","volume":"9","author":"Schoepp","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"D2LC01095J\/cit26\/1","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1073\/pnas.1703736114","volume":"114","author":"Avesar","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2LC01095J\/cit27\/1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1039\/C9LC00684B","volume":"20","author":"Kao","year":"2020","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit28\/1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1039\/C2LC20887C","volume":"12","author":"Cira","year":"2012","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit29\/1","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1021\/acssensors.2c00734","volume":"7","author":"Liu","year":"2022","journal-title":"ACS Sens."},{"key":"D2LC01095J\/cit30\/1","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.3389\/fmicb.2020.01820","volume":"11","author":"Brukner","year":"2020","journal-title":"Front. Microbiol."},{"key":"D2LC01095J\/cit31\/1","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1038\/s41598-020-60381-z","volume":"10","author":"Scheler","year":"2020","journal-title":"Sci. Rep."},{"key":"D2LC01095J\/cit32\/1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.snb.2018.05.047","volume":"270","author":"Lyu","year":"2018","journal-title":"Sens. Actuators, B"},{"key":"D2LC01095J\/cit33\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/acssensors.0c02175","volume":"6","author":"Qin","year":"2021","journal-title":"ACS Sens."},{"key":"D2LC01095J\/cit34\/1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejps.2016.08.042","volume":"95","author":"Kogermann","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"D2LC01095J\/cit35\/1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bios.2017.06.006","volume":"97","author":"Kaushik","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"D2LC01095J\/cit36\/1","doi-asserted-by":"crossref","first-page":"e2101254","DOI":"10.1002\/smtd.202101254","volume":"6","author":"Zhang","year":"2022","journal-title":"Small Methods"},{"key":"D2LC01095J\/cit37\/1","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1039\/D1AN00039J","volume":"146","author":"Zhang","year":"2021","journal-title":"Analyst"},{"key":"D2LC01095J\/cit38\/1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1021\/acs.accounts.1c00729","volume":"55","author":"Postek","year":"2022","journal-title":"Acc. Chem. Res."},{"key":"D2LC01095J\/cit39\/1","doi-asserted-by":"crossref","first-page":"8908","DOI":"10.1002\/anie.201301524","volume":"52","author":"Jakiela","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2LC01095J\/cit40\/1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1039\/C3LC51327K","volume":"14","author":"Zhu","year":"2014","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit41\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.aca.2020.02.010","volume":"1107","author":"Cui","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"D2LC01095J\/cit42\/1","doi-asserted-by":"crossref","first-page":"121426","DOI":"10.1016\/j.talanta.2020.121426","volume":"220","author":"Wu","year":"2020","journal-title":"Talanta"},{"key":"D2LC01095J\/cit43\/1","doi-asserted-by":"crossref","first-page":"9449","DOI":"10.1021\/acs.analchem.8b02096","volume":"90","author":"Hsieh","year":"2018","journal-title":"Anal. Chem."},{"key":"D2LC01095J\/cit44\/1","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.snb.2017.10.006","volume":"256","author":"Song","year":"2018","journal-title":"Sens. Actuators, B"},{"key":"D2LC01095J\/cit45\/1","doi-asserted-by":"crossref","first-page":"e00433-18","DOI":"10.1128\/AAC.00433-18","volume":"62","author":"Smith","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"D2LC01095J\/cit46\/1","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1021\/acsnano.0c04177","volume":"14","author":"Yin","year":"2020","journal-title":"ACS Nano"},{"key":"D2LC01095J\/cit47\/1","doi-asserted-by":"crossref","first-page":"12784","DOI":"10.1021\/acs.analchem.9b02344","volume":"91","author":"Athamanolap","year":"2019","journal-title":"Anal. Chem."},{"key":"D2LC01095J\/cit48\/1","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1039\/D2LC00637E","volume":"22","author":"Cao","year":"2022","journal-title":"Lab Chip"},{"key":"D2LC01095J\/cit49\/1","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1039\/D1LC00609F","volume":"21","author":"Sklavounos","year":"2021","journal-title":"Lab Chip"},{"issue":"51","key":"D2LC01095J\/cit50\/1","doi-asserted-by":"crossref","first-page":"17853","DOI":"10.1021\/acs.analchem.2c03604","volume":"94","author":"Wu","year":"2022","journal-title":"Anal. Chem."},{"key":"D2LC01095J\/cit51\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bios.2018.08.030","volume":"120","author":"Gou","year":"2018","journal-title":"Biosens. Bioelectron."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/LC\/D2LC01095J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:41:00Z","timestamp":1782942060000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/23\/10\/2399-2410\/771194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d2lc01095j","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}