{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:21:49Z","timestamp":1782969709814,"version":"3.54.5"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":180,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["For 630"],"award-info":[{"award-number":["For 630"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    The diarylethyne cobalt carbonyl complex NAHO27 selectively induces apoptosis in cancer cells at low \u03bcM concentrations\n                    <jats:italic>via<\/jats:italic>\n                    the mitochondrial pathway. It is also active against resistant cells, showing a strong synergistic effect with vincristine.\n                  <\/jats:p>","DOI":"10.1039\/d2md00144f","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:20:58Z","timestamp":1656584458000},"page":"1044-1051","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells\n                    <i>in vitro<\/i>"],"prefix":"10.1039","volume":"13","author":[{"given":"Liliane","family":"Abodo Onambele","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology, Children's Hospital of the City of Cologne, Amsterdamer Str. 59, 50735 Cologne, Germany"},{"name":"Department of Pediatric Oncology\/Hematology, University Medical Center Charit\u00e9, Campus Virchow, Augustenburger Pl. 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kater","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology, University Medical Center Charit\u00e9, Campus Virchow, Augustenburger Pl. 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hemmersbach","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg-Martin","family":"Neud\u00f6rfl","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Sitnikov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kater","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology, University Medical Center Charit\u00e9, Campus Virchow, Augustenburger Pl. 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corazon","family":"Frias","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology, University Medical Center Charit\u00e9, Campus Virchow, Augustenburger Pl. 1, 13353 Berlin, Germany"},{"name":"Department of Pediatric Hematology\/Oncology, Helios Clinic Schwerin, 19055 Schwerin, Germany"},{"name":"MSH Medical School Hamburg, Am Kaiserkai 1, 20457 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-1827","authenticated-orcid":false,"given":"Hans-G\u00fcnther","family":"Schmalz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Prokop","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology, Children's Hospital of the City of Cologne, Amsterdamer Str. 59, 50735 Cologne, Germany"},{"name":"Department of Pediatric Oncology\/Hematology, University Medical Center Charit\u00e9, Campus Virchow, Augustenburger Pl. 1, 13353 Berlin, Germany"},{"name":"Department of Pediatric Hematology\/Oncology, Helios Clinic Schwerin, 19055 Schwerin, Germany"},{"name":"MSH Medical School Hamburg, Am Kaiserkai 1, 20457 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2MD00144F\/cit1\/1","volume-title":"Cancer Facts & Figures 2021","author":"American-Cancer-Society","year":"2021","unstructured":"American-Cancer-Society ,  Cancer Facts & Figures 2021 ,  A.C.S. Inc. ,  2021"},{"key":"D2MD00144F\/cit2\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000086183","volume":"14","author":"Luqmani","year":"2005","journal-title":"Med. Princ. Pract."},{"key":"D2MD00144F\/cit3\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/1471-2407-9-449","volume":"9","author":"Cho","year":"2009","journal-title":"BMC Cancer"},{"key":"D2MD00144F\/cit4\/1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.7314\/APJCP.2015.16.6.2129","volume":"16","author":"Goldar","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"D2MD00144F\/cit5a\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbpa.2012.01.013","volume":"16","author":"Gasser","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D2MD00144F\/cit5b\/1","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1021\/om300373t","volume":"31","author":"Hartinger","year":"2012","journal-title":"Organometallics"},{"key":"D2MD00144F\/cit5c\/1","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1039\/b905798f","author":"Gianferrara","year":"2009","journal-title":"Dalton Trans."},{"key":"D2MD00144F\/cit6\/1","first-page":"229145b","volume":"107","author":"Hyama","year":"1987","journal-title":"Chem. Abstr."},{"key":"D2MD00144F\/cit7\/1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ardp.19973300604","volume":"330","author":"Jung","year":"1997","journal-title":"Arch. Pharm."},{"key":"D2MD00144F\/cit8a\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0020-1693(00)00139-0","volume":"306","author":"Schmidt","year":"2000","journal-title":"Inorg. Chim. Acta"},{"key":"D2MD00144F\/cit8b\/1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1021\/jm049326z","volume":"48","author":"Ott","year":"2005","journal-title":"J. Med. Chem."},{"key":"D2MD00144F\/cit9\/1","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1039\/c3mt00117b","volume":"5","author":"Zanellato","year":"2013","journal-title":"Metallomics"},{"key":"D2MD00144F\/cit10a\/1","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1039\/c3mt00117b","volume":"5","author":"Zanellato","year":"2013","journal-title":"Metallomics"},{"key":"D2MD00144F\/cit10b\/1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1002\/cmdc.201900426","volume":"14","author":"Ollivier","year":"2019","journal-title":"ChemMedChem"},{"key":"D2MD00144F\/cit10c\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.redox.2018.10.020","volume":"20","author":"Motterlini","year":"2019","journal-title":"Redox Biol."},{"key":"D2MD00144F\/cit10d\/1","doi-asserted-by":"crossref","first-page":"101521","DOI":"10.1016\/j.redox.2020.101521","volume":"34","author":"El Ali","year":"2020","journal-title":"Redox Biol."},{"key":"D2MD00144F\/cit11\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jinorgbio.2012.10.014","volume":"119","author":"Schimler","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"D2MD00144F\/cit12\/1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jinorgbio.2003.12.008","volume":"98","author":"Ott","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"D2MD00144F\/cit13a\/1","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1021\/jm00010a011","volume":"38","author":"Pettit","year":"1995","journal-title":"J. Med. Chem."},{"key":"D2MD00144F\/cit13b\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1470-2045(00)00224-2","volume":"2","author":"Griggs","year":"2001","journal-title":"Lancet Oncol."},{"key":"D2MD00144F\/cit13c\/1","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1021\/jm0512903","volume":"49","author":"Tron","year":"2006","journal-title":"J. Med. Chem."},{"key":"D2MD00144F\/cit13d\/1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1517\/13543780903213697","volume":"18","author":"Delmonte","year":"2009","journal-title":"Expert Opin. Invest. Drugs"},{"key":"D2MD00144F\/cit13e\/1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2217\/fon.10.90","volume":"6","author":"Nagaiah","year":"2010","journal-title":"Future Oncol."},{"key":"D2MD00144F\/cit13f\/1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.pharep.2016.08.007","volume":"68","author":"Jaroch","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"D2MD00144F\/cit13g\/1","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.3390\/molecules25112560","volume":"25","author":"Karatoprak","year":"2020","journal-title":"Molecules"},{"key":"D2MD00144F\/cit14\/1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2174\/1381612811319100013","volume":"19","author":"Rajak","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"D2MD00144F\/cit15\/1","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1021\/ol202176g","volume":"13","author":"Panteleev","year":"2011","journal-title":"Org. Lett."},{"key":"D2MD00144F\/cit16\/1","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1021\/ja031506v","volume":"126","author":"Gehringer","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"D2MD00144F\/cit17\/1","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.tetlet.2009.02.067","volume":"50","author":"Jeffrey","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"D2MD00144F\/cit18\/1","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.1016\/j.tetlet.2007.07.151","volume":"48","author":"Lara-Ochoa","year":"2007","journal-title":"Tetrahedron Lett."},{"key":"D2MD00144F\/cit19\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4939-7477-1_9","volume":"1709","author":"Kabakov","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"D2MD00144F\/cit20\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0960-9822(98)70182-4","volume":"8","author":"Z\u00f6rnig","year":"1998","journal-title":"Curr. Biol."},{"key":"D2MD00144F\/cit21\/1","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1021\/bi00232a015","volume":"30","author":"Reers","year":"1991","journal-title":"Biochemistry"},{"key":"D2MD00144F\/cit22\/1","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1093\/emboj\/20.23.6627","volume":"20","author":"Adrain","year":"2001","journal-title":"EMBO J."},{"key":"D2MD00144F\/cit23\/1","first-page":"497","volume":"19","author":"Kerridge","year":"1958","journal-title":"Microbiology"},{"key":"D2MD00144F\/cit24\/1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00432-010-0924-6","volume":"137","author":"Kater","year":"2011","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"D2MD00144F\/cit25\/1","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1021\/acsomega.1c04659","volume":"7","author":"Stein","year":"2022","journal-title":"ACS Omega"},{"key":"D2MD00144F\/cit26\/1","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1021\/acs.jmedchem.7b01457","volume":"61","author":"Waghray","year":"2018","journal-title":"J. Med. Chem."},{"key":"D2MD00144F\/cit27\/1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1093\/emboj\/16.7.1686","volume":"16","author":"Inohara","year":"1997","journal-title":"EMBO J."},{"key":"D2MD00144F\/cit28\/1","first-page":"39","volume":"18","author":"Xu","year":"2019","journal-title":"Biosci. Rep."},{"key":"D2MD00144F\/cit29\/1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.semcancer.2015.03.001","volume":"35","author":"Mohammad","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"D2MD00144F\/cit30\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"D2MD00144F\/cit31\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","volume":"17","author":"Carneiro","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D2MD00144F\/cit32\/1","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.3390\/ijms21093233","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D2MD00144F\/cit33\/1","doi-asserted-by":"crossref","first-page":"e0233993","DOI":"10.1371\/journal.pone.0233993","volume":"15","author":"Zahra","year":"2020","journal-title":"PLoS One"},{"key":"D2MD00144F\/cit34\/1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2174\/138945006777709593","volume":"7","author":"Nobili","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"D2MD00144F\/cit35\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01871776","volume":"111","author":"Lambert","year":"1989","journal-title":"J. Membr. Biol."},{"key":"D2MD00144F\/cit36\/1","doi-asserted-by":"crossref","first-page":"a006080","DOI":"10.1101\/cshperspect.a006080","volume":"7","author":"Green","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"D2MD00144F\/cit37\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1756-9966-27-48","volume":"27","author":"Martinez-Ruiz","year":"2008","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"D2MD00144F\/cit38\/1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0006-291X(69)90351-9","volume":"36","author":"McKeehan","year":"1969","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D2MD00144F\/cit39\/1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3748\/wjg.v13.i6.851","volume":"13","author":"Ustundag","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"D2MD00144F\/cit40\/1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/hep.510230641","volume":"23","author":"Bulera","year":"1996","journal-title":"Hepatology"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/MD\/D2MD00144F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:08:48Z","timestamp":1782965328000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/13\/9\/1044-1051\/772063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d2md00144f","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}