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BioSyst."},{"key":"D2MD00175F\/cit121\/1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.bmcl.2016.01.080","volume":"26","author":"Telpoukhovskaia","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D2MD00175F\/cit122\/1","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1039\/c3dt50406a","volume":"42","author":"Nunes","year":"2013","journal-title":"Dalton Trans."},{"key":"D2MD00175F\/cit123\/1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nchem.1243","volume":"4","author":"Bickerton","year":"2012","journal-title":"Nat. Chem."},{"key":"D2MD00175F\/cit124\/1","doi-asserted-by":"crossref","first-page":"112350","DOI":"10.1016\/j.ejmech.2020.112350","volume":"198","author":"Bortolami","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D2MD00175F\/cit125\/1","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.3390\/ijms21165628","volume":"21","author":"Kladnik","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D2MD00175F\/cit126\/1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2174\/138955708784567395","volume":"8","author":"Montuschi","year":"2008","journal-title":"Mini-Rev. Med. Chem."},{"key":"D2MD00175F\/cit127\/1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.pharmthera.2006.05.009","volume":"112","author":"Werz","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"D2MD00175F\/cit128\/1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1165\/rcmb.2005-0336RC","volume":"34","author":"Zaman","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"D2MD00175F\/cit129\/1","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"D2MD00175F\/cit130\/1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/ng.389","volume":"41","author":"Chen","year":"2009","journal-title":"Nat. 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Lett."},{"key":"D2MD00175F\/cit150\/1","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1021\/ic026029g","volume":"42","author":"Puerta","year":"2003","journal-title":"Inorg. Chem."},{"key":"D2MD00175F\/cit151\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00775-005-0053-x","volume":"11","author":"Puerta","year":"2006","journal-title":"J. Biol. Inorg. Chem."},{"key":"D2MD00175F\/cit152\/1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/cmdc.200700290","volume":"3","author":"Agrawal","year":"2008","journal-title":"ChemMedChem"},{"key":"D2MD00175F\/cit153\/1","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1021\/ol0707665","volume":"9","author":"Yan","year":"2007","journal-title":"Org. Lett."},{"key":"D2MD00175F\/cit154\/1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/FJC.0b013e3181a6aa83","volume":"53","author":"Romero-Perez","year":"2009","journal-title":"J. Cardiovasc. 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