{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:23:27Z","timestamp":1782937407196,"version":"3.54.5"},"reference-count":104,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT212969\/Z\/18\/Z"],"award-info":[{"award-number":["WT212969\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C309\/A11566"],"award-info":[{"award-number":["C309\/A11566"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C2739\/A22897"],"award-info":[{"award-number":["C2739\/A22897"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C35696\/A23187"],"award-info":[{"award-number":["C35696\/A23187"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000650","name":"Institute of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000650","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009272","name":"Chordoma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>A brief history of milestones leading to selection and use guidelines for high-quality chemical probes. We highlight their importance to study protein function and illustrate examples of recently developed probes acting through different modalities.<\/jats:p>","DOI":"10.1039\/d2md00291d","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:01:36Z","timestamp":1669618896000},"page":"1446-1459","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["The era of high-quality chemical probes"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3197-4855","authenticated-orcid":false,"given":"Marco P.","family":"Licciardello","sequence":"first","affiliation":[{"name":"Centre for Cancer Drug Discovery, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-3034","authenticated-orcid":false,"given":"Paul","family":"Workman","sequence":"additional","affiliation":[{"name":"Centre for Cancer Drug Discovery, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK"},{"name":"The Chemical Probes Portal, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2MD00291D\/cit1\/1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"D2MD00291D\/cit2\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"D2MD00291D\/cit3\/1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrg3502","volume":"14","author":"Parkes","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"D2MD00291D\/cit4\/1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nrd.2018.52","volume":"17","author":"Oprea","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit5\/1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41592-022-01454-x","volume":"19","author":"Kustatscher","year":"2022","journal-title":"Nat. Methods"},{"key":"D2MD00291D\/cit6\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/470163a","volume":"470","author":"Edwards","year":"2011","journal-title":"Nature"},{"key":"D2MD00291D\/cit7\/1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.chembiol.2010.05.013","volume":"17","author":"Workman","year":"2010","journal-title":"Chem. Biol."},{"key":"D2MD00291D\/cit8\/1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ccell.2017.07.010","volume":"32","author":"Blagg","year":"2017","journal-title":"Cancer Cell"},{"key":"D2MD00291D\/cit9\/1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tips.2020.02.006","volume":"41","author":"Kostic","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"D2MD00291D\/cit10\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ddtec.2019.02.002","volume":"31","author":"Chopra","year":"2019","journal-title":"Drug Discovery Today: Technol."},{"key":"D2MD00291D\/cit11\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cell.2020.12.020","volume":"184","author":"Schreiber","year":"2021","journal-title":"Cell"},{"key":"D2MD00291D\/cit12\/1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/d41573-021-00052-4","volume":"20","author":"Mullard","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit13\/1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrd.2016.29","volume":"15","author":"Scott","year":"2016","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit14\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cbpa.2018.06.004","volume":"44","author":"Ran","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D2MD00291D\/cit15\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem. J."},{"key":"D2MD00291D\/cit16\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/BJ20091428","volume":"425","author":"Cohen","year":"2009","journal-title":"Biochem. J."},{"key":"D2MD00291D\/cit17\/1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nchembio.296","volume":"6","author":"Frye","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit18\/1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nchembio.1197","volume":"9","author":"Bunnage","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit19\/1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nchembio.1867","volume":"11","author":"Arrowsmith","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit20\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1053\/j.seminoncol.2016.06.001","volume":"43","author":"Banerji","year":"2016","journal-title":"Semin. Oncol."},{"key":"D2MD00291D\/cit21\/1","first-page":"23","volume":"21","author":"Rossanese","year":"2016","journal-title":"Radio Sci."},{"key":"D2MD00291D\/cit22\/1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nrd3287","volume":"9","author":"Smith","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit23\/1","doi-asserted-by":"crossref","first-page":"320ps321","DOI":"10.1126\/scitranslmed.aac9888","volume":"8","author":"Kleiman","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"D2MD00291D\/cit24\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/513481a","volume":"513","author":"Baell","year":"2014","journal-title":"Nature"},{"key":"D2MD00291D\/cit25\/1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.chembiol.2021.01.021","volume":"28","author":"Dahlin","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"D2MD00291D\/cit26\/1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1021\/acschembio.1c00036","volume":"16","author":"Lee","year":"2021","journal-title":"ACS Chem. Biol."},{"key":"D2MD00291D\/cit27\/1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nchembio0709-441","volume":"5","author":"Oprea","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit28\/1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/d41573-019-00159-9","volume":"18","author":"Mullard","year":"2019","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"D2MD00291D\/cit30\/1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature13229","volume":"510","author":"Asangani","year":"2014","journal-title":"Nature"},{"key":"D2MD00291D\/cit31\/1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nchembio.2080","volume":"12","author":"Sdelci","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit32\/1","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/acs.jmedchem.8b01947","volume":"62","author":"Watts","year":"2019","journal-title":"J. Med. Chem."},{"key":"D2MD00291D\/cit33\/1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/s41467-019-09672-2","volume":"10","author":"Wu","year":"2019","journal-title":"Nat. Commun."},{"key":"D2MD00291D\/cit34\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41467-018-07905-4","volume":"10","author":"Scheer","year":"2019","journal-title":"Nat. Commun."},{"key":"D2MD00291D\/cit35\/1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.chembiol.2020.12.013","volume":"28","author":"Wells","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"D2MD00291D\/cit36\/1","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1021\/acs.jmedchem.9b01382","volume":"62","author":"Wortmann","year":"2019","journal-title":"J. Med. Chem."},{"key":"D2MD00291D\/cit37\/1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/d41573-022-00071-9","volume":"21","author":"Gollner","year":"2022","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit38\/1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4155\/fmc-2019-0231","volume":"13","author":"Antolin","year":"2021","journal-title":"Future Med. Chem."},{"key":"D2MD00291D\/cit39\/1","first-page":"3757","volume-title":"Nat. Commun.","volume":"13","year":"2022","unstructured":"Nat. Commun. ,  2022 ,  13 ,  3757"},{"key":"D2MD00291D\/cit40\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/D1MD00228G","volume":"13","author":"M\u00fcller","year":"2022","journal-title":"RSC Med. Chem."},{"key":"D2MD00291D\/cit41\/1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac909","author":"Antolin","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"D2MD00291D\/cit42\/1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.chembiol.2017.11.004","volume":"25","author":"Antolin","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"D2MD00291D\/cit43\/1","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkaa1059","volume":"49","author":"Mitsopoulos","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"D2MD00291D\/cit44\/1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/527545a","volume":"527","author":"Baker","year":"2015","journal-title":"Nature"},{"key":"D2MD00291D\/cit45\/1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nchembio1207-739","volume":"3","author":"Weiss","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit46\/1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.molcel.2015.04.028","volume":"58","author":"Boettcher","year":"2015","journal-title":"Mol. Cell"},{"issue":"509","key":"D2MD00291D\/cit47\/1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw8412","volume":"11","author":"Lin","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"D2MD00291D\/cit48\/1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41576-020-0247-7","volume":"21","author":"Lin","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"D2MD00291D\/cit49\/1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.tibtech.2018.06.008","volume":"36","author":"Drewes","year":"2018","journal-title":"Trends Biotechnol."},{"key":"D2MD00291D\/cit50\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cels.2017.11.001","volume":"6","author":"Keenan","year":"2018","journal-title":"Cell Syst."},{"key":"D2MD00291D\/cit51\/1","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"D2MD00291D\/cit52\/1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"D2MD00291D\/cit53\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbapap.2007.08.017","volume":"1784","author":"Duncan","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"D2MD00291D\/cit54\/1","doi-asserted-by":"crossref","first-page":"10288","DOI":"10.1158\/0008-5472.CAN-10-1893","volume":"70","author":"Siddiqui-Jain","year":"2010","journal-title":"Cancer Res."},{"key":"D2MD00291D\/cit55\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tips.2021.02.002","volume":"42","author":"Licciardello","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"D2MD00291D\/cit56\/1","doi-asserted-by":"publisher","DOI":"10.3390\/ph10010007","volume":"10","author":"Castello","year":"2017","journal-title":"Pharmaceuticals"},{"key":"D2MD00291D\/cit57\/1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2020.06.034","volume":"182","author":"Bouhaddou","year":"2020","journal-title":"Cell"},{"key":"D2MD00291D\/cit58\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrm.2016.81","volume":"17","author":"Hendriks","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D2MD00291D\/cit59\/1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1212728","volume":"335","author":"Kessler","year":"2012","journal-title":"Science"},{"key":"D2MD00291D\/cit60\/1","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1038\/onc.2014.319","volume":"34","author":"Licciardello","year":"2015","journal-title":"Oncogene"},{"key":"D2MD00291D\/cit61\/1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.phrs.2016.01.004","volume":"107","author":"Licciardello","year":"2016","journal-title":"Pharmacol. Res."},{"key":"D2MD00291D\/cit62\/1","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nchembio.2463","volume":"13","author":"He","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit63\/1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/nchembio.2496","volume":"13","author":"Schneekloth, Jr.","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit64\/1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1182\/blood-2014-06-584524","volume":"124","author":"Hoellein","year":"2014","journal-title":"Blood"},{"key":"D2MD00291D\/cit65\/1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.tibs.2015.09.006","volume":"40","author":"Eifler","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"D2MD00291D\/cit66\/1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nm.3048","volume":"19","author":"Souers","year":"2013","journal-title":"Nat.\nMed."},{"key":"D2MD00291D\/cit67\/1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1158\/2159-8290.CD-13-0609","volume":"4","author":"Pan","year":"2014","journal-title":"Cancer Discovery"},{"key":"D2MD00291D\/cit68\/1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nchembio.1246","volume":"9","author":"Lessene","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit69\/1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/ml5001867","volume":"5","author":"Tao","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"D2MD00291D\/cit70\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2017.06.009","volume":"170","author":"Simanshu","year":"2017","journal-title":"Cell"},{"key":"D2MD00291D\/cit71\/1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature12796","volume":"503","author":"Ostrem","year":"2013","journal-title":"Nature"},{"key":"D2MD00291D\/cit72\/1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.cell.2018.01.006","volume":"172","author":"Janes","year":"2018","journal-title":"Cell"},{"key":"D2MD00291D\/cit73\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41586-019-1694-1","volume":"575","author":"Canon","year":"2019","journal-title":"Nature"},{"key":"D2MD00291D\/cit74\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1021\/acs.jmedchem.9b01180","volume":"63","author":"Lanman","year":"2020","journal-title":"J. Med. Chem."},{"key":"D2MD00291D\/cit75\/1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1021\/acsmedchemlett.8b00382","volume":"9","author":"Fell","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"D2MD00291D\/cit76\/1","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.1021\/acs.jmedchem.9b02052","volume":"63","author":"Fell","year":"2020","journal-title":"J. Med. Chem."},{"key":"D2MD00291D\/cit77\/1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/2159-8290.CD-19-1167","volume":"10","author":"Hallin","year":"2020","journal-title":"Cancer Discovery"},{"key":"D2MD00291D\/cit78\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pharmthera.2017.02.008","volume":"173","author":"Whittaker","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"D2MD00291D\/cit79\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJMoa1505270","volume":"373","author":"Turner","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"D2MD00291D\/cit80\/1","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1056\/NEJMoa1609709","volume":"375","author":"Hortobagyi","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"D2MD00291D\/cit81\/1","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1200\/JCO.2017.75.6155","volume":"35","author":"Goetz","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"D2MD00291D\/cit82\/1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.chembiol.2018.11.006","volume":"26","author":"Brand","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"D2MD00291D\/cit83\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nchembio.2538","volume":"14","author":"Olson","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit84\/1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nchembio.1952","volume":"11","author":"Dale","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit85\/1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1021\/acs.jmedchem.5b01685","volume":"59","author":"Mallinger","year":"2016","journal-title":"J. Med. Chem."},{"key":"D2MD00291D\/cit86\/1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20722","volume":"5","author":"Clarke","year":"2016","journal-title":"eLife"},{"key":"D2MD00291D\/cit87\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nature13393","volume":"511","author":"Kwiatkowski","year":"2014","journal-title":"Nature"},{"key":"D2MD00291D\/cit88\/1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nchembio.2166","volume":"12","author":"Zhang","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit89\/1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41589-021-00765-y","volume":"17","author":"Jiang","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"D2MD00291D\/cit90\/1","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.drudis.2019.06.020","volume":"24","author":"Carter","year":"2019","journal-title":"Drug Discovery Today"},{"issue":"6424","key":"D2MD00291D\/cit91\/1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0805","volume":"363","author":"Campos","year":"2019","journal-title":"Science"},{"key":"D2MD00291D\/cit92\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrd.2018.53","volume":"17","author":"Gerry","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit93\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrd.2016.213","volume":"16","author":"Goodnow, Jr.","year":"2017","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit94\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrd.2018.77","volume":"17","author":"Renaud","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit95\/1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"D2MD00291D\/cit96\/1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-021-03828-1","volume":"596","author":"Tunyasuvunakool","year":"2021","journal-title":"Nature"},{"key":"D2MD00291D\/cit97\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cell.2016.12.029","volume":"168","author":"Parker","year":"2017","journal-title":"Cell"},{"key":"D2MD00291D\/cit98\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41586-019-0917-9","volume":"566","author":"Lyu","year":"2019","journal-title":"Nature"},{"key":"D2MD00291D\/cit99\/1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrd.2017.111","volume":"16","author":"Moffat","year":"2017","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit100\/1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/acs.jmedchem.6b01055","volume":"60","author":"Cheeseman","year":"2017","journal-title":"J. Med. Chem."},{"key":"D2MD00291D\/cit101\/1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.chembiol.2016.03.008","volume":"23","author":"Sch\u00fcrmann","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"D2MD00291D\/cit102\/1","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.4155\/fmc-2018-0212","volume":"10","author":"Sellwood","year":"2018","journal-title":"Future Med. Chem."},{"key":"D2MD00291D\/cit103\/1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrd.2017.252","volume":"17","author":"Rodgers","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2MD00291D\/cit104\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/d41573-020-00056-6","volume":"19","author":"Superti-Furga","year":"2020","journal-title":"Nat. Rev. Drug Discovery"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/MD\/D2MD00291D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:27:04Z","timestamp":1782930424000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/13\/12\/1446-1459\/772118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":104,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d2md00291d","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}