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African American\/Black adults have higher incidence and mortality rates from sepsis compared to Non-Hispanic White adults. A limited number of studies have traced survival outcomes to molecular changes; however, these studies primarily only included Non-Hispanic White adults. Our goal is to better understand molecular changes that may contribute to differences in sepsis survival in African American\/Black and Non-Hispanic White adults with primary intra-abdominal infection. We employed discovery-based plasma proteomics of patient samples from the Protocolized Care for Early Septic Shock (ProCESS) cohort (N = 107). We identified 49 proteins involved in the acute phase response and complement system whose expression levels are associated with both survival outcome and racial background. Additionally, 82 proteins differentially-expressed in survivors were specific to African American\/Black or Non-Hispanic White patients, suggesting molecular-level heterogeneity in sepsis patients in key inflammatory pathways. A smaller, robust set of 19 proteins were in common in African American\/Black and Non-Hispanic White survivors and may represent potential universal molecular changes in sepsis. Overall, this study identifies molecular factors that may contribute to differences in survival outcomes in African American\/Black patients that are not fully explained by socioeconomic or other non-biological factors.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d2mo00171c","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T04:39:31Z","timestamp":1663043971000},"page":"923-937","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Proteomic changes associated with racial background and sepsis survival outcomes"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-8569","authenticated-orcid":false,"given":"Kathryn L","family":"Kapp","sequence":"first","affiliation":[{"name":"The Vanderbilt Institute of Chemical Biology, Vanderbilt University b , Nashville, TN, 32732, USA \u00a0 rena.as.robinson@vanderbilt.edu \u00a0 +1-615-343-1234 \u00a0 +1-615-343-0129"},{"name":"Department of Chemistry, Vanderbilt University a , 5423 Stevenson Center, Nashville, TN, 37235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert B","family":"Arul","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Vanderbilt University a , 5423 Stevenson Center, Nashville, TN, 37235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center c , Nashville, TN, 37203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Du","sequence":"additional","affiliation":[{"name":"Vanderbilt Center for Quantitative Sciences, Vanderbilt University Medical Center d , Nashville, TN, 37232, USA"},{"name":"Department of Biostatistics, Vanderbilt University Medical Center c , Nashville, TN, 37203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Yende","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Science, University of Pittsburgh g , PA, 15261, USA"},{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh f , PA, 15213, USA"},{"name":"The Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh e , PA, 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Kellum","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh f , PA, 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek C","family":"Angus","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Science, University of Pittsburgh g , PA, 15261, USA"},{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh f , PA, 15213, USA"},{"name":"The Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh e , PA, 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavia M","family":"Peck-Palmer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh h , Pittsburgh, PA, 15213, USA"},{"name":"Department of Clinical and Translational Science, University of Pittsburgh g , PA, 15261, USA"},{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh f , PA, 15213, USA"},{"name":"The Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh e , PA, 15213, 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